ZA949219B - Mixtures of dideoxy-nucleosides and hydroxycarbamide for inhibiting retroviral spread. - Google Patents

Mixtures of dideoxy-nucleosides and hydroxycarbamide for inhibiting retroviral spread.

Info

Publication number
ZA949219B
ZA949219B ZA949219A ZA949219A ZA949219B ZA 949219 B ZA949219 B ZA 949219B ZA 949219 A ZA949219 A ZA 949219A ZA 949219 A ZA949219 A ZA 949219A ZA 949219 B ZA949219 B ZA 949219B
Authority
ZA
South Africa
Prior art keywords
hydroxycarbamide
dideoxy
nucleosides
mixtures
spread
Prior art date
Application number
ZA949219A
Other languages
English (en)
Inventor
Serge D Malley
Jorge R Villa
Original Assignee
Aguettant Dev Cie Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aguettant Dev Cie Sa filed Critical Aguettant Dev Cie Sa
Publication of ZA949219B publication Critical patent/ZA949219B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA949219A 1993-12-20 1994-11-21 Mixtures of dideoxy-nucleosides and hydroxycarbamide for inhibiting retroviral spread. ZA949219B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/169,253 US5521161A (en) 1993-12-20 1993-12-20 Method of treating HIV in humans by administration of ddI and hydroxycarbamide

Publications (1)

Publication Number Publication Date
ZA949219B true ZA949219B (en) 1995-08-01

Family

ID=22614846

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA949219A ZA949219B (en) 1993-12-20 1994-11-21 Mixtures of dideoxy-nucleosides and hydroxycarbamide for inhibiting retroviral spread.

Country Status (13)

Country Link
US (2) US5521161A (da)
EP (1) EP0735890B1 (da)
AT (1) ATE216245T1 (da)
AU (1) AU1821295A (da)
CA (1) CA2179627C (da)
DE (1) DE69430440T2 (da)
DK (1) DK0735890T3 (da)
ES (1) ES2173948T3 (da)
OA (1) OA10721A (da)
PT (1) PT735890E (da)
TW (1) TW283645B (da)
WO (1) WO1995017899A2 (da)
ZA (1) ZA949219B (da)

Families Citing this family (37)

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Publication number Priority date Publication date Assignee Title
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
US5827727A (en) * 1990-02-01 1998-10-27 Emory University Method of resolution of 1,3-oxathiolane nucleoside enantiomers
SE9003151D0 (sv) * 1990-10-02 1990-10-02 Medivir Ab Nucleoside derivatives
ES2191662T3 (es) 1991-10-31 2003-09-16 Molecules For Health Inc Utilizacion de una polihidroxi-benzamida o uno de sus derivados en la fabricacion de un medicamento destinado al tratamiento de infecciones virales.
ATE273700T1 (de) * 1993-05-21 2004-09-15 Us Gov Health & Human Serv Neues verfahen zur hemmung der replication der virus - abhängigen reverse transciptase durch verwendung von dideoxydenucleotide-synthese inhibitoren
US6677310B1 (en) * 1999-04-21 2004-01-13 Nabi Ring-expanded nucleosides and nucleotides
US5521161A (en) * 1993-12-20 1996-05-28 Compagnie De Developpment Aguettant S.A. Method of treating HIV in humans by administration of ddI and hydroxycarbamide
US6093702A (en) * 1993-12-20 2000-07-25 The United States Of America As Represented By The Department Of Health And Human Services Mixtures of dideoxy-nucleosides and hydroxycarbamide for inhibiting retroviral spread
ATE177431T1 (de) * 1994-07-15 1999-03-15 Biosearch Italia Spa Dinukleosid-5',5'- pyrophosphate
US6391859B1 (en) 1995-01-27 2002-05-21 Emory University [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5703058A (en) * 1995-01-27 1997-12-30 Emory University Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US5869493A (en) 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
US6511848B2 (en) * 1996-04-17 2003-01-28 Winfried Albert Process for producing and multiplying lymphocytes
US5719132A (en) * 1996-06-27 1998-02-17 Bristol-Myers Squibb Company Compositions and methods of treating HIV with d4T, 5-fluorouracil/tegafur, and uracil
US5886165A (en) * 1996-09-24 1999-03-23 Hybridon, Inc. Mixed backbone antisense oligonucleotides containing 2'-5'-ribonucleotide- and 3'-5'-deoxyribonucleotides segments
US6218386B1 (en) 1996-11-08 2001-04-17 Dupont Pharmaceuticals A1-(3-aminoindazol-5-yl)-3 butyl-cyclic urea useful as a HIV protease inhibitor
US5932570A (en) * 1996-11-08 1999-08-03 Dupont Pharmaceuticals Company 1-(3-aminoindazol-5-yl)-3-phenylmethyl-cyclic ureas useful as HIV protease inhibitors
US6686462B2 (en) * 1997-02-28 2004-02-03 The Regents Of The University Of California Antiviral compounds and methods of administration
US6114312A (en) * 1997-03-07 2000-09-05 Research Institute For Genetic And Human Therapy (R.I.G.H.T.) Method of inhibiting human immunodeficiency virus by combined use of hydroxyurea, a nucleoside analog, and a protease inhibitor
WO1998042349A1 (en) * 1997-03-20 1998-10-01 Compagnie De Developpement Aguettant Mixtures of at least two reverse transcriptase inhibitors and hydroxycarbamide, in particular for inhibiting retroviral spread
WO1998050347A1 (en) * 1997-05-05 1998-11-12 The Regents Of The University Of California Naphthols useful in antiviral methods
DE69840216D1 (de) * 1997-08-08 2008-12-24 Celmed Oncology Usa Inc Verfahren und Zubereitungen um Resistenz gegen biologische oder chemische Therapien zu Überwinden
US20020022034A1 (en) * 1997-09-15 2002-02-21 Julianna Lisziewicz Therapeutic DNA vaccination
KR100286373B1 (ko) * 1997-10-17 2001-04-16 윤종용 적외선 데이터 통신을 위한 휴대용 컴퓨터
ES2172303T3 (es) 1998-01-23 2002-09-16 Newbiotics Inc Agentes terapeuticos obtenidos por catalisis enzimatica.
US7462605B2 (en) * 1998-01-23 2008-12-09 Celmed Oncology (Usa), Inc. Phosphoramidate compounds and methods of use
US6015796A (en) * 1998-03-11 2000-01-18 Zeria Pharmaceutical Co., Ltd. Method for treating AIDS
US6251874B1 (en) * 1998-03-26 2001-06-26 Research Institute For Genetic And Human Therapy (R.I.G.H.T.) Method of inhibiting human immunodeficiency virus using hydroxurea and a reverse transcriptase inhibitor in vivo
JP2002518452A (ja) * 1998-06-24 2002-06-25 エモリ ユニバーシティ Ｈｉｖの治療薬物の製造のための他の抗ｈｉｖ薬と組み合わせた３’−アジド−２’，３’−ジデオキシウリジンの使用
WO2000045844A1 (en) * 1999-02-03 2000-08-10 Franco Lori Use of hydroxyurea and a reverse transcriptase inhibitor to induce autovaccination by autologous hiv
US6020325A (en) * 1999-03-09 2000-02-01 Zeria Pharmaceutical Co., Ltd. Method for inhibiting replication of HIV
IL147749A0 (en) 1999-07-22 2002-08-14 Newbiotics Inc Methods for treating therapy-resistant tumors
US6683061B1 (en) * 1999-07-22 2004-01-27 Newbiotics, Inc. Enzyme catalyzed therapeutic activation
NL1012825C2 (nl) * 1999-08-13 2001-02-23 Faculteit Geneeskunde Universi Farmaceuticum voor de behandeling van virale infecties in het bijzonder van het humane immunodeficiency virus (HIV).
AU765724B2 (en) 1999-08-13 2003-09-25 University Of Maryland Biotechnology Institute Compositions for treating viral infections, and methods therefor
AU2002241911B9 (en) * 2001-01-19 2007-01-25 Celmed Oncology (Usa), Inc. Methods to treat autoimmune and inflammatory conditions
AU2003233667A1 (en) * 2002-05-23 2003-12-12 Biocryst Pharmaceuticals, Inc. Enhancing the efficacy of reverse transcriptase and dna polymerase inhibitors (nucleoside analogs) using pnp inhibitors and/or 2'-deoxyguanosine and/or prodrug thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8324800D0 (en) * 1983-09-15 1983-10-19 Pasteur Institut Antigens
EP0206497B1 (en) * 1985-05-15 1994-07-20 The Wellcome Foundation Limited Therapeutic nucleosides and their preparation
WO1987001284A1 (en) * 1985-08-26 1987-03-12 United States Of America, Represented By The Unite Inhibition of in vitro infectivity and cytopathic effect of htlv-iii/lav by 2',3'-dideoxynosine, 2',3'-dideoxyguanosine, or 2',3'-dideoxyadenosine
US5110600A (en) * 1988-01-25 1992-05-05 The Regents Of The University Of California Method of treating viral infections with amino acid analogs
US5026687A (en) * 1990-01-03 1991-06-25 The United States Of America As Represented By The Department Of Health And Human Services Treatment of human retroviral infections with 2',3'-dideoxyinosine alone and in combination with other antiviral compounds
US5300059A (en) * 1991-11-19 1994-04-05 Hydro Slip Technologies Inc. Bloodbag and method of making same
ATE273700T1 (de) * 1993-05-21 2004-09-15 Us Gov Health & Human Serv Neues verfahen zur hemmung der replication der virus - abhängigen reverse transciptase durch verwendung von dideoxydenucleotide-synthese inhibitoren
US5521161A (en) * 1993-12-20 1996-05-28 Compagnie De Developpment Aguettant S.A. Method of treating HIV in humans by administration of ddI and hydroxycarbamide

Also Published As

Publication number Publication date
PT735890E (pt) 2002-09-30
WO1995017899A2 (en) 1995-07-06
TW283645B (da) 1996-08-21
US5736527A (en) 1998-04-07
EP0735890A1 (en) 1996-10-09
AU1821295A (en) 1995-07-17
CA2179627A1 (en) 1995-07-06
DE69430440T2 (de) 2002-11-14
DK0735890T3 (da) 2002-08-05
OA10721A (en) 2002-12-09
DE69430440D1 (de) 2002-05-23
ES2173948T3 (es) 2002-11-01
WO1995017899A3 (en) 1995-08-10
CA2179627C (en) 2000-02-22
ATE216245T1 (de) 2002-05-15
US5521161A (en) 1996-05-28
EP0735890B1 (en) 2002-04-17

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