PA8584901A1 - Derivados sustituidos de 1,4-di-piperidin-4-il-piperazina y su uso como antagonistas de neuroquininas - Google Patents

Derivados sustituidos de 1,4-di-piperidin-4-il-piperazina y su uso como antagonistas de neuroquininas

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Publication number
PA8584901A1
PA8584901A1 PA20038584901A PA8584901A PA8584901A1 PA 8584901 A1 PA8584901 A1 PA 8584901A1 PA 20038584901 A PA20038584901 A PA 20038584901A PA 8584901 A PA8584901 A PA 8584901A PA 8584901 A1 PA8584901 A1 PA 8584901A1
Authority
PA
Panama
Prior art keywords
disorders
neuroquinins
same
piperazina
piperidin
Prior art date
Application number
PA20038584901A
Other languages
English (en)
Inventor
Frans Eduard Janssens
Francois Maria Sommen
Boeck Benoit Christian Albert Ghislain De
Joseph Elisabeth Leenaerts
Yves Emiel Maria Van Roosbroeck
Gaston Stanislas Marcella Diels
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2002/014836 external-priority patent/WO2004056772A1/en
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of PA8584901A1 publication Critical patent/PA8584901A1/es

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Abstract

LA INVENCION SE REFIERE A DERIVADOS SUSTITUIDOS DE 1,4-DI-PIPERIDIN-4-IL- PIPERAZINA QUE TIENEN ACTIVIDAD ANTAGONISTA DE LAS NEUROQUININAS, EN PARTICULAR ACTIVIDAD ANTAGONISTA DE NK1, SU PREPARACION, COMPOSICIONES QUE LOS COMPRENDEN Y SU USO COMO MEDICAMENTO, EN PARTICULAR PARA EL TRATAMIENTO DE LA EMESIS, ANSIEDAD, DEPRESION, PANCREATITIS Y SCI. LOS COMPUESTOS DE ACUERDO CON LA INVENCION SE PUEDEN REPRESENTAR MEDIANTE LA FORMULA GENERAL (1). Y COMPRENDEN TAMBIEN LAS SALES DE ADICION CON ACIDOS O BASES ACEPTABLES PARA USO FARMACEUTICO DE LOS MISMOS, LAS FORMAS ESTEREOQUIMICAMENTE ISOMERICAS DE LOS MISMOS, LA FORMA DE N-OXIDO DE LOS MISMOS Y PROFARMACOS DE LOS MISMOS, EN DONDE TODOS LOS SUSTITUYENTES SE DEFINEN COMO EN LA REIVINDICACION 1. EN VISTA DE SU CAPACIDAD PARA ANTAGONIZAR LAS ACCIONES DE LAS NEUROQUININAS POR BLOQUEO DE LOS RECEPTORES DE NEUROQUININAS, Y EN PARTICULAR ANTAGONIZAR LAS ACCIONES DE LA SUSTANCIA P POR BLOQUEO DEL RECEPTOR NK1, LOS COMPUESTOS DE ACUERDO CON LA INVENCION SON UTILES COMO MEDICAMENTOS, EN PARTICULAR EN EL TRATAMIENTO PROFILACTICO Y TERAPEUTICO DE CONDICIONES MEDIADAS POR NEUROQUININAS, TALES COMO, POR EJEMPLO, TRASTORNOS DEL SNC, EN PARTICULAR DE LA DEPRESION, TRASTORNOS DE ANSIEDAD, TRASTORNOS RELACIONADOS CON EL ESTRES, TRASTORNOS DEL SUEÑO, TRASTORNOS COGNITIVOS, TRASTORNOS DE LA PERSONALIDAD, TRASTORNOS ESQUIZOAFECTIVOS, TRASTORNOS DE LA ALIMENTACION, TRASTORNOS NEURODEGENERATIVOS, TRASTORNOS DE ADICCION, TRASTORNOS DEL ANIMO, DISFUNCION SEXUAL, DOLOR Y OTRAS CONDICIONES RELACIONADAS CON EL SNC; INFLAMACION, TRASTORNOS ALERGICOS; EMESIS, TRASTORNOS GASTROINTESTINALES, EN PARTICULAR EL SINDROME DE COLON IRRITABLE (SCI); TRASTORNOS DE LA PIEL; TRASTORNOS VASOESPASTICOS; ENFERMEDADES FIBROSANTES Y DEL COLAGENO; TRASTORNOS RELACIONADOS CON EL INCREMENTO O LA SUPRESION INMUNE Y ENFERMEDADES REUMATICAS Y CONTROL DEL PESO CORPORAL.
PA20038584901A 2002-10-08 2003-10-08 Derivados sustituidos de 1,4-di-piperidin-4-il-piperazina y su uso como antagonistas de neuroquininas PA8584901A1 (es)

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PCT/EP2002/014836 WO2004056772A1 (en) 2002-12-23 2002-12-23 Substituted 1,4-di-piperidin-4-yl-piperazine derivatives and their use as tachykinin antagonists

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JP2006510602A (ja) 2006-03-30
IL167885A (en) 2010-04-29
US20060167008A1 (en) 2006-07-27
EA200500616A1 (ru) 2005-10-27
ES2319642T3 (es) 2009-05-11
KR101049074B1 (ko) 2011-07-15
TW200413319A (en) 2004-08-01
EP1551804B1 (en) 2008-12-24
HK1084394A1 (en) 2006-07-28
ATE418543T1 (de) 2009-01-15
CA2499903A1 (en) 2004-04-22
MY141736A (en) 2010-06-15
BR0315098A (pt) 2005-08-16
EA009217B1 (ru) 2007-12-28
EP1551804A1 (en) 2005-07-13
AU2003282115B2 (en) 2009-10-01
US7410970B2 (en) 2008-08-12
JP4674086B2 (ja) 2011-04-20
AU2003282115A1 (en) 2004-05-04
CA2499903C (en) 2011-06-14
HRP20050309A2 (en) 2006-07-31
AR041545A1 (es) 2005-05-18
WO2004033428A1 (en) 2004-04-22
DE60325493D1 (de) 2009-02-05
TWI324995B (en) 2010-05-21

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