NZ568254A - 1,4-Benzodiazepine-2,5-diones for regulating cell death and treating autoimmune diseases - Google Patents
1,4-Benzodiazepine-2,5-diones for regulating cell death and treating autoimmune diseasesInfo
- Publication number
- NZ568254A NZ568254A NZ568254A NZ56825406A NZ568254A NZ 568254 A NZ568254 A NZ 568254A NZ 568254 A NZ568254 A NZ 568254A NZ 56825406 A NZ56825406 A NZ 56825406A NZ 568254 A NZ568254 A NZ 568254A
- Authority
- NZ
- New Zealand
- Prior art keywords
- compound
- cells
- compounds
- benzodiazepine
- agents
- Prior art date
Links
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- FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 description 1
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- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73204505P | 2005-11-01 | 2005-11-01 | |
| PCT/US2006/042753 WO2007053725A2 (en) | 2005-11-01 | 2006-11-01 | Novel 1,4-benzodiazepine-2,5-diones with therapeutic properties |
Publications (1)
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| NZ568254A true NZ568254A (en) | 2011-06-30 |
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| NZ568254A NZ568254A (en) | 2005-11-01 | 2006-11-01 | 1,4-Benzodiazepine-2,5-diones for regulating cell death and treating autoimmune diseases |
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| US (3) | US8088759B2 (enExample) |
| EP (2) | EP2604269B1 (enExample) |
| JP (1) | JP5241501B2 (enExample) |
| AU (2) | AU2006308655B2 (enExample) |
| CA (2) | CA2628193C (enExample) |
| IL (1) | IL191175A (enExample) |
| NZ (1) | NZ568254A (enExample) |
| WO (1) | WO2007053725A2 (enExample) |
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| CA2372150C (en) * | 1999-04-30 | 2011-08-30 | The Regents Of The University Of Michigan | Therapeutic applications of pro-apoptotic benzodiazepines |
| AU2006203946B2 (en) | 2005-01-03 | 2009-07-23 | The Regents Of The University Of Michigan | Compositions and methods relating to novel compounds and targets thereof |
| EP1893218A4 (en) | 2005-06-01 | 2011-01-12 | Univ Michigan | UNLOCKED BENZODIAZEPINE COMPOSITIONS AND METHOD |
| CA2628193C (en) | 2005-11-01 | 2012-08-14 | The Regents Of The University Of Michigan | Novel 1,4-benzodiazepine-2,5-diones with therapeutic properties |
| US7759338B2 (en) * | 2006-04-27 | 2010-07-20 | The Regents Of The University Of Michigan | Soluble 1,4 benzodiazepine compounds and stable salts thereof |
| MX2008015488A (es) | 2006-06-09 | 2009-02-12 | Univ Michigan | Composiciones y metodos relacionados con compuestos novedosos y objetivos de los mismos. |
| BRPI0808653A2 (pt) | 2007-03-09 | 2014-08-19 | Univ Michigan | Composições e métodos referindo-se a novos compostos e alvos dos mesmos. |
| ES2614498T3 (es) | 2007-09-14 | 2017-05-31 | The Regents Of The University Of Michigan | Inhibidores de ATPasa F1F0 y métodos relacionados |
| AU2008323945B2 (en) | 2007-11-06 | 2013-11-28 | The Regents Of The University Of Michigan | Benzodiazepinone compounds useful in the treatment of skin conditions |
| EP2352724B1 (en) | 2008-09-11 | 2015-04-22 | The Regents of the University of Michigan | Aryl guanidine f1f0-atpase inhibitors and their medical use |
| WO2010121164A2 (en) | 2009-04-17 | 2010-10-21 | The Regents Of The University Of Michigan | 1,4-benzodiazepinone compounds and their use in treating cancer |
| SG10201706590VA (en) | 2009-05-22 | 2017-09-28 | Abbvie Inc | Modulators of 5-ht receptors and methods of use thereof |
| US8673897B2 (en) | 2009-09-18 | 2014-03-18 | The Regents Of The University Of Michigan | Benzodiazepinone compounds and methods of treatment using same |
| CA2780333C (en) | 2009-11-17 | 2016-05-24 | The Regents Of The University Of Michigan | 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties |
| JP5856064B2 (ja) * | 2009-11-17 | 2016-02-09 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 治療特性を有する１，４−ベンゾジアゼピン−２，５−ジオンおよび関連化合物 |
| RU2567751C2 (ru) | 2010-05-21 | 2015-11-10 | Эббви Инк. | Трициклические производные пирролидина, полезные в качестве модуляторов 5-ht рецепторов |
| CN104822374A (zh) | 2012-09-27 | 2015-08-05 | 儿童医学中心公司 | 用于治疗肥胖症的化合物和其使用方法 |
| CN103435562B (zh) * | 2013-08-26 | 2016-02-24 | 华东理工大学 | 6-取代苯并二氮卓-2,4-二酮类化合物及其用途 |
| CN105693634B (zh) * | 2016-03-17 | 2018-12-11 | 清华大学 | 化合物及其用途 |
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-
2006
- 2006-11-01 CA CA2628193A patent/CA2628193C/en not_active Expired - Fee Related
- 2006-11-01 AU AU2006308655A patent/AU2006308655B2/en not_active Ceased
- 2006-11-01 EP EP13151265.9A patent/EP2604269B1/en not_active Not-in-force
- 2006-11-01 CA CA2779041A patent/CA2779041A1/en not_active Abandoned
- 2006-11-01 EP EP06844249A patent/EP1948191B1/en active Active
- 2006-11-01 WO PCT/US2006/042753 patent/WO2007053725A2/en not_active Ceased
- 2006-11-01 JP JP2008539013A patent/JP5241501B2/ja not_active Expired - Fee Related
- 2006-11-01 NZ NZ568254A patent/NZ568254A/en not_active IP Right Cessation
- 2006-11-01 US US11/591,324 patent/US8088759B2/en not_active Expired - Fee Related
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2008
- 2008-04-30 IL IL191175A patent/IL191175A/en not_active IP Right Cessation
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2010
- 2010-11-18 AU AU2010241505A patent/AU2010241505A1/en not_active Abandoned
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2011
- 2011-12-01 US US13/309,233 patent/US20120088757A1/en not_active Abandoned
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Also Published As
| Publication number | Publication date |
|---|---|
| JP5241501B2 (ja) | 2013-07-17 |
| US20070111994A1 (en) | 2007-05-17 |
| AU2006308655B2 (en) | 2010-09-23 |
| JP2009513718A (ja) | 2009-04-02 |
| EP1948191B1 (en) | 2013-01-16 |
| CA2628193C (en) | 2012-08-14 |
| IL191175A0 (en) | 2009-02-11 |
| EP2604269A1 (en) | 2013-06-19 |
| US8088759B2 (en) | 2012-01-03 |
| WO2007053725A3 (en) | 2007-07-19 |
| EP1948191A2 (en) | 2008-07-30 |
| WO2007053725A2 (en) | 2007-05-10 |
| US8791104B2 (en) | 2014-07-29 |
| AU2010241505A1 (en) | 2010-12-09 |
| IL191175A (en) | 2015-01-29 |
| CA2779041A1 (en) | 2007-05-10 |
| EP1948191A4 (en) | 2011-01-05 |
| EP2604269B1 (en) | 2014-09-24 |
| US20120088757A1 (en) | 2012-04-12 |
| CA2628193A1 (en) | 2007-05-10 |
| AU2006308655A1 (en) | 2007-05-10 |
| US20130261110A1 (en) | 2013-10-03 |
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