NZ552159A - Bis(thio-hydrazide amide) salts for treatment of cancers - Google Patents
Bis(thio-hydrazide amide) salts for treatment of cancersInfo
- Publication number
- NZ552159A NZ552159A NZ552159A NZ55215905A NZ552159A NZ 552159 A NZ552159 A NZ 552159A NZ 552159 A NZ552159 A NZ 552159A NZ 55215905 A NZ55215905 A NZ 55215905A NZ 552159 A NZ552159 A NZ 552159A
- Authority
- NZ
- New Zealand
- Prior art keywords
- methyl
- group
- phenyl
- thio
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/38—Amides of thiocarboxylic acids
- C07C327/56—Amides of thiocarboxylic acids having nitrogen atoms of thiocarboxamide groups further bound to another hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58259604P | 2004-06-23 | 2004-06-23 | |
US68136805P | 2005-05-16 | 2005-05-16 | |
PCT/US2005/021642 WO2006009940A1 (en) | 2004-06-23 | 2005-06-20 | Bis(thio-hydrazide amide) salts for treatment of cancers |
Publications (1)
Publication Number | Publication Date |
---|---|
NZ552159A true NZ552159A (en) | 2009-12-24 |
Family
ID=34993190
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NZ552159A NZ552159A (en) | 2004-06-23 | 2005-06-20 | Bis(thio-hydrazide amide) salts for treatment of cancers |
Country Status (22)
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI252847B (en) * | 2001-07-10 | 2006-04-11 | Synta Pharmaceuticals Corp | Synthesis of taxol enhancers |
TWI297335B (en) | 2001-07-10 | 2008-06-01 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
TWI332943B (en) * | 2001-07-10 | 2010-11-11 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
TWI330079B (en) * | 2003-01-15 | 2010-09-11 | Synta Pharmaceuticals Corp | Treatment for cancers |
DK1781604T3 (da) | 2004-06-23 | 2013-09-16 | Synta Pharmaceuticals Corp | Bis(thio-hydrazid-amid)-salte til behandling af cancere |
EP1827410A2 (en) | 2004-11-19 | 2007-09-05 | Synta Pharmaceuticals Corporation | Bis(thio-hydrazide amides) for increasing hsp70 expression |
AU2006236534A1 (en) * | 2005-04-15 | 2006-10-26 | Synta Pharmaceuticals Corp. | Methods of increasing natural killer cell activity for therapy |
WO2006113695A1 (en) | 2005-04-15 | 2006-10-26 | Synta Pharmaceuticals Corp. | Combination cancer therapy with bis(thiohydrazide) amide compounds |
WO2006124736A2 (en) * | 2005-05-16 | 2006-11-23 | Synta Pharmaceuticals Corp. | Synthesis of bis(thio-hydrazide amide) salts |
EP1940375A1 (en) | 2005-08-16 | 2008-07-09 | Synta Pharmaceuticals Corporation | Bis(thio-hydrazide amide) formulation |
US20100310587A1 (en) * | 2005-08-29 | 2010-12-09 | Academia Sinica | Immunomodulatory compositions |
GB0607950D0 (en) * | 2006-04-21 | 2006-05-31 | Novartis Ag | Organic compounds |
JP2010501564A (ja) * | 2006-08-21 | 2010-01-21 | シンタ ファーマシューティカルズ コーポレーション | 黒色腫を治療するためのビス(チオヒドラジドアミド) |
WO2008024304A2 (en) * | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Compounds for treatment of proliferative disorders |
BRPI0716435A2 (pt) * | 2006-08-21 | 2014-03-04 | Synta Pharmaceuticals Corp | Compostos para o tratamento de doenças proliferativas |
AU2007288334A1 (en) * | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Combination with bis(thiohydrazide amides) for treating cancer |
WO2008024301A2 (en) * | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Bis(thiohydrazide amides) for use in preventing or delaying the recurrence of melanoma |
JP2010502616A (ja) * | 2006-08-31 | 2010-01-28 | シンタ ファーマシューティカルズ コーポレーション | 癌を治療するためのビス(チオヒドラジドアミド)の組み合わせ |
US9498528B2 (en) * | 2006-09-13 | 2016-11-22 | Genzyme Corporation | Treatment of multiple sclerosis (MS) |
TW200829543A (en) * | 2006-09-15 | 2008-07-16 | Synta Pharmaceuticals Corp | Purification of bis(thiohydrazide amides) |
US8618170B2 (en) * | 2007-11-09 | 2013-12-31 | Synta Pharmaceuticals Corp. | Oral formulations of bis(thiohydrazide amides) |
WO2009105257A1 (en) | 2008-02-21 | 2009-08-27 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
US8633323B2 (en) * | 2008-03-31 | 2014-01-21 | Synta Pharmaceuticals Corp. | Process for preparing bis(thiohydrazide amides) |
BRPI0919720A2 (pt) * | 2008-10-22 | 2015-12-08 | Synta Pharmaceuticals Corp | complexos de metal de transição de compostos bis-[tio hidrazida amida |
CN102256949B (zh) | 2008-10-22 | 2014-09-24 | 辛塔医药品有限公司 | 双[硫代酰肼酰胺]化合物的过渡金属络合物 |
US8525776B2 (en) * | 2008-10-27 | 2013-09-03 | Lenovo (Singapore) Pte. Ltd | Techniques for controlling operation of a device with a virtual touchscreen |
EP2370402A2 (en) | 2008-12-01 | 2011-10-05 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
US8822532B2 (en) | 2009-12-04 | 2014-09-02 | Synta Pharmaceuticals Corp. | Bis[thiohydrazide amide] compounds for treating leukemia |
US8815945B2 (en) | 2010-04-20 | 2014-08-26 | Masazumi Nagai | Use of bis [thiohydrazide amide] compounds such as elesclomol for treating cancers |
EP2640372A1 (en) | 2010-11-18 | 2013-09-25 | Synta Pharmaceuticals Corp. | Preselection of subjects for therapeutic treatment with elesclomol based on hypoxic status |
JP2014534238A (ja) * | 2011-11-10 | 2014-12-18 | シンタ ファーマシューティカルズ コーポレーション | 癌を治療するためのビス(チオヒドラジドアミド)化合物の投与 |
US20130149392A1 (en) | 2011-12-12 | 2013-06-13 | Synta Pharmaceuticals Corp. | Method of treating non-small cell lung cancer with bis-(thiohydrazide)amide compounds |
US20150057357A1 (en) * | 2012-01-05 | 2015-02-26 | The Board Of Trustees Of The Leland Stanford Junior University | Bis (thiohydrazide amide) compounds for treating cancers |
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US6602907B1 (en) | 2001-06-08 | 2003-08-05 | University Of Central Florida | Treatment of breast cancer |
TWI297335B (en) * | 2001-07-10 | 2008-06-01 | Synta Pharmaceuticals Corp | Taxol enhancer compounds |
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AU2006228035B2 (en) | 2003-01-15 | 2010-02-18 | Synta Pharmaceuticals Corp. | Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancer |
TWI330079B (en) | 2003-01-15 | 2010-09-11 | Synta Pharmaceuticals Corp | Treatment for cancers |
KR101166749B1 (ko) | 2003-02-11 | 2012-07-27 | 베르날리스(캠브리지)리미티드 | 열쇼크 단백질 저해제로서의 이소옥사졸 화합물 |
KR100575251B1 (ko) | 2003-03-03 | 2006-05-02 | 재단법인서울대학교산학협력재단 | p38/JTV-1을 유효성분으로 하는 암 치료용 약학적조성물 및 암 치료용 약학적 조성물의 스크리닝 방법 |
KR100486693B1 (ko) * | 2003-03-17 | 2005-05-03 | 삼성전자주식회사 | 금속 매립 방법 |
EP1493445A1 (en) | 2003-07-04 | 2005-01-05 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Inhibition of stress-induced ligand-dependent EGFR activation |
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KR100544347B1 (ko) | 2003-12-11 | 2006-01-23 | 한국생명공학연구원 | 디아릴이소옥사졸계 화합물을 유효성분으로 함유하는 암 예방 및 치료용 약학적 조성물 |
BRPI0509172A (pt) | 2004-03-26 | 2007-08-28 | Amphora Discovery Corp | pelo menos uma entidade quìmica, composição farmacêutica, métodos para tratar um paciente, para inibir pelo menos uma enzima que utiliza atp, e para tratar pelo menos uma doença, uso de pelo menos uma entidade quìmica, e, método para a fabricação de um medicamento |
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DK1781604T3 (da) * | 2004-06-23 | 2013-09-16 | Synta Pharmaceuticals Corp | Bis(thio-hydrazid-amid)-salte til behandling af cancere |
US20060142393A1 (en) | 2004-09-16 | 2006-06-29 | Sherman Matthew L | Bis(thio-hydrazide amides) for treatment of hyperplasia |
WO2006062732A2 (en) | 2004-11-19 | 2006-06-15 | Synta Pharmaceuticals Corp. | Compounds acting at the centrosome |
EP1827410A2 (en) | 2004-11-19 | 2007-09-05 | Synta Pharmaceuticals Corporation | Bis(thio-hydrazide amides) for increasing hsp70 expression |
AU2006214164B2 (en) | 2005-02-17 | 2010-12-09 | Synta Pharmaceuticals Corp. | Isoxazole combretastin derivatives for the treatment of disorders |
WO2006113493A2 (en) | 2005-04-15 | 2006-10-26 | Synta Pharmaceuticals Corp. | Methods of determining cancer prognosis via natural killer cell activity |
WO2006113695A1 (en) | 2005-04-15 | 2006-10-26 | Synta Pharmaceuticals Corp. | Combination cancer therapy with bis(thiohydrazide) amide compounds |
AU2006236534A1 (en) | 2005-04-15 | 2006-10-26 | Synta Pharmaceuticals Corp. | Methods of increasing natural killer cell activity for therapy |
WO2006124736A2 (en) | 2005-05-16 | 2006-11-23 | Synta Pharmaceuticals Corp. | Synthesis of bis(thio-hydrazide amide) salts |
EP1940375A1 (en) | 2005-08-16 | 2008-07-09 | Synta Pharmaceuticals Corporation | Bis(thio-hydrazide amide) formulation |
EP2034996A2 (en) | 2006-05-25 | 2009-03-18 | Synta Pharmaceuticals Corporation | Triazole compounds that modulate hsp90 activity |
JP2010501564A (ja) | 2006-08-21 | 2010-01-21 | シンタ ファーマシューティカルズ コーポレーション | 黒色腫を治療するためのビス(チオヒドラジドアミド) |
AU2007288334A1 (en) | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Combination with bis(thiohydrazide amides) for treating cancer |
WO2008024298A1 (en) | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Bis(thiohydrazide amides) for inhibiting angiogenesis |
BRPI0716435A2 (pt) | 2006-08-21 | 2014-03-04 | Synta Pharmaceuticals Corp | Compostos para o tratamento de doenças proliferativas |
WO2008024301A2 (en) | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Bis(thiohydrazide amides) for use in preventing or delaying the recurrence of melanoma |
WO2008024302A2 (en) | 2006-08-21 | 2008-02-28 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
JP2010502616A (ja) | 2006-08-31 | 2010-01-28 | シンタ ファーマシューティカルズ コーポレーション | 癌を治療するためのビス(チオヒドラジドアミド)の組み合わせ |
AU2007294969A1 (en) | 2006-09-11 | 2008-03-20 | Synta Pharmaceuticals Corp. | Bis (thiohydrazide amides) formulation |
JP2010503674A (ja) | 2006-09-14 | 2010-02-04 | シンタ ファーマシューティカルズ コーポレーション | 血管形成治療用化合物 |
TW200829543A (en) | 2006-09-15 | 2008-07-16 | Synta Pharmaceuticals Corp | Purification of bis(thiohydrazide amides) |
US20090093538A1 (en) | 2007-01-03 | 2009-04-09 | Synta Pharmaceuticals Corp | Method for treating cancer |
US8093425B2 (en) | 2007-04-30 | 2012-01-10 | Synta Pharmaceuticals Corp. | Compounds for treating proliferative disorders |
TW200922550A (en) | 2007-08-07 | 2009-06-01 | Synta Pharmaceuticals Corp | Compounds for treating proliferative disorders |
US8618170B2 (en) | 2007-11-09 | 2013-12-31 | Synta Pharmaceuticals Corp. | Oral formulations of bis(thiohydrazide amides) |
US8637704B2 (en) | 2007-11-28 | 2014-01-28 | Synta Pharmaceuticals Corp. | Polymorphs of N-malonyl-bis(N′-methyl-N′-thiobenzoylhydrazide) |
JP5091056B2 (ja) | 2008-08-28 | 2012-12-05 | 三甲株式会社 | 密閉容器の蓋部シール構造 |
-
2005
- 2005-06-20 DK DK05762347.2T patent/DK1781604T3/da active
- 2005-06-20 BR BRPI0512526-0A patent/BRPI0512526A/pt not_active IP Right Cessation
- 2005-06-20 RS RS20130458A patent/RS52999B/en unknown
- 2005-06-20 EP EP05762347.2A patent/EP1781604B1/en active Active
- 2005-06-20 US US11/157,213 patent/US7385084B2/en not_active Expired - Fee Related
- 2005-06-20 PT PT57623472T patent/PT1781604E/pt unknown
- 2005-06-20 JP JP2007518152A patent/JP5362986B2/ja not_active Expired - Fee Related
- 2005-06-20 NZ NZ552159A patent/NZ552159A/en not_active IP Right Cessation
- 2005-06-20 PL PL05762347T patent/PL1781604T3/pl unknown
- 2005-06-20 EP EP10009536A patent/EP2305642A3/en not_active Withdrawn
- 2005-06-20 ES ES05762347T patent/ES2430373T3/es active Active
- 2005-06-20 ME MEP-2013-124A patent/ME01644B/me unknown
- 2005-06-20 AU AU2005265202A patent/AU2005265202B2/en not_active Ceased
- 2005-06-20 WO PCT/US2005/021642 patent/WO2006009940A1/en active Application Filing
- 2005-06-20 CA CA2570698A patent/CA2570698C/en not_active Expired - Fee Related
- 2005-06-20 KR KR1020077001513A patent/KR101313027B1/ko not_active IP Right Cessation
- 2005-06-20 RU RU2007101898/04A patent/RU2406722C2/ru not_active IP Right Cessation
- 2005-06-20 CN CN2005800264456A patent/CN1993318B/zh not_active Expired - Fee Related
- 2005-06-21 TW TW094120599A patent/TWI389684B/zh not_active IP Right Cessation
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2006
- 2006-11-27 IL IL179632A patent/IL179632A/en not_active IP Right Cessation
-
2007
- 2007-01-19 NO NO20070378A patent/NO20070378L/no not_active Application Discontinuation
- 2007-11-05 HK HK07112015.9A patent/HK1104526A1/xx not_active IP Right Cessation
-
2008
- 2008-04-18 US US12/148,312 patent/US7579503B2/en not_active Expired - Fee Related
-
2009
- 2009-07-15 US US12/503,661 patent/US7795313B2/en not_active Expired - Fee Related
-
2010
- 2010-08-30 US US12/871,587 patent/US8048925B2/en not_active Expired - Fee Related
- 2010-11-08 RU RU2010145056/04A patent/RU2010145056A/ru not_active Application Discontinuation
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2011
- 2011-10-14 US US13/273,807 patent/US8461208B2/en not_active Expired - Fee Related
-
2013
- 2013-10-29 HR HRP20131023TT patent/HRP20131023T1/hr unknown
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