NZ531814A - Vaccines - Google Patents
VaccinesInfo
- Publication number
- NZ531814A NZ531814A NZ531814A NZ53181402A NZ531814A NZ 531814 A NZ531814 A NZ 531814A NZ 531814 A NZ531814 A NZ 531814A NZ 53181402 A NZ53181402 A NZ 53181402A NZ 531814 A NZ531814 A NZ 531814A
- Authority
- NZ
- New Zealand
- Prior art keywords
- gag
- nucleotide sequence
- nef
- protein
- gene
- Prior art date
Links
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Classifications
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A—HUMAN NECESSITIES
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
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- A—HUMAN NECESSITIES
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- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
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- C12N2740/16011—Human Immunodeficiency Virus, HIV
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- C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
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- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
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- C12N2740/16334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
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- Mycology (AREA)
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- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/GB2001/004207 WO2002024225A1 (en) | 2000-09-20 | 2001-09-20 | Use of immidazoquinolinamines as adjuvants in dna vaccination |
| GB0129604A GB0129604D0 (en) | 2001-12-11 | 2001-12-11 | Novel compounds |
| GB0206462A GB0206462D0 (en) | 2002-03-19 | 2002-03-19 | Vaccines |
| PCT/EP2002/010592 WO2003025003A2 (en) | 2001-09-20 | 2002-09-18 | Hiv-gag codon-optimised dna vaccines |
Publications (1)
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|---|---|
| NZ531814A true NZ531814A (en) | 2005-10-28 |
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| NZ531814A NZ531814A (en) | 2001-09-20 | 2002-09-18 | Vaccines |
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| EP (2) | EP1427826B1 (enExample) |
| JP (1) | JP4601956B2 (enExample) |
| CN (1) | CN100392085C (enExample) |
| AR (1) | AR036566A1 (enExample) |
| AU (1) | AU2002362368B2 (enExample) |
| BR (1) | BR0212619A (enExample) |
| CA (1) | CA2461056A1 (enExample) |
| CO (1) | CO5560591A2 (enExample) |
| HU (1) | HUP0402259A3 (enExample) |
| IL (1) | IL160809A0 (enExample) |
| MX (1) | MXPA04002631A (enExample) |
| NO (1) | NO331826B1 (enExample) |
| NZ (1) | NZ531814A (enExample) |
| PL (1) | PL207168B1 (enExample) |
| WO (1) | WO2003025003A2 (enExample) |
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| EP1487486B1 (en) * | 2002-03-19 | 2009-01-14 | PowderJect Research Limited | Imidazoquinolineamines as adjuvants in hiv dna vaccination |
| GB0225788D0 (en) | 2002-11-05 | 2002-12-11 | Glaxo Group Ltd | Vaccine |
| US8080642B2 (en) | 2003-05-16 | 2011-12-20 | Vical Incorporated | Severe acute respiratory syndrome DNA compositions and methods of use |
| GB2406336A (en) * | 2003-09-24 | 2005-03-30 | Oxxon Pharmaccines Ltd | HIV Pharmaccines |
| GB0417494D0 (en) * | 2004-08-05 | 2004-09-08 | Glaxosmithkline Biolog Sa | Vaccine |
| DE102004049223A1 (de) * | 2004-10-08 | 2006-04-20 | Johannes-Gutenberg-Universität Mainz | Zubereitung zum Impfen, Impfverfahren und Verwendung einer Impf-Zubereitung |
| AU2012201827B2 (en) * | 2005-05-12 | 2014-09-04 | Glaxo Group Limited | Vaccine composition |
| CA2608316A1 (en) * | 2005-05-12 | 2006-11-16 | Glaxo Group Limited | Vaccine composition |
| WO2008133663A2 (en) * | 2006-11-30 | 2008-11-06 | Government Of The United States Of America, As Represented By The Secretary, | Codon modified immunogenic compositions and methods of use |
