NZ536061A - Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereof - Google Patents
Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereofInfo
- Publication number
- NZ536061A NZ536061A NZ536061A NZ53606103A NZ536061A NZ 536061 A NZ536061 A NZ 536061A NZ 536061 A NZ536061 A NZ 536061A NZ 53606103 A NZ53606103 A NZ 53606103A NZ 536061 A NZ536061 A NZ 536061A
- Authority
- NZ
- New Zealand
- Prior art keywords
- chloro
- oxo
- ethyl
- dihydroquinoline
- carboxylic acid
- Prior art date
Links
- -1 quinolone carboxylic acids Chemical class 0.000 title claims abstract description 61
- 230000009471 action Effects 0.000 title claims description 13
- 150000001875 compounds Chemical class 0.000 claims abstract description 117
- 150000003839 salts Chemical class 0.000 claims abstract description 66
- 239000003814 drug Substances 0.000 claims abstract description 48
- 238000004519 manufacturing process Methods 0.000 claims abstract description 37
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 21
- 208000035475 disorder Diseases 0.000 claims abstract description 20
- 239000012453 solvate Substances 0.000 claims abstract description 20
- 208000002193 Pain Diseases 0.000 claims abstract description 15
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims abstract description 8
- 206010022437 insomnia Diseases 0.000 claims abstract description 8
- 208000000094 Chronic Pain Diseases 0.000 claims abstract description 7
- 206010015037 epilepsy Diseases 0.000 claims abstract description 7
- 229910052739 hydrogen Inorganic materials 0.000 claims description 82
- 239000001257 hydrogen Substances 0.000 claims description 82
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 67
- DTYLXDLAOLOTKT-UHFFFAOYSA-N 1,4-dihydroquinoline-3-carboxylic acid Chemical compound C1=CC=C2CC(C(=O)O)=CNC2=C1 DTYLXDLAOLOTKT-UHFFFAOYSA-N 0.000 claims description 51
- 150000002431 hydrogen Chemical group 0.000 claims description 42
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 34
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 30
- 125000000217 alkyl group Chemical group 0.000 claims description 29
- 229910052757 nitrogen Inorganic materials 0.000 claims description 24
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 23
- 125000000623 heterocyclic group Chemical group 0.000 claims description 21
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 20
- 229910052736 halogen Inorganic materials 0.000 claims description 15
- 150000002367 halogens Chemical class 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 15
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- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 10
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 10
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- 125000003118 aryl group Chemical group 0.000 claims description 6
- NDCFBPDNHOZORS-UHFFFAOYSA-N 1,2-dihydroquinoline-3-carboxylic acid Chemical compound C1=CC=C2NCC(C(=O)O)=CC2=C1 NDCFBPDNHOZORS-UHFFFAOYSA-N 0.000 claims description 5
- 208000024827 Alzheimer disease Diseases 0.000 claims description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
- 125000002757 morpholinyl group Chemical group 0.000 claims description 5
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 5
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- FLFWQGUPVISINQ-UHFFFAOYSA-N 6-(1-amino-2,3-dihydroinden-1-yl)-7-chloro-1-ethyl-4-oxoquinoline-3-carboxylic acid Chemical compound C1CC2=CC=CC=C2C1(N)C1=C(Cl)C=C2N(CC)C=C(C(O)=O)C(=O)C2=C1 FLFWQGUPVISINQ-UHFFFAOYSA-N 0.000 claims description 3
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- XBZSEQLJUKDRIJ-UHFFFAOYSA-N 7-chloro-1-ethyl-4-oxo-6-(4-phenylbutylamino)quinoline-3-carboxylic acid Chemical compound ClC=1C=C2N(CC)C=C(C(O)=O)C(=O)C2=CC=1NCCCCC1=CC=CC=C1 XBZSEQLJUKDRIJ-UHFFFAOYSA-N 0.000 claims description 2
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- 150000007942 carboxylates Chemical class 0.000 claims description 2
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- 150000001735 carboxylic acids Chemical class 0.000 claims 9
- IQHSSYROJYPFDV-UHFFFAOYSA-N 2-bromo-1,3-dichloro-5-(trifluoromethyl)benzene Chemical group FC(F)(F)C1=CC(Cl)=C(Br)C(Cl)=C1 IQHSSYROJYPFDV-UHFFFAOYSA-N 0.000 claims 3
- DSGIFDNRYKUMIS-UHFFFAOYSA-N 6-(2-amino-2,3-dihydro-1h-inden-1-yl)-7-chloro-1-ethyl-4-oxoquinoline-3-carboxylic acid Chemical compound NC1CC2=CC=CC=C2C1C1=C(Cl)C=C2N(CC)C=C(C(O)=O)C(=O)C2=C1 DSGIFDNRYKUMIS-UHFFFAOYSA-N 0.000 claims 1
- NLTJREJJMULMPU-UHFFFAOYSA-N 7-chloro-1-ethyl-4-oxo-6-(3-phenylpropylamino)quinoline-3-carboxylic acid Chemical compound ClC=1C=C2N(CC)C=C(C(O)=O)C(=O)C2=CC=1NCCCC1=CC=CC=C1 NLTJREJJMULMPU-UHFFFAOYSA-N 0.000 claims 1
- CGZFHTHUVLPESP-UHFFFAOYSA-N 7-chloro-6-[2-(4-chlorophenyl)ethylamino]-1-ethyl-4-oxoquinoline-3-carboxylic acid Chemical compound ClC=1C=C2N(CC)C=C(C(O)=O)C(=O)C2=CC=1NCCC1=CC=C(Cl)C=C1 CGZFHTHUVLPESP-UHFFFAOYSA-N 0.000 claims 1
- 230000027455 binding Effects 0.000 description 33
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- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38064102P | 2002-05-14 | 2002-05-14 | |
| PCT/US2003/014948 WO2003097564A2 (en) | 2002-05-14 | 2003-05-12 | Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ536061A true NZ536061A (en) | 2008-09-26 |
Family
ID=29549994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ536061A NZ536061A (en) | 2002-05-14 | 2003-05-12 | Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereof |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US7355047B2 (enExample) |
| EP (1) | EP1503759B1 (enExample) |
| JP (1) | JP4532263B2 (enExample) |
| KR (1) | KR20040107525A (enExample) |
| CN (1) | CN1652784A (enExample) |
| AT (1) | ATE417613T1 (enExample) |
| AU (1) | AU2003229043B2 (enExample) |
| BR (1) | BR0309965A (enExample) |
| CA (1) | CA2484308A1 (enExample) |
| DE (1) | DE60325347D1 (enExample) |
| DK (1) | DK1503759T3 (enExample) |
| ES (1) | ES2319176T3 (enExample) |
| IL (1) | IL164734A0 (enExample) |
| MX (1) | MXPA04011156A (enExample) |
| NZ (1) | NZ536061A (enExample) |
| WO (1) | WO2003097564A2 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1503759B1 (en) * | 2002-05-14 | 2008-12-17 | The Regents Of The University Of California | Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereof |
| DE102004004971B3 (de) * | 2004-01-31 | 2005-09-15 | Aventis Pharma Deutschland Gmbh | Cycloalkyl substituierte 7-Amino-4-chinolon-3-carbonsäure-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arnzeimittel |
| US7470706B2 (en) | 2004-01-31 | 2008-12-30 | Sanofi-Aventis Deutschland Gmbh | Cycloalkyl-substituted 7-amino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments |
| US7825278B2 (en) * | 2004-05-06 | 2010-11-02 | The Regents Of The University Of California | Substituted enaminones, their derivatives and uses thereof |
| CA2881078C (en) | 2004-06-24 | 2018-10-02 | Vertex Pharmaceuticals Incorporated | Modulators of atp-binding cassette transporters |
| US8354427B2 (en) * | 2004-06-24 | 2013-01-15 | Vertex Pharmaceutical Incorporated | Modulators of ATP-binding cassette transporters |
| JP4796622B2 (ja) * | 2005-04-11 | 2011-10-19 | エフ．ホフマン−ラ ロシュ アーゲー | （３，４−ジヒドロ−キナゾリン−２−イル）−インダン−１−イル−アミン |
| JP4796624B2 (ja) * | 2005-05-04 | 2011-10-19 | エフ．ホフマン−ラ ロシュ アーゲー | ５−ｈｔ受容体に作用する（３，４−ジヒドロ−キナゾリン−２−イル）−（２−アリールオキシ−エチル）−アミン類 |
| WO2007067489A1 (en) * | 2005-12-05 | 2007-06-14 | Merck & Co., Inc. | Quinolone m1 receptor positive allosteric modulators |
| WO2007075901A2 (en) * | 2005-12-24 | 2007-07-05 | Vertex Pharmaceuticals Incorporated | Quinolin- 4 - one derivatives as modulators of abc transporters |
| LT1993360T (lt) | 2005-12-28 | 2017-06-12 | Vertex Pharmaceuticals Incorporated | N-[2,4-bis(1,1-dimetiletil)-5-hidroksifenil]-1,4-dihidro-4-oksochinolin-3-karboksamido kieta forma |
| AU2007225088B2 (en) * | 2006-03-13 | 2012-09-13 | Kyorin Pharmaceutical Co., Ltd | Aminoquinolones as GSK-3 inhibitors |
| EP1886996A1 (en) * | 2006-08-10 | 2008-02-13 | Ferrer Internacional, S.A. | 1H-Quinolin-4-one compounds, with affinity for the GABA receptor, processes, uses and compositions |
| JP2010500330A (ja) * | 2006-08-10 | 2010-01-07 | フエルレル インターナショナル，ソシエダッド アノニマ | Ｇａｂａａ受容体に対して親和性を有する１ｈ−キノリン−４−オン化合物、方法、使用及び組成物 |
| SI2074123T1 (sl) | 2006-10-16 | 2013-03-29 | Bionomics Limited | Nove anksiolitične spojine |
| US10954231B2 (en) | 2006-10-16 | 2021-03-23 | Bionomics Limited | Anxiolytic compounds |
| WO2009040377A2 (en) * | 2007-09-27 | 2009-04-02 | Ge Healthcare Limited | Imaging agents |
| US20100074949A1 (en) | 2008-08-13 | 2010-03-25 | William Rowe | Pharmaceutical composition and administration thereof |
| US12458635B2 (en) | 2008-08-13 | 2025-11-04 | Vertex Pharmaceuticals Incorporated | Pharmaceutical composition and administrations thereof |
| JP2012506857A (ja) * | 2008-10-23 | 2012-03-22 | メルク・シャープ・エンド・ドーム・コーポレイション | 縮合複素環式ｍ１受容体ポジティブアロステリック調節因子 |
| SI3330255T1 (sl) | 2009-03-20 | 2021-03-31 | Vertex Pharmaceuticals Incorporated | Postopek izdelave regulatorja transmembranske prevodnosti pri cistični fibrozi |
| US20120093917A1 (en) * | 2009-04-02 | 2012-04-19 | Robert Hromas | Metnase and intnase inhibitors and their use in treating cancer |
| US8802700B2 (en) | 2010-12-10 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-Binding Cassette transporters |
| EP2680842A4 (en) * | 2011-03-02 | 2014-10-29 | Bionomics Ltd | METHOD FOR THE TREATMENT OF A DISEASE OR A SENSE OF THE CENTRAL NERVOUS SYSTEM |
| WO2012116415A1 (en) | 2011-03-02 | 2012-09-07 | Bionomics Limited | Novel small-molecules as therapeutics |
| CN103649086A (zh) | 2011-05-12 | 2014-03-19 | 生态学有限公司 | 制备萘啶的方法 |
| EP2819670B1 (en) | 2012-02-27 | 2026-05-20 | Vertex Pharmaceuticals Incorporated | Pharmaceutical Composition and Their Administration |
| CA2963945C (en) | 2014-10-07 | 2023-01-10 | Vertex Pharmaceuticals Incorporated | Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator |
| CN107501107A (zh) * | 2017-09-26 | 2017-12-22 | 兰亚朝 | 喹诺酮药物的中间体合成方法 |
| CN111269131B (zh) * | 2020-03-12 | 2021-12-28 | 江苏飞宇医药科技股份有限公司 | 以三正丙胺为吸酸剂制备环丙乙酯胺化物的工艺 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1433774A (en) * | 1973-02-26 | 1976-04-28 | Allen & Hanburys Ltd | Heterocyclic compounds apparatus for conveying articles |
| JPS5715760B2 (enExample) * | 1974-06-11 | 1982-04-01 | ||
| US4390541A (en) * | 1980-12-19 | 1983-06-28 | Lilly Industries Limited | Quinolone derivatives and their use in a method of controlling an immediate hypersensitivity disease |
| US6248739B1 (en) * | 1999-01-08 | 2001-06-19 | Pharmacia & Upjohn Company | Quinolinecarboxamides as antiviral agents |
| MXPA01011173A (es) * | 1999-05-06 | 2002-04-24 | Neurogen Corp | 4-0x0-quinolin-3-carboxamidas sustituidas: ligandos del receptor cerebro de gaba. |
| GB0127349D0 (en) * | 2001-11-14 | 2002-01-02 | Glaxo Group Ltd | Macrolides |
| EP1503759B1 (en) * | 2002-05-14 | 2008-12-17 | The Regents Of The University Of California | Substituted quinolone carboxylic acids, their derivatives, site of action, and uses thereof |
-
2003
- 2003-05-12 EP EP03726824A patent/EP1503759B1/en not_active Expired - Lifetime
- 2003-05-12 WO PCT/US2003/014948 patent/WO2003097564A2/en not_active Ceased
- 2003-05-12 MX MXPA04011156A patent/MXPA04011156A/es active IP Right Grant
- 2003-05-12 DE DE60325347T patent/DE60325347D1/de not_active Expired - Lifetime
- 2003-05-12 ES ES03726824T patent/ES2319176T3/es not_active Expired - Lifetime
- 2003-05-12 JP JP2004505299A patent/JP4532263B2/ja not_active Expired - Fee Related
- 2003-05-12 US US10/514,808 patent/US7355047B2/en not_active Expired - Fee Related
- 2003-05-12 BR BR0309965-2A patent/BR0309965A/pt not_active IP Right Cessation
- 2003-05-12 AU AU2003229043A patent/AU2003229043B2/en not_active Ceased
- 2003-05-12 NZ NZ536061A patent/NZ536061A/en unknown
- 2003-05-12 CA CA002484308A patent/CA2484308A1/en not_active Abandoned
- 2003-05-12 KR KR10-2004-7018340A patent/KR20040107525A/ko not_active Ceased
- 2003-05-12 CN CNA03810816XA patent/CN1652784A/zh active Pending
- 2003-05-12 AT AT03726824T patent/ATE417613T1/de not_active IP Right Cessation
- 2003-05-12 DK DK03726824T patent/DK1503759T3/da active
-
2004
- 2004-10-20 IL IL16473404A patent/IL164734A0/xx unknown
-
2008
- 2008-02-15 US US12/032,403 patent/US20080176897A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1503759A4 (en) | 2006-02-15 |
| ES2319176T3 (es) | 2009-05-05 |
| AU2003229043B2 (en) | 2008-12-04 |
| JP4532263B2 (ja) | 2010-08-25 |
| MXPA04011156A (es) | 2005-02-17 |
| EP1503759A2 (en) | 2005-02-09 |
| DK1503759T3 (da) | 2009-04-14 |
| IL164734A0 (en) | 2005-12-18 |
| WO2003097564A3 (en) | 2004-02-26 |
| JP2005535592A (ja) | 2005-11-24 |
| DE60325347D1 (de) | 2009-01-29 |
| CA2484308A1 (en) | 2003-11-27 |
| AU2003229043A1 (en) | 2003-12-02 |
| US20060178516A1 (en) | 2006-08-10 |
| US20080176897A1 (en) | 2008-07-24 |
| HK1072905A1 (en) | 2005-09-16 |
| CN1652784A (zh) | 2005-08-10 |
| WO2003097564A2 (en) | 2003-11-27 |
| US7355047B2 (en) | 2008-04-08 |
| ATE417613T1 (de) | 2009-01-15 |
| EP1503759B1 (en) | 2008-12-17 |
| BR0309965A (pt) | 2005-03-01 |
| KR20040107525A (ko) | 2004-12-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) |