OA11733A - Combination chemotherapy. - Google Patents
Combination chemotherapy. Download PDFInfo
- Publication number
- OA11733A OA11733A OA1200100161A OA1200100161A OA11733A OA 11733 A OA11733 A OA 11733A OA 1200100161 A OA1200100161 A OA 1200100161A OA 1200100161 A OA1200100161 A OA 1200100161A OA 11733 A OA11733 A OA 11733A
- Authority
- OA
- OAPI
- Prior art keywords
- iodo
- benzamide
- methyl
- phenylamino
- bromo
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Seasonings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11329198P | 1998-12-22 | 1998-12-22 | |
| US16478899P | 1999-11-10 | 1999-11-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| OA11733A true OA11733A (en) | 2005-05-12 |
Family
ID=26810891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| OA1200100161A OA11733A (en) | 1998-12-22 | 1999-12-21 | Combination chemotherapy. |
Country Status (31)
| Country | Link |
|---|---|
| EP (1) | EP1140291B1 (tr) |
| JP (1) | JP2002532570A (tr) |
| KR (1) | KR20010099877A (tr) |
| CN (1) | CN1333698A (tr) |
| AP (1) | AP2001002175A0 (tr) |
| AT (1) | ATE310567T1 (tr) |
| AU (1) | AU2203900A (tr) |
| BG (1) | BG105715A (tr) |
| BR (1) | BR9916839A (tr) |
| CA (1) | CA2352326A1 (tr) |
| CZ (1) | CZ20012139A3 (tr) |
| DE (1) | DE69928568T2 (tr) |
| EA (1) | EA200100687A1 (tr) |
| EE (1) | EE200100339A (tr) |
| ES (1) | ES2253928T3 (tr) |
| GE (1) | GEP20043172B (tr) |
| HK (1) | HK1042057A1 (tr) |
| HR (1) | HRP20010473A2 (tr) |
| HU (1) | HUP0104844A3 (tr) |
| ID (1) | ID30250A (tr) |
| IL (1) | IL143939A0 (tr) |
| IS (1) | IS5969A (tr) |
| MA (1) | MA26768A1 (tr) |
| NO (1) | NO20013099L (tr) |
| NZ (1) | NZ512859A (tr) |
| OA (1) | OA11733A (tr) |
| PL (1) | PL348326A1 (tr) |
| SK (1) | SK8712001A3 (tr) |
| TR (1) | TR200101871T2 (tr) |
| WO (1) | WO2000037141A1 (tr) |
| YU (1) | YU45401A (tr) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| OA12333A (en) | 2000-07-19 | 2004-04-06 | Warner Lambert Co | Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids. |
| WO2002017952A2 (en) | 2000-09-01 | 2002-03-07 | Van Andel Institute | Inhibition of mitogen-activated protein kinase (mapk) pathway: a selective therapeutic strategy against melanoma |
| CA2442015A1 (en) * | 2001-03-22 | 2002-10-03 | Van Andel Institute | Anthrax lethal factor inhibits tumor growth and angiogenesis |
| IL149462A0 (en) | 2001-05-09 | 2002-11-10 | Warner Lambert Co | Method of treating or inhibiting neutrophil chemotaxis by administering a mek inhibitor |
| CZ20022216A3 (cs) * | 2001-07-02 | 2003-05-14 | Warner-Lambert Company | Kombinační chemoterapie |
| JPWO2005035493A1 (ja) * | 2003-10-08 | 2006-12-21 | 帝人ファーマ株式会社 | アミノピロリジン誘導体の製造方法および中間体化合物 |
| CN100594212C (zh) | 2003-10-21 | 2010-03-17 | 沃纳-兰伯特公司 | N-[(r)-2,3-二羟基-丙氧基]-3,4-二氟-2-(2-氟-4-碘苯基氨基)-苯甲酰胺的多晶型物 |
| BRPI0518192B8 (pt) | 2004-10-20 | 2021-05-25 | Applied Res Systems Ars Holding N V | derivados de 3-arilamino piridina, seu uso e seu processo de fabricação, e composição farmacêutica |
| CN1807413B (zh) * | 2005-09-28 | 2010-05-05 | 中国医学科学院医药生物技术研究所 | 咔唑磺酰胺衍生物及其制备方法 |
| EP1934174B1 (en) | 2005-10-07 | 2011-04-06 | Exelixis, Inc. | Azetidines as mek inhibitors for the treatment of proliferative diseases |
| EP1790342A1 (de) | 2005-11-11 | 2007-05-30 | Zentaris GmbH | Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege |
| CA2628039A1 (en) | 2005-11-11 | 2007-05-18 | Aeterna Zentaris Gmbh | Novel pyridopyrazines and their use as modulators of kinases |
| US8217042B2 (en) | 2005-11-11 | 2012-07-10 | Zentaris Gmbh | Pyridopyrazines and their use as modulators of kinases |
| CA2671982C (en) | 2006-12-14 | 2016-01-26 | Exelixis, Inc. | Methods of using mek inhibitors |
| US9084781B2 (en) | 2008-12-10 | 2015-07-21 | Novartis Ag | MEK mutations conferring resistance to MEK inhibitors |
| WO2011106298A1 (en) | 2010-02-25 | 2011-09-01 | Dana-Farber Cancer Institute, Inc. | Braf mutations conferring resistance to braf inhibitors |
| EP2545187B1 (en) | 2010-03-09 | 2018-09-05 | Dana-Farber Cancer Institute, Inc. | Methods of diagnosing and treating cancer in patients having or developing resistance to a first cancer therapy |
| CN103301096B (zh) * | 2012-03-14 | 2015-05-06 | 中国中化股份有限公司 | 取代二苯胺类化合物作为制备抗肿瘤药物的应用 |
| US20150141470A1 (en) | 2012-05-08 | 2015-05-21 | The Broad Institute, Inc. | Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy |
| GEP201706690B (en) | 2012-10-12 | 2017-06-26 | Exelixis Inc | Novel process for making compounds for use in treatment of cancer |
| JP6465790B2 (ja) * | 2013-02-27 | 2019-02-06 | 第一三共株式会社 | Ｍａｐｋシグナル伝達経路を阻害する化合物に対する応答性を予測する方法 |
| CN105384754B (zh) * | 2014-09-02 | 2018-04-20 | 上海科州药物研发有限公司 | 作为蛋白激酶抑制剂的杂环类化合物及其制备方法和用途 |
| CN111909053B (zh) * | 2020-08-06 | 2022-12-06 | 湖北省生物农药工程研究中心 | 基于二芳胺单元的酰胺类衍生物及其制备方法和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL112248A0 (en) * | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
| AU2092597A (en) * | 1996-03-07 | 1997-09-22 | Novartis Ag | Antiproliferative combinations, containing raf-targeted oligonucleotides and chemotherapeutic compounds |
| US6251943B1 (en) * | 1997-02-28 | 2001-06-26 | Warner-Lambert Company | Method of treating or preventing septic shock by administering a MEK inhibitor |
| JP2001517954A (ja) * | 1997-03-21 | 2001-10-09 | ボード・オヴ・リージェンツ，ザ・ユニヴァーシティ・オヴ・テキサス・システム | Ｎｏｅｙ２遺伝子組成物およびその使用方法 |
| US6002008A (en) * | 1997-04-03 | 1999-12-14 | American Cyanamid Company | Substituted 3-cyano quinolines |
| US6040321A (en) * | 1997-11-12 | 2000-03-21 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
| US5959097A (en) * | 1998-11-20 | 1999-09-28 | Isis Pharmaceuticals, Inc. | Antisense modulation of MEK2 expression |
-
1999
- 1999-12-21 ID IDW00200101616A patent/ID30250A/id unknown
- 1999-12-21 PL PL99348326A patent/PL348326A1/xx not_active Application Discontinuation
- 1999-12-21 BR BR9916839-1A patent/BR9916839A/pt not_active Application Discontinuation
- 1999-12-21 CZ CZ20012139A patent/CZ20012139A3/cs unknown
- 1999-12-21 CA CA002352326A patent/CA2352326A1/en not_active Abandoned
- 1999-12-21 AT AT99966523T patent/ATE310567T1/de not_active IP Right Cessation
- 1999-12-21 EA EA200100687A patent/EA200100687A1/ru unknown
- 1999-12-21 YU YU45401A patent/YU45401A/sh unknown
- 1999-12-21 DE DE69928568T patent/DE69928568T2/de not_active Expired - Fee Related
- 1999-12-21 TR TR2001/01871T patent/TR200101871T2/tr unknown
- 1999-12-21 EP EP99966523A patent/EP1140291B1/en not_active Expired - Lifetime
- 1999-12-21 KR KR1020017007874A patent/KR20010099877A/ko not_active Application Discontinuation
- 1999-12-21 GE GEAP19996007A patent/GEP20043172B/en unknown
- 1999-12-21 SK SK871-2001A patent/SK8712001A3/sk unknown
- 1999-12-21 NZ NZ512859A patent/NZ512859A/en unknown
- 1999-12-21 CN CN99815040A patent/CN1333698A/zh active Pending
- 1999-12-21 AP APAP/P/2001/002175A patent/AP2001002175A0/en unknown
- 1999-12-21 WO PCT/US1999/030485 patent/WO2000037141A1/en active IP Right Grant
- 1999-12-21 ES ES99966523T patent/ES2253928T3/es not_active Expired - Lifetime
- 1999-12-21 OA OA1200100161A patent/OA11733A/en unknown
- 1999-12-21 AU AU22039/00A patent/AU2203900A/en not_active Abandoned
- 1999-12-21 HU HU0104844A patent/HUP0104844A3/hu unknown
- 1999-12-21 JP JP2000589248A patent/JP2002532570A/ja active Pending
- 1999-12-21 EE EEP200100339A patent/EE200100339A/xx unknown
- 1999-12-21 IL IL14393999A patent/IL143939A0/xx unknown
-
2001
- 2001-06-14 IS IS5969A patent/IS5969A/is unknown
- 2001-06-21 HR HR20010473A patent/HRP20010473A2/hr not_active Application Discontinuation
- 2001-06-21 NO NO20013099A patent/NO20013099L/no not_active Application Discontinuation
- 2001-07-18 BG BG105715A patent/BG105715A/xx unknown
- 2001-07-19 MA MA26275A patent/MA26768A1/fr unknown
-
2002
- 2002-05-04 HK HK02103397.1A patent/HK1042057A1/zh unknown
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