NZ578697A - Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof - Google Patents

Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof

Info

Publication number
NZ578697A
NZ578697A NZ578697A NZ57869708A NZ578697A NZ 578697 A NZ578697 A NZ 578697A NZ 578697 A NZ578697 A NZ 578697A NZ 57869708 A NZ57869708 A NZ 57869708A NZ 578697 A NZ578697 A NZ 578697A
Authority
NZ
New Zealand
Prior art keywords
polymorphs
compositions
manufacture
methods
macrocyclic
Prior art date
Application number
NZ578697A
Other languages
English (en)
Inventor
Yu-Hung Chiu
Tessie Mary Che
Alex Romero
Yoshi Ichikawa
Youe-Kong Shue
Original Assignee
Optimer Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38661942&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NZ578697(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Optimer Pharmaceuticals Inc filed Critical Optimer Pharmaceuticals Inc
Priority to NZ601347A priority Critical patent/NZ601347A/xx
Publication of NZ578697A publication Critical patent/NZ578697A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
NZ578697A 2007-01-22 2008-01-22 Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof NZ578697A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NZ601347A NZ601347A (en) 2007-01-22 2008-01-22 Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88195007P 2007-01-22 2007-01-22
US11/831,886 US7378508B2 (en) 2007-01-22 2007-07-31 Polymorphic crystalline forms of tiacumicin B
PCT/US2008/000735 WO2008091554A1 (en) 2007-01-22 2008-01-22 Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof

Publications (1)

Publication Number Publication Date
NZ578697A true NZ578697A (en) 2012-08-31

Family

ID=38661942

Family Applications (2)

Application Number Title Priority Date Filing Date
NZ578697A NZ578697A (en) 2007-01-22 2008-01-22 Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof
NZ601347A NZ601347A (en) 2007-01-22 2008-01-22 Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
NZ601347A NZ601347A (en) 2007-01-22 2008-01-22 Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof

Country Status (23)

Country Link
US (5) US7378508B2 (https=)
EP (3) EP2125850B1 (https=)
JP (2) JP5468388B2 (https=)
KR (2) KR20150006082A (https=)
CN (2) CN101663312B (https=)
BR (1) BRPI0806878A2 (https=)
CA (2) CA2880860A1 (https=)
CY (1) CY1120358T1 (https=)
DK (1) DK2125850T3 (https=)
ES (2) ES2676308T3 (https=)
HR (1) HRP20180912T1 (https=)
HU (2) HUE052444T2 (https=)
IL (2) IL199984A0 (https=)
LT (1) LT2125850T (https=)
MX (2) MX348083B (https=)
NZ (2) NZ578697A (https=)
PL (2) PL3412678T3 (https=)
PT (2) PT2125850T (https=)
RU (1) RU2478643C2 (https=)
SI (1) SI2125850T1 (https=)
TR (1) TR201810589T4 (https=)
TW (2) TWI425942B (https=)
WO (1) WO2008091554A1 (https=)

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JP5113978B2 (ja) * 2003-11-21 2013-01-09 味の素株式会社 グルタミン酸誘導体の有機アミン塩及びその利用
ATE516024T1 (de) * 2004-05-14 2011-07-15 Optimer Pharmaceuticals Inc Behandlung von krankheiten im zusammenhang mit der anwendung von antibiotika
US7906489B2 (en) 2004-05-14 2011-03-15 Optimer Pharmaceuticals, Inc. 18-membered macrocycles and analogs thereof
US7935377B2 (en) * 2004-06-04 2011-05-03 Ajinomoto Co., Inc. Crystals of free (2R, 4R)-monatin and use thereof
US7378508B2 (en) * 2007-01-22 2008-05-27 Optimer Pharmaceuticals, Inc. Polymorphic crystalline forms of tiacumicin B
EP2170062A4 (en) * 2007-07-12 2010-12-29 Tragara Pharmaceuticals Inc METHOD AND COMPOSITIONS FOR THE TREATMENT OF CANCER DISORDERS, TUMORS AND TUMOR-DISORDED DISEASES
TWI523654B (zh) 2007-11-27 2016-03-01 默沙東藥廠 抗生素巨環化合物以及其製造及使用之方法
US9120815B2 (en) 2010-02-05 2015-09-01 Tragara Pharmaceuticals, Inc. Solid state forms of macrocyclic kinase inhibitors
BR112012029262A8 (pt) * 2010-05-18 2018-06-12 Merck Sharp & Dohme Métodos de tratamento de infecção bacteriana recorrente
EP2670407A4 (en) * 2011-02-04 2014-07-23 Optimer Pharmaceuticals Inc TREATMENT OF BACTERIAL INFECTIONS
WO2013138748A1 (en) * 2012-03-16 2013-09-19 Optimer Pharmaceuticals, Inc. Prevention of clostridium difficile infection in high risk patients
US8722863B2 (en) 2012-05-10 2014-05-13 Teva Pharmaceutical Works Ltd. Solid state forms of fidaxomycin and processes for preparation thereof
JP2015516438A (ja) * 2012-05-10 2015-06-11 テヴァ・ファーマシューティカル・ワークス・リミテッド フィダキソマイシンの固体状形態およびその調製方法
JO3464B1 (ar) * 2013-01-15 2020-07-05 Astellas Pharma Europe Ltd التركيبات الخاصة بمركبات التياكوميسين
CN105142612A (zh) 2013-03-08 2015-12-09 奇普拉股份有限公司 用于直肠给药的药物组合物
CN103275152B (zh) * 2013-05-29 2015-11-18 华北制药集团新药研究开发有限责任公司 一种高纯度非达霉素的制备方法
CN103275153B (zh) * 2013-06-27 2016-03-23 华北制药集团新药研究开发有限责任公司 一种非达霉素晶体的制备方法
CN104560766B (zh) * 2013-10-16 2017-07-28 浙江海正药业股份有限公司 一种游动放线菌菌株及其应用
US20150141356A1 (en) * 2013-11-15 2015-05-21 Optimer Pharmaceuticals, Inc. Treatment of Clostridium Difficile Infection in High Risk Patients
WO2015127955A1 (en) 2014-02-25 2015-09-03 Olon S.P.A. A new polymorph of tiacumicin b and process for preparation thereof
EP3110826A1 (en) 2014-02-25 2017-01-04 OLON S.p.A. Process for preparing novel forms of tiacumicin b
HRP20180668T1 (hr) * 2014-03-18 2018-06-15 Xellia Pharmaceuticals Aps Novi oblik polimorfa i novo kruto stanje tiakumicin b
HRP20181756T1 (hr) 2014-05-09 2018-12-28 Astellas Pharma Europe Ltd. Režim liječenja sa spojem tiakumicina
WO2015175695A1 (en) * 2014-05-13 2015-11-19 Debrabander Jef Small molecule compounds selective against gram-negative bacterial infections
CN104098637B (zh) 2014-07-09 2017-01-04 浙江海正药业股份有限公司 一种纯化非达霉素的方法
MA41689A (fr) * 2014-10-15 2017-08-22 Bioxcel Corp Prévention ou traitement de troubles du sommeil au moyen d'une formulation de dexmédétomidine
WO2017005358A1 (en) 2015-07-03 2017-01-12 Astellas Pharma Europe Ltd. Novel dosage regimen tiacumicin compound
CN112190589A (zh) * 2020-11-17 2021-01-08 首都医科大学附属北京胸科医院 非达霉素在制备抑制鸟分枝杆菌活性的产品中的应用

