OA12585A - Compositions including ammonia oxidizind bacteria to increase production of nitric oxide and nitric oxide precursors and methods of using same. - Google Patents
Compositions including ammonia oxidizind bacteria to increase production of nitric oxide and nitric oxide precursors and methods of using same. Download PDFInfo
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- OA12585A OA12585A OA1200300041A OA1200300041A OA12585A OA 12585 A OA12585 A OA 12585A OA 1200300041 A OA1200300041 A OA 1200300041A OA 1200300041 A OA1200300041 A OA 1200300041A OA 12585 A OA12585 A OA 12585A
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- bacteria
- ammonia oxidizing
- oxidizing bacteria
- thebacteria
- nitric oxide
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| US20040018237A1 (en) * | 2002-05-31 | 2004-01-29 | Perricone Nicholas V. | Topical drug delivery using phosphatidylcholine |
| CA2539974A1 (en) * | 2003-09-26 | 2005-04-07 | David R. Whitlock | Methods of using ammonia oxidizing bacteria |
| CN101028229B (zh) * | 2006-03-02 | 2012-09-05 | 北京富丽华德生物医药科技有限公司 | 基于一氧化氮的新型化妆品 |
| EE05341B1 (et) * | 2008-05-13 | 2010-08-16 | O� Tervisliku Piima Biotehnoloogiate Arenduskeskus | Isoleeritud mikroorganismi tvi Lactobacillus plantarum Inducia DSM 21379 kui organismi loomulikku kaitsev?imet t?stev probiootik, seda sisaldav toiduaine ja kompositsioon ning mikroorganismi kasutamine rakulist immuunsust t?stva ravimi valmistamisek |
| EP2300603A4 (en) * | 2008-06-24 | 2011-08-03 | Micropharma Ltd | OXIDE DEVICE AND METHOD FOR WOUND HEALING, TREATMENT OF SKIN DISEASES AND MICROBIAL INFECTIONS |
| US10940169B2 (en) | 2015-11-30 | 2021-03-09 | Joseph E. Kovarik | Method for reducing the likelihood of developing cancer in an individual human being |
| US11191665B2 (en) | 2011-02-04 | 2021-12-07 | Joseph E. Kovarik | Method and system for reducing the likelihood of a porphyromonas gingivalis infection in a human being |
| US10245288B2 (en) | 2011-02-04 | 2019-04-02 | Joseph E. Kovarik | Method and system for reducing the likelihood of developing NASH in an individual diagnosed with non-alcoholic fatty liver disease |
| US10842834B2 (en) | 2016-01-06 | 2020-11-24 | Joseph E. Kovarik | Method and system for reducing the likelihood of developing liver cancer in an individual diagnosed with non-alcoholic fatty liver disease |
| US11951139B2 (en) | 2015-11-30 | 2024-04-09 | Seed Health, Inc. | Method and system for reducing the likelihood of osteoporosis |
| US10111913B2 (en) | 2011-02-04 | 2018-10-30 | Joseph E. Kovarik | Method of reducing the likelihood of skin cancer in an individual human being |
| US10835560B2 (en) | 2013-12-20 | 2020-11-17 | Joseph E. Kovarik | Reducing the likelihood of skin cancer in an individual human being |
| US10010568B2 (en) | 2011-02-04 | 2018-07-03 | Katherine Rose Kovarik | Method and system for reducing the likelihood of a spirochetes infection in a human being |
| US11419903B2 (en) | 2015-11-30 | 2022-08-23 | Seed Health, Inc. | Method and system for reducing the likelihood of osteoporosis |
| US11357722B2 (en) | 2011-02-04 | 2022-06-14 | Seed Health, Inc. | Method and system for preventing sore throat in humans |
| US10086018B2 (en) | 2011-02-04 | 2018-10-02 | Joseph E. Kovarik | Method and system for reducing the likelihood of colorectal cancer in a human being |
| US10548761B2 (en) | 2011-02-04 | 2020-02-04 | Joseph E. Kovarik | Method and system for reducing the likelihood of colorectal cancer in a human being |
| US11844720B2 (en) | 2011-02-04 | 2023-12-19 | Seed Health, Inc. | Method and system to reduce the likelihood of dental caries and halitosis |
| US11523934B2 (en) | 2011-02-04 | 2022-12-13 | Seed Health, Inc. | Method and system to facilitate the growth of desired bacteria in a human's mouth |
| US11998479B2 (en) | 2011-02-04 | 2024-06-04 | Seed Health, Inc. | Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure |
| US9987224B2 (en) | 2011-02-04 | 2018-06-05 | Joseph E. Kovarik | Method and system for preventing migraine headaches, cluster headaches and dizziness |
| US11951140B2 (en) | 2011-02-04 | 2024-04-09 | Seed Health, Inc. | Modulation of an individual's gut microbiome to address osteoporosis and bone disease |
| US10583033B2 (en) | 2011-02-04 | 2020-03-10 | Katherine Rose Kovarik | Method and system for reducing the likelihood of a porphyromonas gingivalis infection in a human being |
| US10512661B2 (en) | 2011-02-04 | 2019-12-24 | Joseph E. Kovarik | Method and system for reducing the likelihood of developing liver cancer in an individual diagnosed with non-alcoholic fatty liver disease |
| US10687975B2 (en) | 2011-02-04 | 2020-06-23 | Joseph E. Kovarik | Method and system to facilitate the growth of desired bacteria in a human's mouth |
| US10085938B2 (en) | 2011-02-04 | 2018-10-02 | Joseph E. Kovarik | Method and system for preventing sore throat in humans |
| US11273187B2 (en) | 2015-11-30 | 2022-03-15 | Joseph E. Kovarik | Method and system for reducing the likelihood of developing depression in an individual |
| CN103547258B (zh) | 2011-03-17 | 2017-10-20 | 特兰斯德梅尔生物工艺股份有限公司 | 局部一氧化氮系统及其使用方法 |
| CA2835320A1 (en) | 2011-05-09 | 2012-11-15 | Topical Therapeutic Agent (Tta) Ltd. | Nitric oxide-sequestering topical formulations |
| US8871262B2 (en) | 2012-09-19 | 2014-10-28 | Transdermal Biotechnology, Inc. | Compositions and methods for treatment of osteoporosis and other indications |
| US8871257B2 (en) | 2012-09-19 | 2014-10-28 | Transdermal Biotechnology, Inc. | Prevention and treatment of cardiovascular diseases using systems and methods for transdermal nitric oxide delivery |
| US8871261B2 (en) | 2012-09-19 | 2014-10-28 | Transdermal Biotechnology, Inc. | Cancer treatments and compositions for use thereof |
| US8871258B2 (en) | 2012-09-19 | 2014-10-28 | Transdermal Biotechnology, Inc. | Treatment and prevention of learning and memory disorders |
| US8871260B2 (en) | 2012-09-19 | 2014-10-28 | Transdermal Biotechnology, Inc. | Methods and compositions for muscular and neuromuscular diseases |
| US8871255B2 (en) | 2012-09-19 | 2014-10-28 | Transdermal Biotechnology, Inc. | Treatment of skin and soft tissue infection with nitric oxide |
| US8871256B2 (en) | 2012-09-19 | 2014-10-28 | Transdermal Biotechnology, Inc. | Methods and systems for treatment of inflammatory diseases with nitric oxide |
| US8871259B2 (en) | 2012-09-19 | 2014-10-28 | Transdermal Biotechnology, Inc. | Techniques and systems for treatment of neuropathic pain and other indications |
| US8871254B2 (en) | 2012-09-19 | 2014-10-28 | Transdermal Biotechnology, Inc. | Systems and methods for treatment of acne vulgaris and other conditions with a topical nitric oxide delivery system |
| US9295637B2 (en) | 2013-03-13 | 2016-03-29 | Transdermal Biotechnology, Inc. | Compositions and methods for affecting mood states |
| US9314423B2 (en) | 2013-03-13 | 2016-04-19 | Transdermal Biotechnology, Inc. | Hair treatment systems and methods using peptides and other compositions |
| US9339457B2 (en) | 2013-03-13 | 2016-05-17 | Transdermal Biotechnology, Inc. | Cardiovascular disease treatment and prevention |
| US9687520B2 (en) | 2013-03-13 | 2017-06-27 | Transdermal Biotechnology, Inc. | Memory or learning improvement using peptide and other compositions |
| US9393265B2 (en) | 2013-03-13 | 2016-07-19 | Transdermal Biotechnology, Inc. | Wound healing using topical systems and methods |
| US20140271937A1 (en) | 2013-03-13 | 2014-09-18 | Transdermal Biotechnology, Inc. | Brain and neural treatments comprising peptides and other compositions |
| US9314417B2 (en) | 2013-03-13 | 2016-04-19 | Transdermal Biotechnology, Inc. | Treatment of skin, including aging skin, to improve appearance |
| US9724419B2 (en) | 2013-03-13 | 2017-08-08 | Transdermal Biotechnology, Inc. | Peptide systems and methods for metabolic conditions |
| US9393264B2 (en) | 2013-03-13 | 2016-07-19 | Transdermal Biotechnology, Inc. | Immune modulation using peptides and other compositions |
| US9295636B2 (en) | 2013-03-13 | 2016-03-29 | Transdermal Biotechnology, Inc. | Wound healing using topical systems and methods |
| US9387159B2 (en) | 2013-03-13 | 2016-07-12 | Transdermal Biotechnology, Inc. | Treatment of skin, including aging skin, to improve appearance |
| US20140271938A1 (en) | 2013-03-13 | 2014-09-18 | Transdermal Biotechnology, Inc. | Systems and methods for delivery of peptides |
| US9320758B2 (en) | 2013-03-13 | 2016-04-26 | Transdermal Biotechnology, Inc. | Brain and neural treatments comprising peptides and other compositions |
| US20140271731A1 (en) | 2013-03-13 | 2014-09-18 | Transdermal Biotechnology, Inc. | Cardiovascular disease treatment and prevention |
| US9750787B2 (en) | 2013-03-13 | 2017-09-05 | Transdermal Biotechnology, Inc. | Memory or learning improvement using peptide and other compositions |
| US9320706B2 (en) | 2013-03-13 | 2016-04-26 | Transdermal Biotechnology, Inc. | Immune modulation using peptides and other compositions |
| US9241899B2 (en) | 2013-03-13 | 2016-01-26 | Transdermal Biotechnology, Inc. | Topical systems and methods for treating sexual dysfunction |
| US9314422B2 (en) | 2013-03-13 | 2016-04-19 | Transdermal Biotechnology, Inc. | Peptide systems and methods for metabolic conditions |
| US9314433B2 (en) | 2013-03-13 | 2016-04-19 | Transdermal Biotechnology, Inc. | Methods and systems for treating or preventing cancer |
| US9295647B2 (en) | 2013-03-13 | 2016-03-29 | Transdermal Biotechnology, Inc. | Systems and methods for delivery of peptides |
| US9849160B2 (en) | 2013-03-13 | 2017-12-26 | Transdermal Biotechnology, Inc. | Methods and systems for treating or preventing cancer |
| US10471109B2 (en) | 2013-05-04 | 2019-11-12 | The Board Of Regents Of The University Of Texas System | Compositions and methods for promoting nitric oxide production through an oral delivery system |
| US9974311B2 (en) * | 2013-09-23 | 2018-05-22 | Stewart Group Trading Inc. | Impregnated odour control products and methods of making the same |
| US11998574B2 (en) | 2013-12-20 | 2024-06-04 | Seed Health, Inc. | Method and system for modulating an individual's skin microbiome |
| US11026982B2 (en) | 2015-11-30 | 2021-06-08 | Joseph E. Kovarik | Method for reducing the likelihood of developing bladder or colorectal cancer in an individual human being |
| US11826388B2 (en) | 2013-12-20 | 2023-11-28 | Seed Health, Inc. | Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation |
| US11833177B2 (en) | 2013-12-20 | 2023-12-05 | Seed Health, Inc. | Probiotic to enhance an individual's skin microbiome |
