NZ712802A - Novel n-acyl-(3-substituted)-(8-substituted)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazines as selective nk-3 receptor antagonists, pharmaceutical composition, methods for use in nk-3 receptor-mediated disorders - Google Patents

Novel n-acyl-(3-substituted)-(8-substituted)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazines as selective nk-3 receptor antagonists, pharmaceutical composition, methods for use in nk-3 receptor-mediated disorders

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Publication number
NZ712802A
NZ712802A NZ712802A NZ71280214A NZ712802A NZ 712802 A NZ712802 A NZ 712802A NZ 712802 A NZ712802 A NZ 712802A NZ 71280214 A NZ71280214 A NZ 71280214A NZ 712802 A NZ712802 A NZ 712802A
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NZ
New Zealand
Prior art keywords
substituted
receptor
pyrazines
triazolo
dihydro
Prior art date
Application number
NZ712802A
Other languages
English (en)
Inventor
Hamid Hoveyda
Guillaume Dutheuil
Graeme Fraser
Original Assignee
Ogeda Sa
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Publication date
Application filed by Ogeda Sa filed Critical Ogeda Sa
Publication of NZ712802A publication Critical patent/NZ712802A/en

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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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NZ712802A 2013-03-29 2014-03-28 Novel n-acyl-(3-substituted)-(8-substituted)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazines as selective nk-3 receptor antagonists, pharmaceutical composition, methods for use in nk-3 receptor-mediated disorders NZ712802A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP13161863 2013-03-29
EP13193025 2013-11-15
EP14154303 2014-02-07
PCT/EP2014/056367 WO2014154895A1 (en) 2013-03-29 2014-03-28 NOVEL N-ACYL-(3-SUBSTITUTED)-(8-SUBSTITUTED)-5,6-DIHYDRO- [1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR-MEDIATED DISORDERS

Publications (1)

Publication Number Publication Date
NZ712802A true NZ712802A (en) 2020-08-28

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NZ712802A NZ712802A (en) 2013-03-29 2014-03-28 Novel n-acyl-(3-substituted)-(8-substituted)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazines as selective nk-3 receptor antagonists, pharmaceutical composition, methods for use in nk-3 receptor-mediated disorders

Country Status (31)

Country Link
US (3) US9422299B2 (OSRAM)
EP (2) EP3219715A1 (OSRAM)
JP (2) JP6316932B2 (OSRAM)
KR (2) KR102364835B1 (OSRAM)
CN (1) CN105229008B (OSRAM)
AU (1) AU2014242906B2 (OSRAM)
BR (1) BR112015024907B1 (OSRAM)
CA (1) CA2907809C (OSRAM)
CY (2) CY1119576T1 (OSRAM)
DK (1) DK2948455T5 (OSRAM)
EA (1) EA027570B1 (OSRAM)
ES (1) ES2646488T3 (OSRAM)
FI (1) FIC20240019I1 (OSRAM)
FR (1) FR24C1020I1 (OSRAM)
HK (1) HK1244273A1 (OSRAM)
HR (1) HRP20171688T1 (OSRAM)
HU (2) HUE035870T2 (OSRAM)
IL (1) IL241473B (OSRAM)
LT (2) LT2948455T (OSRAM)
MX (1) MX370000B (OSRAM)
NL (1) NL301272I2 (OSRAM)
NO (1) NO2948455T3 (OSRAM)
NZ (1) NZ712802A (OSRAM)
PL (1) PL2948455T3 (OSRAM)
PT (1) PT2948455T (OSRAM)
RS (1) RS56501B1 (OSRAM)
SG (1) SG11201508005XA (OSRAM)
SI (1) SI2948455T1 (OSRAM)
SM (1) SMT201700526T1 (OSRAM)
WO (1) WO2014154895A1 (OSRAM)
ZA (1) ZA201506234B (OSRAM)

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HRP20160396T1 (hr) 2011-10-03 2016-07-15 Euroscreen S.A. Novi kiralni n-acil-5,6,7(8-susupstituirani)-tetrahidro-/1,2,4/triazolo/4,3-a/pirazini kao selektivni nk-3 receptor antagonisti, farmaceutski pripravak, i metode za upor
CA2907814C (en) 2013-03-29 2021-07-13 Euroscreen Sa Novel n-acyl-(3-substituted)-(8-methyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective nk-3 receptor antagonists, pharmaceutical composition, methods for use in nk-3 receptor-mediated disorders
AU2014242907B2 (en) 2013-03-29 2018-06-28 Ogeda Sa Novel N-acyl-(3-substituted)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor-mediated disorders
US10183948B2 (en) 2013-03-29 2019-01-22 Ogeda Sa N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists
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CA2961984C (en) 2014-09-25 2023-01-24 Ogeda Sa Novel chiral synthesis of n-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines
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CN113527307B (zh) * 2020-04-20 2024-10-11 上海翰森生物医药科技有限公司 含三唑基的并环类衍生物抑制剂、其制备方法和应用
CN113549074A (zh) * 2020-04-26 2021-10-26 上海翰森生物医药科技有限公司 含三唑基的并环类衍生物抑制剂、其制备方法和应用
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