PE20010695A1 - Pirroles sustituidos como agentes antiproliferativos - Google Patents

Pirroles sustituidos como agentes antiproliferativos

Info

Publication number
PE20010695A1
PE20010695A1 PE2000001072A PE0010722000A PE20010695A1 PE 20010695 A1 PE20010695 A1 PE 20010695A1 PE 2000001072 A PE2000001072 A PE 2000001072A PE 0010722000 A PE0010722000 A PE 0010722000A PE 20010695 A1 PE20010695 A1 PE 20010695A1
Authority
PE
Peru
Prior art keywords
indol
methyl
nitro
alkyl
pyrrol
Prior art date
Application number
PE2000001072A
Other languages
English (en)
Inventor
Allen John Lovey
Nader Fotouhi
Norman Kong
Mullin
Emily Aijun Liu
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20010695A1 publication Critical patent/PE20010695A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A DERIVADOS DE PIRROLES SUSTITUIDOS DE FORMULA I, DONDE R ES CH2OPO3R1R2, CH2OH, CH2OCOR3, CH2OCO2R3, CH2OCONHR3, CONHR3; R1, R2 SON H, Na, NH4, AMBOS NO SON H A LA VEZ; O R1 Y R2 SON AMBOS Ca; R3 ES ALQUILO, OPO3R1R2, OH, ALCOXILO, ARILO, ALQUENILO, HETEROCICLO, ARILO; R4 ES H, Na, ALQUILO; R5 Y R6 SON H, ALQUILO, COR7, O JUNTO CON N FORMAN UN HETEROCICLO DE 5-6 MIEMBROS; R7 ES ALQUILO. SON COMPUESTOS PREFERIDOS SAL MONO-[3-(1-METIL-1H-INDOL-3-IL)-4-(1-METIL-6-NITRO-1H-INDOL)-3-IL)-2,5-DIOXO-2,5-DIHIDRO-PIRROL-1-ILMETIL]SODICA DEL ACIDO FOSFORICO, 1-HIDROXIMETIL-3-(1-METIL-1H-INDOL-3-IL)-4-(1-METIL-6-NITRO-1H-INDOL-3-IL)PIRROL-2,5-DIONA, SAL DE SODIO DEL ESTER MONO-(4-{[3-(1-METIL-1H-INDOL-3-IL)-4-(1-METIL-6-NITRO-1H-INDOL-IL)-2,5-DIOXO-2,5-DIHIDROPIRROL-1-CARBONIL]-AMINO}-BUTILICO) DEL ACIDO FOSFORICO. EL COMPUESTO I INHIBE LA DIVISION CELULAR EN LA FASE G2/M DEL CICLO CELULAR Y PUEDE SER UTIL PARA EL TRATAMIENTO DE UN TRASTORNO PROLIFERATIVO CELULAR COMO CANCER DE MAMA, COLON, PULMONES
PE2000001072A 1999-10-12 2000-10-06 Pirroles sustituidos como agentes antiproliferativos PE20010695A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15886099P 1999-10-12 1999-10-12

Publications (1)

Publication Number Publication Date
PE20010695A1 true PE20010695A1 (es) 2001-07-05

Family

ID=22570037

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000001072A PE20010695A1 (es) 1999-10-12 2000-10-06 Pirroles sustituidos como agentes antiproliferativos

Country Status (30)

Country Link
EP (1) EP1224181B1 (es)
JP (1) JP2003511449A (es)
KR (1) KR20020038817A (es)
CN (1) CN1155595C (es)
AR (1) AR026004A1 (es)
AT (1) ATE255576T1 (es)
AU (1) AU781732B2 (es)
BR (1) BR0014680A (es)
CA (1) CA2385071A1 (es)
CZ (1) CZ20021610A3 (es)
DE (1) DE60006990T2 (es)
DK (1) DK1224181T3 (es)
ES (1) ES2210005T3 (es)
HK (1) HK1050533A1 (es)
HR (1) HRP20020262B1 (es)
HU (1) HUP0203558A3 (es)
IL (1) IL148815A0 (es)
MA (1) MA26830A1 (es)
MX (1) MXPA02003667A (es)
NO (1) NO20021718L (es)
NZ (1) NZ518038A (es)
PE (1) PE20010695A1 (es)
PL (1) PL357441A1 (es)
PT (1) PT1224181E (es)
RU (1) RU2002110111A (es)
TR (1) TR200200987T2 (es)
TW (1) TWI230708B (es)
WO (1) WO2001027106A1 (es)
YU (1) YU25202A (es)
ZA (1) ZA200202231B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6313143B1 (en) * 1999-12-16 2001-11-06 Hoffmann-La Roche Inc. Substituted pyrroles
US7776855B2 (en) 2006-07-27 2010-08-17 Janssen Pharmaceutica N.V. Antimicrobial oxazolidinone prodrugs
WO2010151711A1 (en) * 2009-06-25 2010-12-29 Alkermes, Inc. Prodrugs of nh-acidic compounds
UY34072A (es) 2011-05-17 2013-01-03 Novartis Ag Derivados sustituidos de indol
CA2888194A1 (en) 2012-11-07 2014-05-15 Novartis Ag Substituted indole derivatives
EP3771711A1 (en) 2019-07-29 2021-02-03 Bayer Animal Health GmbH Pyrazole derivatives for controlling arthropods

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4005969A1 (de) * 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
PE91598A1 (es) * 1996-07-29 1998-12-24 Hoffmann La Roche Pirroles sustituidos
CZ299068B6 (cs) * 1998-03-17 2008-04-16 F. Hoffmann-La Roche Ag Substituovaný bisindolylmaleinimid a farmaceutický prostredek s jeho obsahem

Also Published As

Publication number Publication date
JP2003511449A (ja) 2003-03-25
BR0014680A (pt) 2002-06-11
MXPA02003667A (es) 2002-08-30
ES2210005T3 (es) 2004-07-01
ZA200202231B (en) 2003-06-19
HK1050533A1 (en) 2003-06-27
DK1224181T3 (da) 2004-04-13
IL148815A0 (en) 2002-09-12
HRP20020262A2 (en) 2004-04-30
TWI230708B (en) 2005-04-11
CZ20021610A3 (cs) 2002-10-16
NO20021718D0 (no) 2002-04-11
KR20020038817A (ko) 2002-05-23
HUP0203558A3 (en) 2004-01-28
TR200200987T2 (tr) 2002-09-23
EP1224181B1 (en) 2003-12-03
DE60006990D1 (de) 2004-01-15
EP1224181A1 (en) 2002-07-24
WO2001027106A1 (en) 2001-04-19
PL357441A1 (en) 2004-07-26
CN1155595C (zh) 2004-06-30
HRP20020262B1 (en) 2005-06-30
PT1224181E (pt) 2004-04-30
CA2385071A1 (en) 2001-04-19
AR026004A1 (es) 2002-12-26
NZ518038A (en) 2004-02-27
DE60006990T2 (de) 2004-10-28
ATE255576T1 (de) 2003-12-15
AU7911600A (en) 2001-04-23
CN1378545A (zh) 2002-11-06
AU781732B2 (en) 2005-06-09
NO20021718L (no) 2002-04-11
HUP0203558A2 (hu) 2003-02-28
MA26830A1 (fr) 2004-12-20
YU25202A (sh) 2004-12-31
RU2002110111A (ru) 2003-12-20

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Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed