NZ545047A - Combination of a nucleic acid and a vasoactive agent for enhanced gene delivery - Google Patents
Combination of a nucleic acid and a vasoactive agent for enhanced gene deliveryInfo
- Publication number
- NZ545047A NZ545047A NZ545047A NZ54504799A NZ545047A NZ 545047 A NZ545047 A NZ 545047A NZ 545047 A NZ545047 A NZ 545047A NZ 54504799 A NZ54504799 A NZ 54504799A NZ 545047 A NZ545047 A NZ 545047A
- Authority
- NZ
- New Zealand
- Prior art keywords
- percent
- coating composition
- weight
- acid
- chitosan
- Prior art date
Links
- 239000002550 vasoactive agent Substances 0.000 title abstract 3
- 238000001476 gene delivery Methods 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 239000008199 coating composition Substances 0.000 claims description 43
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 39
- 229920001661 Chitosan Polymers 0.000 claims description 28
- 238000000034 method Methods 0.000 claims description 28
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 22
- 238000000576 coating method Methods 0.000 claims description 20
- 239000011248 coating agent Substances 0.000 claims description 18
- 239000002518 antifoaming agent Substances 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 15
- -1 ethyiparaben Chemical compound 0.000 claims description 14
- 235000011054 acetic acid Nutrition 0.000 claims description 13
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- 230000005070 ripening Effects 0.000 claims description 13
- 238000003860 storage Methods 0.000 claims description 13
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 11
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 11
- 229960002216 methylparaben Drugs 0.000 claims description 11
- 239000005980 Gibberellic acid Substances 0.000 claims description 10
- IXORZMNAPKEEDV-UHFFFAOYSA-N gibberellic acid GA3 Natural products OC(=O)C1C2(C3)CC(=C)C3(O)CCC2C2(C=CC3O)C1C3(C)C(=O)O2 IXORZMNAPKEEDV-UHFFFAOYSA-N 0.000 claims description 10
- IXORZMNAPKEEDV-OBDJNFEBSA-N gibberellin A3 Chemical group C([C@@]1(O)C(=C)C[C@@]2(C1)[C@H]1C(O)=O)C[C@H]2[C@]2(C=C[C@@H]3O)[C@H]1[C@]3(C)C(=O)O2 IXORZMNAPKEEDV-OBDJNFEBSA-N 0.000 claims description 10
- 150000007524 organic acids Chemical class 0.000 claims description 10
- 239000004094 surface-active agent Substances 0.000 claims description 10
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- 239000005648 plant growth regulator Substances 0.000 claims description 8
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- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 7
- 239000007864 aqueous solution Substances 0.000 claims description 6
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 6
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 6
- JMGZBMRVDHKMKB-UHFFFAOYSA-L disodium;2-sulfobutanedioate Chemical compound [Na+].[Na+].OS(=O)(=O)C(C([O-])=O)CC([O-])=O JMGZBMRVDHKMKB-UHFFFAOYSA-L 0.000 claims description 6
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- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 6
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- 239000002253 acid Substances 0.000 claims description 5
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- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 3
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- ZNJFBWYDHIGLCU-HWKXXFMVSA-N jasmonic acid Chemical compound CC\C=C/C[C@@H]1[C@@H](CC(O)=O)CCC1=O ZNJFBWYDHIGLCU-HWKXXFMVSA-N 0.000 claims description 3
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- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims description 3
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 3
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- 239000001384 succinic acid Substances 0.000 claims description 3
- CDOUZKKFHVEKRI-UHFFFAOYSA-N 3-bromo-n-[(prop-2-enoylamino)methyl]propanamide Chemical compound BrCCC(=O)NCNC(=O)C=C CDOUZKKFHVEKRI-UHFFFAOYSA-N 0.000 claims description 2
- 241000146226 Physalis ixocarpa Species 0.000 claims description 2
- UQHKFADEQIVWID-UHFFFAOYSA-N cytokinin Natural products C1=NC=2C(NCC=C(CO)C)=NC=NC=2N1C1CC(O)C(CO)O1 UQHKFADEQIVWID-UHFFFAOYSA-N 0.000 claims description 2
- 239000004062 cytokinin Substances 0.000 claims description 2
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 claims description 2
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims description 2
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- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 claims description 2
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- MCSXGCZMEPXKIW-UHFFFAOYSA-N 3-hydroxy-4-[(4-methyl-2-nitrophenyl)diazenyl]-N-(3-nitrophenyl)naphthalene-2-carboxamide Chemical compound Cc1ccc(N=Nc2c(O)c(cc3ccccc23)C(=O)Nc2cccc(c2)[N+]([O-])=O)c(c1)[N+]([O-])=O MCSXGCZMEPXKIW-UHFFFAOYSA-N 0.000 claims 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0083—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the administration regime
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Paints Or Removers (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2177398A | 1998-02-11 | 1998-02-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ545047A true NZ545047A (en) | 2009-05-31 |
Family
ID=21806073
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ545047A NZ545047A (en) | 1998-02-11 | 1999-02-09 | Combination of a nucleic acid and a vasoactive agent for enhanced gene delivery |
Country Status (11)
| Country | Link |
|---|---|
| EP (2) | EP1695719A1 (https=) |
| JP (1) | JP2002502885A (https=) |
| KR (1) | KR20010015915A (https=) |
| CN (2) | CN101186928A (https=) |
| AU (1) | AU2663799A (https=) |
| CA (1) | CA2320302A1 (https=) |
| EA (1) | EA019099B1 (https=) |
| IL (1) | IL137765A0 (https=) |
| NZ (1) | NZ545047A (https=) |
| WO (1) | WO1999040945A2 (https=) |
| ZA (1) | ZA991102B (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001034208A1 (en) * | 1999-11-05 | 2001-05-17 | The Regents Of The University Of California | Techniques and compositions for treating cardiovascular disease by in vivo gene delivery |
| US6752987B1 (en) | 1995-02-28 | 2004-06-22 | The Regents Of The University Of California | Adenovirus encoding human adenylylcyclase (AC) VI |
| WO2000024415A2 (en) | 1998-10-28 | 2000-05-04 | Cornell Research Foundation, Inc. | Methods for regulating angiogenesis and vascular integrity using trk receptor ligands |
| EP1255822A2 (en) | 1999-12-27 | 2002-11-13 | The Regents Of The University Of California | Modified adenylylcyclase type vi useful in gene therapy for congestive heart failure |
| WO2002002148A2 (en) * | 2000-06-30 | 2002-01-10 | Collateral Therapeutics, Inc. | Dual recombinant gene therapy compositions and methods of use |
| JP2005052001A (ja) * | 2001-07-05 | 2005-03-03 | Takara Bio Inc | 遺伝子治療剤 |
| DE602006017071D1 (de) | 2005-01-25 | 2010-11-04 | Five Prime Therapeutics Inc | Zusammensetzungen und verfahren zur behandlung von herzkrankheiten |
| GB2437893A (en) * | 2006-07-25 | 2007-11-07 | Celladon Corp | Extended antegrade epicardial coronary infusion of adeno-associated viral vectors for gene therapy |
| US8157760B2 (en) | 2007-07-18 | 2012-04-17 | Silk Road Medical, Inc. | Methods and systems for establishing retrograde carotid arterial blood flow |
| WO2009105135A1 (en) | 2008-02-19 | 2009-08-27 | Celladon Corporation | Compositions for enhanced uptake of viral vectors in the myocardium |
| US20130096500A1 (en) * | 2011-07-07 | 2013-04-18 | Gabor Rubanyi | Nucleic acid based cardiovascular therapeutics |
| US20140296769A1 (en) * | 2013-03-28 | 2014-10-02 | Silk Road Medical, Inc. | Methods and Systems for Establishing Retrograde Carotid Arterial Blood Flow |
| WO2019089385A1 (en) | 2017-11-02 | 2019-05-09 | Silk Road Medical, Inc. | Fenestrated sheath for embolic protection during transcarotid carotid artery revascularization |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA001616B1 (ru) * | 1995-02-28 | 2001-06-25 | Зе Риджентс Оф Зи Юнивесити Оф Кэлифоньэ | Способ лечения болезни сердца, способ лечения недостаточности периферических сосудов и способ ограничения доставки и экспрессии трансгенной конструкции в определенном органе или структуре |
| US5869230A (en) * | 1995-03-30 | 1999-02-09 | Beth Israel Hospital Association | Gene transfer into the kidney |
| WO1999017807A1 (en) * | 1997-10-08 | 1999-04-15 | Cobra Therapeutics Ltd. | Use of a vasoactive compound in the enhancement of gene delivery |
| US6376471B1 (en) * | 1997-10-10 | 2002-04-23 | Johns Hopkins University | Gene delivery compositions and methods |
-
1999
- 1999-02-09 JP JP2000531196A patent/JP2002502885A/ja active Pending
- 1999-02-09 EP EP05026675A patent/EP1695719A1/en not_active Withdrawn
- 1999-02-09 CA CA002320302A patent/CA2320302A1/en not_active Abandoned
- 1999-02-09 AU AU26637/99A patent/AU2663799A/en not_active Abandoned
- 1999-02-09 CN CNA2007101808364A patent/CN101186928A/zh active Pending
- 1999-02-09 EP EP99906814A patent/EP1053025A2/en not_active Withdrawn
- 1999-02-09 KR KR1020007008781A patent/KR20010015915A/ko not_active Ceased
- 1999-02-09 EA EA200000828A patent/EA019099B1/ru not_active IP Right Cessation
- 1999-02-09 IL IL13776599A patent/IL137765A0/xx unknown
- 1999-02-09 CN CNB998049425A patent/CN100350979C/zh not_active Expired - Fee Related
- 1999-02-09 WO PCT/US1999/002702 patent/WO1999040945A2/en not_active Ceased
- 1999-02-09 NZ NZ545047A patent/NZ545047A/en not_active IP Right Cessation
- 1999-02-11 ZA ZA9901102A patent/ZA991102B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1301181A (zh) | 2001-06-27 |
| ZA991102B (en) | 2000-03-31 |
| JP2002502885A (ja) | 2002-01-29 |
| EA200000828A1 (ru) | 2001-02-26 |
| WO1999040945A3 (en) | 1999-09-30 |
| AU2663799A (en) | 1999-08-30 |
| CN101186928A (zh) | 2008-05-28 |
| EP1695719A1 (en) | 2006-08-30 |
| CN100350979C (zh) | 2007-11-28 |
| IL137765A0 (en) | 2001-10-31 |
| KR20010015915A (ko) | 2001-02-26 |
| EA019099B1 (ru) | 2014-01-30 |
| WO1999040945A2 (en) | 1999-08-19 |
| CA2320302A1 (en) | 1999-08-19 |
| EP1053025A2 (en) | 2000-11-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| EXPY | Patent expired |