PE20020407A1 - Derivados de quinazolina como antagonistas del receptor adrenergico alfa-1 - Google Patents
Derivados de quinazolina como antagonistas del receptor adrenergico alfa-1Info
- Publication number
- PE20020407A1 PE20020407A1 PE2001000870A PE2001000870A PE20020407A1 PE 20020407 A1 PE20020407 A1 PE 20020407A1 PE 2001000870 A PE2001000870 A PE 2001000870A PE 2001000870 A PE2001000870 A PE 2001000870A PE 20020407 A1 PE20020407 A1 PE 20020407A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- metil
- amino
- antagonists
- alpha
- Prior art date
Links
- 102000030619 alpha-1 Adrenergic Receptor Human genes 0.000 title abstract 2
- 108020004102 alpha-1 Adrenergic Receptor Proteins 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title abstract 2
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical class N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 101100295738 Gallus gallus COR3 gene Proteins 0.000 abstract 1
- 201000001880 Sexual dysfunction Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 231100000872 sexual dysfunction Toxicity 0.000 abstract 1
- 210000001635 urinary tract Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Psychiatry (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS DE FORMULA I DONDE R1 ES H, ALQUILO C1-C6; R2 ES ALQUILO C1-C6, HETEROCICLILO CON ARILO, ALCOXI, HALOGENO; R' Y R'' SON ALQUILO C1-C6; A ES H, COR3, SO2R3, COOR3, ENTRE OTROS; R3 ES ALQUILO C1-C6, ARILO, ARILALQUILO, HETEROALQUILO, HETEROARILALQUILIO, CICLOALQUILO; R4 Y R5 SON H; R4 Y R5 JUNTO A C FORMAN UN ANILLO DE 5 A 7 MIEMBROS; R6 ES H, ALQUILO, CIANO; n ES 0-2; SON COMPUESTOS PREFERIDOS 1-(4-{[(4-AMINO-6,7-DIMETOXI-QUINAZOLIN-2-IL)-METIL-AMINO]-METIL}-4-FENIL-PIPERIDIN-1-IL)-1-(TETRAHIDRO-FURAN-2-IL)-METANONA, 1-(4-{[(4-AMINO-6,7-DIMETOXI-QUINAZOLIN-2-IL)-METIL-AMINO]-METIL}-4-FENIL-PIPERIDIN-1-IL)-1-PIRROLIDIN-2-IL-METANONA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS MENCIONADOS SON ANTAGONISTAS DEL RECEPTOR ADRENERGICO ALFA-1 Y SON UTILES PARA EL TRATAMIENTO DE LA DISFUNCION SEXUAL, TRASTORNOS DEL TRACTO URINARIO
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22950300P | 2000-08-31 | 2000-08-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020407A1 true PE20020407A1 (es) | 2002-05-21 |
Family
ID=22861517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001000870A PE20020407A1 (es) | 2000-08-31 | 2001-08-29 | Derivados de quinazolina como antagonistas del receptor adrenergico alfa-1 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6559153B2 (es) |
| EP (1) | EP1315714B1 (es) |
| JP (1) | JP3971299B2 (es) |
| KR (1) | KR100602929B1 (es) |
| CN (1) | CN1308324C (es) |
| AR (1) | AR032475A1 (es) |
| AT (1) | ATE309240T1 (es) |
| AU (2) | AU9378801A (es) |
| BR (1) | BR0113585A (es) |
| CA (1) | CA2420177C (es) |
| DE (1) | DE60114852T2 (es) |
| ES (1) | ES2251512T3 (es) |
| GT (1) | GT200100181A (es) |
| MX (1) | MXPA03001777A (es) |
| PA (1) | PA8527901A1 (es) |
| PE (1) | PE20020407A1 (es) |
| UY (1) | UY26919A1 (es) |
| WO (1) | WO2002018348A2 (es) |
| ZA (1) | ZA200301082B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003014122A1 (en) * | 2001-08-10 | 2003-02-20 | Polychip Pharmaceuticals Pty Ltd | Derivatives of morphine-like opioid compounds |
| AU2003219199A1 (en) * | 2002-04-03 | 2003-10-13 | Orion Corporation | Use of an alfa2-adrenoreceptor antagonist for cns-related diseases |
| TW200403058A (en) * | 2002-04-19 | 2004-03-01 | Bristol Myers Squibb Co | Heterocyclo inhibitors of potassium channel function |
| ITMI20030151A1 (it) * | 2003-01-30 | 2004-07-31 | Recordati Ind Chimica E Farma Ceutica S P A | Uso di antagonisti selettivi del recettore mglu5 per il trattamento di disfunzioni neuromuscolari del tratto urinario inferiore. |
| EP1646615B1 (en) * | 2003-06-06 | 2009-08-26 | Vertex Pharmaceuticals Incorporated | Pyrimidine derivatives as modulators of atp-binding cassette transporters |
| DK1648878T3 (da) * | 2003-07-24 | 2009-08-10 | Euro Celtique Sa | Piperidinforbindelser og farmaceutiske sammensætninger, som indeholder dem |
| WO2006021345A2 (en) * | 2004-08-27 | 2006-03-02 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with adrenergic alpha-1b receptor (adra1b) |
| MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
| US7413607B2 (en) * | 2005-03-31 | 2008-08-19 | 3M Innovative Properties Company | Templated semiconductor particles and methods of making |
| US7344583B2 (en) * | 2005-03-31 | 2008-03-18 | 3M Innovative Properties Company | Methods of making metal particles within cored dendrimers |
| ATE449082T1 (de) * | 2005-05-04 | 2009-12-15 | Hoffmann La Roche | (3,4-dihydro-chinazolin-2-yl)-(2-aryloxy-ethyl) amine mit aktivität am 5-ht-rezeptor |
| EP2043655A2 (en) | 2006-04-25 | 2009-04-08 | Astex Therapeutics Limited | Purine and deazapurine derivatives as pharmaceutical compounds |
| JP5144666B2 (ja) * | 2006-09-19 | 2013-02-13 | スリーエム イノベイティブ プロパティズ カンパニー | 鋳型化された金属酸化物粒子及び製造方法 |
| PL2201012T3 (pl) | 2007-10-11 | 2014-11-28 | Astrazeneca Ab | Pochodne pirolo[2,3-d]pirymidyny jako inhibitory kinazy białkowej b |
| TW200944526A (en) | 2008-04-22 | 2009-11-01 | Vitae Pharmaceuticals Inc | Carbamate and urea inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| ES2761311T3 (es) | 2011-04-01 | 2020-05-19 | Astrazeneca Ab | Tratamiento terapéutico |
| MY175800A (en) | 2011-11-30 | 2020-07-09 | Astrazeneca Ab | Combination treatment of cancer |
| AU2013204533B2 (en) | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
| BR112019018774A2 (pt) | 2017-03-12 | 2020-04-07 | Wang Xiaodong | composto tendo uma estrutura de acordo com a fórmula i, sal farmaceuticamente aceitável, composição farmacêutica, método para prevenir ou tratar uma doença ou afeção e método para imunomodulação, inibição ou prevenção de rejeição de enxertos de órgãos ou pele ou tratamento de tumores ou câncer |
| WO2019088095A1 (ja) * | 2017-11-02 | 2019-05-09 | 国立大学法人九州大学 | 鎮痛剤及びその使用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0853479A4 (en) | 1995-09-29 | 2001-04-11 | Merck & Co Inc | ALPHA 1b ADRENERGIC RECEPTOR ANTAGONISTS |
| GB9526546D0 (en) * | 1995-12-23 | 1996-02-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9700504D0 (en) | 1997-01-11 | 1997-02-26 | Pfizer Ltd | Pharmaceutical compounds |
| US6355641B1 (en) | 1999-03-17 | 2002-03-12 | Syntex (U.S.A.) Llc | Oxazolone derivatives and uses thereof |
-
2001
- 2001-08-23 AU AU9378801A patent/AU9378801A/xx active Pending
- 2001-08-23 BR BR0113585-6A patent/BR0113585A/pt not_active IP Right Cessation
- 2001-08-23 EP EP01974210A patent/EP1315714B1/en not_active Expired - Lifetime
- 2001-08-23 AU AU2001293788A patent/AU2001293788B2/en not_active Ceased
- 2001-08-23 CA CA002420177A patent/CA2420177C/en not_active Expired - Fee Related
- 2001-08-23 MX MXPA03001777A patent/MXPA03001777A/es active IP Right Grant
- 2001-08-23 KR KR1020037002933A patent/KR100602929B1/ko not_active IP Right Cessation
- 2001-08-23 AT AT01974210T patent/ATE309240T1/de not_active IP Right Cessation
- 2001-08-23 CN CNB018165958A patent/CN1308324C/zh not_active Expired - Fee Related
- 2001-08-23 JP JP2002523466A patent/JP3971299B2/ja not_active Expired - Fee Related
- 2001-08-23 WO PCT/EP2001/009749 patent/WO2002018348A2/en active IP Right Grant
- 2001-08-23 DE DE60114852T patent/DE60114852T2/de not_active Expired - Fee Related
- 2001-08-23 ES ES01974210T patent/ES2251512T3/es not_active Expired - Lifetime
- 2001-08-29 US US09/942,385 patent/US6559153B2/en not_active Expired - Fee Related
- 2001-08-29 PE PE2001000870A patent/PE20020407A1/es not_active Application Discontinuation
- 2001-08-30 PA PA20018527901A patent/PA8527901A1/es unknown
- 2001-08-30 UY UY26919A patent/UY26919A1/es not_active Application Discontinuation
- 2001-08-30 GT GT200100181A patent/GT200100181A/es unknown
- 2001-08-30 AR ARP010104130A patent/AR032475A1/es unknown
-
2003
- 2003-02-07 ZA ZA200301082A patent/ZA200301082B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR032475A1 (es) | 2003-11-12 |
| WO2002018348A3 (en) | 2002-07-11 |
| CA2420177C (en) | 2008-07-08 |
| US6559153B2 (en) | 2003-05-06 |
| KR100602929B1 (ko) | 2006-07-20 |
| JP3971299B2 (ja) | 2007-09-05 |
| BR0113585A (pt) | 2003-07-29 |
| EP1315714B1 (en) | 2005-11-09 |
| UY26919A1 (es) | 2002-02-28 |
| WO2002018348A2 (en) | 2002-03-07 |
| EP1315714A2 (en) | 2003-06-04 |
| ES2251512T3 (es) | 2006-05-01 |
| PA8527901A1 (es) | 2002-07-30 |
| AU9378801A (en) | 2002-03-13 |
| GT200100181A (es) | 2002-05-23 |
| MXPA03001777A (es) | 2003-06-04 |
| DE60114852T2 (de) | 2006-07-27 |
| CA2420177A1 (en) | 2002-03-07 |
| AU2001293788B2 (en) | 2007-10-11 |
| KR20030022421A (ko) | 2003-03-15 |
| JP2004507527A (ja) | 2004-03-11 |
| ZA200301082B (en) | 2004-05-07 |
| DE60114852D1 (de) | 2005-12-15 |
| CN1545510A (zh) | 2004-11-10 |
| CN1308324C (zh) | 2007-04-04 |
| US20020045614A1 (en) | 2002-04-18 |
| ATE309240T1 (de) | 2005-11-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |