ATE522523T1 - 1,3,5-trisubstituiertes triazolderivat - Google Patents
1,3,5-trisubstituiertes triazolderivatInfo
- Publication number
- ATE522523T1 ATE522523T1 AT08805280T AT08805280T ATE522523T1 AT E522523 T1 ATE522523 T1 AT E522523T1 AT 08805280 T AT08805280 T AT 08805280T AT 08805280 T AT08805280 T AT 08805280T AT E522523 T1 ATE522523 T1 AT E522523T1
- Authority
- AT
- Austria
- Prior art keywords
- triazole derivative
- trisubstituted
- trisubstituted triazole
- derivative
- triazole
- Prior art date
Links
- -1 1,3,5-TRISUBSTITUTED TRIAZOLE Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07118822 | 2007-10-18 | ||
PCT/EP2008/063844 WO2009050185A1 (en) | 2007-10-18 | 2008-10-15 | 1,3,5-trisubstituted triazole derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE522523T1 true ATE522523T1 (de) | 2011-09-15 |
Family
ID=39047591
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT08805280T ATE522523T1 (de) | 2007-10-18 | 2008-10-15 | 1,3,5-trisubstituiertes triazolderivat |
Country Status (18)
Country | Link |
---|---|
US (1) | US8404851B2 (de) |
EP (1) | EP2205594B1 (de) |
JP (1) | JP2011500624A (de) |
CN (1) | CN101827839B (de) |
AR (1) | AR068919A1 (de) |
AT (1) | ATE522523T1 (de) |
AU (1) | AU2008313775B2 (de) |
CA (1) | CA2697982C (de) |
CL (1) | CL2008003067A1 (de) |
ES (1) | ES2371863T3 (de) |
IL (1) | IL205102A (de) |
JO (1) | JO2784B1 (de) |
MX (1) | MX2010004176A (de) |
PA (1) | PA8799901A1 (de) |
PE (1) | PE20091080A1 (de) |
RU (1) | RU2476433C2 (de) |
TW (1) | TW200934491A (de) |
WO (1) | WO2009050185A1 (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ576570A (en) * | 2006-10-19 | 2010-11-26 | Takeda Pharmaceutical | 7-sulfonylamino-2-thiazol and 2-thiadiazol -indole compounds |
WO2009050186A1 (en) * | 2007-10-18 | 2009-04-23 | Janssen Pharmaceutica Nv | Trisubstituted 1,2,4-triazoles |
ES2442932T3 (es) * | 2008-03-19 | 2014-02-14 | Janssen Pharmaceutica N.V. | 1,2,4-Triazoles trisustituidos como moduladores de receptores nicotínicos de acetilcolina |
EA018187B1 (ru) * | 2008-05-09 | 2013-06-28 | Янссен Фармацевтика Нв | Тризамещенные пиразолы в качестве модуляторов рецепторов ацетилхолина |
JP5865397B2 (ja) | 2011-02-03 | 2016-02-17 | ルピン・リミテッドLupin Limited | α7nAChRのモジュレータとして使用されるピロール誘導体 |
LT2678327T (lt) | 2011-02-23 | 2016-11-25 | Lupin Limited | Heteroarilo dariniai kaip nachr alpha7 moduliatoriai |
CA2824350C (en) | 2011-02-25 | 2019-07-02 | Janssen Pharmaceutica Nv | (pyridin-4-yl)benzylamides as allosteric modulators of alpha 7 nachr |
SG193387A1 (en) | 2011-03-31 | 2013-10-30 | Lupin Ltd | Pyrrole derivatives as nicotinic acetylcholine receptor modulators for use in the treatment of neurodegenerative disorders such as alzheimer's and parkinson's disease |
US8946432B2 (en) | 2011-07-05 | 2015-02-03 | Lupin Limited | Biaryl derivatives as nAChR modulators |
WO2013132380A1 (en) | 2012-03-06 | 2013-09-12 | Lupin Limited | Thiazole derivatives as alpha 7 nachr modulators |