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GB1458512A (en) * 1973-11-22 1976-12-15 Lepetit Spa Antibiotic substance
US4321362A (en) * 1980-06-12 1982-03-23 Eli Lilly And Company De(mycinosyloxy)tylosin and process for its production
US4918174A (en) 1986-09-26 1990-04-17 Abbott Laboratories Tiacumicin compounds
US5698155A (en) 1991-05-31 1997-12-16 Gs Technologies, Inc. Method for the manufacture of pharmaceutical cellulose capsules
US5583115A (en) 1995-05-09 1996-12-10 Abbott Laboratories Dialkyltiacumicin compounds
US5767096A (en) 1996-07-12 1998-06-16 Abbott Laboratories Bromotiacumicin compounds
JP2000072760A (ja) 1998-06-19 2000-03-07 Ajinomoto Co Inc 新規シストチアゾール類縁体
JP2000053514A (ja) 1998-08-06 2000-02-22 Aquas Corp レジオネラ属細菌が生産する殺菌性物質、これを用いた殺菌剤、水処理剤、スライム抑制剤、及びこれらの製造方法
JP2000239266A (ja) 1999-02-17 2000-09-05 Ajinomoto Co Inc 新規ポリエン系抗生物質
EP1652926B1 (en) 2000-04-28 2009-09-30 Kosan Biosciences, Inc. Crystalline epothilone d
WO2002032427A1 (en) 2000-10-20 2002-04-25 Galephar M/F Stable oral formulation containing benzimidazole derivative
AU2003251902B2 (en) * 2002-07-29 2008-03-06 Merck Sharp & Dohme Llc Tiacumicin production
US20070105791A1 (en) * 2002-07-29 2007-05-10 Optimer Pharmaceuticals, Inc. Method of treating clostridium difficile-associated diarrhea
ATE516024T1 (de) 2004-05-14 2011-07-15 Optimer Pharmaceuticals Inc Behandlung von krankheiten im zusammenhang mit der anwendung von antibiotika
US7906489B2 (en) * 2004-05-14 2011-03-15 Optimer Pharmaceuticals, Inc. 18-membered macrocycles and analogs thereof
US7378508B2 (en) * 2007-01-22 2008-05-27 Optimer Pharmaceuticals, Inc. Polymorphic crystalline forms of tiacumicin B
JP5166040B2 (ja) * 2005-01-31 2013-03-21 オプティマー ファーマシューティカルズ、インコーポレイテッド １８員大環状化合物及びその類似化合物
AU2006304868B2 (en) 2005-10-21 2013-02-21 Merck Sharp & Dohme Corp. Method of treating clostridium difficile-associated diarrhea
US20080176927A1 (en) 2007-01-19 2008-07-24 Optimer Pharmaceuticals, Inc. Compositions of stable tiacumicins
ZA200905337B (en) * 2007-01-22 2010-10-27 Optimer Pharmaceuticals Inc Macrocyclic polymorphs, compositions comprising such polymorphs, and methods of use and manufacture thereof
TWI523654B (zh) 2007-11-27 2016-03-01 默沙東藥廠 抗生素巨環化合物以及其製造及使用之方法

Also Published As

Publication number Publication date
JP5468388B2 (ja) 2014-04-09
CA2880860A1 (en) 2008-07-31
EP2468761A1 (en) 2012-06-27
HUE039395T2 (hu) 2018-12-28
TW200840562A (en) 2008-10-16
US7378508B2 (en) 2008-05-27
EP2125850B1 (en) 2018-05-30
LT2125850T (lt) 2018-08-10
CN102746353A (zh) 2012-10-24
CY1120358T1 (el) 2019-07-10
US20090163428A1 (en) 2009-06-25
RU2478643C2 (ru) 2013-04-10
CN101663312B (zh) 2013-10-23
RU2009131727A (ru) 2011-02-27
JP2013241440A (ja) 2013-12-05
NZ601347A (en) 2013-11-29
CA2676061A1 (en) 2008-07-31
KR20150006082A (ko) 2015-01-15
US20080194497A1 (en) 2008-08-14
KR20090117924A (ko) 2009-11-16
CA2676061C (en) 2016-01-19
PT2125850T (pt) 2018-07-11
TWI453015B (zh) 2014-09-21
US8859510B2 (en) 2014-10-14
CN101663312A (zh) 2010-03-03
US20130252914A1 (en) 2013-09-26
US8883986B2 (en) 2014-11-11
JP5764168B2 (ja) 2015-08-12
MX348083B (es) 2017-05-25
IL199984A0 (en) 2010-04-15
ES2676308T3 (es) 2018-07-18
PL2125850T3 (pl) 2018-08-31
BRPI0806878A2 (pt) 2014-06-24
US20070259949A1 (en) 2007-11-08
WO2008091554A1 (en) 2008-07-31
US7863249B2 (en) 2011-01-04
AU2008209580A1 (en) 2008-07-31
IL220255A0 (en) 2012-07-31
JP2010516681A (ja) 2010-05-20
EP2125850A1 (en) 2009-12-02
DK2125850T3 (en) 2018-07-30
TWI425942B (zh) 2014-02-11
EP3412678A1 (en) 2018-12-12
SI2125850T1 (en) 2018-08-31
HUE052444T2 (hu) 2021-05-28
PT3412678T (pt) 2020-09-29
ES2821384T3 (es) 2021-04-26
MX2009007730A (es) 2009-08-07
TW201350114A (zh) 2013-12-16
HRP20180912T1 (hr) 2018-07-27
US20100081800A1 (en) 2010-04-01
EP3412678B1 (en) 2020-08-19
PL3412678T3 (pl) 2020-12-14
TR201810589T4 (tr) 2018-08-27

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