GT200100181A - Derivados de quinazolina como antagonistas adrenergicos alfa-1. - Google Patents

Derivados de quinazolina como antagonistas adrenergicos alfa-1.

Info

Publication number
GT200100181A
GT200100181A GT200100181A GT200100181A GT200100181A GT 200100181 A GT200100181 A GT 200100181A GT 200100181 A GT200100181 A GT 200100181A GT 200100181 A GT200100181 A GT 200100181A GT 200100181 A GT200100181 A GT 200100181A
Authority
GT
Guatemala
Prior art keywords
racemic
alfa
quinazoline
derivatives
adrenergic antagonists
Prior art date
Application number
GT200100181A
Other languages
English (en)
Inventor
Cyrus Kephra Becker
Chris Richard Melville
Juerg Roland Pfister
Xiaoming Zhang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200100181A publication Critical patent/GT200100181A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

LA PRESENTE INVENCION SE REFIERE A COMPUESTOS QUE SON DE UNA FORMA GENERAL ANTAGONISTAS DEL RECEPTOR ADRENERGICO ALFA1B, Y LOS CUALES SE REPRESENTAN POR LA FORMULA (I), DONDE A, R', R'', R1 Y R2 SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. ESTA INVENCION TAMBIEN SE REFIERE A PROFARMACOS, ISOMEROS INDIVIDUALES, MEZCLAS DE ISOMEROS, RACEMICAS O NO RACEMICAS, SALES O SOLVATOS FARMACEUTICAMENTE ACEPTABLES DE ESTOS, ASI MISMO A COMPOSICIONES FARMACEUTICAS QUE CONTIENEN TALES TIPOS DE COMPONENTES, AL USO DE TALES TIPOS DE COMPUESTOS, EN EL CONTROL Y LA PREVENCION DE ENFERMEDADES TALES COMO LOS TRASTORNOS DEL TRACTO URINARIO, LA DISFUNCION SEXUAL, EL DOLOR, O LOS TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL, Y PROCEDIMIENTOS PARA LA PREPARACION DE ESTOS.
GT200100181A 2000-08-31 2001-08-30 Derivados de quinazolina como antagonistas adrenergicos alfa-1. GT200100181A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22950300P 2000-08-31 2000-08-31

Publications (1)

Publication Number Publication Date
GT200100181A true GT200100181A (es) 2002-05-23

Family

ID=22861517

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200100181A GT200100181A (es) 2000-08-31 2001-08-30 Derivados de quinazolina como antagonistas adrenergicos alfa-1.

Country Status (19)

Country Link
US (1) US6559153B2 (es)
EP (1) EP1315714B1 (es)
JP (1) JP3971299B2 (es)
KR (1) KR100602929B1 (es)
CN (1) CN1308324C (es)
AR (1) AR032475A1 (es)
AT (1) ATE309240T1 (es)
AU (2) AU9378801A (es)
BR (1) BR0113585A (es)
CA (1) CA2420177C (es)
DE (1) DE60114852T2 (es)
ES (1) ES2251512T3 (es)
GT (1) GT200100181A (es)
MX (1) MXPA03001777A (es)
PA (1) PA8527901A1 (es)
PE (1) PE20020407A1 (es)
UY (1) UY26919A1 (es)
WO (1) WO2002018348A2 (es)
ZA (1) ZA200301082B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60215195T2 (de) * 2001-08-10 2007-08-23 Monash University, Clayton Derivate morphinähnlicher opioidverbindungen
JP2005521728A (ja) * 2002-04-03 2005-07-21 オリオン コーポレーション ＣＮＳ関連疾患のためのα２−アドレナリン受容体アンタゴニストの使用
TW200403058A (en) * 2002-04-19 2004-03-01 Bristol Myers Squibb Co Heterocyclo inhibitors of potassium channel function
ITMI20030151A1 (it) * 2003-01-30 2004-07-31 Recordati Ind Chimica E Farma Ceutica S P A Uso di antagonisti selettivi del recettore mglu5 per il trattamento di disfunzioni neuromuscolari del tratto urinario inferiore.
EP1646615B1 (en) * 2003-06-06 2009-08-26 Vertex Pharmaceuticals Incorporated Pyrimidine derivatives as modulators of atp-binding cassette transporters
KR100954415B1 (ko) * 2003-07-24 2010-04-26 유로-셀띠끄 소시에떼 아노님 피페리딘 화합물 및 그들을 포함하는 약학적 조성물
WO2006021345A2 (en) * 2004-08-27 2006-03-02 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with adrenergic alpha-1b receptor (adra1b)
MY179032A (en) 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
US7344583B2 (en) * 2005-03-31 2008-03-18 3M Innovative Properties Company Methods of making metal particles within cored dendrimers
US7413607B2 (en) * 2005-03-31 2008-08-19 3M Innovative Properties Company Templated semiconductor particles and methods of making
MX2007013606A (es) * 2005-05-04 2007-12-10 Hoffmann La Roche (3,4-dihidro-quinazolin2-il)-(2-ariloxi-etil)-aminas que tienen una actividad en el receptor 5-ht.
US8796293B2 (en) 2006-04-25 2014-08-05 Astex Therapeutics Limited Purine and deazapurine derivatives as pharmaceutical compounds
WO2008036700A2 (en) * 2006-09-19 2008-03-27 3M Innovative Properties Company Templated metal oxide particles and methods of making
KR101494734B1 (ko) 2007-10-11 2015-02-26 아스트라제네카 아베 단백질 키나제 ｂ 억제제로서 피롤로[2,3-ｄ]피리미딘 유도체
TW200944526A (en) 2008-04-22 2009-11-01 Vitae Pharmaceuticals Inc Carbamate and urea inhibitors of 11β-hydroxysteroid dehydrogenase 1
EP2694056B1 (en) 2011-04-01 2019-10-16 AstraZeneca AB Therapeutic treatment
LT2785349T (lt) 2011-11-30 2019-12-10 Astrazeneca Ab Kombinuotas vėžio gydymas
AU2013204533B2 (en) 2012-04-17 2017-02-02 Astrazeneca Ab Crystalline forms
AU2018236130A1 (en) * 2017-03-12 2019-09-19 Xiaodong Wang Polycyclic amines as opioid receptor modulators
WO2019088095A1 (ja) * 2017-11-02 2019-05-09 国立大学法人九州大学 鎮痛剤及びその使用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0853479A4 (en) 1995-09-29 2001-04-11 Merck & Co Inc ALPHA 1b ADRENERGIC RECEPTOR ANTAGONISTS
NZ325248A (en) * 1995-12-23 1999-09-29 Pfizer Res & Dev Quinoline and quinazoline compounds useful in therapy
GB9700504D0 (en) 1997-01-11 1997-02-26 Pfizer Ltd Pharmaceutical compounds
US6355641B1 (en) 1999-03-17 2002-03-12 Syntex (U.S.A.) Llc Oxazolone derivatives and uses thereof

Also Published As

Publication number Publication date
DE60114852D1 (de) 2005-12-15
AR032475A1 (es) 2003-11-12
WO2002018348A2 (en) 2002-03-07
JP3971299B2 (ja) 2007-09-05
PE20020407A1 (es) 2002-05-21
AU9378801A (en) 2002-03-13
ES2251512T3 (es) 2006-05-01
KR100602929B1 (ko) 2006-07-20
US6559153B2 (en) 2003-05-06
UY26919A1 (es) 2002-02-28
CN1308324C (zh) 2007-04-04
CA2420177A1 (en) 2002-03-07
WO2002018348A3 (en) 2002-07-11
CN1545510A (zh) 2004-11-10
ATE309240T1 (de) 2005-11-15
JP2004507527A (ja) 2004-03-11
CA2420177C (en) 2008-07-08
KR20030022421A (ko) 2003-03-15
ZA200301082B (en) 2004-05-07
EP1315714A2 (en) 2003-06-04
MXPA03001777A (es) 2003-06-04
DE60114852T2 (de) 2006-07-27
BR0113585A (pt) 2003-07-29
AU2001293788B2 (en) 2007-10-11
EP1315714B1 (en) 2005-11-09
PA8527901A1 (es) 2002-07-30
US20020045614A1 (en) 2002-04-18

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