PE20020407A1 - Derivados de quinazolina como antagonistas del receptor adrenergico alfa-1 - Google Patents
Derivados de quinazolina como antagonistas del receptor adrenergico alfa-1Info
- Publication number
- PE20020407A1 PE20020407A1 PE2001000870A PE2001000870A PE20020407A1 PE 20020407 A1 PE20020407 A1 PE 20020407A1 PE 2001000870 A PE2001000870 A PE 2001000870A PE 2001000870 A PE2001000870 A PE 2001000870A PE 20020407 A1 PE20020407 A1 PE 20020407A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- metil
- amino
- antagonists
- alpha
- Prior art date
Links
- 102000030619 alpha-1 Adrenergic Receptor Human genes 0.000 title abstract 2
- 108020004102 alpha-1 Adrenergic Receptor Proteins 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title abstract 2
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical class N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 101100295738 Gallus gallus COR3 gene Proteins 0.000 abstract 1
- 201000001880 Sexual dysfunction Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 231100000872 sexual dysfunction Toxicity 0.000 abstract 1
- 210000001635 urinary tract Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Psychiatry (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22950300P | 2000-08-31 | 2000-08-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020407A1 true PE20020407A1 (es) | 2002-05-21 |
Family
ID=22861517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001000870A PE20020407A1 (es) | 2000-08-31 | 2001-08-29 | Derivados de quinazolina como antagonistas del receptor adrenergico alfa-1 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6559153B2 (enExample) |
| EP (1) | EP1315714B1 (enExample) |
| JP (1) | JP3971299B2 (enExample) |
| KR (1) | KR100602929B1 (enExample) |
| CN (1) | CN1308324C (enExample) |
| AR (1) | AR032475A1 (enExample) |
| AT (1) | ATE309240T1 (enExample) |
| AU (2) | AU9378801A (enExample) |
| BR (1) | BR0113585A (enExample) |
| CA (1) | CA2420177C (enExample) |
| DE (1) | DE60114852T2 (enExample) |
| ES (1) | ES2251512T3 (enExample) |
| GT (1) | GT200100181A (enExample) |
| MX (1) | MXPA03001777A (enExample) |
| PA (1) | PA8527901A1 (enExample) |
| PE (1) | PE20020407A1 (enExample) |
| UY (1) | UY26919A1 (enExample) |
| WO (1) | WO2002018348A2 (enExample) |
| ZA (1) | ZA200301082B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE341552T1 (de) * | 2001-08-10 | 2006-10-15 | Neuro Therapeutics Ltd | Derivate morphinähnlicher opioidverbindungen |
| JP2005521728A (ja) * | 2002-04-03 | 2005-07-21 | オリオン コーポレーション | ＣＮＳ関連疾患のためのα２−アドレナリン受容体アンタゴニストの使用 |
| TW200403058A (en) * | 2002-04-19 | 2004-03-01 | Bristol Myers Squibb Co | Heterocyclo inhibitors of potassium channel function |
| ITMI20030151A1 (it) * | 2003-01-30 | 2004-07-31 | Recordati Ind Chimica E Farma Ceutica S P A | Uso di antagonisti selettivi del recettore mglu5 per il trattamento di disfunzioni neuromuscolari del tratto urinario inferiore. |
| ATE440825T1 (de) * | 2003-06-06 | 2009-09-15 | Vertex Pharma | Pyrimidin-derivate zur verwendung als modulatoren von atp-bindende kassette transportern |
| DE602004020994D1 (de) * | 2003-07-24 | 2009-06-18 | Euro Celtique Sa | Piperidinverbindungen und pharmazeutische zusammensetzungen, die diese enthalten |
| WO2006021345A2 (en) * | 2004-08-27 | 2006-03-02 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with adrenergic alpha-1b receptor (adra1b) |
| MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
| US7413607B2 (en) * | 2005-03-31 | 2008-08-19 | 3M Innovative Properties Company | Templated semiconductor particles and methods of making |
| US7344583B2 (en) * | 2005-03-31 | 2008-03-18 | 3M Innovative Properties Company | Methods of making metal particles within cored dendrimers |
| BRPI0611537A2 (pt) * | 2005-05-04 | 2010-09-21 | Hoffmann La Roche | (3,4-diidro-quinazolin-2-il) -(2-arilóxi-etil)-aminas tendo uma atividade sobre o receptor de 5-ht |
| FI3719018T3 (fi) | 2006-04-25 | 2025-10-07 | Astex Therapeutics Ltd | Puriini- ja deatsapuriinijohdannaisia farmaseuttisina yhdisteinä |
| WO2008036700A2 (en) * | 2006-09-19 | 2008-03-27 | 3M Innovative Properties Company | Templated metal oxide particles and methods of making |
| MX2010003927A (es) | 2007-10-11 | 2010-04-30 | Astrazeneca Ab | Derivados de pirrolo [2,3-d] pirimidina como inhibidores de proteinas cinasas b. |
| TW200944526A (en) | 2008-04-22 | 2009-11-01 | Vitae Pharmaceuticals Inc | Carbamate and urea inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| KR101851820B1 (ko) | 2011-04-01 | 2018-06-04 | 아스트라제네카 아베 | 치료적 요법 |
| SG11201401471PA (en) | 2011-11-30 | 2014-08-28 | Astrazeneca Ab | Combination treatment of cancer |
| AU2013204533B2 (en) | 2012-04-17 | 2017-02-02 | Astrazeneca Ab | Crystalline forms |
| CN110662541B (zh) * | 2017-03-12 | 2023-02-10 | 王晓冬 | 多环胺作为阿片受体调节剂 |
| WO2019088095A1 (ja) * | 2017-11-02 | 2019-05-09 | 国立大学法人九州大学 | 鎮痛剤及びその使用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0853479A4 (en) | 1995-09-29 | 2001-04-11 | Merck & Co Inc | ALPHA 1B ADRENERGIC RECEPTOR ANTAGONISTS |
| GB9526546D0 (en) * | 1995-12-23 | 1996-02-28 | Pfizer Ltd | Compounds useful in therapy |
| GB9700504D0 (en) | 1997-01-11 | 1997-02-26 | Pfizer Ltd | Pharmaceutical compounds |
| US6355641B1 (en) | 1999-03-17 | 2002-03-12 | Syntex (U.S.A.) Llc | Oxazolone derivatives and uses thereof |
-
2001
- 2001-08-23 CA CA002420177A patent/CA2420177C/en not_active Expired - Fee Related
- 2001-08-23 AU AU9378801A patent/AU9378801A/xx active Pending
- 2001-08-23 MX MXPA03001777A patent/MXPA03001777A/es active IP Right Grant
- 2001-08-23 JP JP2002523466A patent/JP3971299B2/ja not_active Expired - Fee Related
- 2001-08-23 EP EP01974210A patent/EP1315714B1/en not_active Expired - Lifetime
- 2001-08-23 ES ES01974210T patent/ES2251512T3/es not_active Expired - Lifetime
- 2001-08-23 KR KR1020037002933A patent/KR100602929B1/ko not_active Expired - Fee Related
- 2001-08-23 DE DE60114852T patent/DE60114852T2/de not_active Expired - Fee Related
- 2001-08-23 AT AT01974210T patent/ATE309240T1/de not_active IP Right Cessation
- 2001-08-23 CN CNB018165958A patent/CN1308324C/zh not_active Expired - Fee Related
- 2001-08-23 WO PCT/EP2001/009749 patent/WO2002018348A2/en not_active Ceased
- 2001-08-23 AU AU2001293788A patent/AU2001293788B2/en not_active Ceased
- 2001-08-23 BR BR0113585-6A patent/BR0113585A/pt not_active IP Right Cessation
- 2001-08-29 PE PE2001000870A patent/PE20020407A1/es not_active Application Discontinuation
- 2001-08-29 US US09/942,385 patent/US6559153B2/en not_active Expired - Fee Related
- 2001-08-30 PA PA20018527901A patent/PA8527901A1/es unknown
- 2001-08-30 GT GT200100181A patent/GT200100181A/es unknown
- 2001-08-30 AR ARP010104130A patent/AR032475A1/es unknown
- 2001-08-30 UY UY26919A patent/UY26919A1/es not_active Application Discontinuation
-
2003
- 2003-02-07 ZA ZA200301082A patent/ZA200301082B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR032475A1 (es) | 2003-11-12 |
| AU2001293788B2 (en) | 2007-10-11 |
| ATE309240T1 (de) | 2005-11-15 |
| CA2420177A1 (en) | 2002-03-07 |
| GT200100181A (es) | 2002-05-23 |
| KR100602929B1 (ko) | 2006-07-20 |
| WO2002018348A3 (en) | 2002-07-11 |
| EP1315714B1 (en) | 2005-11-09 |
| JP2004507527A (ja) | 2004-03-11 |
| KR20030022421A (ko) | 2003-03-15 |
| CA2420177C (en) | 2008-07-08 |
| PA8527901A1 (es) | 2002-07-30 |
| AU9378801A (en) | 2002-03-13 |
| ZA200301082B (en) | 2004-05-07 |
| BR0113585A (pt) | 2003-07-29 |
| EP1315714A2 (en) | 2003-06-04 |
| JP3971299B2 (ja) | 2007-09-05 |
| MXPA03001777A (es) | 2003-06-04 |
| US20020045614A1 (en) | 2002-04-18 |
| CN1308324C (zh) | 2007-04-04 |
| US6559153B2 (en) | 2003-05-06 |
| DE60114852T2 (de) | 2006-07-27 |
| UY26919A1 (es) | 2002-02-28 |
| WO2002018348A2 (en) | 2002-03-07 |
| ES2251512T3 (es) | 2006-05-01 |
| DE60114852D1 (de) | 2005-12-15 |
| CN1545510A (zh) | 2004-11-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |