PE20010992A1 - Formulacion de liberacion sostenida de un inhibidor de ciclooxigenasa-2 - Google Patents
Formulacion de liberacion sostenida de un inhibidor de ciclooxigenasa-2Info
- Publication number
- PE20010992A1 PE20010992A1 PE2000001394A PE0013942000A PE20010992A1 PE 20010992 A1 PE20010992 A1 PE 20010992A1 PE 2000001394 A PE2000001394 A PE 2000001394A PE 0013942000 A PE0013942000 A PE 0013942000A PE 20010992 A1 PE20010992 A1 PE 20010992A1
- Authority
- PE
- Peru
- Prior art keywords
- placement
- release
- drug
- cyclooxygenase
- inhibitor
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Abstract
SE REFIERE A UNA COMPOSICION ORAL QUE COMPRENDE 1)UN INHIBIDOR DE CICLOOXIGENASA 2 DE BAJA SOLUBILIDAD EN AGUA COMO UN COMPUESTO DE FORMULA I; R3 ES METILO AMINO, R4 ES H, ALQUILO, ALCOXI C1-C4; X ES N, CR5; R5 ES H, HALOGENO; Y Y Z SON C, N, QUE DEFINEN ATOMOS ADYACENTES A UN ANILLO DE 5-6 MIEMBROS COMO CICLOPENTENONA, FURANONA, METILPIRAZOL, ENTRE OTROS; SIENDO OTROS INHIBIDORES CELECOXIB (10mg A 1000mg), DERACOXIB, VALDECOXIB, ROFECOXIB, 5-CLORO-3-(4-METILSULFONIL)FENIL-2-(2-METIL-5-PIRIDINIL)PIRIDINA, 2-(3,5-DIFLUORFENIL)-3-[4-(METILSULFONIL)FENIL]-2-CICLOPENTENO-1-ONA; (S)-6,8-DICLORO-2-TRIFLUOROMETIL)-2H-1-BENZOPIRANO-3-ACIDO CARBOXILICO; 2)POLIMEROS SUSCEPTIBLES DE HINCHAZON O EROSION DONDE LA COMPOSICION PROPORCIONA UN PERFIL DE DISOLUCION DE LIBERACION SOSTENIDA IN VITRO DESPUES DE LA COLOCACION EN UN MEDIO DE DISOLUCION ESTANDAR QUE MUESTRA a)UNA LIBERACION DE 5% A 35% DE LA DROGA 2 HORAS DESPUES DE LA COLOCACION; b)LIBERACION DE 10% A 85% DE LA DROGA 8 HORAS DESPUES DE LA COLOCACION; c)UNA LIBERACION DE 30% A 90% DE LA DROGA 18 HORAS DESPUES DE LA COLOCACION; LA COMPOSICION PUEDE ESTAR PARCIAL O TOTALMENTE a)DISTRIBUIDA EN UNA MATRIZ QUE COMPRENDE DE 0,1% A 40% HIDROXIPROPILMETILCELULOSA CON UNA VISCOSIDAD NOMINAL, 2% DE AGUA, b)CON UN RECUBRIMIENTO QUE COMPRENDE UN POLIMERO SUCEPTIBLE DE HINCHAZON O EROSION
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17173899P | 1999-12-22 | 1999-12-22 | |
US18163500P | 2000-02-10 | 2000-02-10 | |
US20226900P | 2000-05-05 | 2000-05-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20010992A1 true PE20010992A1 (es) | 2001-09-21 |
Family
ID=27390016
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2000001394A PE20010992A1 (es) | 1999-12-22 | 2000-12-22 | Formulacion de liberacion sostenida de un inhibidor de ciclooxigenasa-2 |
Country Status (17)
Country | Link |
---|---|
US (2) | US20020015735A1 (es) |
EP (1) | EP1239856A1 (es) |
JP (1) | JP2003518061A (es) |
KR (1) | KR20020082473A (es) |
CN (1) | CN1434713A (es) |
AU (1) | AU2731401A (es) |
BR (1) | BR0016629A (es) |
CA (1) | CA2394222A1 (es) |
CZ (1) | CZ20022140A3 (es) |
IL (1) | IL150352A0 (es) |
MX (1) | MXPA02006150A (es) |
NO (1) | NO20022988L (es) |
NZ (1) | NZ519466A (es) |
PE (1) | PE20010992A1 (es) |
PL (1) | PL355391A1 (es) |
SK (1) | SK9022002A3 (es) |
WO (1) | WO2001045705A1 (es) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002094320A1 (fr) | 2001-05-23 | 2002-11-28 | Tanabe Seiyaku Co., Ltd. | Compositions therapeutiques permettant de reparer la chondropathie |
US20040146561A1 (en) | 2001-05-23 | 2004-07-29 | Naoki Sakurai | Compositions for promoting healing of bone fracture |
US7338971B2 (en) * | 2001-08-30 | 2008-03-04 | El-Naggar Mawaheb M | Treatment of inflammatory, cancer, and thrombosis disorders |
US7927613B2 (en) * | 2002-02-15 | 2011-04-19 | University Of South Florida | Pharmaceutical co-crystal compositions |
US20030224006A1 (en) | 2002-03-01 | 2003-12-04 | Zaworotko Michael J. | Multiple-component solid phases containing at least one active pharmaceutical ingredient |
US7790905B2 (en) * | 2002-02-15 | 2010-09-07 | Mcneil-Ppc, Inc. | Pharmaceutical propylene glycol solvate compositions |
US20100311701A1 (en) * | 2002-02-15 | 2010-12-09 | Transform Pharmaceuticals, Inc | Pharmaceutical Co-Crystal Compositions |
AU2003243699B2 (en) * | 2002-06-21 | 2009-01-15 | Transform Pharmaceuticals, Inc. | Pharmaceutical compositions with improved dissolution |
US20050226926A1 (en) * | 2002-07-25 | 2005-10-13 | Pfizer Inc | Sustained-release tablet composition of pramipexole |
PA8578501A1 (es) * | 2002-07-25 | 2005-02-04 | Pharmacia Corp | Forma de dosificacion una vez al dia de pramipexol |
US20060052432A1 (en) * | 2002-09-20 | 2006-03-09 | Julius Remenar | Pharmaceutical compositions with improved dissolution |
US8183290B2 (en) | 2002-12-30 | 2012-05-22 | Mcneil-Ppc, Inc. | Pharmaceutically acceptable propylene glycol solvate of naproxen |
US20050163839A1 (en) * | 2003-01-29 | 2005-07-28 | Sun Pharmaceutical Industries Limited | Oral controlled release pharmaceutical composition containing metaxalone as active agent |
SI2821067T1 (en) * | 2003-09-12 | 2018-03-30 | Amgen Inc. | Quick spray formulation of cinacalcet |
SE0302488D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | New combination |
RS52057B2 (sr) * | 2004-08-13 | 2018-03-30 | Boehringer Ingelheim Int | Formulacija tablete sa produženim oslobađanjem koja sadrži pramipeksol ili njegovu farmaceutski prihvatljivu so |
AU2005271193B2 (en) * | 2004-08-13 | 2011-11-24 | Boehringer Ingelheim International Gmbh | Extended release pellet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof |
CA2589167A1 (en) | 2004-11-23 | 2006-06-01 | Pliva Hrvatska D.O.O. | Extended release pharmaceutical composition of celecoxib |
FR2881049B1 (fr) * | 2005-01-24 | 2008-12-26 | Vetoquinol Sa Sa | Medicament destine a etre administre par voie orale comprenant un inhibiteur de la cyclo-oxygenase-2, et son procede de preparation |
EP1858493A4 (en) * | 2005-03-14 | 2010-12-01 | Sun Pharmaceutical Ind Ltd | SYSTEM FOR ORAL ADMINISTRATION OF MEDICINAL PRODUCTS |
ATE480229T1 (de) * | 2005-05-24 | 2010-09-15 | Flamel Tech Sa | Orale pharmazeutische zusammensetzung zur behandlung einer cox-2-vermittelten erkrankung |
JP2009501785A (ja) | 2005-07-20 | 2009-01-22 | パナセア バイオテック リミテッド | 新規な調節放出性医薬製剤シクロオキシゲナーゼ酵素阻害剤 |
US7964215B1 (en) * | 2006-01-24 | 2011-06-21 | Emet Pharmaceuticals, LLC | Delayed release dosage form |
US20090098202A1 (en) * | 2006-02-10 | 2009-04-16 | Boehringer Ingelheim International Gmbh | Extended Release Formulation |
EP1988875A2 (en) * | 2006-02-10 | 2008-11-12 | Boehringer Ingelheim International GmbH | Modified release formulation |
WO2008114859A1 (ja) * | 2007-03-22 | 2008-09-25 | Astellas Pharma Inc. | ピラゾール誘導体を含有する医薬組成物 |
US20080279930A1 (en) * | 2007-05-07 | 2008-11-13 | Bernd Terhaag | Controlled-Release Flupirtine Compositions, Compacts, Kits and Methods of Making and Use Thereof |
DE102010005849B4 (de) | 2010-01-26 | 2012-04-19 | Sig Technology Ag | Verfahren zur Herstellung eines Behälters für Nahrungsmittel aus einem aluminiumfreien flächenförmigen Verbund mit einer Innenschicht durch Heissfalten |
CN103462920A (zh) * | 2012-06-06 | 2013-12-25 | 南京亿华药业有限公司 | 一种口服环加氧酶-2抑制剂塞来昔布的组合物 |
HUE056810T2 (hu) | 2012-11-02 | 2022-03-28 | Murray & Poole Entpr Ltd | Szív- és érrendszeri események kezelése és megelõzése kolchicin alkalmazásával |
SG11201508571WA (en) | 2013-04-16 | 2015-11-27 | Murray And Poole Entpr Ltd | Sustained-release formulations of colchicine and methods of using same |
TW201639581A (zh) * | 2015-05-07 | 2016-11-16 | Univ China Medical | 希樂葆(celecoxib)用於製備抗口腔癌的醫藥品之用途 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR9709097A (pt) * | 1996-05-17 | 1999-08-03 | Merck & Co Inc | Composição farmacêutica para o tratamento de doenças mediadas por ciclooxigenase processo para tratar uma doença inflamatória suscetível de tratamento com um agente antinflamatório n o esteróide uso e forma oral de dose unitária |
JP2001513563A (ja) * | 1997-08-27 | 2001-09-04 | ヘキサル アーゲー | 溶解性および生物学的利用能の改良されたメロキシカムの医薬組成物 |
SA99191255B1 (ar) * | 1998-11-30 | 2006-11-25 | جي دي سيرل اند كو | مركبات سيليكوكسيب celecoxib |
-
2000
- 2000-12-20 AU AU27314/01A patent/AU2731401A/en not_active Abandoned
- 2000-12-20 CA CA002394222A patent/CA2394222A1/en not_active Abandoned
- 2000-12-20 US US09/742,906 patent/US20020015735A1/en not_active Abandoned
- 2000-12-20 KR KR1020027008098A patent/KR20020082473A/ko not_active Application Discontinuation
- 2000-12-20 CZ CZ20022140A patent/CZ20022140A3/cs unknown
- 2000-12-20 SK SK902-2002A patent/SK9022002A3/sk not_active Application Discontinuation
- 2000-12-20 BR BR0016629-4A patent/BR0016629A/pt not_active IP Right Cessation
- 2000-12-20 CN CN00818950A patent/CN1434713A/zh active Pending
- 2000-12-20 IL IL15035200A patent/IL150352A0/xx unknown
- 2000-12-20 WO PCT/US2000/034752 patent/WO2001045705A1/en not_active Application Discontinuation
- 2000-12-20 PL PL00355391A patent/PL355391A1/xx not_active Application Discontinuation
- 2000-12-20 MX MXPA02006150A patent/MXPA02006150A/es not_active Application Discontinuation
- 2000-12-20 NZ NZ519466A patent/NZ519466A/en unknown
- 2000-12-20 EP EP00990268A patent/EP1239856A1/en not_active Withdrawn
- 2000-12-20 JP JP2001546644A patent/JP2003518061A/ja not_active Withdrawn
- 2000-12-22 PE PE2000001394A patent/PE20010992A1/es not_active Application Discontinuation
-
2002
- 2002-06-20 NO NO20022988A patent/NO20022988L/no not_active Application Discontinuation
-
2003
- 2003-01-28 US US10/352,449 patent/US20030170303A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
MXPA02006150A (es) | 2004-09-06 |
EP1239856A1 (en) | 2002-09-18 |
PL355391A1 (en) | 2004-04-19 |
NO20022988D0 (no) | 2002-06-20 |
US20030170303A1 (en) | 2003-09-11 |
CN1434713A (zh) | 2003-08-06 |
NZ519466A (en) | 2004-02-27 |
SK9022002A3 (en) | 2003-03-04 |
IL150352A0 (en) | 2002-12-01 |
CZ20022140A3 (cs) | 2002-11-13 |
CA2394222A1 (en) | 2001-06-28 |
NO20022988L (no) | 2002-08-21 |
BR0016629A (pt) | 2002-09-03 |
KR20020082473A (ko) | 2002-10-31 |
US20020015735A1 (en) | 2002-02-07 |
JP2003518061A (ja) | 2003-06-03 |
AU2731401A (en) | 2001-07-03 |
WO2001045705A1 (en) | 2001-06-28 |
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