HUP0303105A2 - Új amino-ciklohexán-származékok, eljárás az előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk - Google Patents

Új amino-ciklohexán-származékok, eljárás az előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk

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Publication number
HUP0303105A2
HUP0303105A2 HU0303105A HUP0303105A HUP0303105A2 HU P0303105 A2 HUP0303105 A2 HU P0303105A2 HU 0303105 A HU0303105 A HU 0303105A HU P0303105 A HUP0303105 A HU P0303105A HU P0303105 A2 HUP0303105 A2 HU P0303105A2
Authority
HU
Hungary
Prior art keywords
lower alkyl
group
cycloalkyl
aryl
hydroxy
Prior art date
Application number
HU0303105A
Other languages
English (en)
Inventor
Jean Ackermann
Johannes Aebi
Denise Blum
Alexander Chucholowski
Henrietta Dehmlow
Hans-Peter Maerki
Elisabeth Mark
Olivier Morand
Rene Trussardi
Sabine Wallbaum
Thomas Weller
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of HUP0303105A2 publication Critical patent/HUP0303105A2/hu
Publication of HUP0303105A3 publication Critical patent/HUP0303105A3/hu

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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07C311/20—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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  • Pyrrole Compounds (AREA)

Abstract

z (I) általános képletű vegyületek[mely képletben U jelentése O vagymagányos elektronpár; V O, S, -CH2-, -CH=CH- vagy -C<C-; W jelentéseCO, COO, CONR1, CSO, CSNR1, SO2 vagy SO2NR1; m és n jelentéseegymástól függetlenül 0-7 és m+n értéke 0-7, azzal a feltétellel, hogyha V jelentése O vagy S, úgy m értéke nem lehet 0; A1 jelentésehidrogénatom, kis szénatomszámú alkil-, hidroxi-(kis szénatomszámúalkil)- vagy kis szénatomszámú alkenilcsoport; A2 jelentése adottesetben R2 által helyettesített kis szénatomszámú alkil-, cikloalkil-,cikloalkil-(kis szénatomszámú alkil)-csoport, vagy kis szénatomszámúalkenilcsoport; A3 és A4 jelentése hidrogénatom vagy kis szénatomszámúalkil-csoport; vagy A1 és A2 vagy A1 és A3 összekapcsolódva gyűrűtképez; és -Al-A2- vagy -A1-A3- jelentése adott esetben R2 csoporttalhelyettesített kis szénatomszámú alkiléncsoport vagy kis szénatomszámúalkeniléncsoport: ahol is -A1-A2- vagy -A1-A3- egyik -CH2-csoportjahelyén adott esetben NR3, S vagy O lehet jelen; vagy A3 és A4 aszénatommal együtt, amelyhez kapcsolódik, gyűrűt képez, és -A3-A4-jelentése adott esetben egy vagy több kis szénatomszámúalkilcsoporttal helyettesített -(CH2)2-5 A5 jelentése hidrogénatom,kis szénatomszámú alkil-, kis szénatomszámú alkenil- vagy aril-(kisszénatomszámú alkil)-csoport; A6 jelentése kis szénatomszámú alkil-,cikloalkil-, aril-, aril-(kis szénatomszámú alkil)-, heteroaril-,heteroaril-(kis szénatomszámú alkil)- vagy kis szénatomszámú alkoxi-karbonil-(kis szénatomszámú alkil)-csoport; R2 jelentése hidroxi-,hidroxi-(kis szénatomszámú alkil)-, kis szénatomszámú alkoxi-, kisszénatomszámú alkoxi-karbonit-, N(R4,R5) vagy tio-(kis szénatomszámúalkoxi)-csoport; R1, R3, R4 és R5 jelentése egymástól függetlenülhidrogénatom vagy kis szénatomszámú alkilcsoport] és gyógyászatilagalkalmas sóik OSC-vet társult betegségek kezelésére és/vagymegelőzésére alkalmazhatók, különösen az alábbi indikációkban:hiperkoleszterolémia, hiperlipémia, arterioszklerózis, érbetegségek,mikózisok, parazitafertőzések, epekövek, tumorok és/vagyhiperburjánzásos rendellenességek, károsodott glükóztolerancia ésdiabétesz. A találmány kiterjed a vegyületek előállítására, ezekettartalmazó gyógyszerkészítményekre is. Ó
HU0303105A 2000-08-16 2001-08-08 Novel aminocyclohexane derivatives, process for their preparation, pharmaceutical compositions containing them and their use HUP0303105A3 (en)

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CN115780487B (zh) * 2023-01-05 2023-05-05 河北东丽新材料有限公司 一种萃取剂及利用其处理4,4`-联苯醚二酐生产固废的方法

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US20050176766A1 (en) 2005-08-11
MA26941A1 (fr) 2004-12-20
CA2418744A1 (en) 2002-02-21
NZ523879A (en) 2004-09-24
KR100566175B1 (ko) 2006-03-29
EP1311475B1 (en) 2008-08-06
PE20020367A1 (es) 2002-05-11
US7335687B2 (en) 2008-02-26
HUP0303105A3 (en) 2005-05-30
JP2004506037A (ja) 2004-02-26
ES2311547T3 (es) 2009-02-16
DE60135230D1 (de) 2008-09-18
HRP20030086A2 (en) 2005-02-28
US6858651B2 (en) 2005-02-22
CN1468214A (zh) 2004-01-14
AR030712A1 (es) 2003-09-03
ATE403646T1 (de) 2008-08-15
CA2418744C (en) 2010-04-20
JP4244139B2 (ja) 2009-03-25
RU2225393C1 (ru) 2004-03-10
MXPA03001269A (es) 2003-06-09
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NO20030657D0 (no) 2003-02-10
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WO2002014267A1 (en) 2002-02-21
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US20020045777A1 (en) 2002-04-18
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