PA8465101A1 - Compuestos de triazina - Google Patents

Compuestos de triazina

Info

Publication number
PA8465101A1
PA8465101A1 PA19988465101A PA8465101A PA8465101A1 PA 8465101 A1 PA8465101 A1 PA 8465101A1 PA 19988465101 A PA19988465101 A PA 19988465101A PA 8465101 A PA8465101 A PA 8465101A PA 8465101 A1 PA8465101 A1 PA 8465101A1
Authority
PA
Panama
Prior art keywords
triazine compounds
profarmacs
solvates
salts
compound
Prior art date
Application number
PA19988465101A
Other languages
English (en)
Inventor
Brian Cox
Mark Patrick Healy
Malcolm Stuart Nobbs
Gita Punjabhai Shah
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PA8465101A1 publication Critical patent/PA8465101A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

UN COMPUESTO DE LA FORMULA (1) Y LOS PROFARMACOS, SALES O SOLVATOS DEL MISMO ACEPTABLES FARMACEUTICAMENTE.
PA19988465101A 1997-12-22 1998-12-21 Compuestos de triazina PA8465101A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9726987.2A GB9726987D0 (en) 1997-12-22 1997-12-22 Compounds

Publications (1)

Publication Number Publication Date
PA8465101A1 true PA8465101A1 (es) 2000-09-29

Family

ID=10823992

Family Applications (1)

Application Number Title Priority Date Filing Date
PA19988465101A PA8465101A1 (es) 1997-12-22 1998-12-21 Compuestos de triazina

Country Status (34)

Country Link
US (2) US6265405B1 (es)
EP (1) EP1042304A1 (es)
JP (1) JP2001526275A (es)
KR (1) KR20010024800A (es)
CN (1) CN1284951A (es)
AP (1) AP2000001846A0 (es)
AR (1) AR014146A1 (es)
AU (1) AU753874B2 (es)
BR (1) BR9814495A (es)
CA (1) CA2315620A1 (es)
CO (1) CO5011066A1 (es)
EA (1) EA200000561A1 (es)
EE (1) EE200000391A (es)
GB (1) GB9726987D0 (es)
GT (1) GT199800203A (es)
HN (1) HN1998000193A (es)
HR (1) HRP20000419A2 (es)
HU (1) HUP0100611A3 (es)
ID (1) ID25449A (es)
IL (1) IL136867A0 (es)
IS (1) IS5542A (es)
JO (1) JO2065B1 (es)
MA (1) MA26587A1 (es)
NO (1) NO20003211L (es)
NZ (1) NZ505254A (es)
PA (1) PA8465101A1 (es)
PE (1) PE20000063A1 (es)
PL (1) PL341392A1 (es)
SK (1) SK9592000A3 (es)
SV (1) SV1998000151A (es)
TR (1) TR200001970T2 (es)
WO (1) WO1999032462A1 (es)
YU (1) YU39600A (es)
ZA (1) ZA9811725B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0002666D0 (en) 2000-02-04 2000-03-29 Univ London Blockade of voltage dependent sodium channels
ATE359783T1 (de) * 2001-12-27 2007-05-15 Ortho Mcneil Pharm Inc Aroylpyrrolheteroeryl und methanole zur behandlung von störungen des zentralnervensystems
ES2323268T3 (es) * 2002-07-29 2009-07-10 Glaxo Group Ltd Formulaciones de liberacion prolongada que contienen lamotrigina.
JP2006515326A (ja) * 2003-01-30 2006-05-25 ダイノジェン ファーマシューティカルズ， インコーポレイテッド 胃腸管障害を処置するためのナトリウムチャネルモジュレーターの使用
AR044503A1 (es) 2003-03-18 2005-09-14 Merck & Co Inc Triazoles sustituidos con biarilo como bloqueantes del canal de sodio
DE10332472A1 (de) * 2003-07-16 2005-02-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Ambroxol für die Behandlung von Tinnitus
CA2536764C (en) * 2003-08-25 2013-09-17 Newron Pharmaceuticals, S.P.A. .alpha.-aminoamide derivatives useful as anti-inflammatory agents
US20060115865A1 (en) * 2004-10-25 2006-06-01 Anlong Ouyang Lamotrigine analogs
GB201111712D0 (en) 2011-07-08 2011-08-24 Gosforth Ct Holdings Pty Ltd Pharmaceutical compositions
EP3524605B1 (en) * 2018-02-13 2019-11-27 F.I.S.- Fabbrica Italiana Sintetici S.p.A. New efficient process for the preparation of sitagliptin
CN114796146B (zh) * 2022-04-28 2023-03-28 上海奥科达医药科技股份有限公司 一种拉莫三嗪的缓释制剂及其制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3637688A (en) 1970-01-09 1972-01-25 American Home Prod 6-(fluoro and trifluoromethyl phenyl)-3 5-diamino - 1 2 4 - triazines and substituted - 6 - phenylalkyl-3,5-diamino-1 2 4-triazines
EP0021120B1 (en) 1979-06-01 1983-04-06 The Wellcome Foundation Limited 3,5-diamino-1,2,4-triazine derivatives, process for preparing such compounds and pharmaceutical compositions containing them
AU530999B2 (en) 1979-06-01 1983-08-04 Wellcome Foundation Limited, The Substituted amino triazines and their use in treatment of cns disorders
IT1145308B (it) 1979-08-16 1986-11-05 Wellcome Found Composti aromatici sostituiti
GB8328757D0 (en) 1983-10-27 1983-11-30 Wellcome Found Chemical compounds
GB9012316D0 (en) 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
GB9012311D0 (en) 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
GB9012312D0 (en) 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
GB9203483D0 (en) 1992-02-19 1992-04-08 Wellcome Found Anti-inflammatory compounds
JP3439211B2 (ja) 1992-06-12 2003-08-25 ザ ウエルカム ファウンデーション リミテッド 薬物に対する依存性，耐性および感作の処置および予防における３，５−ジアミノ−６−（２，３−ジクロロフェニル）−１，２，４−トリアジン イセチオネートの使用
AU5704594A (en) 1992-12-18 1994-07-19 Wellcome Foundation Limited, The Pyrimidine, pyridine, pteridinone and indazole derivatives as enzyme inhibitors
US5866597A (en) 1993-03-19 1999-02-02 Glaxo Wellcome Inc. Use of triazine compounds for the treatment of memory and learning disorders
GB9305692D0 (en) 1993-03-19 1993-05-05 Wellcome Found Therapeutic triazine compounds and use
GB9426448D0 (en) * 1994-12-30 1995-03-01 Wellcome Found Process
FR2741879A1 (fr) 1995-12-05 1997-06-06 Esteve Labor Dr Derives de fluorophenyl-triazines et pyrimidines, leur preparation et leur application en tant que medicament