EP2945936A1 (de) | 2012-11-12 | 2015-11-25 | Lupin Limited | Thiazolderivate als alpha-7-nachr-modulatoren |
EP2945941B1 (de) | 2013-01-16 | 2016-12-07 | Lupin Limited | Pyrrolderivate als alpha-7-nachr-modulatoren |
EP2970180A1 (de) | 2013-03-13 | 2016-01-20 | Lupin Limited | Pyrrolderivate als alpha-7-nachr-modulatoren |
TW201446243A (zh) | 2013-06-03 | 2014-12-16 | Lupin Ltd | 4-(5-(4-氯苯基)-2-(2-環丙基乙醯基)-1,4-二甲基-1氫-吡咯-3-基)苯磺醯胺作為α7尼古丁乙醯膽鹼受體調節劑 |
US9504680B2 (en) | 2013-06-17 | 2016-11-29 | Lupin Limited | Pyrrole derivatives as alpha 7 nAChR modulators |
Family Cites Families (46)
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BE795907A (fr) | 1972-02-25 | 1973-06-18 | Luso Farmaco Inst | 2-amino-4-arylthiazoles 5-substitues et leur preparation |
EP0248523B1 (de) | 1986-05-07 | 1991-10-16 | FISONS plc | Pyrazole |
JPS6339868A (ja) | 1986-08-04 | 1988-02-20 | Otsuka Pharmaceut Factory Inc | ジ低級アルキルフエノ−ル誘導体 |
US4761422A (en) | 1986-11-20 | 1988-08-02 | Lusofarmaco Istituto Lusofarmaco D'italia Spa | (2-amino-4-aryl-thiazole-5-yl)ethanols and their derivatives having diuretic activity and methods for preparing the same |
JPH10504542A (ja) | 1994-07-27 | 1998-05-06 | ジー.ディー.サール アンド カンパニー | 炎症処置用の置換チアゾール化合物 |
EP0783502A1 (de) | 1995-08-02 | 1997-07-16 | J. URIACH & CIA. S.A. | Carboxamide mit antifungaler wirkung |
FR2754258B1 (fr) | 1996-10-08 | 1998-12-31 | Sanofi Sa | Derives d'aminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant |
US6187797B1 (en) | 1996-12-23 | 2001-02-13 | Dupont Pharmaceuticals Company | Phenyl-isoxazoles as factor XA Inhibitors |
ATE236890T1 (de) | 1996-12-23 | 2003-04-15 | Bristol Myers Squibb Pharma Co | Sauerstoff oder schwefel enthaltende 5-gliedrige heteroaromatishe derivative als factor xa hemmer |
WO1999021555A2 (en) | 1997-10-27 | 1999-05-06 | Takeda Chemical Industries, Ltd. | Adenosine a3 receptor antagonists |
FR2792314B1 (fr) | 1999-04-15 | 2001-06-01 | Adir | Nouveaux composes aminotriazoles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
PT1070708E (pt) | 1999-07-21 | 2004-05-31 | Hoffmann La Roche | Derivados de triazol |
WO2001010865A1 (fr) | 1999-08-06 | 2001-02-15 | Takeda Chemical Industries, Ltd. | INHIBITEURS DE p38MAP KINASE |
FR2802530B1 (fr) | 1999-12-17 | 2002-02-22 | Sanofi Synthelabo | Nouveaux derives amino substitues ramifies du 3-amino-1-phenyl-1h[1,2,4]triazole, procedes pour leur preparation et compositions pharmaceutiques les contenant |
WO2001064674A1 (en) | 2000-03-01 | 2001-09-07 | Janssen Pharmaceutica N.V. | 2,4-disubstituted thiazolyl derivatives |
US6586453B2 (en) | 2000-04-03 | 2003-07-01 | 3-Dimensional Pharmaceuticals, Inc. | Substituted thiazoles and the use thereof as inhibitors of plasminogen activator inhibitor-1 |
JP2004509863A (ja) | 2000-09-21 | 2004-04-02 | ブリストル−マイヤーズ スクイブ カンパニー | コルチコトロピン放出因子のインヒビターとしての置換アゾール誘導体 |
GB0028383D0 (en) | 2000-11-21 | 2001-01-03 | Novartis Ag | Organic compounds |
