PE20000419A1 - Derivados de cromanona y tiocromanona - Google Patents

Derivados de cromanona y tiocromanona

Info

Publication number
PE20000419A1
PE20000419A1 PE1999000280A PE00028099A PE20000419A1 PE 20000419 A1 PE20000419 A1 PE 20000419A1 PE 1999000280 A PE1999000280 A PE 1999000280A PE 00028099 A PE00028099 A PE 00028099A PE 20000419 A1 PE20000419 A1 PE 20000419A1
Authority
PE
Peru
Prior art keywords
alkyl
ona
sulfamate
androgen
chromanone
Prior art date
Application number
PE1999000280A
Other languages
English (en)
Inventor
Peter Nussbaumer
Erwin Schreiner
Ingeborg Schuster
Andreas Billich
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PE20000419A1 publication Critical patent/PE20000419A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

SE REFIERE A DERIVADOS DE CROMANONA Y TIOCROMANONA DE FORMULA I, DONDE R1 Y R2 SON H, ACILO, ALCOXICARBONILO, ALQUILO, LA CADENA SULFAMOILOXI ESTA ENLAZADA EN POSICION 6 o 7; R3 ES ALQUILO, ALQUENILO, ALQUINILO, UNA FRACCION DE CICLOALQUILO SUSTITUIDA POR ALQUILO, ALCOXI, HALOGENO, ENTRE OTROS; R4 ES H, ALQUILO, HIDROXI, ALCOXI; X ES O, S. SON COMPUESTOS PREFERIDOS 2-BUTILOTERCIARIO-4H-CROMEN-4-ONA-6-O-SULFAMATO; 2-(1-ADAMANTIL)-4H-CROMEN-4-ONA-6-O-SULFAMATO, 2-(1-ADAMANTIL)-4H-TIOCROMEN-4-ONA-6-O-SULFAMATO. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I ES UN INHIBIDOR DE ESTEROIDE SULFATASA REDUCIENDO LOS NIVELES ENDOGENOS DE ANDROGENOS Y/O ESTROGENOS EN LA PIEL Y PUEDE SER UTIL PARA EL TRATAMIENTO DE DESORDENES DEPENDIENTES DE ANDROGENOS DE LA UNIDAD PILOSEBACEA (ACNE, SEBORREA, ALOPECIA ANDROGENICA, HIRSUTISMO), EL TRATAMIENTO LOCAL DE CARCINOMA DE CELULAS ESCAMOSAS
PE1999000280A 1998-04-09 1999-04-07 Derivados de cromanona y tiocromanona PE20000419A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9807779.5A GB9807779D0 (en) 1998-04-09 1998-04-09 Organic compounds

Publications (1)

Publication Number Publication Date
PE20000419A1 true PE20000419A1 (es) 2000-05-29

Family

ID=10830229

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999000280A PE20000419A1 (es) 1998-04-09 1999-04-07 Derivados de cromanona y tiocromanona

Country Status (16)

