NZ509974A - Immunological herpes simplex virus antigens and methods for use thereof - Google Patents
Immunological herpes simplex virus antigens and methods for use thereofInfo
- Publication number
- NZ509974A NZ509974A NZ509974A NZ50997499A NZ509974A NZ 509974 A NZ509974 A NZ 509974A NZ 509974 A NZ509974 A NZ 509974A NZ 50997499 A NZ50997499 A NZ 50997499A NZ 509974 A NZ509974 A NZ 509974A
- Authority
- NZ
- New Zealand
- Prior art keywords
- seq
- hsv
- amino acids
- polypeptide
- cell
- Prior art date
Links
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- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 210000005135 veiled cell Anatomy 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- MJIBOYFUEIDNPI-HBNMXAOGSA-L zinc 5-[2,3-dihydroxy-5-[(2R,3R,4S,5R,6S)-4,5,6-tris[[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyl)oxybenzoyl]oxy]-2-[[3,4-dihydroxy-5-(3,4,5-trihydroxybenzoyl)oxybenzoyl]oxymethyl]oxan-3-yl]oxycarbonylphenoxy]carbonyl-3-hydroxybenzene-1,2-diolate Chemical class [Zn++].Oc1cc(cc(O)c1O)C(=O)Oc1cc(cc(O)c1O)C(=O)OC[C@H]1O[C@@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)[C@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)[C@@H](OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)[C@@H]1OC(=O)c1cc(O)c(O)c(OC(=O)c2cc(O)c([O-])c([O-])c2)c1 MJIBOYFUEIDNPI-HBNMXAOGSA-L 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/245—Herpetoviridae, e.g. herpes simplex virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/464838—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
- C12N2710/16634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9572398P | 1998-08-07 | 1998-08-07 | |
| US9572498P | 1998-08-07 | 1998-08-07 | |
| PCT/US1999/017803 WO2000008051A2 (fr) | 1998-08-07 | 1999-08-05 | Antigenes immunologiques de l'herpes simplex virus |
Publications (1)
| Publication Number | Publication Date |
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| NZ509974A true NZ509974A (en) | 2003-10-31 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ509974A NZ509974A (en) | 1998-08-07 | 1999-08-05 | Immunological herpes simplex virus antigens and methods for use thereof |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US6375952B1 (fr) |
| EP (2) | EP1102790B1 (fr) |
| JP (1) | JP2002522451A (fr) |
| KR (1) | KR20010085348A (fr) |
| CN (1) | CN1348463A (fr) |
| AR (1) | AR020134A1 (fr) |
| AU (1) | AU5467899A (fr) |
| BR (1) | BR9912671A (fr) |
| CA (1) | CA2336523C (fr) |
| DK (1) | DK2272859T3 (fr) |
| IL (1) | IL141044A0 (fr) |
| NO (1) | NO20010576L (fr) |
| NZ (1) | NZ509974A (fr) |
| PL (1) | PL346213A1 (fr) |
| TR (1) | TR200100373T2 (fr) |
| WO (1) | WO2000008051A2 (fr) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8460674B2 (en) | 2009-02-07 | 2013-06-11 | University Of Washington | HSV-1 epitopes and methods for using same |
| US9044447B2 (en) | 2009-04-03 | 2015-06-02 | University Of Washington | Antigenic peptide of HSV-2 and methods for using same |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030185830A1 (en) * | 1997-02-25 | 2003-10-02 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US7517952B1 (en) | 1997-02-25 | 2009-04-14 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| US20060024301A1 (en) * | 1997-02-25 | 2006-02-02 | Corixa Corporation | Prostate-specific polypeptides and fusion polypeptides thereof |
| KR20010085348A (ko) * | 1998-08-07 | 2001-09-07 | 추후보정 | 면역능을 갖는 헤르페스 심플렉스 바이러스 항원 및 이를이용하는 방법 |
| AU2695101A (en) | 2000-01-21 | 2001-07-31 | Biovex Ltd | Virus strains |
| US7217770B2 (en) * | 2000-05-17 | 2007-05-15 | Samyang Corporation | Stable polymeric micelle-type drug composition and method for the preparation thereof |
| US6821519B2 (en) | 2000-06-29 | 2004-11-23 | Corixa Corporation | Compositions and methods for the diagnosis and treatment of herpes simplex virus infection |
| US7048931B1 (en) * | 2000-11-09 | 2006-05-23 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of prostate cancer |
| ATE488249T1 (de) | 2001-07-31 | 2010-12-15 | Univ Washington | Immunologisch bedeutende herpes-simplex-virus- antigene und verfahren für ihre verwendung |
| DK1523582T3 (da) | 2002-07-18 | 2009-03-02 | Univ Washington | Hurtig, effektiv rensning af HSV-specifikke T-lymfocytter samt HSV-antigener identificeret derved |
| AU2004274430A1 (en) | 2003-09-12 | 2005-03-31 | Antigenics, Inc. | Vaccine for treatment and prevention of herpes simplex virus infection |
| US7211272B2 (en) * | 2003-12-22 | 2007-05-01 | Bausch & Lomb Incorporated | Drug delivery device |
| JP5872755B2 (ja) | 2006-07-20 | 2016-03-01 | バイカル インコーポレイテッド | 抗ｈｓｖ−２ワクチン接種のための組成物および方法 |
| CA2663109A1 (fr) * | 2006-09-08 | 2008-03-13 | The Trustees Of The University Of Pennsylvania | Vaccins contre le hsv-1 et le hsv-2 et methodes d'utilisation |
| EP2185145A1 (fr) | 2007-04-04 | 2010-05-19 | Board of Trustees of the University of Arkansas | Réponse d'hypersensibilité de type retardé non spécifique pour traiter une infection par le virus de l'herpès simplex |
| MY159500A (en) * | 2009-05-22 | 2017-01-13 | Genocea Biosciences Inc | Vaccines against herpes simplex virus type 2: compositions and methods for eliciting an immune response |
| US20130224236A1 (en) * | 2010-11-03 | 2013-08-29 | University Of Washington | Hsv-1 epitopes and methods for using same |
| WO2012074881A2 (fr) | 2010-11-24 | 2012-06-07 | Genocea Biosciences, Inc. | Vaccins contre le virus de type 2 de l'herpès simplex: compositions et procédés pour la stimulation d'une réponse immunitaire |
| BR112013020875A2 (pt) | 2011-02-15 | 2019-09-24 | Immune Design Corp | método para indução de uma resposta imune específica para um imunógeno em um indivíduo. |
| AU2012243039B2 (en) * | 2011-04-08 | 2017-07-13 | Immune Design Corp. | Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses |
| US20120288515A1 (en) * | 2011-04-27 | 2012-11-15 | Immune Design Corp. | Synthetic long peptide (slp)-based vaccines |
| JP6205360B2 (ja) * | 2011-08-22 | 2017-09-27 | ナノバイオ コーポレーション | 単純ヘルペスウイルスのナノエマルジョンワクチン |
| WO2013078299A1 (fr) | 2011-11-23 | 2013-05-30 | Genocea Biosciences, Inc. | Vaccins à acide nucléique contre le virus d'herpès simplex de type 2 : compositions et procédés pour susciter une réponse immunitaire |
| RS57420B1 (sr) | 2012-05-16 | 2018-09-28 | Immune Design Corp | Vakcine za hsv-2 |
| WO2014164699A1 (fr) * | 2013-03-11 | 2014-10-09 | The Regents Of The University Of California | Vaccins et traitements contre le virus de l'herpès |
