OA04852A - Procédé de préparation de 1,3-dihydrospiro[isobenzofurannes] substitués. - Google Patents

Procédé de préparation de 1,3-dihydrospiro[isobenzofurannes] substitués.

Info

Publication number
OA04852A
OA04852A OA55362A OA55362A OA04852A OA 04852 A OA04852 A OA 04852A OA 55362 A OA55362 A OA 55362A OA 55362 A OA55362 A OA 55362A OA 04852 A OA04852 A OA 04852A
Authority
OA
OAPI
Prior art keywords
isobenzofurans
dihydrospiro
preparing substituted
substituted
preparing
Prior art date
Application number
OA55362A
Other languages
English (en)
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of OA04852A publication Critical patent/OA04852A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/17—Unsaturated ethers containing halogen
    • C07C43/174—Unsaturated ethers containing halogen containing six-membered aromatic rings
    • C07C43/1742—Unsaturated ethers containing halogen containing six-membered aromatic rings with halogen atoms bound to the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/28—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of CHx-moieties
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/38—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
    • C07C47/45—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
OA55362A 1973-12-12 1974-12-11 Procédé de préparation de 1,3-dihydrospiro[isobenzofurannes] substitués. OA04852A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42411773A 1973-12-12 1973-12-12
US05/502,650 US3959475A (en) 1973-12-12 1974-09-03 Substituted 1,3-dihydrospiro(isobenzofuran)s

Publications (1)

Publication Number Publication Date
OA04852A true OA04852A (fr) 1980-10-31

Family

ID=27026243

Family Applications (1)

Application Number Title Priority Date Filing Date
OA55362A OA04852A (fr) 1973-12-12 1974-12-11 Procédé de préparation de 1,3-dihydrospiro[isobenzofurannes] substitués.

Country Status (18)

Country Link
US (1) US3959475A (fr)
JP (1) JPS5833876B2 (fr)
CA (1) CA1051428A (fr)
CH (3) CH617938A5 (fr)
DE (1) DE2458177A1 (fr)
DK (1) DK144214C (fr)
EG (1) EG12110A (fr)
FI (1) FI58128C (fr)
FR (1) FR2254331B1 (fr)
GB (1) GB1465999A (fr)
HU (1) HU169546B (fr)
IE (1) IE40298B1 (fr)
IL (1) IL46201A (fr)
LU (1) LU71461A1 (fr)
NL (1) NL7416115A (fr)
NO (1) NO146062C (fr)
OA (1) OA04852A (fr)
SE (1) SE419761B (fr)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4024263A (en) * 1975-04-30 1977-05-17 American Hoechst Corporation 1,3-Dihydrospiro[isobenzofuran-1,4'-piperidine]s
US3980786A (en) * 1975-07-15 1976-09-14 American Hoechst Corporation 1,3-Dihydro-3-phenyl-1'-(2-propynyl)spiro[isobenzofuran]s
US3980787A (en) * 1975-08-25 1976-09-14 American Hoechst Corporation 3-Phenylspiro[isobenzofuran-1,4'-piperidine]sulfenamides and derivatives
US3996354A (en) * 1976-01-26 1976-12-07 American Hoechst Corporation 1,3-Dihydro-1'-dimethylphosphinylalkyl-3-phenylspiro(isobenzofuran)s
US4031224A (en) * 1976-04-29 1977-06-21 American Hoechst Corporation 1,3-Dihydro-heteroarylspiro (isobenzofuran)s
US4241071A (en) * 1977-01-27 1980-12-23 American Hoechst Corporation Antidepressant (α-phenyl-2-tolyl)azacycloalkanes
EG13536A (en) * 1977-12-02 1981-12-31 Hoechst Ag Substituted 1,3-dihydrospiro(benzo(c)thiophene)s
US4409229A (en) * 1977-12-02 1983-10-11 Hoechst-Roussel Pharmaceuticals, Inc. Antidepressive and tranquilizing substituted 1,3-dihydrospiro[benzo(c)thiophene]s
US4166120A (en) * 1978-04-14 1979-08-28 American Hoechst Corporation Analgesic and tranquilizing benzoylpropyl-spiro[dihydrobenzofuran]piperidines and pyrrolidines
US4166119A (en) * 1978-04-14 1979-08-28 American Hoechst Corporation Analgesic and tranquilizing spiro[dihydrobenzofuran]piperidines and pyrrolidines
US4263317A (en) * 1979-09-06 1981-04-21 Hoechst-Roussel Pharmaceuticals, Inc. Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s
US4301292A (en) * 1979-09-06 1981-11-17 Hoechst-Roussel Pharmaceuticals, Incorporated 1-[2-(4,5-Dihydro-4,4-dialkyl-2-oxazolyl)phenyl]-4-(dialkylamino)cyclohexanol
US4260623A (en) * 1979-11-26 1981-04-07 Warner-Lambert Company Hexahydro-1-arylspiro(3H-oxazolo(3,4-A)pyridine-3,4'-piperidene) antidepressants, pharmaceutical compositions thereof and method of use thereof
US4268515A (en) * 1980-02-04 1981-05-19 Hoechst-Roussel Pharmaceuticals Inc. Spiro[dihydrobenzofuran-piperidines and-pyrrolidines], pharmaceutical compositions thereof and methods of use thereof
US4304941A (en) * 1980-08-01 1981-12-08 Hoechst Roussel Pharmaceuticals, Inc. Method of preparing poly-substituted acylbenzenes
US4517311A (en) * 1981-10-19 1985-05-14 Hoechst-Roussel Pharmaceuticals Inc. 2'-Substituted-spiro[benzofuran-2(3H),1'-cycloalkanes] and their analgesic and anti-depressant compositions
US4404221A (en) * 1981-10-19 1983-09-13 Hoechst-Roussel Pharmaceuticals Inc. 2'-Substituted-spiro[benzofuran-2(3H),1'-cyclohexanes] and its pharmaceutical use
US4524207A (en) * 1981-10-20 1985-06-18 Hoechst-Roussel Pharmaceuticals Inc. Process for preparing substituted 1,3-dihydrospiro[benzo(c)thiophene]s
CA1315279C (fr) * 1987-01-12 1993-03-30 Nancy Grace Bollinger Agents antiinflammatoires
IL96507A0 (en) * 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
CA2037287A1 (fr) * 1990-03-02 1991-09-03 Ben E. Evans Antagonistes de l'oxytocine spirocyclique
EP0445974A3 (en) * 1990-03-05 1992-04-29 Merck Sharp & Dohme Ltd. Spirocyclic antipsychotic agents
US5693643A (en) * 1991-09-16 1997-12-02 Merck & Co., Inc. Hydantoin and succinimide-substituted derivatives of spiroindanylcamphorsulfonyl oxytocin antagonists
EP0600318B1 (fr) * 1992-11-29 1998-04-08 Clariant GmbH Benzophénones asymétriques, halogénées et procédé de préparation
US6374762B1 (en) * 1997-10-27 2002-04-23 Correct Craft, Inc. Water sport towing apparatus
US6433196B1 (en) * 2000-02-17 2002-08-13 Sumika Fine Chemicals Co., Ltd. Production method of citalopram, intermediate therefor and production method of the intermediate
GB0213715D0 (en) * 2002-06-14 2002-07-24 Syngenta Ltd Chemical compounds
US7786141B2 (en) * 2004-08-19 2010-08-31 Vertex Pharmaceuticals Incorporated Dihydrospiroindene modulators of muscarinic receptors
MX2007002033A (es) 2004-08-19 2007-04-26 Vertex Pharma Moduladores de receptores muscarinicos.
KR20070086756A (ko) * 2004-11-29 2007-08-27 버텍스 파마슈티칼스 인코포레이티드 무스카린성 수용체의 조절제
EP1943250A1 (fr) 2005-09-09 2008-07-16 Euro-Celtique S.A. Composes fondus et spirocycle ainsi que l'utilisation de ceux-ci
EP1973543A2 (fr) * 2005-12-22 2008-10-01 Vertex Pharmaceuticals Incorporated Modulateurs de recepteurs muscariniques
CA2642649A1 (fr) * 2006-02-22 2007-09-07 Vertex Pharmaceuticals Incorporated Modulateurs des recepteurs muscariniques
JP2009527568A (ja) 2006-02-22 2009-07-30 バーテックス ファーマシューティカルズ インコーポレイテッド ムスカリン受容体の調節剤
EP1847542A1 (fr) * 2006-04-21 2007-10-24 Laboratorios del Dr. Esteve S.A. Dérivés de spiro[benzopyran] ou de spiro[benzofuran] comme antagonistes du récepteur sigma
CN101500565A (zh) * 2006-06-29 2009-08-05 弗特克斯药品有限公司 毒蕈碱性受体的调节剂
CN101553231A (zh) * 2006-08-15 2009-10-07 弗特克斯药品有限公司 毒蕈碱受体调节剂
CA2660974A1 (fr) * 2006-08-18 2008-02-21 Vertex Pharmaceuticals Incorporated Modulateurs des recepteurs muscariniques
MX2010003373A (es) * 2007-10-03 2010-04-30 Vertex Pharma Moduladores de receptores muscarinicos.
US8785634B2 (en) * 2010-04-26 2014-07-22 Merck Sharp & Dohme Corp Spiropiperidine prolylcarboxypeptidase inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3686186A (en) * 1970-10-05 1972-08-22 William J Houlihan Substituted isochroman or phthalan piperidenes

Also Published As

Publication number Publication date
FI58128B (fi) 1980-08-29
GB1465999A (en) 1977-03-02
DK144214C (da) 1982-06-21
SE419761B (sv) 1981-08-24
FR2254331A1 (fr) 1975-07-11
CA1051428A (fr) 1979-03-27
LU71461A1 (fr) 1976-11-11
JPS50100052A (fr) 1975-08-08
EG12110A (en) 1981-03-31
DK644974A (fr) 1975-08-18
NL7416115A (nl) 1975-06-16
CH619229A5 (fr) 1980-09-15
DE2458177A1 (de) 1976-09-30
IL46201A (en) 1982-04-30
IL46201A0 (en) 1975-03-13
US3959475A (en) 1976-05-25
NO146062C (no) 1982-08-11
JPS5833876B2 (ja) 1983-07-22
IE40298B1 (en) 1979-04-25
FI58128C (fi) 1980-12-10
NO744471L (fr) 1975-07-07
FI355474A (fr) 1975-06-13
SE7415521L (fr) 1975-06-13
AU7624674A (en) 1976-06-10
CH619228A5 (fr) 1980-09-15
FR2254331B1 (fr) 1978-07-21
HU169546B (fr) 1976-12-28
DK144214B (da) 1982-01-18
NO146062B (no) 1982-04-13
CH617938A5 (fr) 1980-06-30

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