ATE522523T1 - 1,3,5-trisubstituiertes triazolderivat - Google Patents
1,3,5-trisubstituiertes triazolderivatInfo
- Publication number
- ATE522523T1 ATE522523T1 AT08805280T AT08805280T ATE522523T1 AT E522523 T1 ATE522523 T1 AT E522523T1 AT 08805280 T AT08805280 T AT 08805280T AT 08805280 T AT08805280 T AT 08805280T AT E522523 T1 ATE522523 T1 AT E522523T1
- Authority
- AT
- Austria
- Prior art keywords
- triazole derivative
- trisubstituted
- trisubstituted triazole
- derivative
- triazole
- Prior art date
Links
- -1 1,3,5-TRISUBSTITUTED TRIAZOLE Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07118822 | 2007-10-18 | ||
PCT/EP2008/063844 WO2009050185A1 (en) | 2007-10-18 | 2008-10-15 | 1,3,5-trisubstituted triazole derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE522523T1 true ATE522523T1 (de) | 2011-09-15 |
Family
ID=39047591
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT08805280T ATE522523T1 (de) | 2007-10-18 | 2008-10-15 | 1,3,5-trisubstituiertes triazolderivat |
Country Status (18)
Country | Link |
---|---|
US (1) | US8404851B2 (de) |
EP (1) | EP2205594B1 (de) |
JP (1) | JP2011500624A (de) |
CN (1) | CN101827839B (de) |
AR (1) | AR068919A1 (de) |
AT (1) | ATE522523T1 (de) |
AU (1) | AU2008313775B2 (de) |
CA (1) | CA2697982C (de) |
CL (1) | CL2008003067A1 (de) |
ES (1) | ES2371863T3 (de) |
IL (1) | IL205102A (de) |
JO (1) | JO2784B1 (de) |
MX (1) | MX2010004176A (de) |
PA (1) | PA8799901A1 (de) |
PE (1) | PE20091080A1 (de) |
RU (1) | RU2476433C2 (de) |
TW (1) | TW200934491A (de) |
WO (1) | WO2009050185A1 (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008050821A1 (en) * | 2006-10-19 | 2008-05-02 | Takeda Pharmaceutical Company Limited | Indole compound |
AU2008313776B2 (en) * | 2007-10-18 | 2013-12-05 | Janssen Pharmaceutica Nv | Trisubstituted 1,2,4-triazoles |
KR101564303B1 (ko) * | 2008-03-19 | 2015-11-06 | 얀센 파마슈티카 엔.브이. | 니코틴성 아세틸콜린 수용체 조절제로서의 삼치환된 1,2,4-트리아졸 |
WO2009135944A1 (en) * | 2008-05-09 | 2009-11-12 | Janssen Pharmaceutica Nv | Trisubstituted pyrazoles as acetylcholine receptor modulators |
CA2825519A1 (en) | 2011-02-03 | 2012-09-08 | Lupin Limited | Pyrrole derivatives used as modulators of alpha7 nachr |
DK2678327T3 (en) | 2011-02-23 | 2016-12-12 | Lupin Ltd | Heteroaryl derivatives which ALFA7 nAChR modulators |
EP2678315B1 (de) | 2011-02-25 | 2015-12-16 | Janssen Pharmaceutica, N.V. | (Pyridin-4-yl-)benzylamide als allosterische Modulatoren von alpha-7-nAChR |
KR20140025395A (ko) | 2011-03-31 | 2014-03-04 | 루핀 리미티드 | 알츠하이머병 및 파킨슨병을 포함하는 신경병성 장애 치료용 니코틴성 아세틸콜린 수용체 조절인자로서의 피롤 유도체 |
US8946432B2 (en) | 2011-07-05 | 2015-02-03 | Lupin Limited | Biaryl derivatives as nAChR modulators |
NZ629453A (en) | 2012-03-06 | 2016-04-29 | Lupin Ltd | Thiazole derivatives as alpha 7 nachr modulators |
US20150299178A1 (en) | 2012-11-12 | 2015-10-22 | Lupin Limited | Thiazole Derivatives as Alpha 7 NACHR Modulators |
US9617211B2 (en) | 2013-01-16 | 2017-04-11 | Lupin Limited | Pyrrole derivatives as alpha 7 nAChR modulators |
JP2016512225A (ja) | 2013-03-13 | 2016-04-25 | ルピン・リミテッドLupin Limited | アルファー7nachrモジュレータとしてのピロール誘導体 |
TW201446243A (zh) | 2013-06-03 | 2014-12-16 | Lupin Ltd | 4-(5-(4-氯苯基)-2-(2-環丙基乙醯基)-1,4-二甲基-1氫-吡咯-3-基)苯磺醯胺作為α7尼古丁乙醯膽鹼受體調節劑 |
CA2913987A1 (en) | 2013-06-17 | 2014-12-24 | Lupin Limited | Pyrrole derivatives as alpha 7 nachr modulators |
Family Cites Families (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE795907A (fr) * | 1972-02-25 | 1973-06-18 | Luso Farmaco Inst | 2-amino-4-arylthiazoles 5-substitues et leur preparation |
EP0248523B1 (de) | 1986-05-07 | 1991-10-16 | FISONS plc | Pyrazole |
JPS6339868A (ja) | 1986-08-04 | 1988-02-20 | Otsuka Pharmaceut Factory Inc | ジ低級アルキルフエノ−ル誘導体 |
US4761422A (en) | 1986-11-20 | 1988-08-02 | Lusofarmaco Istituto Lusofarmaco D'italia Spa | (2-amino-4-aryl-thiazole-5-yl)ethanols and their derivatives having diuretic activity and methods for preparing the same |
CA2195847A1 (en) | 1994-07-27 | 1996-02-08 | John J. Talley | Substituted thiazoles for the treatment of inflammation |
JPH10507205A (ja) | 1995-08-02 | 1998-07-14 | ホータ.ウリアッヒ イ シイア.エセ.アー. | 抗真菌活性を有する新規カルボンアミド |
FR2754258B1 (fr) | 1996-10-08 | 1998-12-31 | Sanofi Sa | Derives d'aminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant |
CA2276034A1 (en) | 1996-12-23 | 1998-07-02 | Mimi Lifen Quan | Oxygen or sulfur containing 5-membered heteroaromatics as factor xa inhibitors |
US6187797B1 (en) * | 1996-12-23 | 2001-02-13 | Dupont Pharmaceuticals Company | Phenyl-isoxazoles as factor XA Inhibitors |
WO1999021555A2 (en) | 1997-10-27 | 1999-05-06 | Takeda Chemical Industries, Ltd. | Adenosine a3 receptor antagonists |
FR2792314B1 (fr) * | 1999-04-15 | 2001-06-01 | Adir | Nouveaux composes aminotriazoles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
DE60007697T2 (de) | 1999-07-21 | 2004-12-09 | F. Hoffmann-La Roche Ag | Triazolderivate |
AU6471300A (en) | 1999-08-06 | 2001-03-05 | Takeda Chemical Industries Ltd. | P38map kinase inhibitors |
FR2802530B1 (fr) | 1999-12-17 | 2002-02-22 | Sanofi Synthelabo | Nouveaux derives amino substitues ramifies du 3-amino-1-phenyl-1h[1,2,4]triazole, procedes pour leur preparation et compositions pharmaceutiques les contenant |
ES2317889T3 (es) | 2000-03-01 | 2009-05-01 | Janssen Pharmaceutica Nv | Derivados de tiazolilo 2,4-disustituido. |
AU2001249670A1 (en) | 2000-04-03 | 2001-10-15 | 3-Dimensional Pharmaceuticals, Inc. | Substituted thiazoles and the use thereof as inhibitors of plasminogen activatorinhibitor-1 |
US6515005B2 (en) | 2000-09-21 | 2003-02-04 | Bristol-Myers Squibb Company | Substituted azole derivatives as inhibitors of corticotropin releasing factor |
GB0028383D0 (en) | 2000-11-21 | 2001-01-03 | Novartis Ag | Organic compounds |
MXPA03005777A (es) | 2000-12-22 | 2005-02-14 | Johnson & Johnson | Derivados de triazol diaminas sustituidos como inhibidores de cinasa. |
MXPA04001399A (es) | 2001-08-13 | 2004-05-27 | Janssen Pharmaceutica Nv | Derivados de tiazolilo 2-amino-4,5-trisustituidos. |
US20050004134A1 (en) * | 2001-11-08 | 2005-01-06 | Hideo Tsutsumi | Thiazole derivative and pharmaceutical use thereof |
CA2474322A1 (en) | 2002-01-25 | 2003-07-31 | Kylix Pharmaceuticals B.V. | 4(hetero-) aryl substituted (thia-/oxa-/pyra) zoles for inhibition of tie-2 |
MXPA04004037A (es) * | 2002-01-28 | 2004-07-23 | Fuji Yakuhin Co Ltd | Compuestos novedosos de 1, 2, 4-de triazol. |
CA2480488A1 (en) | 2002-05-07 | 2003-11-20 | Neurosearch A/S | Novel diazabicyclic biaryl derivatives |
ATE389646T1 (de) * | 2002-07-29 | 2008-04-15 | Hoffmann La Roche | Neue benzodioxole |
TWI335913B (en) * | 2002-11-15 | 2011-01-11 | Vertex Pharma | Diaminotriazoles useful as inhibitors of protein kinases |
US20070191267A1 (en) | 2003-04-28 | 2007-08-16 | Ab Science | Use of tyrosine kinase inhibitors for treating cerebral ischemia |
AU2004247013B2 (en) | 2003-05-14 | 2010-07-08 | Neurogenetic Pharmaceuticals, Inc. | Compounds and uses thereof in modulating amyloid beta |
PL1635824T3 (pl) * | 2003-06-03 | 2010-01-29 | Novartis Ag | 5-Członowe heterocykliczne inhibitory P-38 |
EP1648876A1 (de) * | 2003-07-24 | 2006-04-26 | Pharmagene Laboratories Ltd | 5-ht sb 2b/sb rezeptor-antagonisten |
FR2862647B1 (fr) | 2003-11-25 | 2008-07-04 | Aventis Pharma Sa | Derives de pyrazolyle, procede de preparation et intermediaires de ce procede a titre de medicaments et de compositions pharmaceutiques les renfermant |
GB0401336D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
CN1942450A (zh) * | 2004-02-11 | 2007-04-04 | 詹森药业有限公司 | 取代三唑化合物的制备方法 |
MX2007003154A (es) * | 2004-09-17 | 2007-05-15 | Vertex Pharma | Compuestos de diaminotriazol de utilidad como inhibidores de proteina quinasa. |
US7645775B2 (en) | 2004-10-21 | 2010-01-12 | Vertex Pharmaceuticals Incorporated | Triazoles useful as inhibitors of protein kinases |
WO2006064375A2 (en) | 2004-12-16 | 2006-06-22 | Ab Science | Aminoaryl substituted five-membered ring heterocyclic compounds for the treatment of diseases |
JP2008527043A (ja) * | 2005-01-19 | 2008-07-24 | ブリストル−マイヤーズ スクイブ カンパニー | 血栓塞栓障害治療用のp2y1受容体阻害剤としての2−フェノキシ−n−(1,3,4−チアジアゾール−2−イル)ピリジン−3−アミン誘導体および関連化合物 |
WO2007031440A2 (en) | 2005-09-13 | 2007-03-22 | Janssen Pharmaceutica N.V. | 2-aniline-4-aryl substituted thiazole derivatives |
JO3019B1 (ar) * | 2006-04-19 | 2016-09-05 | Janssen Pharmaceutica Nv | ثلاثي مستبدل 4،2،1-ثلاثي زولات |
AU2008313776B2 (en) * | 2007-10-18 | 2013-12-05 | Janssen Pharmaceutica Nv | Trisubstituted 1,2,4-triazoles |
KR101564303B1 (ko) * | 2008-03-19 | 2015-11-06 | 얀센 파마슈티카 엔.브이. | 니코틴성 아세틸콜린 수용체 조절제로서의 삼치환된 1,2,4-트리아졸 |
AU2009237649B2 (en) | 2008-04-17 | 2012-07-26 | Proximagen Limited | Indole modulators of the alpha 7 nicotinic acetylcholine receptor |
WO2009135944A1 (en) * | 2008-05-09 | 2009-11-12 | Janssen Pharmaceutica Nv | Trisubstituted pyrazoles as acetylcholine receptor modulators |
CA2770932C (en) * | 2009-09-17 | 2017-04-25 | Janssen Pharmaceutica Nv | Substituted n-phenyl-1-(4-pyridinyl)-1h-pyrazol-3-amines |
JO3078B1 (ar) * | 2009-11-27 | 2017-03-15 | Janssen Pharmaceutica Nv | مورفولينوثيازولات بصفتها منظمات الوستيرية نوع الفا 7 موجبة |
EP2678315B1 (de) | 2011-02-25 | 2015-12-16 | Janssen Pharmaceutica, N.V. | (Pyridin-4-yl-)benzylamide als allosterische Modulatoren von alpha-7-nAChR |
-
2008
- 2008-09-15 JO JO2008412A patent/JO2784B1/en active
- 2008-10-15 MX MX2010004176A patent/MX2010004176A/es active IP Right Grant
- 2008-10-15 ES ES08805280T patent/ES2371863T3/es active Active
- 2008-10-15 EP EP08805280A patent/EP2205594B1/de active Active
- 2008-10-15 CN CN2008801119538A patent/CN101827839B/zh not_active Expired - Fee Related
- 2008-10-15 AU AU2008313775A patent/AU2008313775B2/en not_active Ceased
- 2008-10-15 AT AT08805280T patent/ATE522523T1/de not_active IP Right Cessation
- 2008-10-15 WO PCT/EP2008/063844 patent/WO2009050185A1/en active Application Filing
- 2008-10-15 CA CA2697982A patent/CA2697982C/en not_active Expired - Fee Related
- 2008-10-15 US US12/738,725 patent/US8404851B2/en active Active
- 2008-10-15 JP JP2010529360A patent/JP2011500624A/ja active Pending
- 2008-10-15 RU RU2010119458/04A patent/RU2476433C2/ru active
- 2008-10-16 CL CL2008003067A patent/CL2008003067A1/es unknown
- 2008-10-17 AR ARP080104545A patent/AR068919A1/es not_active Application Discontinuation
- 2008-10-17 TW TW097139807A patent/TW200934491A/zh unknown
- 2008-10-17 PE PE2008001789A patent/PE20091080A1/es active IP Right Grant
- 2008-10-17 PA PA20088799901A patent/PA8799901A1/es unknown
-
2010
- 2010-04-15 IL IL205102A patent/IL205102A/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
CL2008003067A1 (es) | 2009-11-27 |
TW200934491A (en) | 2009-08-16 |
IL205102A0 (en) | 2010-11-30 |
PE20091080A1 (es) | 2009-08-03 |
AU2008313775B2 (en) | 2012-12-13 |
CN101827839A (zh) | 2010-09-08 |
PA8799901A1 (es) | 2009-05-15 |
AU2008313775A1 (en) | 2009-04-23 |
JO2784B1 (en) | 2014-03-15 |
MX2010004176A (es) | 2010-05-03 |
CA2697982C (en) | 2015-09-22 |
RU2476433C2 (ru) | 2013-02-27 |
AR068919A1 (es) | 2009-12-16 |
US8404851B2 (en) | 2013-03-26 |
WO2009050185A1 (en) | 2009-04-23 |
EP2205594B1 (de) | 2011-08-31 |
IL205102A (en) | 2015-04-30 |
CA2697982A1 (en) | 2009-04-23 |
ES2371863T3 (es) | 2012-01-10 |
EP2205594A1 (de) | 2010-07-14 |
US20100240707A1 (en) | 2010-09-23 |
JP2011500624A (ja) | 2011-01-06 |
RU2010119458A (ru) | 2011-11-27 |
CN101827839B (zh) | 2012-10-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |