PE106300A1 - Imidazoquinoxalinas como inhibidores de la proteina tirosina cinasa - Google Patents
Imidazoquinoxalinas como inhibidores de la proteina tirosina cinasaInfo
- Publication number
- PE106300A1 PE106300A1 PE1998000776A PE00077698A PE106300A1 PE 106300 A1 PE106300 A1 PE 106300A1 PE 1998000776 A PE1998000776 A PE 1998000776A PE 00077698 A PE00077698 A PE 00077698A PE 106300 A1 PE106300 A1 PE 106300A1
- Authority
- PE
- Peru
- Prior art keywords
- alkynyl
- alkyl
- compound
- imidazoquinoxalins
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A UNA IMIDAZOQUINOXALINA DE FORMULA I DONDE p ES 0-4; R1, R2 Y R3 SON H, R6, OH, OR6, SH, SR6, C(O)qH, -OC(O)qR6, SO3H, HALO, CIANO, ENTRE OTROS; q ES 1 o 2; R6 ES ALQUILO, ALQUENILO, ALQUINILO, ENTRE OTROS; R4 Y R5 SON H, R6 o -C(O)R6 o JUNTO CON N FORMAN UN ANILLO DE 3-8 MIEMBROS, OPCIONALMENTE SUSTITUIDO POR Z1, Z2 Y Z3; R7, R8, R9, R10, R11 Y R12 SON H, R6, O R7 Y R8 O R9, R10 Y R11 SON ALQUILENO O ALQUENILENO FORMANDO PARTE DE UN ANILLO DE 3-8 MIEMBROS; R13, R14 Y R15 SON ALQUILO O FENILO; Z1, Z2, Z3 SON H, Z6, OH, OZ6, SH, SZ6, C(O)qH, -OC(O)qZ6, ENTRE OTROS; Z6 ES ALQUILO, ALQUENILO, ALQUINILO, CICLOALQUILO, ENTRE OTROS. UN COMPUESTO PREFERIDO ES N-(2-CLORO-6-METILFENIL)-8-NITROIMIDAZO[1,5-a]-QUINOXALIN-4-AMINA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. TAMBIEN JUNTO AL COMPUESTO I SE UTILIZA UN ANTIINFLAMATORIO, ANTIPROLIFERATIVO, INMUNOSUPRESOR. EL COMPUESTO I PUEDE SER UTIL PARA TRATAR UN PADECIMIENTO O DESORDEN ASOCIADO CON LA PROTEINA TIROSINA CINASA COMO RECHAZO DE TRANSPLANTE, ARTRITIS REUMATOIDE, ESCLEROSIS MULTIPLE, LUPUS, INJERTO, HIPERSENSIBILIDAD MEDIADA POR LAS CELULAS T, PSORIASIS, TIROIDITIS DE HASHIMOTO, SINDROME DE GUILLEN-BARRE, DERMATITIS, ASMA, CANCER
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5677097P | 1997-08-25 | 1997-08-25 | |
US6915997P | 1997-12-09 | 1997-12-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE106300A1 true PE106300A1 (es) | 2000-01-23 |
Family
ID=26735691
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1998000776A PE106300A1 (es) | 1997-08-25 | 1998-08-25 | Imidazoquinoxalinas como inhibidores de la proteina tirosina cinasa |
Country Status (5)
Country | Link |
---|---|
US (1) | US6235740B1 (es) |
AR (1) | AR013441A1 (es) |
AU (1) | AU8681798A (es) |
PE (1) | PE106300A1 (es) |
WO (1) | WO1999009845A1 (es) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2322311C (en) * | 1998-03-04 | 2009-10-13 | Bristol-Myers Squibb Company | Heterocyclo-substituted imidazopyrazine protein tyrosine kinase inhibitors |
US20040214836A1 (en) * | 1998-05-29 | 2004-10-28 | Cheresh David A. | Method of treatment of myocardial infarction |
US20060258686A1 (en) * | 1998-05-29 | 2006-11-16 | Cheresh David A | Method of treatment of myocardial infarction |
US20030130209A1 (en) * | 1999-12-22 | 2003-07-10 | Cheresh David A. | Method of treatment of myocardial infarction |
EP1206260A4 (en) | 1999-06-30 | 2002-10-30 | Merck & Co Inc | SRC-KINASE INHIBITING COMPOUNDS |
CA2376951A1 (en) | 1999-06-30 | 2001-01-04 | Peter J. Sinclair | Src kinase inhibitor compounds |
DE60006541D1 (de) | 1999-06-30 | 2003-12-18 | Merck & Co Inc | Src-kinase hemmende verbindungen |
US6506769B2 (en) | 1999-10-06 | 2003-01-14 | Boehringer Ingelheim Pharmaceuticals, Inc. | Heterocyclic compounds useful as inhibitors of tyrosine kinases |
US7101869B2 (en) | 1999-11-30 | 2006-09-05 | Pfizer Inc. | 2,4-diaminopyrimidine compounds useful as immunosuppressants |