PL363316A1 (en) | 2000-12-22 | 2004-11-15 | Ortho Mc Neil Pharmaceutical, Inc. | Substituted triazole diamine derivatives as kinase inhibitors |
IL160329A0 (en) | 2001-08-13 | 2004-07-25 | Janssen Pharmaceutica Nv | 2-amino-4,5-trisubstituted thiazolyl derivatives |
JP2005510508A (ja) | 2001-11-08 | 2005-04-21 | 藤沢薬品工業株式会社 | アデノシンアンタゴニストとしてのチアゾールピリダジノン類 |
CA2474322A1 (en) | 2002-01-25 | 2003-07-31 | Kylix Pharmaceuticals B.V. | 4(hetero-) aryl substituted (thia-/oxa-/pyra) zoles for inhibition of tie-2 |
DK1471065T3 (da) * | 2002-01-28 | 2008-03-25 | Fuji Yakuhin Co Ltd | Hidtil ukendt 1,2,4-triazolforbindelse |
ATE348831T1 (de) | 2002-05-07 | 2007-01-15 | Neurosearch As | Diazabicyclische biarylderivate |
WO2004013120A1 (en) * | 2002-07-29 | 2004-02-12 | F. Hoffmann-La Roche Ag | Novel benzodioxoles |
CL2003002353A1 (es) * | 2002-11-15 | 2005-02-04 | Vertex Pharma | Compuestos derivados de diaminotriazoles, inhibidores d ela proteina quinasa; composicion farmaceutica; procedimiento de preparacion; y su uso del compuesto en el tratamiento de enfermedades de desordenes alergicos, proliferacion, autoinmunes, condic |
US20070191267A1 (en) | 2003-04-28 | 2007-08-16 | Ab Science | Use of tyrosine kinase inhibitors for treating cerebral ischemia |
EP1628666B1 (de) | 2003-05-14 | 2015-09-23 | NeuroGenetic Pharmaceuticals, Inc. | Verbindungen und ihre verwendungen zur modulierung von amyloid beta |
EP1635824B1 (de) | 2003-06-03 | 2009-08-19 | Novartis AG | 5-gliedrige heterocyclische p-38 inhibitoren |
JP2006528617A (ja) * | 2003-07-24 | 2006-12-21 | ファーマジーン ラボラトリーズ リミテッド | 5−ht2b受容体アンタゴニスト |
FR2862647B1 (fr) | 2003-11-25 | 2008-07-04 | Aventis Pharma Sa | Derives de pyrazolyle, procede de preparation et intermediaires de ce procede a titre de medicaments et de compositions pharmaceutiques les renfermant |
GB0401336D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
CN1942450A (zh) * | 2004-02-11 | 2007-04-04 | 詹森药业有限公司 | 取代三唑化合物的制备方法 |
MX2007003154A (es) | 2004-09-17 | 2007-05-15 | Vertex Pharma | Compuestos de diaminotriazol de utilidad como inhibidores de proteina quinasa. |
PL1811998T3 (pl) | 2004-10-21 | 2011-05-31 | Vertex Pharma | Triazole użyteczne jako inhibitory kinaz białkowych |
WO2006064375A2 (en) | 2004-12-16 | 2006-06-22 | Ab Science | Aminoaryl substituted five-membered ring heterocyclic compounds for the treatment of diseases |
WO2006078621A2 (en) * | 2005-01-19 | 2006-07-27 | Bristol-Myers Squibb Company | 2-phenoxy-n- (1, 3 , 4-thiadizol-2-yl) pyridin-3-amine derivatives and related compounds as p2y1 receptor inhibitors for the treatment of thromboembolic disorders |
CA2617394C (en) | 2005-09-13 | 2014-06-03 | Janssen Pharmaceutica N.V. | 2-aniline-4-aryl substituted thiazole derivatives |
JO3019B1 (ar) | 2006-04-19 | 2016-09-05 | Janssen Pharmaceutica Nv | ثلاثي مستبدل 4،2،1-ثلاثي زولات |
WO2009050186A1 (en) | 2007-10-18 | 2009-04-23 | Janssen Pharmaceutica Nv | Trisubstituted 1,2,4-triazoles |