| US11529379B2 (en) | 2013-12-20 | 2022-12-20 | Seed Health, Inc. | Method and system for reducing the likelihood of developing colorectal cancer in an individual human being |
| US12005085B2 (en) | 2013-12-20 | 2024-06-11 | Seed Health, Inc. | Probiotic method and composition for maintaining a healthy vaginal microbiome |
| US11969445B2 (en) | 2013-12-20 | 2024-04-30 | Seed Health, Inc. | Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH |
| US11839632B2 (en) | 2013-12-20 | 2023-12-12 | Seed Health, Inc. | Topical application of CRISPR-modified bacteria to treat acne vulgaris |
| US11642382B2 (en) | 2013-12-20 | 2023-05-09 | Seed Health, Inc. | Method for treating an individual suffering from bladder cancer |
| US11980643B2 (en) | 2013-12-20 | 2024-05-14 | Seed Health, Inc. | Method and system to modify an individual's gut-brain axis to provide neurocognitive protection |
| US11213552B2 (en) | 2015-11-30 | 2022-01-04 | Joseph E. Kovarik | Method for treating an individual suffering from a chronic infectious disease and cancer |
| US11672835B2 (en) | 2013-12-20 | 2023-06-13 | Seed Health, Inc. | Method for treating individuals having cancer and who are receiving cancer immunotherapy |
| CA2946050C (en) * | 2014-04-15 | 2023-08-29 | Aobiome Llc | Ammonia-oxidizing nitrosomonas eutropha strain d23 |
| US11225640B2 (en) | 2014-04-15 | 2022-01-18 | Aobiome Llc | Ammonia oxidizing bacteria for treatment of psoriasis |
| JP7088986B2 (ja) * | 2014-04-15 | 2022-06-21 | エーオーバイオーム， エルエルシー． | アンモニア酸化Ｎｉｔｒｏｓｏｍｏｎａｓ ｅｕｔｒｏｐｈａ株Ｄ２３ |
| EP3145519B1 (en) * | 2014-05-22 | 2021-08-04 | Aobiome LLC | Systems and methods for storage and delivery of ammonia oxidizing bacteria |
| CN106471129A (zh) * | 2014-05-22 | 2017-03-01 | Ao生物医学有限责任公司 | 用氨氧化细菌制备材料和测试材料的氨氧化细菌的方法 |
| US11020330B2 (en) | 2014-12-26 | 2021-06-01 | Colgate-Palmolive Company | Personal care composition with Zinc phosphate active |
| CN108367029A (zh) * | 2015-07-02 | 2018-08-03 | Ao生物医学有限责任公司 | 用于治疗痤疮的氨氧化细菌 |
| US10086024B2 (en) | 2015-11-30 | 2018-10-02 | Joseph E. Kovarik | Method and system for protecting honey bees, bats and butterflies from neonicotinoid pesticides |
| US11529412B2 (en) | 2015-11-30 | 2022-12-20 | Seed Health, Inc. | Method and system for protecting honey bees from pesticides |
| US10675347B2 (en) | 2015-11-30 | 2020-06-09 | Joseph E. Kovarik | Method and system for protecting honey bees from fipronil pesticides |
| US10933128B2 (en) | 2015-11-30 | 2021-03-02 | Joseph E. Kovarik | Method and system for protecting honey bees from pesticides |
| US10568916B2 (en) | 2015-11-30 | 2020-02-25 | Joseph E. Kovarik | Method and system for protecting honey bees, bats and butterflies from neonicotinoid pesticides |
| US10806769B2 (en) | 2016-03-31 | 2020-10-20 | Gojo Industries, Inc. | Antimicrobial peptide stimulating cleansing composition |
| JP2019510036A (ja) | 2016-03-31 | 2019-04-11 | ゴジョ・インダストリーズ・インコーポレイテッド | プロバイオティクス／プレバイオティクス有効成分を含む清浄剤組成物 |
| US20190247446A1 (en) | 2016-07-19 | 2019-08-15 | Aobiome Llc | Ammonia oxidizing microorganisms for use and delivery to the gastrointestinal system |
| MX2019003191A (es) | 2016-09-21 | 2019-12-05 | Aobiome Llc | Microorganismos oxidantes de amoníaco para uso y suministro al sistema intranasal. |
| AU2017365019A1 (en) | 2016-11-23 | 2019-07-11 | Gojo Industries, Inc. | Sanitizer composition with probiotic/prebiotic active ingredient |
| AU2017375944A1 (en) | 2016-12-12 | 2019-07-04 | Aobiome Llc | Ammonia oxidizing microorganisms for the regulation of blood pressure |
| WO2018231994A1 (en) | 2017-06-13 | 2018-12-20 | Aobiome Llc | Ammonia oxidizing microorganisms for dispersing biofilms |
| EP3415595A1 (en) * | 2017-06-16 | 2018-12-19 | The Procter & Gamble Company | Surface treatment composition comprising microbial consortium for suppressing non-gras microorganisms on a surface |
| US20200179458A1 (en) * | 2017-07-18 | 2020-06-11 | Aobiome Llc | Microorganisms for use and delivery to the respiratory system |
| US20200171100A1 (en) * | 2017-07-18 | 2020-06-04 | Aobiome Llc | Ammonia oxidizing microorganisms for use and delivery to the visual and auditory systems |
| TW201919671A (zh) * | 2017-08-30 | 2019-06-01 | 美商微辰生命有限公司 | 用於治療尿布疹、香港腳、接觸性皮膚炎、出汗及體臭之氨氧化微生物 |
| US11305026B2 (en) | 2017-11-03 | 2022-04-19 | Amgen Inc. | Systems and approaches for sterilizing a drug delivery device |
| TW201927292A (zh) | 2017-12-13 | 2019-07-16 | 大陸商上海小午醫藥科技有限公司 | 一種用於預防或治療與ｅｇｆｒ被抑制相關疾病的方法 |
| US20210000138A1 (en) * | 2017-12-22 | 2021-01-07 | Aobiome Llc | Veterinary use and delivery of ammonia oxidizing microorganisms |
| CN113975264A (zh) | 2018-04-16 | 2022-01-28 | 上海岸阔医药科技有限公司 | 预防或治疗肿瘤疗法副作用的方法 |
| CN113003723B (zh) * | 2021-02-08 | 2022-05-17 | 清华大学 | 一种耦合菌群生物膜的制备方法 |
| WO2024189071A1 (en) | 2023-03-13 | 2024-09-19 | Universität Wien | Skin archaea preparation |
Family Cites Families (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3984575A (en) | 1974-02-06 | 1976-10-05 | Microlife Technics, Inc. | Bacterial compositions for changing the digestive system bacteria in animals |
| US4147807A (en) | 1977-09-06 | 1979-04-03 | Microlife Technics, Inc. | Process for the treatment of meat with compositions including Micrococcus varians and a lactic acid producing bacteria |
| US4335107A (en) | 1978-06-05 | 1982-06-15 | Snoeyenbos Glenn H | Mixture to protect poultry from salmonella |
| FI59925C (fi) | 1980-01-11 | 1981-11-10 | Esko Viljo Nurmi | Foerfarande foer framstaellning av ett bakteriepreparat anvaendbart foer foerhindrande av salmonellainfektion hos fjaederfae |
| JPS59135845A (ja) * | 1983-01-25 | 1984-08-04 | Sohei Sawamura | 有効土壌菌を含む飼料用添加原剤 |
| US4720344A (en) | 1985-04-18 | 1988-01-19 | Ganczarczyk Jerzy J | Nitrification process in waste water treatment |
| IT1227154B (it) | 1988-08-05 | 1991-03-19 | A Tosi Farmaceutici S R L Nova | Composizioni farmaceutiche per uso ginecologico a base di lattobacilli |
| JPH02121665A (ja) * | 1988-11-01 | 1990-05-09 | Mitsubishi Mining & Cement Co Ltd | 紙オムツ |
| JPH0688028B2 (ja) * | 1988-12-21 | 1994-11-09 | 三菱マテリアル株式会社 | 速効性尿石溶解剤 |
| SE465206B (sv) | 1989-12-22 | 1991-08-12 | Eva Grahn | Farmaceutisk beredning foer bekaempning av patogena tarmbakterier |
| JPH03289957A (ja) * | 1990-03-06 | 1991-12-19 | Daio Paper Corp | 紙おむつ |
| US5139792A (en) | 1990-07-19 | 1992-08-18 | Bio-Techniques Laboratories, Inc. | Method and system for dispensing live bacteria into animal feed and drinking water |
| US5570683A (en) | 1990-12-05 | 1996-11-05 | The General Hospital Corporation | Methods and devices for treating pulmonary vasoconstriction and asthma |
| US5396882A (en) | 1992-03-11 | 1995-03-14 | The General Hospital Corporation | Generation of nitric oxide from air for medical uses |
| SG47527A1 (en) | 1990-12-05 | 1998-04-17 | Gen Hospital Corp | Devices for treating pulmonary vasoconstriction and asthma |
| US5380758A (en) | 1991-03-29 | 1995-01-10 | Brigham And Women's Hospital | S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof |
| US5455279A (en) | 1991-04-19 | 1995-10-03 | The Children's Medical Center Corporation | Regimen method of mediating neuronal damage using nitroglycerine |
| EP1243278B1 (en) | 1992-02-07 | 2007-01-03 | Vasogen Ireland Limited | Use of blood having an increased concentration of nitric oxide for the manufacture of a medicament |
| US5814666A (en) | 1992-04-13 | 1998-09-29 | The United States As Represented By The Department Of Health And Human Services | Encapsulated and non-encapsulated nitric oxide generators used as antimicrobial agents |
| US5278192A (en) | 1992-07-02 | 1994-01-11 | The Research Foundation Of State University Of New York | Method of vasodilator therapy for treating a patient with a condition |
| US5646181A (en) | 1992-07-02 | 1997-07-08 | Research Foundation Of State University Of New York | Method and compositions for treating impotence |
| US5340577A (en) | 1992-07-29 | 1994-08-23 | The United States Of America, As Represented By The Secretary Of Agriculture | Probiotic for control of salmonella |
| US5632981A (en) | 1992-08-24 | 1997-05-27 | The United States Of America As Represented By The Department Of Health And Human Services | Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same |
| US5910316A (en) | 1992-08-24 | 1999-06-08 | The United States Of America, As Represented By The Department Of Health And Human Services | Use of nitric oxide-releasing agents to treat impotency |
| US5650447A (en) | 1992-08-24 | 1997-07-22 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nitric oxide-releasing polymers to treat restenosis and related disorders |
| US5385940A (en) | 1992-11-05 | 1995-01-31 | The General Hospital Corporation | Treatment of stroke with nitric-oxide releasing compounds |
| EP0689381B1 (en) | 1993-03-16 | 2000-01-05 | THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF AGRICULTURE | Mucosal competitive exclusion flora |
| US5427797A (en) | 1993-04-06 | 1995-06-27 | Brigham And Women's Hospital | Systemic effects of nitric oxide inhalation |
| GB2279014B (en) | 1993-06-02 | 1997-07-16 | Niall Keaney | Device for controlling delivery of respiratory drugs |
| US5861168A (en) | 1993-06-11 | 1999-01-19 | The Board Of Trustees Of The Leland Stanford Junior University | Intramural delivery of nitric oxide enhancer for inhibiting lesion formation after vascular injury |
| US5314542A (en) * | 1993-08-06 | 1994-05-24 | Precision Aquarium Testing, Inc. | Nitrosomonas preservation and reactivation for aquaria |
| US5728705A (en) | 1993-10-04 | 1998-03-17 | The Trustees Of Columbia University In The City Of New York | Method of inducing vasorelaxation to treat pulmonary hypertension |
| GB9320978D0 (en) | 1993-10-12 | 1993-12-01 | Higenbottam Timohy W | Nitric oxide treatment |
| ATE192922T1 (de) | 1993-11-02 | 2000-06-15 | Us Health | Verwendung von stickstoffoxid freisetzenden verbindungen zur herstellung eines arzneimittels zum schutz gegen die ischämischen reperfusionsschäden |
| US5470847A (en) | 1993-12-10 | 1995-11-28 | Board Of Regents, The University Of Texas System | Ovulation control by regulating nitric oxide levels with arginine derivatives |
| WO1995032715A1 (en) | 1994-05-27 | 1995-12-07 | Neptune Pharmaceutical Corporation | Nitric oxide donor composition and method for treatment of anal disorders |
| US5543430A (en) | 1994-10-05 | 1996-08-06 | Kaesemeyer; W. H. | Method and formulation of stimulating nitric oxide synthesis |
| US5519020A (en) | 1994-10-28 | 1996-05-21 | The University Of Akron | Polymeric wound healing accelerators |
| US5648101A (en) | 1994-11-14 | 1997-07-15 | Tawashi; Rashad | Drug delivery of nitric oxide |
| EP1609477B1 (en) | 1994-12-12 | 2011-11-09 | Omeros Corporation | Irrigation solution and use thereof for the perioperative inhibition of pain/inflammation and/or spasm at a vascular structure |
| US6063407A (en) | 1995-02-16 | 2000-05-16 | The General Hospital Corporation | Treatment of vascular thrombosis and restenosis with inhaled nitric oxide |
| US5595753A (en) | 1995-04-14 | 1997-01-21 | President And Fellows Of Harvard College | Topical formulations and methods for treating hemorrhoidal pain and sphincter and smooth muscle spasm in the gastrointestinal tract |
| US5665077A (en) | 1995-04-24 | 1997-09-09 | Nitrosci Pharmaceuticals Llc | Nitric oxide-releasing nitroso compositions and methods and intravascular devices for using them to prevent restenosis |
| US5645839A (en) | 1995-06-07 | 1997-07-08 | Trustees Of Boston University | Combined use of angiotensin inhibitors and nitric oxide stimulators to treat fibrosis |
| US5534253A (en) | 1995-06-07 | 1996-07-09 | Biogaia Ab | Method of treating enteropathogenic bacterial infections in poultry |
| US5900433A (en) | 1995-06-23 | 1999-05-04 | Cormedics Corp. | Vascular treatment method and apparatus |
| US5714511A (en) | 1995-07-31 | 1998-02-03 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs |
| US5876603A (en) | 1995-08-10 | 1999-03-02 | Hitachi Plant Engineering & Construction Co., Ltd. | Method of biologically removing nitrogen and system therefor |
| JP3252888B2 (ja) * | 1995-09-11 | 2002-02-04 | 日立プラント建設株式会社 | 生物学的窒素除去装置 |
| EP0780419A1 (en) | 1995-12-22 | 1997-06-25 | Holland Biomaterials Group B.V. | Multi-functional site containing polymers, and applications thereof |
| US5849192A (en) | 1996-02-12 | 1998-12-15 | Basf Corporation | Procedure to recover from nitrification upsets |
| US5725492A (en) | 1996-03-04 | 1998-03-10 | Cormedics Corp | Extracorporeal circulation apparatus and method |
| US5910482A (en) | 1996-03-19 | 1999-06-08 | Board Of Regents, The University Of Texas System | Treatment or prevention of preeclampsia, eclampsia with calcitonin gene related peptide, CGRP analog, progestational agent, nitric oxide source, and cyclooxygenase inhibitor |
| US5824669A (en) | 1996-03-22 | 1998-10-20 | Nitromed, Inc. | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders |
| US5765548A (en) | 1996-05-07 | 1998-06-16 | Perry; Bryan J. | Use of nitric oxide in the treatment of exercised induced pulmonary hemorrhaging in equine |
| US5821112A (en) * | 1996-10-04 | 1998-10-13 | Botto; Willism S. | Biological odor metabolizing compositions and methods of use |
| US5807546A (en) | 1996-10-11 | 1998-09-15 | The United States Of America As Represented By The Secretary Of Agriculture | Livestock mucosal competitive exclusion culture to reduce enteropathogenic bacteria |
| US5958427A (en) | 1996-11-08 | 1999-09-28 | Salzman; Andrew L. | Nitric oxide donor compounds and pharmaceutical compositions for pulmonary hypertension and other indications |
| US5891472A (en) | 1996-11-19 | 1999-04-06 | Meri Charmyne Russell | Treatment of equine laminitis |
| US20050036996A1 (en) | 1996-12-24 | 2005-02-17 | Edmond Roussel | Absorbable composition containing propionic bacteria capable of releasing nitric oxide in the human or animal alimentary canal |
| FR2764802A1 (fr) * | 1996-12-24 | 1998-12-24 | Standa Lab Sa | Composition adsorbable renfermant des bacteries propioniques susceptible de degager du monoxyde d'azote dans le tube digestif humain ou animal |
| US5912019A (en) | 1997-02-07 | 1999-06-15 | Musc Foundation For Research Development | Compounds for reducing ischemia/reperfusion injury |
| US5895658A (en) | 1997-09-17 | 1999-04-20 | Fossel; Eric T. | Topical delivery of L-arginine to cause tissue warming |
| US5994444A (en) | 1997-10-16 | 1999-11-30 | Medtronic, Inc. | Polymeric material that releases nitric oxide |
| CA2243011C (en) * | 1998-07-13 | 2007-02-13 | Life Science Technology Group, Inc. | Odor control agent for carpet and the like and method of use thereof |
| US20050244382A9 (en) | 2002-01-11 | 2005-11-03 | Whitlock David R | Compositions including ammonia oxidizing bacteria and methods of using same |
| CA2539974A1 (en) | 2003-09-26 | 2005-04-07 | David R. Whitlock | Methods of using ammonia oxidizing bacteria |
-
2001
- 2001-08-10 WO PCT/US2001/025248 patent/WO2002013982A1/en active Application Filing
- 2001-08-10 EA EA200300253A patent/EA005649B1/ru not_active IP Right Cessation
- 2001-08-10 MX MXPA03001280A patent/MXPA03001280A/es active IP Right Grant
- 2001-08-10 CN CNB018137946A patent/CN1267212C/zh not_active Expired - Lifetime
- 2001-08-10 OA OA1200300041A patent/OA12585A/en unknown
- 2001-08-10 CA CA2414941A patent/CA2414941C/en not_active Expired - Lifetime
- 2001-08-10 AU AU8484901A patent/AU8484901A/xx active Pending
- 2001-08-10 JP JP2002519111A patent/JP2004506028A/ja active Pending
- 2001-08-10 IL IL15395601A patent/IL153956A0/xx unknown
- 2001-08-10 KR KR10-2003-7001998A patent/KR20030065463A/ko not_active Application Discontinuation
- 2001-08-10 US US10/332,933 patent/US7820420B2/en not_active Expired - Fee Related
- 2001-08-10 AU AU2001284849A patent/AU2001284849B2/en not_active Expired
- 2001-08-10 BR BRPI0113085-4A patent/BRPI0113085B1/pt not_active IP Right Cessation
- 2001-08-10 DE DE60136366T patent/DE60136366D1/de not_active Expired - Lifetime
- 2001-08-10 AT AT01963935T patent/ATE412475T1/de not_active IP Right Cessation
- 2001-08-10 AP APAP/P/2003/002721A patent/AP1682A/en active
- 2001-08-10 EP EP01963935A patent/EP1313574B1/en not_active Expired - Lifetime
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2003
- 2003-01-14 ZA ZA200300377A patent/ZA200300377B/en unknown
- 2003-01-14 IL IL153956A patent/IL153956A/en active IP Right Grant
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2010
- 2010-09-24 US US12/889,936 patent/US8388989B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200300377B (en) | 2004-01-22 |
| EP1313574B1 (en) | 2008-10-29 |
| IL153956A (en) | 2012-01-31 |
| DE60136366D1 (de) | 2008-12-11 |
| AP1682A (en) | 2006-11-27 |
| BRPI0113085B8 (ru) | 2021-05-25 |
| AU2001284849B2 (en) | 2006-11-30 |
| WO2002013982A1 (en) | 2002-02-21 |
| US8388989B2 (en) | 2013-03-05 |
| US20040014188A1 (en) | 2004-01-22 |
| BR0113085A (pt) | 2003-07-22 |
| US7820420B2 (en) | 2010-10-26 |
| US20110232650A1 (en) | 2011-09-29 |
| EA200300253A1 (ru) | 2003-08-28 |
| CN1446128A (zh) | 2003-10-01 |
| EP1313574A4 (en) | 2004-09-22 |
| AP2003002721A0 (en) | 2003-06-30 |
| AU8484901A (en) | 2002-02-25 |
| EP1313574A1 (en) | 2003-05-28 |
| IL153956A0 (en) | 2003-07-31 |
| KR20030065463A (ko) | 2003-08-06 |
| CN1267212C (zh) | 2006-08-02 |
| JP2004506028A (ja) | 2004-02-26 |
| ATE412475T1 (de) | 2008-11-15 |
| MXPA03001280A (es) | 2004-07-30 |
| BRPI0113085B1 (pt) | 2017-09-19 |
| EA005649B1 (ru) | 2005-04-28 |
| CA2414941C (en) | 2010-12-14 |
| CA2414941A1 (en) | 2002-02-21 |
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