OA11991A - Monoclonal antibodies and antibody cocktail for detection of prion protein as an indication of transmissible spongiform encephalopathies. - Google Patents

Monoclonal antibodies and antibody cocktail for detection of prion protein as an indication of transmissible spongiform encephalopathies. Download PDF

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Publication number
OA11991A
OA11991A OA1200200014A OA1200200014A OA11991A OA 11991 A OA11991 A OA 11991A OA 1200200014 A OA1200200014 A OA 1200200014A OA 1200200014 A OA1200200014 A OA 1200200014A OA 11991 A OA11991 A OA 11991A
Authority
OA
OAPI
Prior art keywords
prp
monoclonal antibody
tissue
epitope
monoclonal
Prior art date
Application number
OA1200200014A
Other languages
English (en)
Inventor
Katherine I O'rourke
Original Assignee
Us Agriculture
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Agriculture filed Critical Us Agriculture
Publication of OA11991A publication Critical patent/OA11991A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2872—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against prion molecules, e.g. CD230
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4709—Amyloid plaque core protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
OA1200200014A 1999-07-15 2000-07-14 Monoclonal antibodies and antibody cocktail for detection of prion protein as an indication of transmissible spongiform encephalopathies. OA11991A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/353,348 US6261790B1 (en) 1999-07-15 1999-07-15 Monoclonal antibodies and antibody cocktail for detection of prion protein as an indication of transmissible spongiform encephalopathies

Publications (1)

Publication Number Publication Date
OA11991A true OA11991A (en) 2006-04-18

Family

ID=23388730

Family Applications (1)

Application Number Title Priority Date Filing Date
OA1200200014A OA11991A (en) 1999-07-15 2000-07-14 Monoclonal antibodies and antibody cocktail for detection of prion protein as an indication of transmissible spongiform encephalopathies.

Country Status (25)

Country Link
US (1) US6261790B1 (cs)
EP (1) EP1212082A4 (cs)
JP (1) JP2003504087A (cs)
KR (1) KR20020034158A (cs)
CN (1) CN1450909A (cs)
AU (1) AU773078B2 (cs)
BG (1) BG106415A (cs)
BR (1) BR0012468A (cs)
CA (1) CA2379349A1 (cs)
CZ (1) CZ295412B6 (cs)
EA (1) EA005239B1 (cs)
EE (1) EE200200009A (cs)
GE (1) GEP20043256B (cs)
HU (1) HUP0202183A2 (cs)
IL (1) IL147517A0 (cs)
MX (1) MXPA02000445A (cs)
NO (1) NO20020190L (cs)
NZ (1) NZ517075A (cs)
OA (1) OA11991A (cs)
PL (1) PL199345B1 (cs)
SK (1) SK282002A3 (cs)
TR (1) TR200200071T2 (cs)
UA (1) UA72532C2 (cs)
WO (1) WO2001005426A1 (cs)
ZA (1) ZA200200969B (cs)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9610580A (pt) 1995-09-14 2000-10-24 Univ California Anticorpos especìficos para prpse nativos
US7041807B1 (en) 1999-06-23 2006-05-09 Caprion Pharmaceuticals, Inc. Antibodies to a YYX epitope of a mammalian prion protein
US7098317B1 (en) * 2000-05-23 2006-08-29 Blood Transfusion Center Of Slovenia Antibodies capable to selectively detect prion PrPSc isoforms
US6537548B1 (en) * 2000-07-27 2003-03-25 The Regents Of The University Of California Antibodies specific for ungulate PrP
WO2002046236A1 (fr) * 2000-12-08 2002-06-13 Fujirebio Inc. Anticorps monoclonal dirigé contre un prion anormal, procédé de production correspondant, et procédé d'essai immunologique l'utilisant
DE10120562C2 (de) * 2001-04-26 2003-04-10 Horst Messer Verfahren zur Diagnose von übertragbaren spongiformen Enzephalopathien
KR20020033126A (ko) * 2002-03-08 2002-05-04 김용선 병원성 프리온 단백의 n말단의 비효소적 당화반응 최종산물의 검출에 의한 프리온 질환의 진단
US20040175775A1 (en) * 2002-11-08 2004-09-09 Neil Cashman Method of detecting PrPsc in eye fluid
CA2836951C (en) * 2002-12-03 2017-01-10 North Carolina State University Prion protein ligands and methods of use
US20050282238A1 (en) * 2003-09-23 2005-12-22 Bowen David J High-sensitivity chemiluminescent ELISA prion detection method
AU2005209592B2 (en) 2004-09-30 2012-07-12 Ortho-Clinical Diagnostics, Inc. Peptides for discrimination of prions
GB0501564D0 (en) * 2005-01-25 2005-03-02 Univ Cambridge Tech Test for prion disease
WO2006102099A2 (en) * 2005-03-18 2006-09-28 The Regents Of The University Of California ANTIBODIES SPECIFIC FOR HUMAN AND BOVINE PrP
JP4724816B2 (ja) * 2005-09-06 2011-07-13 シャープ株式会社 タンパク質の測定方法
EP1931695B1 (en) 2005-09-09 2013-04-10 Novartis AG Prion-specific peptoid reagents
US20070196863A1 (en) * 2006-02-17 2007-08-23 Hanson Technologies, Inc. Prion protein detection
ES2373762T3 (es) * 2007-04-04 2012-02-08 Novartis Ag Ensayo de priones.
CA2743361C (en) 2008-10-06 2021-05-25 Neil R. Cashman Methods and systems for predicting misfolded protein epitopes
US8821879B2 (en) 2009-09-04 2014-09-02 Xoma Technology Ltd. Anti-botulism antibody coformulations
WO2011028962A1 (en) * 2009-09-04 2011-03-10 Xoma Technology Ltd. Antibody coformulations
CN102558349B (zh) * 2012-01-12 2013-12-11 吉林大学 一种识别天然结构梅花鹿朊蛋白的单克隆抗体及制备方法
CN104031148B (zh) * 2014-05-15 2018-03-13 中国科学院动物研究所 针对人PrPc的单克隆抗体及其应用
KR20220110539A (ko) * 2019-12-04 2022-08-08 에이씨 이뮨 에스에이 치료 및 진단용 신규 분자

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4806627A (en) 1987-05-29 1989-02-21 Research Foundation Of Mental Hygiene Inc. Hybrid cell lines producing monoclonal antibodies dircted against scrapie-associated fibril proteins
CA2124953C (en) * 1991-12-03 2008-02-05 Robert V. Fishleigh Peptides related to prion proteins
US5565186A (en) 1994-05-13 1996-10-15 The Regents Of The University Of California Method of detecting prions in a sample and transgenic animal used for same
BR9610580A (pt) 1995-09-14 2000-10-24 Univ California Anticorpos especìficos para prpse nativos
DE19741607A1 (de) * 1997-09-20 1999-03-25 Prionics Ag Synthetische Polypeptide zur Diagnose und Therapie von Prionerkrankungen
US6165784A (en) 1997-10-14 2000-12-26 The United States Of America As Represented By The Secretary Of Agriculture Antibodies for the detection of prion protein as an indication of transmissible spongiform encephalopathies

Also Published As

Publication number Publication date
JP2003504087A (ja) 2003-02-04
UA72532C2 (en) 2005-03-15
PL199345B1 (pl) 2008-09-30
TR200200071T2 (tr) 2005-05-23
EA200200164A1 (ru) 2002-10-31
EP1212082A4 (en) 2005-09-21
EE200200009A (et) 2003-02-17
EA005239B1 (ru) 2004-12-30
AU6346600A (en) 2001-02-05
CZ200225A3 (cs) 2002-08-14
SK282002A3 (en) 2002-09-10
EP1212082A1 (en) 2002-06-12
BG106415A (bg) 2002-12-29
AU773078B2 (en) 2004-05-13
CA2379349A1 (en) 2001-01-25
BR0012468A (pt) 2002-10-22
NO20020190L (no) 2002-03-12
CN1450909A (zh) 2003-10-22
ZA200200969B (en) 2003-04-30
NZ517075A (en) 2004-03-26
US6261790B1 (en) 2001-07-17
MXPA02000445A (es) 2002-07-02
CZ295412B6 (cs) 2005-08-17
IL147517A0 (en) 2002-08-14
WO2001005426A1 (en) 2001-01-25
PL354512A1 (en) 2004-01-26
KR20020034158A (ko) 2002-05-08
NO20020190D0 (no) 2002-01-14
GEP20043256B (en) 2004-06-25
HUP0202183A2 (en) 2002-10-28

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