Also Published As

Publication number Publication date
MA26587A1 (fr) 2004-12-20
NO20003211L (no) 2000-08-21
HRP20000419A2 (en) 2000-12-31
HUP0100611A2 (hu) 2001-09-28
ZA9811725B (en) 2000-06-27
HUP0100611A3 (en) 2003-03-28
BR9814495A (pt) 2000-10-10
CA2315620A1 (en) 1999-07-01
PL341392A1 (en) 2001-04-09
GT199800203A (es) 2000-06-14
EP1042304A1 (en) 2000-10-11
JO2065B1 (en) 2000-05-21
TR200001970T2 (tr) 2001-01-22
WO1999032462A1 (en) 1999-07-01
AU2414799A (en) 1999-07-12
EE200000391A (et) 2002-02-15
SK9592000A3 (en) 2001-03-12
GB9726987D0 (en) 1998-02-18
AP2000001846A0 (en) 2000-06-30
CN1284951A (zh) 2001-02-21
US6465461B1 (en) 2002-10-15
US6265405B1 (en) 2001-07-24
AU753874B2 (en) 2002-10-31
PE20000063A1 (es) 2000-02-16
JP2001526275A (ja) 2001-12-18
CO5011066A1 (es) 2001-02-28
IL136867A0 (en) 2001-06-14
SV1998000151A (es) 1999-07-05
NO20003211D0 (no) 2000-06-21
YU39600A (sh) 2002-11-15
AR014146A1 (es) 2001-02-07
KR20010024800A (ko) 2001-03-26
NZ505254A (en) 2002-06-28
IS5542A (is) 2000-06-20
HN1998000193A (es) 2000-04-05
EA200000561A1 (ru) 2001-04-23
ID25449A (id) 2000-10-05

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