PE15197A1 - Proteinas anti-obesidad - Google Patents

Proteinas anti-obesidad

Info

Publication number
PE15197A1
PE15197A1 PE1996000072A PE00007296A PE15197A1 PE 15197 A1 PE15197 A1 PE 15197A1 PE 1996000072 A PE1996000072 A PE 1996000072A PE 00007296 A PE00007296 A PE 00007296A PE 15197 A1 PE15197 A1 PE 15197A1
Authority
PE
Peru
Prior art keywords
xaa
gln
asn
glu
leu
Prior art date
Application number
PE1996000072A
Other languages
English (en)
Inventor
Richard Dennis Dimarchi
Jr William Francis Heath
Margaret Barbara Basinski
Brigitte Elisabeth Schoner
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE15197A1 publication Critical patent/PE15197A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

SE REFIERE A PROTEINAS DE FORMULA GENERAL I, DONDE: Xaa EN LAS POSICIONES 4, 7, 28, 34, 56, 62, 63, 75, 130, 134 Y 139 ES GLN O GLU 0 PUEDE ESTAR AUSENTE (SOLO EN 28); Xaa EN 54, 68 Y 136 ES MET, LEU, ENTRE OTROS; Xaa EN 22 Y 72 ES ASN, ASP O GLU; Xaa EN 78 Y 82 ES GLN, ASN O ASP; Xaa EN 27 ES THR O ALA; Xaa EN 77 ES SER O ALA; Xaa EN 118 ES GLY O LEU; Y QUE TIENE COMO MINIMO UNA SUSTITUCION EN LAS POSICIONES 97, 100, 101, 102, 103, 105, 106, 107, 108, 111, 138 Y/O EXISTEN UNIONES DISULFURO ENTRE CYS EN 96 Y CIS EN 146, PARA LOGRAR MEJORAR LA ESTABILIDAD DE LA PROTEINA. TAMBIEN SE REFIERE AL PROCESO DE HACER LAS PROTEINAS DE FORMULA GENERAL I, QUE COMPRENDE: A) TRANSFORMAR UN MINERAL CON INCLUSION DE CELULAS CON DNA, QUE CODIFICA CUALQUIERA DE LAS PROTEINAS, PROVISTAS OPCIONALMENTE DE UNA SECUENCIA GUIA OPCIONAL, QUE ES MET-R1, DONDE R1 ES UN AMINOACIDO, PREFERENTEMENTE ARG, EXCEPTO PRO; B) CULTIVAR UN MINERAL CON INCLUSION DE CELULAS Y AISLAR LA PROTEINA CODIFICADA EN (A); Y OPC. C) PARTIR ENZIMATICAMENTE LA SECUENCIA LIDER. ESTAS AGENTES TERAPEUTICOS REGULAN EL TEJIDO ADIPOSO, NORMALIZANDO EL RIESGO DE DIABETES MELLITUS TIPO II, ENFERMEDADES CARDIOVASCULARES Y EL CANCER
PE1996000072A 1995-01-31 1996-01-30 Proteinas anti-obesidad PE15197A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US38104895A 1995-01-31 1995-01-31
US38363895A 1995-02-06 1995-02-06
US45095P 1995-06-22 1995-06-22
US216195P 1995-08-11 1995-08-11

Publications (1)

Publication Number Publication Date
PE15197A1 true PE15197A1 (es) 1997-05-22

Family

ID=27484996

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1996000072A PE15197A1 (es) 1995-01-31 1996-01-30 Proteinas anti-obesidad

Country Status (15)

Country Link
JP (1) JPH10513451A (es)
KR (1) KR19980701798A (es)
AR (1) AR002956A1 (es)
AU (1) AU703316B2 (es)
BR (1) BR9606999A (es)
CA (1) CA2211784A1 (es)
CO (1) CO4480035A1 (es)
CZ (1) CZ240497A3 (es)
FI (1) FI973162A (es)
NO (1) NO973515L (es)
NZ (1) NZ301589A (es)
PE (1) PE15197A1 (es)
PL (1) PL321702A1 (es)
TR (1) TR199600085A2 (es)
YU (1) YU5296A (es)

Also Published As

Publication number Publication date
CZ240497A3 (cs) 1998-01-14
AU703316B2 (en) 1999-03-25
CO4480035A1 (es) 1997-07-09
KR19980701798A (ko) 1998-06-25
JPH10513451A (ja) 1998-12-22
PL321702A1 (en) 1997-12-22
NZ301589A (en) 1999-02-25
BR9606999A (pt) 1997-10-28
NO973515D0 (no) 1997-07-30
TR199600085A2 (tr) 1996-08-21
CA2211784A1 (en) 1996-08-08
AR002956A1 (es) 1998-05-27
FI973162A (fi) 1997-09-30
NO973515L (no) 1997-09-29
FI973162A0 (fi) 1997-07-30
AU4705296A (en) 1996-08-21
YU5296A (sh) 1998-08-14

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Legal Events

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