| GB0700914D0 (en) * | 2007-01-18 | 2007-02-28 | Animal Health Inst | Polynucleotides and uses thereof |
| HUE031411T2 (en) | 2007-03-02 | 2017-07-28 | Glaxosmithkline Biologicals Sa | New Methods and Preparations |
| US20090035360A1 (en) | 2007-05-24 | 2009-02-05 | Dominique Ingrid Lemoine | Lyophilised antigen composition |
| WO2009092113A2 (en) * | 2008-01-19 | 2009-07-23 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods and compositions for the delivery of vaccines to disrupted epithelium |
| EP2485759A4 (en) * | 2009-10-09 | 2013-07-24 | Univ New York | METHOD, AGENTS AND PEPTIDES FOR GENERATING A BORN IMMUNE RESPONSE IN HIV VACCINATION |
| BRPI0914507A2 (pt) * | 2009-12-23 | 2012-04-10 | Fundacao Oswaldo Cruz | vacina para lentivìrus baseada em vìrus recombinante vacinal da febre amarela |
| CA2793959C (en) | 2010-03-25 | 2019-06-04 | Oregon Health & Science University | Cmv glycoproteins and recombinant vectors |
| TR201802741T4 (tr) | 2010-05-14 | 2018-03-21 | Univ Oregon Health & Science | Rekombinant hcmv ve rhcmv vektörleri ve bunların kullanımları. |
| GB201022007D0 (en) | 2010-12-24 | 2011-02-02 | Imp Innovations Ltd | DNA-sensor |
| PT2691530T (pt) | 2011-06-10 | 2018-05-10 | Univ Oregon Health & Science | Glicoproteínas e vectores recombinantes cmv |
| EP2620446A1 (en) | 2012-01-27 | 2013-07-31 | Laboratorios Del Dr. Esteve, S.A. | Immunogens for HIV vaccination |
| AU2014225886B2 (en) | 2013-03-05 | 2020-04-16 | Oregon Health & Science University | Cytomegalovirus vectors enabling control of T cell targeting |
| EP3083618B1 (en) | 2013-12-17 | 2018-02-21 | Pfizer Inc | Novel 3,4-disubstituted-1h-pyrrolo[2,3-b]pyridines and 4,5-disubstituted-7h-pyrrolo[2,3-c]pyridazines as lrrk2 inhibitors |
| CN113528466B (zh) | 2014-07-16 | 2024-12-24 | 俄勒冈健康与科学大学 | 包含外源抗原的人巨细胞病毒 |
| MA40783A (fr) * | 2014-10-03 | 2017-08-08 | Los Alamos Nat Security Llc | Vaccins contre le vih comprenant un ou plusieurs antigènes episensus de population |
| SG11201706454VA (en) | 2015-02-10 | 2017-09-28 | Univ Oregon Health & Science | Methods and compositions useful in generating non canonical cd8+ t cell responses |
| EP3350178B1 (en) | 2015-09-14 | 2021-10-20 | Pfizer Inc. | Novel imidazo [4,5-c]quinoline and imidazo [4,5-c][1,5]naphthyridine derivatives as lrrk2 inhibitors |
| CN108474003A (zh) | 2015-11-20 | 2018-08-31 | 俄勒冈健康与科学大学 | 包含微小rna识别元件的cmv载体 |
| BR112019007982A2 (pt) | 2016-10-18 | 2019-07-02 | Univ Oregon Health & Science | vetores de citomegalovírus elicitando células t restringidas por moléculas do complexo de histocompatibilidade e principal |
| EP4058058A1 (en) | 2019-11-14 | 2022-09-21 | Aelix Therapeutics S.L. | Dosage regimens for vaccines |
Family Cites Families (29)
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|---|---|---|---|---|
| US4436727A (en) | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
| US4866034A (en) | 1982-05-26 | 1989-09-12 | Ribi Immunochem Research Inc. | Refined detoxified endotoxin |
| US4877611A (en) | 1986-04-15 | 1989-10-31 | Ribi Immunochem Research Inc. | Vaccine containing tumor antigens and adjuvants |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| ATE162219T1 (de) | 1989-11-16 | 1998-01-15 | Univ Duke | Transformation von tierischen hautzellen mit hilfe von partikeln |
| US5697901A (en) | 1989-12-14 | 1997-12-16 | Elof Eriksson | Gene delivery by microneedle injection |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| US5583035A (en) * | 1992-12-07 | 1996-12-10 | Bayer Aktiengesellschaft | HIV antisense expression vectors |
| US5654186A (en) | 1993-02-26 | 1997-08-05 | The Picower Institute For Medical Research | Blood-borne mesenchymal cells |
| WO1995019799A1 (en) | 1994-01-21 | 1995-07-27 | Agracetus, Inc. | Gas driven gene delivery instrument |
| EP0772619B2 (en) | 1994-07-15 | 2010-12-08 | The University of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| US5786464C1 (en) * | 1994-09-19 | 2012-04-24 | Gen Hospital Corp | Overexpression of mammalian and viral proteins |
| GB9502879D0 (en) | 1995-02-14 | 1995-04-05 | Oxford Biosciences Ltd | Particle delivery |
| WO1997031115A2 (en) * | 1996-02-22 | 1997-08-28 | Merck & Co., Inc. | Synthetic hiv genes |
| US5856462A (en) | 1996-09-10 | 1999-01-05 | Hybridon Incorporated | Oligonucleotides having modified CpG dinucleosides |
| AU7332198A (en) * | 1997-03-06 | 1998-09-22 | Klaus Uberla | Lentivirus based vector and vector system |
| US5993412A (en) | 1997-05-19 | 1999-11-30 | Bioject, Inc. | Injection apparatus |
| GB9727262D0 (en) | 1997-12-24 | 1998-02-25 | Smithkline Beecham Biolog | Vaccine |
| EP1980617A1 (en) * | 1998-12-31 | 2008-10-15 | Novartis Vaccines and Diagnostics, Inc. | Improved expression of HIV polypeptides and production of virus-like particles |
| WO2000039304A2 (en) * | 1998-12-31 | 2000-07-06 | Chiron Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
| US7332588B1 (en) * | 1999-11-16 | 2008-02-19 | Geneart Ag | Genome of the HIV-1 inter-subtype (C/B) and use thereof |
| EP1242441A4 (en) * | 1999-12-17 | 2004-04-14 | Merck & Co Inc | CODON OPTIMIZED HIV-1 NEF AND MODIFIED HIV-1 NEF EXPRESSING POLYNUCLEOTID VACCINE |
| US6656706B2 (en) * | 1999-12-23 | 2003-12-02 | The United States Of America As Represented By The Department Of Health And Human Services | Molecular clones with mutated HIV gag/pol, SIV gag and SIV env genes |
| WO2001047955A2 (en) * | 1999-12-23 | 2001-07-05 | Medical Research Council | Improvements in or relating to immune responses to hiv |
| EP1156112B1 (en) * | 2000-05-18 | 2006-03-01 | Geneart GmbH | Synthetic gagpol genes and their uses |
| WO2002032943A2 (en) * | 2000-08-14 | 2002-04-25 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Modifications of hiv env, gag, and pol enhance immunogenicity for genetic immunization |
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- 2002-09-18 US US10/490,011 patent/US20070015721A1/en not_active Abandoned
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- 2002-09-18 EP EP10180900A patent/EP2322626A1/en not_active Ceased
- 2002-09-18 NZ NZ531814A patent/NZ531814A/en not_active IP Right Cessation
- 2002-09-18 IL IL16080902A patent/IL160809A0/xx unknown
- 2002-09-18 WO PCT/EP2002/010592 patent/WO2003025003A2/en not_active Ceased
- 2002-09-18 CA CA002461056A patent/CA2461056A1/en not_active Abandoned
- 2002-09-20 AR ARP020103561A patent/AR036566A1/es active IP Right Grant
-
2004
- 2004-03-17 CO CO04025208A patent/CO5560591A2/es not_active Application Discontinuation
- 2004-03-19 NO NO20041157A patent/NO331826B1/no not_active IP Right Cessation
-
2008
- 2008-01-17 US US12/015,756 patent/US20090203144A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0402259A2 (hu) | 2005-01-28 |
| PL207168B1 (pl) | 2010-11-30 |
| JP4601956B2 (ja) | 2010-12-22 |
| EP1427826B1 (en) | 2011-04-20 |
| CN100392085C (zh) | 2008-06-04 |
| AU2002362368B2 (en) | 2006-09-21 |
| WO2003025003A3 (en) | 2003-12-04 |
| IL160809A0 (en) | 2004-08-31 |
| HUP0402259A3 (en) | 2010-01-28 |
| US20070015721A1 (en) | 2007-01-18 |
| CN1606624A (zh) | 2005-04-13 |
| CO5560591A2 (es) | 2005-09-30 |
| MXPA04002631A (es) | 2004-07-08 |
| BR0212619A (pt) | 2004-08-17 |
| AR036566A1 (es) | 2004-09-15 |
| NO20041157L (no) | 2004-05-19 |
| NO331826B1 (no) | 2012-04-16 |
| WO2003025003A2 (en) | 2003-03-27 |
| EP2322626A1 (en) | 2011-05-18 |
| EP1427826A2 (en) | 2004-06-16 |
| US20090203144A1 (en) | 2009-08-13 |
| CA2461056A1 (en) | 2003-03-27 |
| PL370359A1 (en) | 2005-05-16 |
| JP2005511019A (ja) | 2005-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| LAPS | Patent lapsed |