CN101186928A - 核酸和血管活性剂相组合用于加强的基因投递 - Google Patents

核酸和血管活性剂相组合用于加强的基因投递 Download PDF

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Publication number
CN101186928A
CN101186928A CNA2007101808364A CN200710180836A CN101186928A CN 101186928 A CN101186928 A CN 101186928A CN A2007101808364 A CNA2007101808364 A CN A2007101808364A CN 200710180836 A CN200710180836 A CN 200710180836A CN 101186928 A CN101186928 A CN 101186928A
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China
Prior art keywords
vector
injection
histamine
fgf
artery
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Pending
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CNA2007101808364A
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English (en)
Chinese (zh)
Inventor
H·K·哈蒙德
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University of California San Diego UCSD
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University of California San Diego UCSD
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Publication date
Application filed by University of California San Diego UCSD filed Critical University of California San Diego UCSD
Publication of CN101186928A publication Critical patent/CN101186928A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0083—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the administration regime
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Paints Or Removers (AREA)
CNA2007101808364A 1998-02-11 1999-02-09 核酸和血管活性剂相组合用于加强的基因投递 Pending CN101186928A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2177398A 1998-02-11 1998-02-11
US09/021,773 1998-02-11

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNB998049425A Division CN100350979C (zh) 1998-02-11 1999-02-09 核酸和血管活性剂相组合用于加强的基因投递

Publications (1)

Publication Number Publication Date
CN101186928A true CN101186928A (zh) 2008-05-28

Family

ID=21806073

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA2007101808364A Pending CN101186928A (zh) 1998-02-11 1999-02-09 核酸和血管活性剂相组合用于加强的基因投递
CNB998049425A Expired - Fee Related CN100350979C (zh) 1998-02-11 1999-02-09 核酸和血管活性剂相组合用于加强的基因投递

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNB998049425A Expired - Fee Related CN100350979C (zh) 1998-02-11 1999-02-09 核酸和血管活性剂相组合用于加强的基因投递

Country Status (11)

Country Link
EP (2) EP1695719A1 (https=)
JP (1) JP2002502885A (https=)
KR (1) KR20010015915A (https=)
CN (2) CN101186928A (https=)
AU (1) AU2663799A (https=)
CA (1) CA2320302A1 (https=)
EA (1) EA019099B1 (https=)
IL (1) IL137765A0 (https=)
NZ (1) NZ545047A (https=)
WO (1) WO1999040945A2 (https=)
ZA (1) ZA991102B (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001034208A1 (en) * 1999-11-05 2001-05-17 The Regents Of The University Of California Techniques and compositions for treating cardiovascular disease by in vivo gene delivery
US6752987B1 (en) 1995-02-28 2004-06-22 The Regents Of The University Of California Adenovirus encoding human adenylylcyclase (AC) VI
WO2000024415A2 (en) 1998-10-28 2000-05-04 Cornell Research Foundation, Inc. Methods for regulating angiogenesis and vascular integrity using trk receptor ligands
EP1255822A2 (en) 1999-12-27 2002-11-13 The Regents Of The University Of California Modified adenylylcyclase type vi useful in gene therapy for congestive heart failure
WO2002002148A2 (en) * 2000-06-30 2002-01-10 Collateral Therapeutics, Inc. Dual recombinant gene therapy compositions and methods of use
JP2005052001A (ja) * 2001-07-05 2005-03-03 Takara Bio Inc 遺伝子治療剤
DE602006017071D1 (de) 2005-01-25 2010-11-04 Five Prime Therapeutics Inc Zusammensetzungen und verfahren zur behandlung von herzkrankheiten
GB2437893A (en) * 2006-07-25 2007-11-07 Celladon Corp Extended antegrade epicardial coronary infusion of adeno-associated viral vectors for gene therapy
US8157760B2 (en) 2007-07-18 2012-04-17 Silk Road Medical, Inc. Methods and systems for establishing retrograde carotid arterial blood flow
WO2009105135A1 (en) 2008-02-19 2009-08-27 Celladon Corporation Compositions for enhanced uptake of viral vectors in the myocardium
US20130096500A1 (en) * 2011-07-07 2013-04-18 Gabor Rubanyi Nucleic acid based cardiovascular therapeutics
US20140296769A1 (en) * 2013-03-28 2014-10-02 Silk Road Medical, Inc. Methods and Systems for Establishing Retrograde Carotid Arterial Blood Flow
WO2019089385A1 (en) 2017-11-02 2019-05-09 Silk Road Medical, Inc. Fenestrated sheath for embolic protection during transcarotid carotid artery revascularization

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA001616B1 (ru) * 1995-02-28 2001-06-25 Зе Риджентс Оф Зи Юнивесити Оф Кэлифоньэ Способ лечения болезни сердца, способ лечения недостаточности периферических сосудов и способ ограничения доставки и экспрессии трансгенной конструкции в определенном органе или структуре
US5869230A (en) * 1995-03-30 1999-02-09 Beth Israel Hospital Association Gene transfer into the kidney
WO1999017807A1 (en) * 1997-10-08 1999-04-15 Cobra Therapeutics Ltd. Use of a vasoactive compound in the enhancement of gene delivery
US6376471B1 (en) * 1997-10-10 2002-04-23 Johns Hopkins University Gene delivery compositions and methods

Also Published As

Publication number Publication date
CN1301181A (zh) 2001-06-27
ZA991102B (en) 2000-03-31
JP2002502885A (ja) 2002-01-29
EA200000828A1 (ru) 2001-02-26
WO1999040945A3 (en) 1999-09-30
AU2663799A (en) 1999-08-30
NZ545047A (en) 2009-05-31
EP1695719A1 (en) 2006-08-30
CN100350979C (zh) 2007-11-28
IL137765A0 (en) 2001-10-31
KR20010015915A (ko) 2001-02-26
EA019099B1 (ru) 2014-01-30
WO1999040945A2 (en) 1999-08-19
CA2320302A1 (en) 1999-08-19
EP1053025A2 (en) 2000-11-22

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PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20080528