NZ708654A - Diagnostic markers for treating cell proliferative disorders with telomerase inhibitors - Google Patents

Diagnostic markers for treating cell proliferative disorders with telomerase inhibitors

Info

Publication number
NZ708654A
NZ708654A NZ708654A NZ70865413A NZ708654A NZ 708654 A NZ708654 A NZ 708654A NZ 708654 A NZ708654 A NZ 708654A NZ 70865413 A NZ70865413 A NZ 70865413A NZ 708654 A NZ708654 A NZ 708654A
Authority
NZ
New Zealand
Prior art keywords
cell proliferative
proliferative disorders
diagnostic markers
telomerase inhibitors
treating cell
Prior art date
Application number
NZ708654A
Other languages
English (en)
Inventor
Ekaterina Bassett
Bart Burington
Hui Wang
Kevin Eng
Original Assignee
Geron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/802,035 external-priority patent/US9200327B2/en
Application filed by Geron Corp filed Critical Geron Corp
Priority to NZ748624A priority Critical patent/NZ748624A/en
Publication of NZ708654A publication Critical patent/NZ708654A/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7125Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531Production of immunochemical test materials
    • G01N33/532Production of labelled immunochemicals
    • G01N33/533Production of labelled immunochemicals with fluorescent label
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/91Transferases (2.)
    • G01N2333/912Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205Phosphotransferases in general
    • G01N2333/91245Nucleotidyltransferases (2.7.7)
    • G01N2333/9125Nucleotidyltransferases (2.7.7) with a definite EC number (2.7.7.-)
    • G01N2333/9128RNA-directed DNA polymerases, e.g. RT (2.7.7.49)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Neurology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
NZ708654A 2012-11-30 2013-11-27 Diagnostic markers for treating cell proliferative disorders with telomerase inhibitors NZ708654A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NZ748624A NZ748624A (en) 2012-11-30 2013-11-27 Methods of selecting an individual who will benefit from treatment with a telomerase inhibitor using a formalin fixed paraffin embedded (ffpe) biological sample of solid tumor cancer cells

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201261732263P 2012-11-30 2012-11-30
US201361780851P 2013-03-13 2013-03-13
US13/802,035 US9200327B2 (en) 2012-11-30 2013-03-13 Diagnostic markers for treating cell proliferative disorders with telomerase inhibitors
US201361798478P 2013-03-15 2013-03-15
US201361809228P 2013-04-05 2013-04-05
PCT/US2013/072302 WO2014085632A1 (en) 2012-11-30 2013-11-27 Diagnostic markers for treating cell proliferative disorders with telomerase inhibitors

Publications (1)

Publication Number Publication Date
NZ708654A true NZ708654A (en) 2020-04-24

Family

ID=50828470

Family Applications (2)

Application Number Title Priority Date Filing Date
NZ708654A NZ708654A (en) 2012-11-30 2013-11-27 Diagnostic markers for treating cell proliferative disorders with telomerase inhibitors
NZ748624A NZ748624A (en) 2012-11-30 2013-11-27 Methods of selecting an individual who will benefit from treatment with a telomerase inhibitor using a formalin fixed paraffin embedded (ffpe) biological sample of solid tumor cancer cells

Family Applications After (1)

Application Number Title Priority Date Filing Date
NZ748624A NZ748624A (en) 2012-11-30 2013-11-27 Methods of selecting an individual who will benefit from treatment with a telomerase inhibitor using a formalin fixed paraffin embedded (ffpe) biological sample of solid tumor cancer cells

Country Status (24)

Country Link
EP (4) EP3882355B1 (enExample)
JP (2) JP6359028B2 (enExample)
KR (3) KR20210112394A (enExample)
CN (2) CN104937110A (enExample)
AU (4) AU2013352105B2 (enExample)
BR (1) BR112015012507B1 (enExample)
CA (1) CA2892445C (enExample)
CY (1) CY1124140T1 (enExample)
DK (2) DK2925889T3 (enExample)
ES (3) ES2972330T3 (enExample)
HR (2) HRP20181991T1 (enExample)
HU (1) HUE054053T2 (enExample)
IL (3) IL282112B (enExample)
LT (2) LT3495495T (enExample)
MX (1) MX362094B (enExample)
NZ (2) NZ708654A (enExample)
PL (2) PL3495495T3 (enExample)
PT (2) PT2925889T (enExample)
RS (1) RS61513B1 (enExample)
SG (1) SG11201504209YA (enExample)
SI (2) SI3495495T1 (enExample)
SM (1) SMT202100142T1 (enExample)
WO (1) WO2014085632A1 (enExample)
ZA (2) ZA201900759B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2342360T3 (en) 2008-10-17 2016-04-11 Geron Corp Method for identification of sensitivity of a patient to telomerase inhibition therapy
US9375485B2 (en) 2012-12-07 2016-06-28 Geron Corporation Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms
EP3318276A1 (en) 2016-11-04 2018-05-09 Janssen Biotech, Inc. Combinations of a telomerase inhibitor and a bcl-2 inhibitor for the treatment of hematological cancers
WO2018207952A1 (ja) * 2017-05-12 2018-11-15 国立大学法人九州大学 発毛及び/又は育毛用組成物
TWI879717B (zh) 2017-07-28 2025-04-11 美商傑龍公司 治療骨髓增生不良症候群之方法
CA3104537A1 (en) * 2018-07-31 2020-02-06 Geron Corporation Methods of identifying patients likely to benefit from treatment with a telomerase inhibitor
GB201818792D0 (en) * 2018-11-19 2019-01-02 Telonostix Ltd Compounds for telomere length-related treatment of cancer
CA3120704A1 (en) 2018-11-29 2020-06-04 Geron Corporation Methods of treating myelodysplastic syndrome
EP3674418A1 (en) * 2018-12-26 2020-07-01 Life Length S.L. Method for measuring telomere associated variables and uses thereof for the diagnosis and/or prognosis of telomeric-associated diseases
CN114306602B (zh) * 2020-09-28 2024-06-11 中国科学院上海营养与健康研究所 靶向tert在调节皮肤及毛发色素中的应用
CN115463122B (zh) * 2022-08-16 2025-03-25 吕梁学院 一种增强盐霉素抗癌活性的方法及应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5489508A (en) 1992-05-13 1996-02-06 University Of Texas System Board Of Regents Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
US5583016A (en) 1994-07-07 1996-12-10 Geron Corporation Mammalian telomerase
US5958680A (en) 1994-07-07 1999-09-28 Geron Corporation Mammalian telomerase
US5760062A (en) 1995-04-18 1998-06-02 Geron Corporation Telomerase inhibitors
US5656638A (en) 1995-04-18 1997-08-12 Geron Corporation Telomerase inhibitors
US5863936A (en) 1995-04-18 1999-01-26 Geron Corporation Telomerase inhibitors
US5770613A (en) 1995-09-29 1998-06-23 Geron Corporation Telomerase inhibitors
US5767278A (en) 1995-10-06 1998-06-16 Geron Corporation Telomerase inhibitors
US6261836B1 (en) 1996-10-01 2001-07-17 Geron Corporation Telomerase
US6444650B1 (en) 1996-10-01 2002-09-03 Geron Corporation Antisense compositions for detecting and inhibiting telomerase reverse transcriptase
AU733610B2 (en) 1996-12-20 2001-05-17 Geron Corporation Methods for detecting and inhibiting the RNA component of telomerase
JPH11276182A (ja) * 1997-12-26 1999-10-12 Chugai Pharmaceut Co Ltd 逆転写酵素モチーフを有する新規遺伝子
US6331399B1 (en) 2000-05-16 2001-12-18 Isis Pharmaceuticals, Inc. Antisense inhibition of tert expression
US7695904B2 (en) 2002-01-31 2010-04-13 University Of Utah Research Foundation Reducing non-target nucleic acid dependent amplifications: amplifying repetitive nucleic acid sequences
US20040234961A1 (en) * 2002-04-22 2004-11-25 Fordyce Colleen A. Telomere length determination and applications
CA2513747C (en) 2003-01-24 2017-03-07 University Of Utah Methods of predicting mortality risk by determining telomere length
ES2662196T3 (es) * 2003-09-09 2018-04-05 Geron Corporation Oligonucleótidos modificados para la inhibición de la telomerasa
PT3296312T (pt) 2004-07-02 2021-05-11 Geron Corp Síntese de monómeros nucleosídeos 3'-amino 5'-fosforamidite protegidos
CN101193643A (zh) * 2005-03-25 2008-06-04 Alt解决方案公司 端粒酶阳性细胞中端粒长度的调节和癌症治疗
WO2006113470A2 (en) * 2005-04-15 2006-10-26 Geron Corporation Cancer treatment by combined inhibition of proteasome and telomerase activities
DK2342360T3 (en) * 2008-10-17 2016-04-11 Geron Corp Method for identification of sensitivity of a patient to telomerase inhibition therapy
AU2009329987B2 (en) 2008-12-22 2016-08-04 University Of Utah Research Foundation Monochrome multiplex quantitative PCR
US20110207128A1 (en) 2010-02-16 2011-08-25 Cawthon Richard M Methods and kits for determining biological age and longevity based on gene expression profiles
WO2012135125A1 (en) * 2011-03-28 2012-10-04 Geron Corporation Telomere length measurement in formalin-fixed, paraffin embedded (ffpe) samples by quantitative pcr

Also Published As

Publication number Publication date
AU2022202808A1 (en) 2022-05-19
BR112015012507A8 (pt) 2019-10-08
BR112015012507B1 (pt) 2023-03-07
JP2016501523A (ja) 2016-01-21
NZ748624A (en) 2020-08-28
IL282112B (en) 2022-09-01
EP2925889B1 (en) 2018-09-05
KR102348240B1 (ko) 2022-01-10
MX2015006538A (es) 2015-09-23
RS61513B1 (sr) 2021-03-31
AU2013352105B2 (en) 2019-09-19
KR20210112394A (ko) 2021-09-14
KR20150091491A (ko) 2015-08-11
EP4497441A2 (en) 2025-01-29
KR20200128446A (ko) 2020-11-12
WO2014085632A1 (en) 2014-06-05
CN111494629A (zh) 2020-08-07
SI3495495T1 (sl) 2021-07-30
CA2892445C (en) 2022-06-28
IL270636B (en) 2021-04-29
EP2925889A4 (en) 2016-06-15
PT3495495T (pt) 2021-03-22
CA2892445A1 (en) 2014-06-05
ZA201900759B (en) 2020-10-28
KR102174763B1 (ko) 2020-11-06
AU2013352105A1 (en) 2015-06-18
DK3495495T3 (da) 2021-03-22
AU2019283840A1 (en) 2020-01-23
IL239035B (en) 2020-09-30
ES2865446T3 (es) 2021-10-15
PL3495495T3 (pl) 2021-08-30
LT2925889T (lt) 2018-12-27
EP3882355A1 (en) 2021-09-22
MX362094B (es) 2019-01-07
ES2703914T3 (es) 2019-03-13
HRP20210451T1 (hr) 2021-05-14
EP3882355C0 (en) 2023-12-20
HUE054053T2 (hu) 2021-08-30
HRP20181991T1 (hr) 2019-03-08
PT2925889T (pt) 2018-12-12
AU2025201333B2 (en) 2025-10-16
CY1124140T1 (el) 2022-05-27
SMT202100142T1 (it) 2021-05-07
CN104937110A (zh) 2015-09-23
JP6359028B2 (ja) 2018-07-18
ZA202101317B (en) 2023-03-29
AU2022202808B2 (en) 2024-11-28
EP3495495A1 (en) 2019-06-12
LT3495495T (lt) 2021-02-25
IL239035A0 (en) 2015-07-30
HK1215874A1 (en) 2016-09-23
DK2925889T3 (da) 2019-01-02
EP3495495B1 (en) 2020-12-23
PL2925889T3 (pl) 2019-02-28
EP2925889A1 (en) 2015-10-07
SI2925889T1 (sl) 2019-01-31
BR112015012507A2 (pt) 2017-07-11
EP3882355B1 (en) 2023-12-20
ES2972330T3 (es) 2024-06-12
IL282112A (en) 2021-05-31
SG11201504209YA (en) 2015-06-29
JP2018099127A (ja) 2018-06-28
AU2025201333A1 (en) 2025-03-20

Similar Documents

Publication Publication Date Title
NZ708654A (en) Diagnostic markers for treating cell proliferative disorders with telomerase inhibitors
MX2014005800A (es) Mutaciones del receptor notch humano y su uso.
NZ703411A (en) Use of markers in the diagnosis and treatment of prostate cancer
PH12014500995A1 (en) Pak inhibitors for the treatment of cell proliferative disorders
MX355728B (es) Inhibidores de cinasas.
EA201490814A1 (ru) Лечение злокачественной опухоли ингибиторами tor-киназы
IN2015DN00438A (enExample)
MX369691B (es) Inhibidores de glutaminasa y métodos de empleo.
UA123212U (uk) Спосіб лікування раку молочної залози
BR112015021423A2 (pt) métodos de tratamento de câncer, de células de câncer e de câncer resistente a antagonista de egfr, métodos de aumento da sensibilidade e da eficácia de tratamento de câncer e métodos de atraso, de tratamento de indivíduos com câncer e de extensão
UY34230A (es) Terapia de combinación para tumores malignos de células b cd19+ que comprende un inmunoconjugado maitansinoide anti-cd19 y rituximab
MY180834A (en) Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer
MX2015013177A (es) Combinacion de tratamientod de cancer usando microarns e inhibidores de egfr-tki.
MX374415B (es) Composiciones y métodos para identificar un riesgo de cáncer en un sujeto.
WO2013081645A3 (en) Erbb3 mutations in cancer
MX2015010776A (es) Metodos y composiciones para detectar y tratar mutantes de akt resistentes a farmacos.
GB2510539A (en) Biomarkers of cancer
TN2014000443A1 (en) Biomarkers for iap inhibitor therapy
WO2013132354A3 (en) Gene signatures associated with efficacy of postmastectomy radiotherapy in breast cancer
MX2016010948A (es) Composiciones y metodos para identificar neoplasias de celulas b sensibles a terapia de reduccion de celulas b.
MX2013011184A (es) Composiciones y metodos para tratar, diagnosticar y vigilar enfermedades.
WO2013040504A3 (en) Srpx for treatment of cancer

Legal Events

Date Code Title Description
PSEA Patent sealed
RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 27 NOV 2021 BY CPA GLOBAL

Effective date: 20201015

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 27 NOV 2022 BY CPA GLOBAL

Effective date: 20211014

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 27 NOV 2023 BY CPA GLOBAL

Effective date: 20221015

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 27 NOV 2024 BY CPA GLOBAL

Effective date: 20231013

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 27 NOV 2025 BY ABHISHEK KUMAR - CPA-PTO PAYMENTS

Effective date: 20241011

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 27 NOV 2026 BY ABHISHEK KUMAR - CPA-PTO PAYMENTS

Effective date: 20251018