US20030176454A1 (en) * | 2000-05-15 | 2003-09-18 | Akira Yamada | N-coating heterocyclic compounds |
ES2260300T3 (es) * | 2000-10-03 | 2006-11-01 | Bristol-Myers Squibb Company | Compuestos tetraciclicos sustituidos con amino utiles como agentes antiinflamatorios y composiciones farmaceuticas que comprenden los mismos. |
US6869956B2 (en) * | 2000-10-03 | 2005-03-22 | Bristol-Myers Squibb Company | Methods of treating inflammatory and immune diseases using inhibitors of IκB kinase (IKK) |
CZ20032287A3 (cs) * | 2001-02-01 | 2004-02-18 | Bristol-Myers Squibb Company | Způsoby léčení zánětlivých a imunitních nemocí za použití inhibitorů IkB kinázy (IKK) |
GB0127922D0 (en) * | 2001-11-21 | 2002-01-16 | Novartis Ag | Organic compounds |
US6821988B2 (en) * | 2001-11-27 | 2004-11-23 | Wyeth Holdings Corporation | 3-cyanoquinolines as inhibitors of EGF-R and HER2 kinases |
WO2004012769A1 (en) * | 2002-08-02 | 2004-02-12 | The Regents Of The University Of California | Therapeutic inhibitionof protein kinases in cancer cells |
US20040180898A1 (en) * | 2003-03-03 | 2004-09-16 | Bang-Chi Chen | Processes for preparing imidazoquinoxalinones, heterocyclic-substituted imidazopyrazinones, imidazoquinoxalines and heterocyclic-substituted imidazopyrazines |
US7880017B2 (en) * | 2003-11-11 | 2011-02-01 | Allergan, Inc. | Process for the synthesis of imidazoles |
US7183305B2 (en) * | 2003-11-11 | 2007-02-27 | Allergan, Inc. | Process for the synthesis of imidazoles |
US20060025419A1 (en) * | 2004-06-25 | 2006-02-02 | Ann Richmond | Imidazoquinoxaline compound for the treatment of melanoma |
US8003657B2 (en) * | 2004-10-13 | 2011-08-23 | Merck Patent Gmbh | Heterocyclic substituted bisarylurea derivatives |
WO2007106884A2 (en) | 2006-03-15 | 2007-09-20 | Theralogics, Inc. | Methods of treating muscular wasting diseases using nf-kb activation inhibitors |
CA2646539A1 (en) | 2006-03-23 | 2007-09-27 | Novartis Ag | Imidazoquinoxaline compounds as immunomodulators |
US20080076770A1 (en) * | 2006-09-25 | 2008-03-27 | Arete Therapeutics, Inc. | Soluble epoxide hydrolase inhibitors |
CN101616919B (zh) * | 2006-12-28 | 2012-10-10 | 雅培制药有限公司 | 聚(adp核糖)聚合酶抑制剂 |
WO2008130619A2 (en) * | 2007-04-20 | 2008-10-30 | Trustees Of Boston College | A composition comprising an inhibitor of pde4 and/or pde7 |
CA2706866A1 (en) * | 2007-11-30 | 2009-06-04 | Biotie Therapies Gmbh | Aryl and heteroaryl fused imidazo[1,5-a]pyrazines as inhibitors of phosphodiesterase 10 |
WO2009070583A1 (en) * | 2007-11-30 | 2009-06-04 | Wyeth | Pyrido[3,2-e]pyrazines, process for preparing the same, and their use as inhibitors of phosphodiesterase 10 |
EP2227472A1 (en) * | 2007-11-30 | 2010-09-15 | Elbion Gmbh | Aryl and heteroaryl fused imidazo (1,5-a) pyrazines as inhibitors of phosphodiesterase 10 |
US20100227853A1 (en) * | 2008-04-18 | 2010-09-09 | Trustees Of Boston College | Inhibitors of cyclic amp phosphodiesterases |
WO2010025073A1 (en) * | 2008-08-28 | 2010-03-04 | Takeda Pharmaceutical Company Limited | Dihydroimidazo [ 1, 5-f] pteridines as polo-like kinase inhibitors |
US8475790B2 (en) | 2008-10-06 | 2013-07-02 | Bristol-Myers Squibb Company | Combination of CD137 antibody and CTLA-4 antibody for the treatment of proliferative diseases |
CN102341399A (zh) | 2009-03-05 | 2012-02-01 | 安斯泰来制药株式会社 | 喹喔啉化合物 |
US8361962B2 (en) * | 2009-07-27 | 2013-01-29 | Roche Palo Alto Llc | Tricyclic inhibitors of JAK |
KR101481872B1 (ko) * | 2009-09-10 | 2015-01-12 | 에프. 호프만-라 로슈 아게 | Jak의 억제제 |
CN102498113B (zh) * | 2009-09-21 | 2014-11-26 | 弗·哈夫曼-拉罗切有限公司 | Jak的大环抑制剂 |
GB201007286D0 (en) | 2010-04-30 | 2010-06-16 | Astex Therapeutics Ltd | New compounds |
AU2011299936A1 (en) | 2010-09-07 | 2013-03-28 | Astellas Pharma Inc. | Quinoxaline compound |
US9540379B2 (en) * | 2011-01-31 | 2017-01-10 | Boehringer Ingelheim International Gmbh | (1,2,4)triazolo[4,3-A]quinoxaline derivatives as inhibitors of phosphodiesterases |
HUE053654T2 (hu) | 2014-03-26 | 2021-07-28 | Astex Therapeutics Ltd | FGFR- és CMET-inhibitorok kombinációi a rák kezelésére |
JO3512B1 (ar) | 2014-03-26 | 2020-07-05 | Astex Therapeutics Ltd | مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز |
JP6980385B2 (ja) | 2014-03-26 | 2021-12-15 | アステックス、セラピューティックス、リミテッドAstex Therapeutics Limited | Fgfr阻害剤とigf1r阻害剤の組合せ |
JOP20200201A1 (ar) | 2015-02-10 | 2017-06-16 | Astex Therapeutics Ltd | تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين |
BR112018005637B1 (pt) | 2015-09-23 | 2023-11-28 | Janssen Pharmaceutica Nv | Compostos derivados de quinoxalina, quinolina e quinazolinona,composições farmacêuticas que os compreende, e uso dos referidos compostos |
KR20180052631A (ko) | 2015-09-23 | 2018-05-18 | 얀센 파마슈티카 엔.브이. | 비-헤테로아릴 치환된 1,4-벤조디아제핀 및 암의 치료를 위한 이의 용도 |
WO2024027370A1 (zh) * | 2022-08-03 | 2024-02-08 | 上海和誉生物医药科技有限公司 | 一种含氮三稠环prmt5抑制剂,其制备方法和药学上的用途 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4229452A (en) | 1977-01-07 | 1980-10-21 | Westwood Pharmaceuticals, Inc. | Treatment of inflammatory disorders with 4-trifluoromethylimidazo[1,2-a]quinoxaline |
US4236015A (en) | 1977-01-07 | 1980-11-25 | Westwood Pharmaceuticals, Inc. | 1-(2-Acylaminophenyl)imidazoles |
US4225724A (en) | 1977-01-07 | 1980-09-30 | Westwood Pharmaceuticals, Inc. | 1-(2-Phenylureylene)imidazoles |
US4197403A (en) | 1977-01-07 | 1980-04-08 | Westwood Pharmaceuticals Inc. | 4-Aminosubstituted imidazo(1,2-A)quinoxalines |
US4191766A (en) | 1977-01-07 | 1980-03-04 | Westwood Pharmaceuticals, Inc. | Method for reducing immunological response |
US4198508A (en) | 1977-01-07 | 1980-04-15 | Westwood Pharmaceuticals Inc. | Process for preparing 4-substituted imidazo[1,2-a]quinoxalines |
US4200750A (en) | 1977-01-07 | 1980-04-29 | Westwood Pharmaceuticals Inc. | 4-Substituted imidazo [1,2-a]quinoxalines |
US4172947A (en) | 1977-01-07 | 1979-10-30 | Westwood Pharmaceuticals, Inc. | 1-(2-Acylaminophenyl)imidazoles |
US4191767A (en) | 1977-01-07 | 1980-03-04 | Westwood Pharmaceuticals, Inc. | Method for treating fungal infection in mammals with imidazo [1,2-a]quinoxalines |
US4160097A (en) | 1977-01-07 | 1979-07-03 | Westwind Pharmaceuticals, Inc. | 1-(2-Phenylureylene)imidazoles |
JPS5632549A (en) | 1979-08-27 | 1981-04-02 | Toyo Ink Mfg Co Ltd | Pigment composition |
US4440929A (en) | 1981-07-16 | 1984-04-03 | Usv Pharmaceutical Corporation | Imidazoquinoxaline compounds |
DK161148C (da) | 1988-06-14 | 1991-11-18 | Novo Nordisk As | Imidazoquinoxalinforbindelser, fremgangsmaade til fremstilling deraf samt farmaceutiske praeprater indeholdende forbindelserne |
DK151890D0 (da) * | 1990-06-22 | 1990-06-22 | Ferrosan As | Heterocykliske forbindelser deres fremstilling og brug |
US5276028A (en) | 1990-06-22 | 1994-01-04 | Nordisk A/S | Imidazoquinoxaline compounds |
DE19506742A1 (de) | 1995-02-27 | 1996-08-29 | Bayer Ag | Verwendung von Chinoxalinen in Kombination mit Protease-Inhibitoren als Arzneimittel zur Behandlung von AIDS und/oder HIV-Infektionen |