ES2442932T3 (es) | 2008-03-19 | 2014-02-14 | Janssen Pharmaceutica N.V. | 1,2,4-Triazoles trisustituidos como moduladores de receptores nicotínicos de acetilcolina |
JP2011516599A (ja) | 2008-04-17 | 2011-05-26 | グラクソ グループ リミテッド | ニコチン性アセチルコリン受容体サブタイプα7のモジュレーターとしてのインドール類 |
EA018187B1 (ru) | 2008-05-09 | 2013-06-28 | Янссен Фармацевтика Нв | Тризамещенные пиразолы в качестве модуляторов рецепторов ацетилхолина |
US8791144B2 (en) | 2009-09-17 | 2014-07-29 | Janssen Pharmaceutica Nv | Substituted N-phenyl-1-(4-Pyridinyl)-1H-pyrazol-3-amines |
JO3078B1 (ar) | 2009-11-27 | 2017-03-15 | Janssen Pharmaceutica Nv | مورفولينوثيازولات بصفتها منظمات الوستيرية نوع الفا 7 موجبة |
CA2824350C (en) | 2011-02-25 | 2019-07-02 | Janssen Pharmaceutica Nv | (pyridin-4-yl)benzylamides as allosteric modulators of alpha 7 nachr |
-
2008
- 2008-09-15 JO JO2008412A patent/JO2784B1/en active
- 2008-10-15 CN CN2008801119538A patent/CN101827839B/zh not_active Expired - Fee Related
- 2008-10-15 CA CA2697982A patent/CA2697982C/en active Active
- 2008-10-15 AT AT08805280T patent/ATE522523T1/de not_active IP Right Cessation
- 2008-10-15 ES ES08805280T patent/ES2371863T3/es active Active
- 2008-10-15 AU AU2008313775A patent/AU2008313775B2/en not_active Ceased
- 2008-10-15 MX MX2010004176A patent/MX2010004176A/es active IP Right Grant
- 2008-10-15 WO PCT/EP2008/063844 patent/WO2009050185A1/en active Application Filing
- 2008-10-15 US US12/738,725 patent/US8404851B2/en active Active
- 2008-10-15 RU RU2010119458/04A patent/RU2476433C2/ru active
- 2008-10-15 JP JP2010529360A patent/JP2011500624A/ja active Pending
- 2008-10-15 EP EP08805280A patent/EP2205594B1/de active Active
- 2008-10-16 CL CL2008003067A patent/CL2008003067A1/es unknown
- 2008-10-17 TW TW097139807A patent/TW200934491A/zh unknown
- 2008-10-17 PE PE2008001789A patent/PE20091080A1/es active IP Right Grant
- 2008-10-17 AR ARP080104545A patent/AR068919A1/es not_active Application Discontinuation
- 2008-10-17 PA PA20088799901A patent/PA8799901A1/es unknown
-
2010
- 2010-04-15 IL IL205102A patent/IL205102A/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
JP2011500624A (ja) | 2011-01-06 |
US8404851B2 (en) | 2013-03-26 |
ES2371863T3 (es) | 2012-01-10 |
PA8799901A1 (es) | 2009-05-15 |
TW200934491A (en) | 2009-08-16 |
AR068919A1 (es) | 2009-12-16 |
IL205102A (en) | 2015-04-30 |
CA2697982C (en) | 2015-09-22 |
CL2008003067A1 (es) | 2009-11-27 |
IL205102A0 (en) | 2010-11-30 |
MX2010004176A (es) | 2010-05-03 |
RU2010119458A (ru) | 2011-11-27 |
US20100240707A1 (en) | 2010-09-23 |
AU2008313775A1 (en) | 2009-04-23 |
AU2008313775B2 (en) | 2012-12-13 |
CN101827839B (zh) | 2012-10-24 |
EP2205594A1 (de) | 2010-07-14 |
CN101827839A (zh) | 2010-09-08 |
WO2009050185A1 (en) | 2009-04-23 |
EP2205594B1 (de) | 2011-08-31 |
CA2697982A1 (en) | 2009-04-23 |
RU2476433C2 (ru) | 2013-02-27 |
PE20091080A1 (es) | 2009-08-03 |
JO2784B1 (en) | 2014-03-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |