OA10721A - Mixtures of dideoxy-inosine and hydroxycarbamide for inhibiting retroviral spread - Google Patents

Mixtures of dideoxy-inosine and hydroxycarbamide for inhibiting retroviral spread Download PDF

Info

Publication number
OA10721A
OA10721A OA60849A OA60849A OA10721A OA 10721 A OA10721 A OA 10721A OA 60849 A OA60849 A OA 60849A OA 60849 A OA60849 A OA 60849A OA 10721 A OA10721 A OA 10721A
Authority
OA
OAPI
Prior art keywords
amount
dideoxy
hiv
inosine
aconcentration
Prior art date
Application number
OA60849A
Other languages
English (en)
Inventor
Serge D Malley
Jorge R Vila
Original Assignee
Cie De Dev Aguettant
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cie De Dev Aguettant filed Critical Cie De Dev Aguettant
Publication of OA10721A publication Critical patent/OA10721A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
OA60849A 1993-12-20 1996-06-20 Mixtures of dideoxy-inosine and hydroxycarbamide for inhibiting retroviral spread OA10721A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/169,253 US5521161A (en) 1993-12-20 1993-12-20 Method of treating HIV in humans by administration of ddI and hydroxycarbamide

Publications (1)

Publication Number Publication Date
OA10721A true OA10721A (en) 2002-12-09

Family

ID=22614846

Family Applications (1)

Application Number Title Priority Date Filing Date
OA60849A OA10721A (en) 1993-12-20 1996-06-20 Mixtures of dideoxy-inosine and hydroxycarbamide for inhibiting retroviral spread

Country Status (13)