IT1276167B1 (it) | 1995-11-24 | 1997-10-27 | Foscama Biomed Chim Farma | Imidazo(1,2-alfa)chinossalin-4-ammine attivi come antagonisti adenosinici,procedimento per la loro preparazione e loro composizioni |
-
1998
- 1998-06-15 US US09/097,338 patent/US6235740B1/en not_active Expired - Lifetime
- 1998-08-03 AU AU86817/98A patent/AU8681798A/en not_active Abandoned
- 1998-08-03 WO PCT/US1998/016027 patent/WO1999009845A1/en active Application Filing
- 1998-08-25 AR ARP980104209A patent/AR013441A1/es unknown
- 1998-08-25 PE PE1998000776A patent/PE106300A1/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1999009845A1 (en) | 1999-03-04 |
US6235740B1 (en) | 2001-05-22 |
AU8681798A (en) | 1999-03-16 |
AR013441A1 (es) | 2000-12-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE106300A1 (es) | Imidazoquinoxalinas como inhibidores de la proteina tirosina cinasa | |
PE129799A1 (es) | Inhibidores de benzotiazol de la proteina tirosina cinasa | |
MX9304646A (es) | Nuevas 7-(sustituido)-8-(sustituido)d-9-[(glicilo sustituido)amido]-6-desmetil-6-desoxitetraciclinasy metodo para su produccion. | |
AU6691094A (en) | Heteroatom substituted alkyl benzylaminoquinuclidines as substance p antagonists | |
MX9304647A (es) | 7-(sustituido)-9-[(glicilo sustituido)amido]-6-desmetil-6-desoxitetraciclinas y metodo para su produccion. | |
PT723538E (pt) | Compostos triciclicos de carbamato uteis para a ainibicao da funcao da proteina g e para o tratamento de doencas proliferativas | |
AU584663B2 (en) | Thieno-triazolo-1,4-diazepino-2-carboxylic acid amides | |
MX9302214A (es) | Derivados de taxol y proceso para su preparacion | |
ES2190440T3 (es) | Compuestos antitumorales, composiciones farmaceuticas, modos de preparacion y para el tratamiento. | |
NO932872L (no) | Nye 7-(substituerte)-8-(substituerte)-9-(substituert amino)-6-demetyl-6-deoksy-tetracykliner | |
BR9906905A (pt) | Composto, composição farmacêutica, uso de um composto, e, processos para a preparação de um composto, para tratamento e/ou prevenção de ansiedade e para o tratamento e/ou prevenção de convulsões. | |
MX9302169A (es) | Fenoxialquilisoxazolas de 1,2,4-oxadiazolilo y su uso como agentes antivirales. | |
NZ330244A (en) | Isoxazole derivatives useful in the treatment of inflammatory diseases | |
AU554959B2 (en) | Triazolo(4,3-a) quinazolin-5-ones | |
AU4844290A (en) | Halo substituted aminotetralins | |
ATE174327T1 (de) | Bicyclo (2.2.2) oktan-derivate mit cholecystokinin und/oder gastrin antagonistischer wirkung | |
PT93126A (pt) | Processo para a preparacao de eteres carboxialquilicos da 2-amino-7- -hidroxitetralina | |
ES2074508T3 (es) | Benzocicloalquilaminopiridinaminas y compuestos afines, un procedimiento e intermediarios para su preparacion y su uso como medicamentos. | |
EA200100141A1 (ru) | Терапевтическая композиция на основе изофлавоноидов для применения в лечении опухолей цитотоксическими агентами | |
NZ333229A (es) | ||
SE8304545D0 (sv) | Benzamide derivatives | |
ATE216233T1 (de) | Indolditerpen alkaloide | |
AR021094A1 (es) | Compuestos heterociclicos inhibidores de la fosfodiesterasa iv y su uso para el tratamiento de enfermedades inflamatorias | |
ES2074618T3 (es) | 3-(1h-indazol-3-il)-4-piridinaminas, un procedimiento e intermediarios para su preparacion y su uso como medicamentos. | |
PT1019347E (pt) | Metodo para a sintese de taxanos |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |