PE20010125A1 - Compuestos derivados de piperazinil-pirazina que se unen al receptor 5-ht 2c - Google Patents

Compuestos derivados de piperazinil-pirazina que se unen al receptor 5-ht 2c

Info

Publication number
PE20010125A1
PE20010125A1 PE2000000479A PE0004792000A PE20010125A1 PE 20010125 A1 PE20010125 A1 PE 20010125A1 PE 2000000479 A PE2000000479 A PE 2000000479A PE 0004792000 A PE0004792000 A PE 0004792000A PE 20010125 A1 PE20010125 A1 PE 20010125A1
Authority
PE
Peru
Prior art keywords
alkyl
aryl
piperazinyl
receptor
phenoxy
Prior art date
Application number
PE2000000479A
Other languages
English (en)
Inventor
Mattias Jonsson
Bjorn Nilsson
Jonas Nilsson
Markus Thor
Erik Ringberg
Jan Tejbrant
Benjamin Pelcman
Original Assignee
Biovitrum Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biovitrum Ab filed Critical Biovitrum Ab
Publication of PE20010125A1 publication Critical patent/PE20010125A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/18—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE: Ar ES ARILO, HETEROARILO OPCIONALMENTE SUSTITUIDO CON ALQUILO C1-C6, ALCOXILO C1-C6, ALQUILTIO C1-C6, ENTRE OTROS; A ES Cl, O, S, SO2, NH, N SUSTITUIDO CON ALQUILO C1-C4, ARILO C1-C6, ENTRE OTROS; B ES CR4R5, OCOR4R5, NR6CR4R5, ENTRE OTROS; R ES CICLOALQUILO C3-C8 ARILO, HETEROARILO; R1 ES ANILLO AZACICLICO, IMINOAZACICLICO, ENTRE OTROS; R2 Y R3 SON H, ALQUILO C1-C6, ACILO C1-C6, CONR7R8, ARILO, ENTRE OTROS; R4 Y R5 SON H, ALQUILO C1-C6; R6 ES H, ALQUILO C1-C6; R7 Y R8 SON H, ALQUILO C1-C6, ARILO, ENTRE OTROS; n ES 0-1; x ES 2-4; CON LA CONDICION QUE CUANDO A-R ES FENOXI O FENILTIO, ENTONCES Ar ES DISTINTO DE QUINOXALINILO, PIRIDILO, ENTRE OTRAS CONDICIONES. SON COMPUESTOS PREFERIDOS 2-(2-FENOXI)ETIL-3-(1-PIPERAZINIL)-2-PIRAZINIL ETER; 2-(2-FENOXI)ETIL-3-(1-PIPERAZINIL)-2-PIRAZINILETER, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I SE UNE AL RECEPTOR PARA SEROTONINA SUBTIPO 5-HT2C POR LO QUE PUEDE SER UTIL PARA TRASTORNOS DE LA ALIMENTACION, OBESIDAD, AFECCIONES DE LA MEMORIA, TRASTORNOS DEL COMPORTAMIENTO
PE2000000479A 1999-05-21 2000-05-19 Compuestos derivados de piperazinil-pirazina que se unen al receptor 5-ht 2c PE20010125A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9901884A SE9901884D0 (sv) 1999-05-21 1999-05-21 Novel compounds their use and preparation

Publications (1)

Publication Number Publication Date
PE20010125A1 true PE20010125A1 (es) 2001-02-06

Family

ID=20415714

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2000000479A PE20010125A1 (es) 1999-05-21 2000-05-19 Compuestos derivados de piperazinil-pirazina que se unen al receptor 5-ht 2c

Country Status (6)

Country Link
JP (1) JP4831903B2 (es)
AR (1) AR030022A1 (es)
MY (1) MY135666A (es)
PE (1) PE20010125A1 (es)
SE (1) SE9901884D0 (es)
ZA (1) ZA200109571B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004083235A2 (en) * 2003-03-19 2004-09-30 Exelixis Inc. Tie-2 modulators and methods of use
CL2004000826A1 (es) * 2003-04-25 2005-03-04 Pfizer Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129
CA2599331A1 (en) 2005-02-28 2006-09-08 Meiji Dairies Corporation Hydroquinone long-chain derivatives and/or phenoxy long-chain derivatives, and pharmaceuticals preparation comprising the same
US8097610B2 (en) * 2005-08-26 2012-01-17 Shionogi & Co., Ltd. Derivative having PPAR agonistic activity
JP6635999B2 (ja) * 2017-10-13 2020-01-29 株式会社ダイセル カリウム塩の製造方法、及びカリウム塩

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI193974A (es) * 1973-07-13 1975-01-14 Merck & Co Inc
GB9420999D0 (en) * 1994-10-18 1994-12-07 Smithkline Beecham Plc Novel compounds

Also Published As

Publication number Publication date
ZA200109571B (en) 2002-11-20
SE9901884D0 (sv) 1999-05-21
AR030022A1 (es) 2003-08-13
MY135666A (en) 2008-06-30
JP4831903B2 (ja) 2011-12-07
JP2003502317A (ja) 2003-01-21

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