OA12097A - 2,4-Diaminopyrimidine compounds useful as immunosuppressants. - Google Patents
2,4-Diaminopyrimidine compounds useful as immunosuppressants. Download PDFInfo
- Publication number
- OA12097A OA12097A OA1200200156A OA1200200156A OA12097A OA 12097 A OA12097 A OA 12097A OA 1200200156 A OA1200200156 A OA 1200200156A OA 1200200156 A OA1200200156 A OA 1200200156A OA 12097 A OA12097 A OA 12097A
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- OA
- OAPI
- Prior art keywords
- alkyl
- dihydro
- aryl
- heteroaryl
- composition according
- Prior art date
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- 229960003444 immunosuppressant agent Drugs 0.000 title description 2
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- VINHZULRPKYOFW-UHFFFAOYSA-N 5,6,7,8-tetrahydropyrido[2,3-e][1,2,4]triazine Chemical compound C1=NN=C2CCCNC2=N1 VINHZULRPKYOFW-UHFFFAOYSA-N 0.000 claims 1
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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Landscapes
- Health & Medical Sciences (AREA)
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- Medicinal Chemistry (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16822499P | 1999-11-30 | 1999-11-30 |
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| OA12097A true OA12097A (en) | 2006-05-04 |
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| OA1200200156A OA12097A (en) | 1999-11-30 | 2000-11-09 | 2,4-Diaminopyrimidine compounds useful as immunosuppressants. |
Country Status (33)
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| JP (1) | JP3955468B2 (cs) |
| KR (1) | KR20020059826A (cs) |
| CN (1) | CN1402720A (cs) |
| AP (1) | AP2002002530A0 (cs) |
| AT (1) | ATE315036T1 (cs) |
| AU (1) | AU1047601A (cs) |
| BG (1) | BG106695A (cs) |
| BR (1) | BR0015995A (cs) |
| CA (1) | CA2392971C (cs) |
| CO (1) | CO5261519A1 (cs) |
| CZ (1) | CZ20021703A3 (cs) |
| DE (1) | DE60025385T2 (cs) |
| EA (1) | EA200200411A1 (cs) |
| EE (1) | EE200200275A (cs) |
| ES (1) | ES2253266T3 (cs) |
| GT (1) | GT200000200A (cs) |
| HN (1) | HN2000000264A (cs) |
| HU (1) | HUP0203300A3 (cs) |
| IL (1) | IL149103A0 (cs) |
| IS (1) | IS6339A (cs) |
| MA (1) | MA26846A1 (cs) |
| MX (1) | MXPA02005350A (cs) |
| NO (1) | NO20022557L (cs) |
| OA (1) | OA12097A (cs) |
| PA (1) | PA8506801A1 (cs) |
| PE (1) | PE20010900A1 (cs) |
| PL (1) | PL355946A1 (cs) |
| SV (1) | SV2002000231A (cs) |
| TN (1) | TNSN00232A1 (cs) |
| TR (1) | TR200201431T2 (cs) |
| UY (1) | UY26455A1 (cs) |
| WO (1) | WO2001040215A1 (cs) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1429222A (zh) * | 2000-02-17 | 2003-07-09 | 安姆根有限公司 | 激酶抑制剂 |
| BR0113574A (pt) * | 2000-08-31 | 2003-07-22 | Pfizer Prod Inc | Derivados de pirazol e uso dos mesmos como inibidores de proteìna quinase |
| US7473691B2 (en) | 2000-09-15 | 2009-01-06 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| KR20030030005A (ko) | 2000-09-15 | 2003-04-16 | 버텍스 파마슈티칼스 인코포레이티드 | 단백질 키나제 억제제로서 유용한 피라졸 화합물 |
| US6660731B2 (en) | 2000-09-15 | 2003-12-09 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| EP1345927B1 (en) | 2000-12-21 | 2006-05-17 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
| WO2003030909A1 (en) * | 2001-09-25 | 2003-04-17 | Bayer Pharmaceuticals Corporation | 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer |
| MY141867A (en) | 2002-06-20 | 2010-07-16 | Vertex Pharma | Substituted pyrimidines useful as protein kinase inhibitors |
| KR20050032105A (ko) | 2002-08-02 | 2005-04-06 | 버텍스 파마슈티칼스 인코포레이티드 | Ｇｓｋ-3의 억제제로서 유용한 피라졸 조성물 |
| US20040204458A1 (en) | 2002-08-16 | 2004-10-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Use of Lck inhibitors for treatment of immunologic diseases |
| DE10237423A1 (de) * | 2002-08-16 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen |
| WO2005068437A1 (en) * | 2004-01-16 | 2005-07-28 | Novartis Ag | 2, 4 - diaminopyrimidines and their use for inducing cardiomyogenesis |
| JP2008515980A (ja) * | 2004-10-12 | 2008-05-15 | デコード ジェネティクス イーエイチエフ | 閉塞性動脈疾患のためのアリールスルホンアミドぺリ置換二環式化合物 |
| US20060161001A1 (en) * | 2004-12-20 | 2006-07-20 | Amgen Inc. | Substituted heterocyclic compounds and methods of use |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| WO2007056163A2 (en) | 2005-11-03 | 2007-05-18 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as kinase inhibitors |
| RU2475488C2 (ru) | 2006-02-14 | 2013-02-20 | Вертекс Фармасьютикалз Инкорпорейтед | Дигидродиазепины, которые можно использовать в качестве ингибиторов протеинкиназ |
| WO2007109045A1 (en) * | 2006-03-16 | 2007-09-27 | Novartis Ag | Heterocyclic organic compounds for the treatment of in particular melanoma |
| EA017249B8 (ru) | 2007-05-10 | 2013-01-30 | Олбани Молекьюлар Рисерч, Инк. | Арил- и гетероарилзамещенные тетрагидробензо-1,4-диазепины и их применение для блокирования обратного захвата норэпинефрина, допамина и серотонина |
| US8232287B2 (en) * | 2007-10-16 | 2012-07-31 | Daiichi Sankyo Company, Limited | Pyrimidyl indoline compound |
| EP2480550B1 (en) | 2009-09-25 | 2016-02-10 | Vertex Pharmaceuticals Incorporated | Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors |
| BR112012006639A2 (pt) | 2009-09-25 | 2015-09-08 | Vertex Pharma | métodos para preparar derivados de pirimidina úteis como inibidores de protéina quinase |
| TWI513694B (zh) * | 2010-05-11 | 2015-12-21 | Amgen Inc | 抑制間變性淋巴瘤激酶的嘧啶化合物 |
| KR101708761B1 (ko) * | 2012-04-13 | 2017-02-21 | 주식회사 머쉬메드 | 퓨린 유도체 또는 그의 염을 포함하는 아토피성 피부염의 예방 또는 치료용 조성물 |
| US10125144B2 (en) | 2013-10-07 | 2018-11-13 | Kadmon Corporation, Llc | Rho kinase inhibitors |
| ES2969536T3 (es) | 2017-06-30 | 2024-05-21 | Beijing Tide Pharmaceutical Co Ltd | Inhibidor de la proteína cinasa asociada a rho, composición farmacéutica que lo comprende, y su método de preparación y uso |
| KR102563325B1 (ko) * | 2017-06-30 | 2023-08-03 | 베이징 타이드 파마슈티컬 코퍼레이션 리미티드 | Ｒｈｏ-관련 단백질 키나아제 억제제, Ｒｈｏ-관련 단백질 키나아제 억제제를 함유하는 약학 조성물, 제조 방법 및 약학 조성물의 용도 |
| WO2019000683A1 (zh) | 2017-06-30 | 2019-01-03 | 北京泰德制药股份有限公司 | Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9523675D0 (en) * | 1995-11-20 | 1996-01-24 | Celltech Therapeutics Ltd | Chemical compounds |
| EP0837063A1 (en) * | 1996-10-17 | 1998-04-22 | Pfizer Inc. | 4-Aminoquinazoline derivatives |
| GB9905075D0 (en) * | 1999-03-06 | 1999-04-28 | Zeneca Ltd | Chemical compounds |
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- 2000-11-09 KR KR1020027006941A patent/KR20020059826A/ko not_active Ceased
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