PA8799901A1 - Derivado de triazol 1,3,5-trisustituido - Google Patents

Derivado de triazol 1,3,5-trisustituido

Info

Publication number
PA8799901A1
PA8799901A1 PA20088799901A PA8799901A PA8799901A1 PA 8799901 A1 PA8799901 A1 PA 8799901A1 PA 20088799901 A PA20088799901 A PA 20088799901A PA 8799901 A PA8799901 A PA 8799901A PA 8799901 A1 PA8799901 A1 PA 8799901A1
Authority
PA
Panama
Prior art keywords
trisustituted
triazol
invention refers
triazol derivative
derivative
Prior art date
Application number
PA20088799901A
Other languages
English (en)
Inventor
Johannes Wilhelmus John F Thuring
Theodorus Dinklo
Anne Simone Josephine Lesage
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PA8799901A1 publication Critical patent/PA8799901A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

ESTA INVENCIÒN SE REFIERE A 2-(2,6-DIMETIL-PIRIDIN-4-IL)-[1,2,4]TRIAZOL-1-IL]-N-ETIL-ACETAMIDA Y ANÀLOGOS O SUS SALES ACEPTABLES PARA USO FARMACÈUTICO A PROCESOS PARA PREPARARLOS, A COMPOSICIONES FARMACÈUTICAS QUE LOS CONTIENEN Y A SU USO EN TERAPIA. LA INVENCIÒN SE REFIERE EN PARTICULAR A UN MODULADOR ALOSTÈRICO POSITIVO POTENTE DE LOS RECEPTORES NICOTINICOS DE LA ACETICOLINA QUE TIENEN LA CAPACIDAD DE AUMENTAR LA EFICACIA DE LOS AGONISTAS DE LOS RECEPTORES NICOTÌNICOS.
PA20088799901A 2007-10-18 2008-10-17 Derivado de triazol 1,3,5-trisustituido PA8799901A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07118822 2007-10-18

Publications (1)

Publication Number Publication Date
PA8799901A1 true PA8799901A1 (es) 2009-05-15

Family

ID=39047591

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20088799901A PA8799901A1 (es) 2007-10-18 2008-10-17 Derivado de triazol 1,3,5-trisustituido

Country Status (18)

Country Link
US (1) US8404851B2 (es)
EP (1) EP2205594B1 (es)
JP (1) JP2011500624A (es)
CN (1) CN101827839B (es)
AR (1) AR068919A1 (es)
AT (1) ATE522523T1 (es)
AU (1) AU2008313775B2 (es)
CA (1) CA2697982C (es)
CL (1) CL2008003067A1 (es)
ES (1) ES2371863T3 (es)
IL (1) IL205102A (es)
JO (1) JO2784B1 (es)
MX (1) MX2010004176A (es)
PA (1) PA8799901A1 (es)
PE (1) PE20091080A1 (es)
RU (1) RU2476433C2 (es)
TW (1) TW200934491A (es)
WO (1) WO2009050185A1 (es)

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BRPI0912196A2 (pt) * 2008-05-09 2015-10-06 Janssen Pharmaceutica Nv pirazóis trissubstituídos como moduladores do receptor de acetilcolina.
CA2825519A1 (en) 2011-02-03 2012-09-08 Lupin Limited Pyrrole derivatives used as modulators of alpha7 nachr
CA2826792A1 (en) 2011-02-23 2012-08-30 Lupin Limited Heteroaryl derivatives as alpha7 nachr modulators
EP2678315B1 (en) 2011-02-25 2015-12-16 Janssen Pharmaceutica, N.V. (Pyridin-4-yl)benzylamides as allosteric modulators of alpha 7 nAChR
EP2691368A1 (en) 2011-03-31 2014-02-05 Lupin Limited Pyrrole derivatives as nicotinic acetylcholine receptor modulators for use in the treatment of neurodegenerative disorders such as alzheimer's and parkinson's disease
US8946432B2 (en) 2011-07-05 2015-02-03 Lupin Limited Biaryl derivatives as nAChR modulators
US9388196B2 (en) 2012-03-06 2016-07-12 Lupin Limited Thiazole derivatives as alpha 7 nAChR modulators
WO2014072957A1 (en) 2012-11-12 2014-05-15 Lupin Limited Thiazole derivatives as alpha 7 nachr modulators
EP2945941B1 (en) 2013-01-16 2016-12-07 Lupin Limited Pyrrole derivatives as alpha 7 nachr modulators
EP2970180A1 (en) 2013-03-13 2016-01-20 Lupin Limited Pyrrole derivatives as alpha 7 nachr modulators
TW201446243A (zh) 2013-06-03 2014-12-16 Lupin Ltd 4-(5-(4-氯苯基)-2-(2-環丙基乙醯基)-1,4-二甲基-1氫-吡咯-3-基)苯磺醯胺作為α7尼古丁乙醯膽鹼受體調節劑
US9504680B2 (en) 2013-06-17 2016-11-29 Lupin Limited Pyrrole derivatives as alpha 7 nAChR modulators

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US4761422A (en) 1986-11-20 1988-08-02 Lusofarmaco Istituto Lusofarmaco D'italia Spa (2-amino-4-aryl-thiazole-5-yl)ethanols and their derivatives having diuretic activity and methods for preparing the same
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KR970705560A (ko) 1995-08-02 1997-10-09 호아껭 우리아치 토렐로 항진균 활성을 갖는 신규한 카르복사미드(new carboxamides with antifungal activity)
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AU2009226988B2 (en) * 2008-03-19 2013-05-23 Janssen Pharmaceutica Nv Trisubstituted 1, 2, 4 -triazoles as nicotinic acetylcholine receptor modulators
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BRPI0912196A2 (pt) * 2008-05-09 2015-10-06 Janssen Pharmaceutica Nv pirazóis trissubstituídos como moduladores do receptor de acetilcolina.
KR101710197B1 (ko) * 2009-09-17 2017-02-24 얀센 파마슈티카 엔.브이. 치환된 ｎ-페닐-1-(4-피리디닐)-1ｈ-피라졸-3-아민
JO3078B1 (ar) * 2009-11-27 2017-03-15 Janssen Pharmaceutica Nv مورفولينوثيازولات بصفتها منظمات الوستيرية نوع الفا 7 موجبة
EP2678315B1 (en) 2011-02-25 2015-12-16 Janssen Pharmaceutica, N.V. (Pyridin-4-yl)benzylamides as allosteric modulators of alpha 7 nAChR

Also Published As

Publication number Publication date
AR068919A1 (es) 2009-12-16
CA2697982C (en) 2015-09-22
ES2371863T3 (es) 2012-01-10
RU2476433C2 (ru) 2013-02-27
EP2205594A1 (en) 2010-07-14
US8404851B2 (en) 2013-03-26
CN101827839A (zh) 2010-09-08
AU2008313775B2 (en) 2012-12-13
JO2784B1 (en) 2014-03-15
CL2008003067A1 (es) 2009-11-27
IL205102A (en) 2015-04-30
CA2697982A1 (en) 2009-04-23
CN101827839B (zh) 2012-10-24
EP2205594B1 (en) 2011-08-31
ATE522523T1 (de) 2011-09-15
WO2009050185A1 (en) 2009-04-23
TW200934491A (en) 2009-08-16
AU2008313775A1 (en) 2009-04-23
JP2011500624A (ja) 2011-01-06
US20100240707A1 (en) 2010-09-23
RU2010119458A (ru) 2011-11-27
MX2010004176A (es) 2010-05-03
PE20091080A1 (es) 2009-08-03
IL205102A0 (en) 2010-11-30

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