Country Link
US (2) US5521161A (da)
EP (1) EP0735890B1 (da)
AT (1) ATE216245T1 (da)
AU (1) AU1821295A (da)
CA (1) CA2179627C (da)
DE (1) DE69430440T2 (da)
DK (1) DK0735890T3 (da)
ES (1) ES2173948T3 (da)
OA (1) OA10721A (da)
PT (1) PT735890E (da)
TW (1) TW283645B (da)
WO (1) WO1995017899A2 (da)
ZA (1) ZA949219B (da)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
US6346627B1 (en) * 1990-02-01 2002-02-12 Emory University Intermediates in the synthesis of 1,3-oxathiolane nucleoside enantiomers
SE9003151D0 (sv) * 1990-10-02 1990-10-02 Medivir Ab Nucleoside derivatives
DE69232911T2 (de) 1991-10-31 2003-11-13 Inc. Molecules For Health Verwendung eines polyhydroxybenzamids oder dessen Derivat zur Herstellung eines Medikaments für die Behandlung von viralen Infektionen
AU685128B2 (en) * 1993-05-21 1998-01-15 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The New procedure to block the replication of reverse transcriptase dependent viruses by the use of inhibitors of deoxynucleotides synthesis
US6677310B1 (en) * 1999-04-21 2004-01-13 Nabi Ring-expanded nucleosides and nucleotides
US5521161A (en) * 1993-12-20 1996-05-28 Compagnie De Developpment Aguettant S.A. Method of treating HIV in humans by administration of ddI and hydroxycarbamide
US6093702A (en) * 1993-12-20 2000-07-25 The United States Of America As Represented By The Department Of Health And Human Services Mixtures of dideoxy-nucleosides and hydroxycarbamide for inhibiting retroviral spread
EP0773951B1 (en) * 1994-07-15 1999-03-10 Biosearch Italia S.p.A. Dinucleoside-5',5'-pyrophosphates
US5703058A (en) * 1995-01-27 1997-12-30 Emory University Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US6391859B1 (en) 1995-01-27 2002-05-21 Emory University [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5869493A (en) 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
US6511848B2 (en) * 1996-04-17 2003-01-28 Winfried Albert Process for producing and multiplying lymphocytes
US5719132A (en) * 1996-06-27 1998-02-17 Bristol-Myers Squibb Company Compositions and methods of treating HIV with d4T, 5-fluorouracil/tegafur, and uracil
US5886165A (en) * 1996-09-24 1999-03-23 Hybridon, Inc. Mixed backbone antisense oligonucleotides containing 2'-5'-ribonucleotide- and 3'-5'-deoxyribonucleotides segments
US5932570A (en) * 1996-11-08 1999-08-03 Dupont Pharmaceuticals Company 1-(3-aminoindazol-5-yl)-3-phenylmethyl-cyclic ureas useful as HIV protease inhibitors
US6218386B1 (en) 1996-11-08 2001-04-17 Dupont Pharmaceuticals A1-(3-aminoindazol-5-yl)-3 butyl-cyclic urea useful as a HIV protease inhibitor
US6686462B2 (en) * 1997-02-28 2004-02-03 The Regents Of The University Of California Antiviral compounds and methods of administration
US6114312A (en) * 1997-03-07 2000-09-05 Research Institute For Genetic And Human Therapy (R.I.G.H.T.) Method of inhibiting human immunodeficiency virus by combined use of hydroxyurea, a nucleoside analog, and a protease inhibitor
CA2284483A1 (en) * 1997-03-20 1998-10-01 Compagnie De Developpement Aguettant Mixtures of at least two reverse transcriptase inhibitors and hydroxycarbamide, in particular for inhibiting retroviral spread
WO1998050347A1 (en) * 1997-05-05 1998-11-12 The Regents Of The University Of California Naphthols useful in antiviral methods
DE69840216D1 (de) * 1997-08-08 2008-12-24 Celmed Oncology Usa Inc Verfahren und Zubereitungen um Resistenz gegen biologische oder chemische Therapien zu Überwinden
US20020022034A1 (en) * 1997-09-15 2002-02-21 Julianna Lisziewicz Therapeutic DNA vaccination
KR100286373B1 (ko) * 1997-10-17 2001-04-16 윤종용 적외선 데이터 통신을 위한 휴대용 컴퓨터
US7462605B2 (en) * 1998-01-23 2008-12-09 Celmed Oncology (Usa), Inc. Phosphoramidate compounds and methods of use
TWI244924B (en) 1998-01-23 2005-12-11 Newbiotics Inc Enzyme catalyzed therapeutic agents
US6015796A (en) * 1998-03-11 2000-01-18 Zeria Pharmaceutical Co., Ltd. Method for treating AIDS
US6251874B1 (en) * 1998-03-26 2001-06-26 Research Institute For Genetic And Human Therapy (R.I.G.H.T.) Method of inhibiting human immunodeficiency virus using hydroxurea and a reverse transcriptase inhibitor in vivo
BR9911457A (pt) * 1998-06-24 2001-12-11 Univ Emory Uso de 3'-azida-2', 3'-dideoxiuridina em combinaçãocom drogas anti-hiv adicionais para a manufaturade um medicamento para o tratamento de hiv
EP1146904A4 (en) * 1999-02-03 2004-09-15 Franco Lori USE OF HYDROXY URINE AND AN INHIBITOR OF REVERSE TRANSCRIPTASE FOR INDUCING AUTOVACCATION BY AUTOLOGICAL HIV
US6020325A (en) * 1999-03-09 2000-02-01 Zeria Pharmaceutical Co., Ltd. Method for inhibiting replication of HIV
IL147749A0 (en) 1999-07-22 2002-08-14 Newbiotics Inc Methods for treating therapy-resistant tumors
US6683061B1 (en) * 1999-07-22 2004-01-27 Newbiotics, Inc. Enzyme catalyzed therapeutic activation
NL1012825C2 (nl) * 1999-08-13 2001-02-23 Faculteit Geneeskunde Universi Farmaceuticum voor de behandeling van virale infecties in het bijzonder van het humane immunodeficiency virus (HIV).
CA2380924C (en) 1999-08-13 2008-02-19 University Of Maryland Biotechnology Institute Compositions for treating viral infections, and methods therefor
EP1359921A4 (en) * 2001-01-19 2006-09-06 Newbiotics Inc METHOD FOR THE TREATMENT OF AUTOIMMUNE DISEASES AND INFLAMMATORY DISEASES
WO2003100009A2 (en) * 2002-05-23 2003-12-04 Biocryst Pharmaceuticals, Inc. Enhancing the efficacy of reverse transcriptase and dna polymerase inhibitors (nucleoside analogs) using pnp inhibitors and/or 2'-deoxyguanosine and/or prodrug thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8324800D0 (en) * 1983-09-15 1983-10-19 Pasteur Institut Antigens
DK224286A (da) * 1985-05-15 1986-11-16 Wellcome Found 2',3'-dideoxy-nucleosider
AU570853B2 (en) * 1985-08-26 1988-03-24 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Inhibition of infectivity and cytopathic effect of htlv-111/ lav by purine bases
US5110600A (en) * 1988-01-25 1992-05-05 The Regents Of The University Of California Method of treating viral infections with amino acid analogs
US5026687A (en) * 1990-01-03 1991-06-25 The United States Of America As Represented By The Department Of Health And Human Services Treatment of human retroviral infections with 2',3'-dideoxyinosine alone and in combination with other antiviral compounds
US5300059A (en) * 1991-11-19 1994-04-05 Hydro Slip Technologies Inc. Bloodbag and method of making same
AU685128B2 (en) * 1993-05-21 1998-01-15 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The New procedure to block the replication of reverse transcriptase dependent viruses by the use of inhibitors of deoxynucleotides synthesis
US5521161A (en) * 1993-12-20 1996-05-28 Compagnie De Developpment Aguettant S.A. Method of treating HIV in humans by administration of ddI and hydroxycarbamide

Also Published As

Publication number Publication date
US5736527A (en) 1998-04-07
CA2179627A1 (en) 1995-07-06
WO1995017899A2 (en) 1995-07-06
DE69430440T2 (de) 2002-11-14
CA2179627C (en) 2000-02-22
AU1821295A (en) 1995-07-17
US5521161A (en) 1996-05-28
EP0735890B1 (en) 2002-04-17
EP0735890A1 (en) 1996-10-09
WO1995017899A3 (en) 1995-08-10
DK0735890T3 (da) 2002-08-05
TW283645B (da) 1996-08-21
DE69430440D1 (de) 2002-05-23
PT735890E (pt) 2002-09-30
ZA949219B (en) 1995-08-01
ATE216245T1 (de) 2002-05-15
ES2173948T3 (es) 2002-11-01

Similar Documents

Publication Publication Date Title
EP0735890B1 (en) Mixtures of 2&#39;,3&#39;-dideoxy-inosine and hydroxycarbamide for inhibiting retroviral spread
US6093702A (en) Mixtures of dideoxy-nucleosides and hydroxycarbamide for inhibiting retroviral spread
Sarin et al. Inhibition of replication of the etiologic agent of acquired immune deficiency syndrome (human T-lymphotropic retrovirus/lymphadenopathy-associated virus) by avarol and avarone
RU2016572C1 (ru) Композиция для лечения спида
WO2011088561A1 (en) Anti-viral compounds and compositions
JPH0125A (ja) ｄｓＲＮＡと逆転写酵素インヒビターを含んで成るＨＩＶ感染治療のための医薬組成物
Ichimura et al. Polymerase substrate depletion: a novel strategy for inhibiting the replication of the human immunodeficiency virus
TURANO et al. Inhibitory effect of papaverine on HIV replication in vitro
US5254539A (en) Method of treating HIV with 2&#39;,3&#39;-dideoxyinosine
DK175094B1 (da) Anvendelse af N-butyl-derivatet af deoxynojirimycin til fremstilling af farmaceutisk præparat
ES2148234T3 (es) Composicion farmaceutica a base de flavopereirina y su utilizacion en el tratamiento del virus vih.
EP0255420B1 (en) Antiviral agent for inhibiting growth of virus of acquired immune deficiency syndrome (aids)
AU718325B2 (en) Mixtures of dideoxy-nucleosides and hydroxycarbamide for inhibiting retroviral spread
WO1995017875A2 (en) MIXTURES OF DIDEOXYNUCLEOSIDES AND D-ASPARTIC ACID β-HYDROXAMATE FOR INHIBITING RETROVIRAL SPREAD
JPH0262533B2 (da)
WO1992003052A1 (en) Method for suppression of hiv replication by ascorbate for chronic and acute hiv infection
JPH03264530A (ja) 抗レトロウイルス剤
EP0655919A1 (en) Treatment of human viral infections
JPH03227925A (ja) エイズ原因ウィルスに対する抗ウイルス剤
US5182306A (en) Use of colchicine for the control of retroviruses
AU743942B2 (en) Mixtures of at least two reverse transcriptase inhibitors and hydroxycarbamide, in particular for inhibiting retroviral spread
JPH083038A (ja) 抗ｈｉｖ剤
WO1998031375A1 (en) Enhanced suppression of hiv-1 by the combination of cytidine nucleoside analogues and ctp synthase inhibitors
JPH0551566B2 (da)
WO1998031375A9 (en) Enhanced suppression of hiv-1 by the combination of cytidine nucleoside analogues and ctp synthase inhibitors