PA8525101A1 - Nuevos derivados de aminociclohexanol - Google Patents

Nuevos derivados de aminociclohexanol

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Publication number
PA8525101A1
PA8525101A1 PA20018525101A PA8525101A PA8525101A1 PA 8525101 A1 PA8525101 A1 PA 8525101A1 PA 20018525101 A PA20018525101 A PA 20018525101A PA 8525101 A PA8525101 A PA 8525101A PA 8525101 A1 PA8525101 A1 PA 8525101A1
Authority
PA
Panama
Prior art keywords
aminociclohexanol
new derivatives
prevention
treatment
pharmaceutically acceptable
Prior art date
Application number
PA20018525101A
Other languages
English (en)
Inventor
Jean Ackermann
Johannes Aebi
Denise Blum
Alexander Chucholowski
Henrietta Dehmlow
Hans-Peter Maerki
Olivier Morand
Rene Trussardi
Der Mark Elisabeth Von
Sabine Wallbaum
Thomas Weller
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PA8525101A1 publication Critical patent/PA8525101A1/es

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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
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    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07C233/23Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
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    • C07C233/67Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/74Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
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    • C07C235/44Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/54Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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    • C07C235/70Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/84Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C255/00Carboxylic acid nitriles
    • C07C255/49Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
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    • C07C271/06Esters of carbamic acids
    • C07C271/40Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/42Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/52Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
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    • C07C271/56Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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    • C07C275/30Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
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    • C07C291/02Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
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    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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Abstract

LA PRESENTE INVENCION SE REFIERE A COMPUESTOS DE FORMULA (I) EN DONDE U,V,W,A1,A2,A3,A4,A5,A6, m Y n SON COMO SE HA DEFINIDO EN LA DESCRIPCION Y LAS REIVINDICACIONES Y SALES FARMACEUTICAMENTE ACEPTABLES Y/O ESTERES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS. LOS COMPUESTOS SON UTILES PARA EL TRATAMIENTO Y/O PREVENCION DE ENFERMEDADES QUE ESTAN ASOCIADAS CON LA 2,3-OXIDOESCUALENO-LANOSTEROL CICLASA COMO LA HIPERCOLESTEROLEMIA, HIPERLIPEMIA, ARTERIOSCLEROSIS, ENFERMEDADES VASCULARES, MICOSIS, CALCULOS BILIARES, TUMORES Y/O TRANSTORNOS HIPERPROLIFERATIVOS, Y EL TRATAMIENTO Y/O LA PREVENCION DE LA TOLERANCIA A GLUCOSA DEFICIENTE Y LA DIABETES.
PA20018525101A 2000-08-16 2001-08-13 Nuevos derivados de aminociclohexanol PA8525101A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00117611 2000-08-16
EP01113646 2001-06-19

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PA8525101A1 true PA8525101A1 (es) 2002-07-30

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Publication number Priority date Publication date Assignee Title
US6604158B1 (en) * 1999-03-11 2003-08-05 Realtime Data, Llc System and methods for accelerated data storage and retrieval
RU2225393C1 (ru) * 2000-08-16 2004-03-10 Ф.Хоффманн-Ля Рош Аг Новые производные аминоциклогексана
EA010267B1 (ru) 2002-10-07 2008-06-30 Те Риджентс Оф Те Юниверсити Оф Калифорния Модуляция тревоги через блокаду гидролиза анандамида
TW200524849A (en) * 2003-07-02 2005-08-01 Hoffmann La Roche Hydroxyalkylamide derivatives
US20080096922A1 (en) * 2004-04-06 2008-04-24 Dainippon Sumitomo Pharma Co., Ltd. Novel Sulfonamide derivative
JP4339913B2 (ja) * 2004-07-09 2009-10-07 エフ.ホフマン−ラ ロシュ アーゲー ヒドロキシアルキルアミド類
TW200808695A (en) * 2006-06-08 2008-02-16 Amgen Inc Benzamide derivatives and uses related thereto
US8273900B2 (en) 2008-08-07 2012-09-25 Novartis Ag Organic compounds
RU2449988C1 (ru) * 2011-04-29 2012-05-10 Федеральное Государственное Бюджетное Учреждение Науки Институт Физиологически Активных Веществ Российской Академии Наук (Ифав Ран) 2,2,2-трифтор-1-трифторметилэтиловый эфир циклогексилкарбаминовой кислоты в качестве эффективного средства для селективного необратимого ингибирования карбоксилэстеразы
CN102584618A (zh) * 2012-01-18 2012-07-18 浙江工业大学 一种4-取代酰氨基环己酮的制备方法
CN113600163B (zh) * 2021-09-13 2022-06-14 厦门大学 一种光催化剂及其应用、n-烷基哌嗪及其衍生物的制备方法
CN115780487B (zh) * 2023-01-05 2023-05-05 河北东丽新材料有限公司 一种萃取剂及利用其处理4,4`-联苯醚二酐生产固废的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO122123B (es) 1966-03-25 1971-05-24 Miles Lab
US3592824A (en) 1970-03-12 1971-07-13 Miles Lab 3-substituted amino-1,2,3,4-tetrahydrocarbazoles
DE4239151A1 (de) * 1992-11-20 1994-05-26 Thomae Gmbh Dr K N,N-Disubstituierte Arylcycloalkylamine, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung
TW438774B (en) 1993-07-14 2001-06-07 Hoffmann La Roche Pharmaceutical composition for lowering cholesterol containing phenalkylamines and certain novel phenalkylamines
CA2190699A1 (en) * 1995-12-08 1997-06-09 Johannes Aebi Tertiary amines
RU2225393C1 (ru) * 2000-08-16 2004-03-10 Ф.Хоффманн-Ля Рош Аг Новые производные аминоциклогексана
US6964974B2 (en) 2000-09-08 2005-11-15 Hoffmann-La Roche Inc. 2,3-oxidosqualene-lanosterol cyclase inhibitors
KR100545430B1 (ko) 2000-11-02 2006-01-24 에프. 호프만-라 로슈 아게 콜레스테롤 저하성 벤조[b]티오펜 및 벤조[d]이소티아졸
US7012077B2 (en) * 2001-12-20 2006-03-14 Hoffmann-La Roche Inc. Substituted cyclohexane derivatives

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CA2418744C (en) 2010-04-20
ATE403646T1 (de) 2008-08-15
EP1311475B1 (en) 2008-08-06
EP1311475A1 (en) 2003-05-21
RU2225393C1 (ru) 2004-03-10
CA2418744A1 (en) 2002-02-21
JP2004506037A (ja) 2004-02-26
KR20030048010A (ko) 2003-06-18
MA26941A1 (fr) 2004-12-20
US6858651B2 (en) 2005-02-22
JP4244139B2 (ja) 2009-03-25
CZ2003451A3 (cs) 2003-10-15
MXPA03001269A (es) 2003-06-09
US20020045777A1 (en) 2002-04-18
CN1468214A (zh) 2004-01-14
US7335687B2 (en) 2008-02-26
HUP0303105A3 (en) 2005-05-30
WO2002014267A1 (en) 2002-02-21
IL154172A0 (en) 2003-07-31
KR100566175B1 (ko) 2006-03-29
PL361783A1 (en) 2004-10-04
HUP0303105A2 (hu) 2004-03-01
PE20020367A1 (es) 2002-05-11
CN100455566C (zh) 2009-01-28
YU12003A (sh) 2006-05-25
ES2311547T3 (es) 2009-02-16
DE60135230D1 (de) 2008-09-18
US20050176766A1 (en) 2005-08-11
HRP20030086A2 (en) 2005-02-28
AU9374401A (en) 2002-02-25
UY26891A1 (es) 2002-02-28
NO20030657L (no) 2003-02-13
BR0113408A (pt) 2003-06-17
AR030712A1 (es) 2003-09-03
AU2001293744B2 (en) 2007-05-10
NZ523879A (en) 2004-09-24

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