Country Link
US (1) US6346626B1 (es)
EP (1) EP1070059B1 (es)
JP (1) JP3425424B2 (es)
AR (1) AR018178A1 (es)
AT (1) ATE224885T1 (es)
AU (1) AU3605499A (es)
CO (1) CO5031242A1 (es)
DE (1) DE69903143T2 (es)
DK (1) DK1070059T3 (es)
ES (1) ES2184439T3 (es)
GB (1) GB9807779D0 (es)
MY (1) MY118897A (es)
PE (1) PE20000419A1 (es)
PT (1) PT1070059E (es)
TW (1) TW513420B (es)
WO (1) WO1999052890A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO5261573A1 (es) 1999-11-19 2003-03-31 Novartis Ag Derivados de benzoxa y bezotiazol, compuesto y composicion farmaceutica que los contiene y proceso para la preparacion de la mencionada composicion
JP2002020362A (ja) * 2000-07-06 2002-01-23 Nippon Oruganon Kk 新規ビフェニル誘導体
GB0020498D0 (en) 2000-08-18 2000-10-11 Sterix Ltd Compound
GB0127923D0 (en) 2001-11-21 2002-01-16 Sterix Ltd Compound
CA2482041C (en) 2002-04-17 2012-06-05 Cytokinetics, Inc. 4-chromanone derivatives for treating cellular proliferative diseases and disorders
WO2004000345A1 (ja) * 2002-06-19 2003-12-31 Takeda Pharmaceutical Company Limited 骨・関節疾患の予防・治療剤
AU2003252025A1 (en) 2002-07-17 2004-02-02 Cytokinetics, Inc. Compounds, compositions, and methods
DE10260955A1 (de) * 2002-12-20 2004-07-08 Henkel Kgaa Verwendung von Steroidsulfatase-Inhibitoren zur Verminderung von Haarausfall
TW200524588A (en) * 2003-09-22 2005-08-01 Nippon Shinyaku Co Ltd Hair restorer
TW200533668A (en) 2003-12-15 2005-10-16 Theramex 1-n-phenyl-amino-1h-imidazole derivatives and pharmaceutical compositions containing them
GB0411562D0 (en) 2004-05-24 2004-06-23 Sterix Ltd Compound
GB0412492D0 (en) 2004-06-04 2004-07-07 Sterix Ltd Compound
GB0505541D0 (en) * 2005-03-17 2005-04-27 Novartis Ag Organic compounds
GB0513702D0 (en) 2005-07-04 2005-08-10 Sterix Ltd Compound
GB0604142D0 (en) 2006-03-01 2006-04-12 Sterix Ltd Compound
GB0706072D0 (en) 2007-03-28 2007-05-09 Sterix Ltd Compound
EP2207544A2 (en) 2007-09-17 2010-07-21 PregLem S.A. Treatment of oestrogen dependant conditions in pre-menopausal women
GB0722779D0 (en) 2007-11-20 2008-01-02 Sterix Ltd Compound
GB0914767D0 (en) 2009-08-24 2009-09-30 Sterix Ltd Compound
CA2807199C (en) * 2010-07-27 2020-07-07 Trustees Of Boston University Flavonoid-derived aryl hydrocarbon receptor modulators useful in the treatment of cancer
EP3260445A1 (en) * 2016-06-24 2017-12-27 Universität Konstanz Compounds for use as an anti-bacterial or anti-fungal agent and as a zinc sensor
EP3502095A1 (en) 2017-12-22 2019-06-26 Universität Konstanz Compound for use against pathogenic neisseria and haemophilus species and moraxella catarrhalis

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH619701A5 (es) * 1975-08-07 1980-10-15 Bayer Ag
US4060619A (en) * 1976-01-14 1977-11-29 Ayerst Mckenna And Harrison Ltd. 1,4-Dihydro-4-oxo-benzothiopyrano (4,3-b)pyridine-2-carboxylates and derivatives
DE3243158A1 (de) 1982-11-23 1984-05-24 Basf Ag, 6700 Ludwigshafen Neue sulfonsaeureester von hydroxycumarinen, ihre herstellung und sie enthaltende arzneimittel
FR2543140B1 (fr) 1983-03-24 1985-06-21 Cortial Nouveaux acides flavone-carboxyliques-4', leur methode de preparation et leur application en therapeutique
IN164232B (es) * 1986-04-11 1989-02-04 Hoechst India
GB8800199D0 (en) 1988-01-06 1988-02-10 Beecham Group Plc Pharmaceutical preparation
US5194446A (en) 1989-06-12 1993-03-16 A. H. Robins Company, Incorporated Compounds having one or more aminosulfaonyloxy radicals useful as pharmaceuticals
US5273993A (en) 1989-06-12 1993-12-28 A. H. Robins Company, Incorporated Compounds having one or more aminosulfonyloxy radicals useful as pharmaceuticals
PT94305B (pt) 1989-06-12 1997-02-28 Robins Co Inc A H Processo para a preparacao de compostos tendo um ou mais radicais aminossulfoniloxi uteis como produtos farmaceuticos
US5025031A (en) 1989-11-30 1991-06-18 A. H. Robins Co., Inc. Aryl and aryloxyalkyl sulfamate esters useful as anticonvulsants
GB9603325D0 (en) 1996-02-16 1996-04-17 Imperial College A compound
GB9118478D0 (en) 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
DE4308451A1 (de) 1992-09-10 1994-04-14 Bayer Ag 3-Aryl-pyron-Derivate
DE69531048T2 (de) 1994-04-05 2004-05-06 Celltech Therapeutics Ltd., Slough Verwendung von steroidsulphatase-hemmern
US5556847A (en) 1994-10-27 1996-09-17 Duquesne University Of The Holy Ghost Methods of effecting memory enhancement mediated by steroid sulfatase inhibitors
US5567831A (en) 1995-08-16 1996-10-22 Duguesne University Of The Holy Ghost Non-steroidal sulfatase inhibitor compounds and their method of use
DE19532311A1 (de) 1995-09-01 1997-03-06 Basf Ag Benzoylderivate
ATE286038T1 (de) * 1996-03-05 2005-01-15 Sterix Ltd Verbindungen mit sulfonsäure-amidgruppe
US6218427B1 (en) * 1996-08-27 2001-04-17 Shionogi & Co., Ltd. Chromene-3-carboxylate derivatives
US5763492A (en) 1996-10-01 1998-06-09 Duguesne University Of The Holy Ghost Methods for effecting memory enhancement mediated by non-steroidal sulfatase inhibitors
US6028088A (en) * 1998-10-30 2000-02-22 The University Of Mississippi Flavonoid derivatives

