AR035408A1 - Compuestos derivados de dihidroindol y tetrahidroquinoleina, su empleo, un procedimiento para fabricarlos y composiciones farmaceuticas que los comprenden - Google Patents
Compuestos derivados de dihidroindol y tetrahidroquinoleina, su empleo, un procedimiento para fabricarlos y composiciones farmaceuticas que los comprendenInfo
- Publication number
- AR035408A1 AR035408A1 ARP010105925A ARP010105925A AR035408A1 AR 035408 A1 AR035408 A1 AR 035408A1 AR P010105925 A ARP010105925 A AR P010105925A AR P010105925 A ARP010105925 A AR P010105925A AR 035408 A1 AR035408 A1 AR 035408A1
- Authority
- AR
- Argentina
- Prior art keywords
- lower alkyl
- hydroxy
- optionally substituted
- alkoxy
- cycloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Compuestos derivados de dihidroindol y tetrahidroquinoileína de fórmula (1) en la cual: U es O o un par suelto; V es a) O, s, NR1 o CH2, y L es alquileno inferior o alquenileno inferior; b) es -CH=CH- o -C:::C-, y L es alquileno inferior o un único enlace; W es CO, COO, CONR2, CSO, CSNR2, SO2 o SO2NR2; X es hidrógeno o uno o más sustituyentes halógeno y/o alquilo inferior opcionales; m es 1 o 2; n oscila entre 0 y 7; A1 es hidrógeno, alquenilo inferior, o alquilo inferior opcionalmente sustituido por hidroxi, alcoxi inferior o tio-alcoxi inferior; A2 es cicloalquilo, cicloalquil-alquilo-inferior, alquenilo inferior, alquinilo inferior o alquilo inferior opcionalmente sustituido por hidroxi, alcoxi inferior o tio-alcoxi inferior; A3 y A4 son independientemente uno del otro hidrógeno o alquilo inferior, o A1 y A2 o A1 y A3 están unidos entre sí para formar un anillo y -A1-A2- o -A1-A3- son alquileno inferior o alquenileno inferior opcionalmente sustituido por R3, donde un grupo -CH2- de -A1-A2- o -A1-A3- puede reemplazarse opcionalmente por NR4, S u O; A5 es cicloalquilo, cicloalquilo-alquilo inferior, heterocicloalquilo-alquilo inferior, arilo, arilo-alquilo inferior, heteroarilo, heteroarilo-alquilo inferior, alquilo inferior, opcionalmente sustituido por hidroxi o alcoxi inferior, alquenilo opcionalmente sustituido por hidroxi, o alcadienilo opcionalmente sustituido por hidroxi, R3 es hidroxi, alcoxi inferior, tio-alcoxi inferior, N(R5,R6) o alquilo inferior, opcionalmente sustituido por hidroxi; R1, R2, R4, R5 y R6 son independientemente uno de otro, hidrógeno o alquilo inferior, y sales farmacéuticamente aceptables y/o ésteres farmacéuticamente aceptables de los mismos. Los compuestos son útiles en el tratamiento y/o profilaxis de enfermedades que están asociadas a la 2,3-oxidoescualeno-lanosterol ciclasa, tales como hipercolesterolemia, hiperlipemia, arteriosclerosis, enfermedades vasculares, micosis, infecciones parasitarias, cálculos biliares, tumores y/o alteraciones hiperproliferantes, y/o para el tratamiento y/o profilaxis de tolerancia deteriorada a la glucosa y diabetes. Su empleo, un procedimiento para fabricarlos y composiciones farmacéuticas que los comprenden.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00128063 | 2000-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR035408A1 true AR035408A1 (es) | 2004-05-26 |
Family
ID=8170751
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010105925A AR035408A1 (es) | 2000-12-21 | 2001-12-20 | Compuestos derivados de dihidroindol y tetrahidroquinoleina, su empleo, un procedimiento para fabricarlos y composiciones farmaceuticas que los comprenden |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6706751B2 (es) |
| EP (1) | EP1358162B1 (es) |
| JP (1) | JP4068459B2 (es) |
| KR (1) | KR100530408B1 (es) |
| CN (1) | CN1208322C (es) |
| AR (1) | AR035408A1 (es) |
| AT (1) | ATE317386T1 (es) |
| AU (2) | AU1917602A (es) |
| BR (1) | BR0116263A (es) |
| CA (1) | CA2431100C (es) |
| DE (1) | DE60117096T2 (es) |
| ES (1) | ES2257381T3 (es) |
| MX (1) | MXPA03005395A (es) |
| WO (1) | WO2002050041A1 (es) |
| ZA (1) | ZA200304646B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20040522A1 (es) | 2002-05-29 | 2004-09-28 | Novartis Ag | Derivados de diarilurea dependientes de la cinasa de proteina |
| US7186746B2 (en) * | 2002-08-29 | 2007-03-06 | Merck & Co., Inc. | Indoles having anti-diabetic activity |
| TW200510271A (en) * | 2003-08-08 | 2005-03-16 | Ube Industries | Alkynyl substituded condensed heterocyclic compound, method for producing the same and organic electroluminescence element using the same |
| TWI329102B (en) * | 2006-08-15 | 2010-08-21 | Nat Health Research Institutes | Thiourea compounds and method for inhibiting hepatitis c virus infection |
| US7985763B2 (en) * | 2007-04-10 | 2011-07-26 | National Health Research Institutes | Hepatitis C virus inhibitors |
| US7897764B2 (en) * | 2007-06-08 | 2011-03-01 | National Health Research Institutes | Thiourea derivatives |
| TWI361808B (en) * | 2008-01-08 | 2012-04-11 | Nat Health Research Institutes | Imidazolidinone and imidazolidinethione derivatives |
| US8198284B2 (en) * | 2008-04-30 | 2012-06-12 | National Health Research Institutes | Treatment of neurodegenerative disorders with thiourea compounds |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3997542A (en) * | 1975-06-23 | 1976-12-14 | Sterling Drug Inc. | 1-(Halogenated-acetyl)-1,2,3,4-tetrahydro-6-quinolinols and esters thereof |
| NZ227042A (en) | 1987-11-27 | 1991-05-28 | Banyu Pharma Co Ltd | Substituted alkylamine derivatives and pharmaceutical compositions |
| US5288749A (en) | 1991-12-20 | 1994-02-22 | Abbott Laboratories | Tertiary and secondary amines as alpha-2 antagonists and serotonin uptake inhibitors |
| TW438774B (en) | 1993-07-14 | 2001-06-07 | Hoffmann La Roche | Pharmaceutical composition for lowering cholesterol containing phenalkylamines and certain novel phenalkylamines |
| WO1997028128A1 (en) | 1996-02-02 | 1997-08-07 | Zeneca Limited | Heterocyclic compounds useful as pharmaceutical agents |
| DE19727117A1 (de) | 1997-06-26 | 1999-01-07 | Boehringer Ingelheim Pharma | Phenylalkylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| CA2408913A1 (en) | 2000-05-16 | 2001-11-22 | Takeda Chemical Industries, Ltd. | Melanin-concentrating hormone antagonist |
-
2001
- 2001-12-11 US US10/014,959 patent/US6706751B2/en not_active Expired - Fee Related
- 2001-12-12 AT AT01271362T patent/ATE317386T1/de not_active IP Right Cessation
- 2001-12-12 AU AU1917602A patent/AU1917602A/xx active Pending
- 2001-12-12 CN CNB018210120A patent/CN1208322C/zh not_active Expired - Fee Related
- 2001-12-12 EP EP01271362A patent/EP1358162B1/en not_active Expired - Lifetime
- 2001-12-12 DE DE60117096T patent/DE60117096T2/de not_active Expired - Lifetime
- 2001-12-12 JP JP2002551538A patent/JP4068459B2/ja not_active Expired - Fee Related
- 2001-12-12 AU AU2002219176A patent/AU2002219176B2/en not_active Ceased
- 2001-12-12 CA CA002431100A patent/CA2431100C/en not_active Expired - Fee Related
- 2001-12-12 MX MXPA03005395A patent/MXPA03005395A/es active IP Right Grant
- 2001-12-12 WO PCT/EP2001/014620 patent/WO2002050041A1/en active IP Right Grant
- 2001-12-12 BR BR0116263-2A patent/BR0116263A/pt not_active IP Right Cessation
- 2001-12-12 ES ES01271362T patent/ES2257381T3/es not_active Expired - Lifetime
- 2001-12-12 KR KR10-2003-7008393A patent/KR100530408B1/ko not_active IP Right Cessation
- 2001-12-20 AR ARP010105925A patent/AR035408A1/es unknown
-
2003
- 2003-06-13 ZA ZA200304646A patent/ZA200304646B/en unknown
- 2003-08-26 US US10/648,451 patent/US7102007B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP4068459B2 (ja) | 2008-03-26 |
| CA2431100C (en) | 2009-03-24 |
| CN1208322C (zh) | 2005-06-29 |
| AU2002219176B2 (en) | 2006-02-09 |
| CA2431100A1 (en) | 2002-06-27 |
| DE60117096T2 (de) | 2006-11-23 |
| MXPA03005395A (es) | 2003-09-25 |
| EP1358162B1 (en) | 2006-02-08 |
| KR20030063453A (ko) | 2003-07-28 |
| ATE317386T1 (de) | 2006-02-15 |
| US20050020624A1 (en) | 2005-01-27 |
| KR100530408B1 (ko) | 2005-11-22 |
| WO2002050041A1 (en) | 2002-06-27 |
| DE60117096D1 (de) | 2006-04-20 |
| BR0116263A (pt) | 2003-12-30 |
| AU1917602A (en) | 2002-07-01 |
| ES2257381T3 (es) | 2006-08-01 |
| JP2004519441A (ja) | 2004-07-02 |
| EP1358162A1 (en) | 2003-11-05 |
| US20030004156A1 (en) | 2003-01-02 |
| US7102007B2 (en) | 2006-09-05 |
| CN1481366A (zh) | 2004-03-10 |
| ZA200304646B (en) | 2004-09-13 |
| US6706751B2 (en) | 2004-03-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA200500814A1 (ru) | Производные пирролопиримидина | |
| AR029634A1 (es) | Compuestos derivados heterociclicos utiles como agentes anticancerosos, composicion farmaceutica y procedimiento de tratamiento | |
| DOP2001000170A (es) | Derivados de tiofeno utiles como agentes anticancesoros | |
| MY139446A (en) | Novel quinoline derivatives | |
| EA200500018A1 (ru) | Бензконденсированные гетероариламидные производные тиенопиридинов, применяемые в качестве терапевтических агентов, фармацевтические композиции, включающие их, и способы их применения | |
| CY1116103T1 (el) | Υποκατεστημενα παραγωγα 1,2,3,4-τετραϋδροϊσοκινολινης | |
| PT1029853E (pt) | Derivados biciclicos heteroaromaticos uteis como agentes anticancerigenos | |
| TW200607807A (en) | Macrocyclic beta-secretase inhibitors | |
| TW200621249A (en) | Substituted amide beta secretase inhibitors | |
| TR200102136T2 (tr) | Antikanser maddeleri olarak faydaı ikame-edilmiş bisiklik türevler. | |
| WO2002055496A8 (en) | Aryl piperidine and piperazine derivatives as inducers of ldl-receptor expression | |
| BRPI0413876A (pt) | tienopiridin-fenilacetamidas e seus derivados úteis como agentes antiangiogênicos | |
| CY1108347T1 (el) | Ενωσεις ιμιδαζολιου για την θεραπεια νευροεκφυλιστικων διαταραχων | |
| BRPI0409611A (pt) | derivados de piperazina e uso dos mesmos para o tratamento de doenças neurológicas e psiquiátricas | |
| BR9805734A (pt) | Derivados de imidazolin-4-ona úteis como agentes anticancerìgenos. | |
| AR054347A1 (es) | Combinaciones terapeuticas para el tratamiento o la prevencion de la depresion | |
| CY1114803T1 (el) | Παραγωγα πυριμιδινο σουλφοναμιδιου ως ρυθμιστες υποδοχεων χημειοκινης | |
| AR043658A1 (es) | Derivados 8-substituidos-6,7,8,9-tetrahidropirimido[1,2-a]pirimidin-4-ona | |
| ECSP045469A (es) | El uso de cianopirrolidinas sustituidas y preparaciones de combinacion que las contienen para tratar hiperlipidemia y enfermedades asociadas | |
| AR035408A1 (es) | Compuestos derivados de dihidroindol y tetrahidroquinoleina, su empleo, un procedimiento para fabricarlos y composiciones farmaceuticas que los comprenden | |
| AR045694A1 (es) | Derivados de quinazolina para el tratamiento de enfermedades proliferativas, composiciones farmaceuticas que los contienen y proceso para su preparacion | |
| MX2021000461A (es) | Derivados de tiadiazina. | |
| WO2007064620A3 (en) | Compositions comprising a combination of ccr5 and cxcr4 antagonists | |
| PT649846E (pt) | Derivados da galantamina processo para a sua preparacao e sua utilizacao como medicamentos | |
| EA202190245A1 (ru) | Производные спирохромана |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |