NZ533987A - Uses of mammalian cytokine; agonists and antagonists for modulating antigen presenting cell priming of T cells - Google Patents

Info

Publication number

NZ533987A

NZ533987A NZ533987A NZ53398703A NZ533987A NZ 533987 A NZ533987 A NZ 533987A NZ 533987 A NZ533987 A NZ 533987A NZ 53398703 A NZ53398703 A NZ 53398703A NZ 533987 A NZ533987 A NZ 533987A

Authority

NZ

New Zealand

Prior art keywords

leu

ser

val

thr

glu

Prior art date

2002-02-01

Links

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• 210000001744 T-lymphocyte Anatomy 0.000 title claims abstract description 134
• 239000000556 agonist Substances 0.000 title claims abstract description 40
• 210000000612 antigen-presenting cell Anatomy 0.000 title claims abstract description 38
• 239000005557 antagonist Substances 0.000 title claims abstract description 30
• 230000037452 priming Effects 0.000 title claims abstract description 12
• 102000004127 Cytokines Human genes 0.000 title claims description 64
• 108090000695 Cytokines Proteins 0.000 title claims description 64
• 101000845170 Homo sapiens Thymic stromal lymphopoietin Proteins 0.000 claims abstract description 156
• 102100031294 Thymic stromal lymphopoietin Human genes 0.000 claims abstract description 152
• 210000004443 dendritic cell Anatomy 0.000 claims abstract description 128
• 238000000034 method Methods 0.000 claims abstract description 41
• 239000003814 drug Substances 0.000 claims abstract description 24
• 230000000735 allogeneic effect Effects 0.000 claims abstract description 18
• 208000026278 immune system disease Diseases 0.000 claims abstract description 14
• 210000004027 cell Anatomy 0.000 claims description 71
• 108090000978 Interleukin-4 Proteins 0.000 claims description 32
• 102000003816 Interleukin-13 Human genes 0.000 claims description 30
• 108090000176 Interleukin-13 Proteins 0.000 claims description 30
• 238000011282 treatment Methods 0.000 claims description 26
• 108010002616 Interleukin-5 Proteins 0.000 claims description 23
• 230000035755 proliferation Effects 0.000 claims description 23
• 241000282414 Homo sapiens Species 0.000 claims description 21
• 239000012634 fragment Substances 0.000 claims description 19
• 230000004044 response Effects 0.000 claims description 16
• 208000006673 asthma Diseases 0.000 claims description 15
• 230000003993 interaction Effects 0.000 claims description 13
• 238000004519 manufacturing process Methods 0.000 claims description 12
• 210000003071 memory t lymphocyte Anatomy 0.000 claims description 11
• 238000002360 preparation method Methods 0.000 claims description 11
• 201000004681 Psoriasis Diseases 0.000 claims description 9
• 239000012636 effector Substances 0.000 claims description 9
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 9
• 208000027866 inflammatory disease Diseases 0.000 claims description 8
• 239000003153 chemical reaction reagent Substances 0.000 claims description 7
• 230000001684 chronic effect Effects 0.000 claims description 6
• 208000036142 Viral infection Diseases 0.000 claims description 5
• 230000000890 antigenic effect Effects 0.000 claims description 5
• 230000002685 pulmonary effect Effects 0.000 claims description 5
• 206010061598 Immunodeficiency Diseases 0.000 claims description 4
• 208000029462 Immunodeficiency disease Diseases 0.000 claims description 4
• 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims description 4
• 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims description 4
• 230000007813 immunodeficiency Effects 0.000 claims description 4
• 230000001939 inductive effect Effects 0.000 claims description 4
• 230000004968 inflammatory condition Effects 0.000 claims description 4
• 230000009385 viral infection Effects 0.000 claims description 4
• 206010062016 Immunosuppression Diseases 0.000 claims description 3
• 208000019693 Lung disease Diseases 0.000 claims description 3
• 201000001263 Psoriatic Arthritis Diseases 0.000 claims description 3
• 208000036824 Psoriatic arthropathy Diseases 0.000 claims description 3
• 230000001506 immunosuppresive effect Effects 0.000 claims description 3
• 230000028709 inflammatory response Effects 0.000 claims description 3
• 230000000414 obstructive effect Effects 0.000 claims description 3
• 108010062796 arginyllysine Proteins 0.000 claims 3
• 108010050848 glycylleucine Proteins 0.000 claims 3
• 108010051242 phenylalanylserine Proteins 0.000 claims 3
• 108010026333 seryl-proline Proteins 0.000 claims 3
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• MUJQWSAWLLRJCE-KATARQTJSA-N Ser-Leu-Thr Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(O)=O MUJQWSAWLLRJCE-KATARQTJSA-N 0.000 claims 2
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• 108010012581 phenylalanylglutamate Proteins 0.000 claims 2
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• HXNNRBHASOSVPG-GUBZILKMSA-N Ala-Glu-Leu Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(O)=O HXNNRBHASOSVPG-GUBZILKMSA-N 0.000 claims 1
• HMRWQTHUDVXMGH-GUBZILKMSA-N Ala-Glu-Lys Chemical compound C[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H](C(O)=O)CCCCN HMRWQTHUDVXMGH-GUBZILKMSA-N 0.000 claims 1
• PUBLUECXJRHTBK-ACZMJKKPSA-N Ala-Glu-Ser Chemical compound C[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(O)=O PUBLUECXJRHTBK-ACZMJKKPSA-N 0.000 claims 1
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• DWYROCSXOOMOEU-CIUDSAMLSA-N Ala-Met-Glu Chemical compound C[C@@H](C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)O)C(=O)O)N DWYROCSXOOMOEU-CIUDSAMLSA-N 0.000 claims 1
• GKAZXNDATBWNBI-DCAQKATOSA-N Ala-Met-Lys Chemical compound C[C@@H](C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)O)N GKAZXNDATBWNBI-DCAQKATOSA-N 0.000 claims 1
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• NGYHSXDNNOFHNE-AVGNSLFASA-N Arg-Pro-Leu Chemical compound [H]N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(O)=O NGYHSXDNNOFHNE-AVGNSLFASA-N 0.000 claims 1
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• XEDQMTWEYFBOIK-ACZMJKKPSA-N Asp-Ala-Glu Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(O)=O XEDQMTWEYFBOIK-ACZMJKKPSA-N 0.000 claims 1
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• VZNOVQKGJQJOCS-SRVKXCTJSA-N Asp-Asp-Tyr Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O VZNOVQKGJQJOCS-SRVKXCTJSA-N 0.000 claims 1
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• NDUSUIGBMZCOIL-ZKWXMUAHSA-N Cys-Asn-Val Chemical compound CC(C)[C@@H](C(=O)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CS)N NDUSUIGBMZCOIL-ZKWXMUAHSA-N 0.000 claims 1
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