Also Published As

Publication number Publication date
DE69903143T2 (de) 2003-06-05
MY118897A (en) 2005-02-28
JP3425424B2 (ja) 2003-07-14
JP2002511459A (ja) 2002-04-16
PT1070059E (pt) 2003-01-31
AR018178A1 (es) 2001-10-31
WO1999052890A1 (en) 1999-10-21
ES2184439T3 (es) 2003-04-01
US6346626B1 (en) 2002-02-12
TW513420B (en) 2002-12-11
DE69903143D1 (de) 2002-10-31
AU3605499A (en) 1999-11-01
EP1070059A1 (en) 2001-01-24
DK1070059T3 (da) 2002-12-16
EP1070059B1 (en) 2002-09-25
GB9807779D0 (en) 1998-06-10
CO5031242A1 (es) 2001-04-27
ATE224885T1 (de) 2002-10-15

Similar Documents

Publication Publication Date Title
PE20000419A1 (es) Derivados de cromanona y tiocromanona
EP1047420B1 (en) Modulation of hair growth
ATE192649T1 (de) Stereochemische wortmanninderivate
PE20010126A1 (es) Pirrolotriazinas como inhibidores de cinasas
KR960704555A (ko) 5-알파 환원효소 억제제를 사용한 안드로겐성 탄모증의 치료 방법(Method of treating androgenic alopecia with 5-alpha reductase inhibitors)
ATE341306T1 (de) Verwendung von idebenon zum schutz von zubereitungen
AR012531A1 (es) Composicion para cuidado personal, composicion para repasador y metodo para minimizar o reducir la comezon o quemado de la piel a causa de composicionespara cuidado personal que contienen acido.
BRPI0113670B8 (pt) composição farmacêutica e método para tratar hipogonadismo
DE69329149T2 (de) 4-azasteroide als 5-alpha-reduktase
BG104761A (en) Benzofurylpyrone derivatives
PE20030548A1 (es) Acilsulfonamidas como inhibidores de sulfatasa esteroide
ATE437865T1 (de) Flavanoide derivate als chemotherapeutika, chemopreventiva bzw. antiangiogenetische wirkstoffe
PE109898A1 (es) Nuevo uso de los derivados de benzopirano
ATE295165T1 (de) Mittel zur adjuvanten therapie von demenzen enthaltend alpha-liponsäure
PE20011012A1 (es) Benzoxa y benzotiazoles como inhibidores de sulfatasa de esteroide
DE68918219T2 (de) 3-Beta, 17-beta Hydroxy-Steroide und ähnliche Steroid-Verbindungen.
NZ505200A (en) Carboxyl substituted chroman derivatives useful as beta 3 adrenoreceptor agonists
EP0998930A4 (en) REPAIR AGENT AGAINST Baldness AND OTHER DISEASES
DE69615046D1 (de) 17-alkyl-7-substituierte-4-aza-steroidderivate
ES2168062B1 (es) Composiciones para control de cucarachas
PE20060337A1 (es) 17alfa-fluoroesteroides
KR910004573A (ko) 이미다졸 유도체, 그의 제조방법 및 그를 함유하는 항궤양제
PE20020752A1 (es) Esteroides con doble enlace delta 14 sustituido en las posiciones 13 y 14 con actividad androgenica y progestagena
DK1137660T3 (da) 22S-hydroxycholesta-8,14-dienderivater med meioseregulerende aktivitet
ECSP992907A (es) Derivados de cromanona y tiocromanona

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed