OA12200A - Polymorphs of N-methyl-N-(3-ä3-Ä2-thienylcarbonylÜ-pyrazol-Ä1-5-aÜ-pyrimidin-7-YLüphenyl)acetamide and compositions and methods related thereto. - Google Patents

Polymorphs of N-methyl-N-(3-ä3-Ä2-thienylcarbonylÜ-pyrazol-Ä1-5-aÜ-pyrimidin-7-YLüphenyl)acetamide and compositions and methods related thereto. Download PDF

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Publication number
OA12200A
OA12200A OA1200200057A OA1200200057A OA12200A OA 12200 A OA12200 A OA 12200A OA 1200200057 A OA1200200057 A OA 1200200057A OA 1200200057 A OA1200200057 A OA 1200200057A OA 12200 A OA12200 A OA 12200A
Authority
OA
OAPI
Prior art keywords
polymorph
pyrimidin
methyl
substantially pure
acetamide
Prior art date
Application number
OA1200200057A
Other languages
English (en)
Inventor
William J Thiele
Patrick B O'donnell
Original Assignee
Neurocrine Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurocrine Biosciences Inc filed Critical Neurocrine Biosciences Inc
Publication of OA12200A publication Critical patent/OA12200A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
OA1200200057A 1999-09-02 2000-09-01 Polymorphs of N-methyl-N-(3-ä3-Ä2-thienylcarbonylÜ-pyrazol-Ä1-5-aÜ-pyrimidin-7-YLüphenyl)acetamide and compositions and methods related thereto. OA12200A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38952499A 1999-09-02 1999-09-02
US42162099A 1999-10-19 1999-10-19

Publications (1)

Publication Number Publication Date
OA12200A true OA12200A (en) 2006-05-09

Family

ID=27012737

Family Applications (1)

Application Number Title Priority Date Filing Date
OA1200200057A OA12200A (en) 1999-09-02 2000-09-01 Polymorphs of N-methyl-N-(3-ä3-Ä2-thienylcarbonylÜ-pyrazol-Ä1-5-aÜ-pyrimidin-7-YLüphenyl)acetamide and compositions and methods related thereto.

Country Status (26)

Country Link
EP (2) EP1477169A1 (fr)
JP (1) JP4592241B2 (fr)
KR (1) KR20020035585A (fr)
CN (2) CN1198824C (fr)
AP (1) AP1631A (fr)
AT (1) ATE269082T1 (fr)
AU (2) AU769856B2 (fr)
BR (1) BR0014459A (fr)
CA (1) CA2382588C (fr)
CZ (1) CZ2002783A3 (fr)
DE (1) DE60011638T2 (fr)
DK (1) DK1214075T3 (fr)
EA (1) EA004706B1 (fr)
ES (1) ES2222920T3 (fr)
HK (1) HK1047407B (fr)
HU (1) HUP0202698A3 (fr)
IL (2) IL148242A0 (fr)
MX (1) MXPA02002314A (fr)
NO (1) NO322752B1 (fr)
NZ (1) NZ517298A (fr)
OA (1) OA12200A (fr)
PL (1) PL353362A1 (fr)
PT (1) PT1214075E (fr)
SK (1) SK2782002A3 (fr)
TR (1) TR200200534T2 (fr)
WO (1) WO2001015700A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP2005003220A0 (en) * 2002-08-26 2005-03-31 Neurocrine Biosciences Inc Novel polymorph of N-Methyl-N-(3-{3-[2-Thienylcarbonyl]-Pyrazol-[1,5-Alpha]-Pyrimidin-7-YI}Phenyl) Acetanide and compositions and methods related thereto.
WO2004110454A1 (fr) * 2003-06-13 2004-12-23 Ishihara Sangyo Kaisha, Ltd. Composition de traitement ou de prevention de maladies necessitant l'administration d'un agoniste du recepteur a2a de l'adenosine
US7371906B2 (en) 2004-08-24 2008-05-13 Eastman Kodak Company Process for photo-oxidative stability improvements
EP1956021A1 (fr) * 2006-10-11 2008-08-13 Ferrer Internacional, S.A. Procédé de préparation d'un pyrazole[1,5-a]pyrimidine en forme crystalline
EP1918290A1 (fr) * 2006-10-11 2008-05-07 Ferrer Internacional, S.A. La polymorphe B de la N-{2-fluoro-5-[3-thiophèn-2-carbonyle)-pyrazolo[1,5-a]pyrimidin-7-yl]-phènyl}-N-methyle-acetamide
CN101177427B (zh) * 2006-11-09 2011-07-20 中国人民解放军军事医学科学院放射与辐射医学研究所 一种用于催眠的化合物的多晶型α和溶剂化物,其制备方法及含该物质的组合物
WO2010109480A2 (fr) * 2009-03-24 2010-09-30 Glenmark Generics Limited Procédés de préparation de l'indiplon et de ses intermédiaires

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4626538A (en) * 1983-06-23 1986-12-02 American Cyanamid Company [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
NZ208554A (en) * 1983-06-23 1987-06-30 American Cyanamid Co (aryl and heteroaryl)-(7-(aryl and heteroaryl)-pyrazolo (1,5-a) pyrimidin-3-yl)-methanone derivatives and pharmaceutical compositions
US4654347A (en) * 1983-06-23 1987-03-31 American Cyanamid Company Aryl and heteroaryl[[7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]methanones
US4521422A (en) * 1983-06-23 1985-06-04 American Cyanamid Company Aryl and heteroaryl[7-(aryl and heteroaryl)pyrazolo[1,5-a]pyrimidin-3-yl]methanones
DE3689294T2 (de) * 1985-05-13 1994-06-09 American Cyanamid Co [7-(3-Disubstituierte Amino)phenyl]pyrazolo[1,5-a]-pyrimidine.
US5421422A (en) * 1993-11-19 1995-06-06 Boretec Inc Roller cutter mount for tunneling machine

Also Published As

Publication number Publication date
HK1047407B (zh) 2004-12-24
NZ517298A (en) 2004-01-30
AP2002002428A0 (en) 2002-03-31
CN1680376A (zh) 2005-10-12
AU6949100A (en) 2001-03-26
NO322752B1 (no) 2006-12-04
CZ2002783A3 (cs) 2004-01-14
EP1214075B1 (fr) 2004-06-16
EA200200320A1 (ru) 2002-08-29
CN1198824C (zh) 2005-04-27
TR200200534T2 (tr) 2002-06-21
PL353362A1 (en) 2003-11-17
EP1214075A1 (fr) 2002-06-19
WO2001015700A9 (fr) 2002-09-12
HUP0202698A3 (en) 2004-12-28
DE60011638T2 (de) 2004-10-21
PT1214075E (pt) 2004-11-30
DE60011638D1 (de) 2004-07-22
MXPA02002314A (es) 2002-08-12
AU2004201356A1 (en) 2004-04-29
DK1214075T3 (da) 2004-10-25
JP2003508440A (ja) 2003-03-04
JP4592241B2 (ja) 2010-12-01
AP1631A (en) 2006-07-12
AU769856B2 (en) 2004-02-05
BR0014459A (pt) 2002-07-16
CA2382588C (fr) 2008-11-25
HK1047407A1 (en) 2003-02-21
HUP0202698A2 (hu) 2002-12-28
IL148242A (en) 2006-12-10
ES2222920T3 (es) 2005-02-16
CN1331865C (zh) 2007-08-15
EP1214075A4 (fr) 2003-05-02
IL148242A0 (en) 2002-09-12
NO20021041D0 (no) 2002-03-01
NO20021041L (no) 2002-04-03
SK2782002A3 (en) 2003-04-01
ATE269082T1 (de) 2004-07-15
EP1477169A1 (fr) 2004-11-17
CN1374866A (zh) 2002-10-16
KR20020035585A (ko) 2002-05-11
EA004706B1 (ru) 2004-06-24
CA2382588A1 (fr) 2001-03-08
WO2001015700A1 (fr) 2001-03-08

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