OA04289A - Dérivés de la pyrimidone-(4) substitués par une base et procédés de préparation de ces dérivés. - Google Patents

Dérivés de la pyrimidone-(4) substitués par une base et procédés de préparation de ces dérivés.

Info

Publication number
OA04289A
OA04289A OA54767A OA54767A OA04289A OA 04289 A OA04289 A OA 04289A OA 54767 A OA54767 A OA 54767A OA 54767 A OA54767 A OA 54767A OA 04289 A OA04289 A OA 04289A
Authority
OA
OAPI
Prior art keywords
derivatives
processes
preparation
base
substituted pyrimidone
Prior art date
Application number
OA54767A
Other languages
English (en)
French (fr)
Inventor
Dr Hermann Amschler
Walter Kratinat
Original Assignee
Byk Gulden Lomberg Chem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chem Fab filed Critical Byk Gulden Lomberg Chem Fab
Publication of OA04289A publication Critical patent/OA04289A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
OA54767A 1971-12-02 1972-11-30 Dérivés de la pyrimidone-(4) substitués par une base et procédés de préparation de ces dérivés. OA04289A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU64387 1971-12-02

Publications (1)

Publication Number Publication Date
OA04289A true OA04289A (fr) 1979-12-31

Family

ID=19726894

Family Applications (1)

Application Number Title Priority Date Filing Date
OA54767A OA04289A (fr) 1971-12-02 1972-11-30 Dérivés de la pyrimidone-(4) substitués par une base et procédés de préparation de ces dérivés.

Country Status (11)

Country Link
JP (1) JPS4862774A (ja)
BE (1) BE792206A (ja)
DD (1) DD106646A5 (ja)
DE (1) DE2258561A1 (ja)
FR (1) FR2162106A1 (ja)
HU (1) HU164196B (ja)
IL (1) IL40971A0 (ja)
LU (1) LU64387A1 (ja)
NL (1) NL7216309A (ja)
OA (1) OA04289A (ja)
ZA (1) ZA728536B (ja)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3222914A1 (de) * 1982-06-18 1983-12-22 Beiersdorf Ag, 2000 Hamburg Substituierte 5-phenylthio-6-amino-pyrimidinone, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
IT1153066B (it) * 1982-11-18 1987-01-14 Mentedison S P A Derivati del pirimidin-4-one ad attivita' erbicida
JPS6172764A (ja) * 1984-09-17 1986-04-14 Hokuriku Seiyaku Co Ltd キナゾリノン誘導体
JPH0696561B2 (ja) * 1985-08-30 1994-11-30 正幸 石川 新規な２−（４−フエニル−１−ピペラジニルアルキル）アミノピリミジン誘導体及びその酸付加塩
DE4425143A1 (de) * 1994-07-15 1996-01-18 Basf Ag Substituierte Pyrimidinverbindungen und deren Verwendung
HUT76266A (en) * 1995-10-31 1997-07-28 Egyt Gyogyszervegyeszeti Gyar New piperazinyl-alkylthio-pyrimidine derivatives, pharmaceutical compositions containing them, and process for producing the active components
DE19600934A1 (de) 1996-01-12 1997-07-17 Basf Ag Substituierte Aza- und Diazacycloheptan- und Cyclooctanverbindungen und deren Verwendung
EP1407774A1 (en) * 2002-09-10 2004-04-14 LION Bioscience AG 2-Amino-4-quinazolinones as LXR nuclear receptor binding compounds
WO2005005395A2 (en) * 2003-07-02 2005-01-20 F. Hoffmann-La Roche Ag Arylamine-substituted quinazolinone compounds
EP1911754B1 (en) * 2003-08-13 2013-10-09 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
ZA200602051B (en) 2003-08-13 2007-10-31 Takeda Pharmaceutical 4-pyrimidone derivatives and their use as peptidyl peptidase inhibitors
WO2005026148A1 (en) 2003-09-08 2005-03-24 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
CA2546002C (en) 2003-11-20 2012-09-18 Janssen Pharmaceutica N.V. 7-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors
CA2546300C (en) 2003-11-20 2012-10-02 Janssen Pharmaceutica N.V. 6-alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors
CN102127053A (zh) 2004-03-15 2011-07-20 武田药品工业株式会社 二肽基肽酶抑制剂
ES2563954T3 (es) 2004-06-30 2016-03-16 Janssen Pharmaceutica Nv Derivados de ftalazina como inhibidores de PARP
MXPA06014543A (es) * 2004-06-30 2007-03-23 Janssen Pharmaceutica Nv Derivados de quinazolinona como inhibidores de la poli(adp-ribosa)polimerasa-i.
CN1980913B (zh) 2004-06-30 2011-12-14 詹森药业有限公司 作为parp抑制剂的喹唑啉二酮衍生物
FR2877005A1 (fr) * 2004-10-22 2006-04-28 Bioprojet Soc Civ Ile Nouveaux derives d'arylpiperazine
US7872124B2 (en) 2004-12-21 2011-01-18 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
CN101142195A (zh) * 2005-01-07 2008-03-12 伊斯特芬博士实验室有限公司 用于治疗cns紊乱、疼痛、中风、上瘾和癫痫症的取代2－氨基－喹唑啉－4－氰基化合物及其制备方法和其作为媒介的应用
DK1942898T4 (da) 2005-09-14 2014-06-02 Takeda Pharmaceutical Dipeptidylpeptidase-inhibitorer til behandling af diabetes
KR101368988B1 (ko) 2005-09-16 2014-02-28 다케다 야쿠힌 고교 가부시키가이샤 디펩티딜 펩티다제 억제제
US8324383B2 (en) 2006-09-13 2012-12-04 Takeda Pharmaceutical Company Limited Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
TW200838536A (en) 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
WO2008107478A1 (en) 2007-03-08 2008-09-12 Janssen Pharmaceutica Nv Quinolinone derivatives as parp and tank inhibitors
US8093236B2 (en) 2007-03-13 2012-01-10 Takeda Pharmaceuticals Company Limited Weekly administration of dipeptidyl peptidase inhibitors
JP5525447B2 (ja) 2007-10-26 2014-06-18 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｐａｒｐ阻害剤としてのキノリノン誘導体
WO2009118382A1 (en) 2008-03-27 2009-10-01 Janssen Pharmaceutica Nv Tetrahydrophenanthridinones and tetrahydrocyclopentaquinolinones as parp and tubulin polymerization inhibitors
JP5464609B2 (ja) 2008-03-27 2014-04-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ チューブリン重合阻害剤としてのキナゾリノン誘導体
CN107226808B (zh) * 2016-03-23 2021-01-01 北京四环制药有限公司 端锚聚合酶抑制剂

Also Published As

Publication number Publication date
ZA728536B (en) 1973-09-26
HU164196B (ja) 1974-01-28
JPS4862774A (ja) 1973-09-01
NL7216309A (ja) 1973-06-05
IL40971A0 (en) 1973-01-30
BE792206A (ja) 1973-06-01
FR2162106A1 (en) 1973-07-13
DE2258561A1 (de) 1973-06-20
DD106646A5 (ja) 1974-06-20
LU64387A1 (ja) 1973-07-16

Similar Documents

Publication Publication Date Title
OA04289A (fr) Dérivés de la pyrimidone-(4) substitués par une base et procédés de préparation de ces dérivés.
OA03930A (fr) Procédé de préparation d'azapurinones.
CH498845A (fr) Procédé de préparation de nouveaux dérivés de la N-(triméthoxy-3,4,5-cinnamoyl) pipérazine
SE422325B (sv) Forfarande for framstellning av vissa angivna 1,2,4-triazolderivat
SE389331B (sv) Forfarande for framstellning av vissa angivna 2,2-metylendifenoler.
OA03907A (fr) Procédé de préparation de nouveaux dérivés de l'isoindoline.
FI49503C (fi) Analogiamenetelmä 1,2,3,4-tetrahydro-4-fenyyli-isokinoliinijohdannaist en valmistamiseksi.
OA04406A (fr) Procédé de préparation de dérivés de 14-hydroxy-morphinane.
OA04074A (fr) Dérivés de 3-nitropyrazole.
OA04093A (fr) Procédé de préparation d'aryl-guanidines ortho-disubstituées.
DK123357B (da) Analogifremgangsmåde til fremstilling af N(6)-benzyl-adenosin-derivater.
OA03104A (fr) Procédé de préparation de dérivés d'alcoyl-2-diphényl-4,5 pyrrole.
OA03731A (fr) Procédé de préparation de 7-halogénolincomycines.
OA04182A (fr) Procédé de préparation de 3-hydroxyméthyl-isoquinoléines substituées et dérivés.
OA04641A (fr) Prcédé de préparation de 3-fluorocéphalosporines.
OA04412A (fr) Procédé de préparation de compositions pharmaceutiques à base de dérivés comportant le squelette de l'éburnane.
CH522670A (de) Procédé de préparation de 3-amino-5-benzyl-1,2,4-oxadiazoles
FI56176B (fi) Foerfarande foer framstaellning av 2,4-diamino-5-bensylpyrimidiner
OA04212A (fr) Procédé de préparation de dérivés de la quinazoline.
CH550195A (fr) Procede de preparation de derives d'isoxazolopyridinecetones.
CH522655A (fr) Procédé de préparation de pipérazines n.n'-disubstituées
OA03929A (fr) Procédé de préparation de dérivés actifs de l'indole.
OA03394A (fr) Procédés pour la préparation des dérivés de la dihydrotriazine.
OA04432A (fr) Procédé de préparation de 3-amino-pyrazolones-(5).
OA04162A (fr) Procédé de préparation de dérivés de la phénothiazine antispastiques.