| EP3104878B1 (fr) | 2014-02-14 | 2019-05-22 | Immune Design Corp. | Immunothérapie du cancer par combinaison de stimulation immunitaire locale et systémique |
| WO2016011083A1 (fr) | 2014-07-15 | 2016-01-21 | Immune Design Corp. | Régimes de primo-vaccination/rappel avec un adjuvant d'agoniste tlr4 et un vecteur lentiviral |
| KR20160073707A (ko) | 2014-12-17 | 2016-06-27 | 삼성중공업 주식회사 | 액화천연가스 운반선의 운용방법 |
| CA2976268C (fr) | 2015-02-26 | 2021-07-06 | Squarex, Llc | Reponse d'hypersensibilite de type retarde non specifique pour traiter une infection par le virus herpes simplex |
| CA3012267C (fr) * | 2016-02-01 | 2023-09-19 | Simplexia Ab | Glycoproteine g tronquee du virus herpes simplex 2 |
| JP2019512501A (ja) * | 2016-03-14 | 2019-05-16 | レッドバイオテック・アーゲーＲｅｄｂｉｏｔｅｃ Ａｇ | Ｈｓｖを処置するための手段及び方法 |
| KR20230051602A (ko) | 2016-04-15 | 2023-04-18 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Icos 리간드 변이체 면역조절 단백질 및 그의 용도 |
| NZ746934A (en) | 2016-04-15 | 2023-11-24 | Alpine Immune Sciences Inc | Cd80 variant immunomodulatory proteins and uses thereof |
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| WO2018022946A1 (fr) | 2016-07-28 | 2018-02-01 | Alpine Immune Sciences, Inc. | Protéines immunomodulatrices à variants de cd155 et leurs utilisations |
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| JP2019537555A (ja) | 2016-09-28 | 2019-12-26 | ジェノセア バイオサイエンシーズ， インコーポレイテッド | ヘルペスを処置するための方法および組成物 |
| CN110809581A (zh) | 2017-03-16 | 2020-02-18 | 高山免疫科学股份有限公司 | Pd-l2变体免疫调节蛋白及其用途 |
| SG11201907769XA (en) | 2017-03-16 | 2019-09-27 | Alpine Immune Sciences Inc | Cd80 variant immunomodulatory proteins and uses thereof |
| RS64870B1 (sr) | 2017-03-16 | 2023-12-29 | Alpine Immune Sciences Inc | Imunomodulatorni proteini varijante pd-l1 i njihove upotrebe |
| SG11201908280SA (en) | 2017-03-30 | 2019-10-30 | Univ Queensland | "chimeric molecules and uses thereof" |
| US20190031739A1 (en) * | 2017-07-30 | 2019-01-31 | Raymond Joel Rairie | Pinball herpes antibody system |
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| WO2019136179A1 (fr) | 2018-01-03 | 2019-07-11 | Alpine Immune Sciences, Inc. | Protéines immunomodulatrices multi-domaine et leurs méthodes d'utilisation |
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| AU2019345151A1 (en) | 2018-09-19 | 2021-04-29 | Alpine Immune Sciences, Inc. | Methods and uses of variant CD80 fusion proteins and related constructs |
| WO2020113141A2 (fr) | 2018-11-30 | 2020-06-04 | Alpine Immune Sciences, Inc. | Protéines immunomodulatrices à variants cd86 et leurs utilisations |
| CN114302736A (zh) | 2019-04-17 | 2022-04-08 | 高山免疫科学股份有限公司 | 变体icos配体(icosl)融合蛋白的方法和用途 |
| MX2022013998A (es) | 2020-05-08 | 2023-02-16 | Alpine Immune Sciences Inc | Proteinas inmunomoduladoras inhibidoras de april y baff con y sin una proteina inhibidora de celulas t y metodos de uso de las mismas. |
| US20240279310A1 (en) | 2021-05-07 | 2024-08-22 | Alpine Immune Sciences, Inc. | Methods of dosing and treatment with a taci-fc fusion immunomodulatory protein |
| WO2023172883A1 (fr) | 2022-03-07 | 2023-09-14 | Alpine Immune Sciences, Inc. | Protéines immunomodulatrices de polypeptides cd80 variants, thérapies cellulaires associées et méthodes et utilisations associés |
| CN115808528B (zh) * | 2022-09-21 | 2023-08-01 | 武汉滨会生物科技股份有限公司 | 溶瘤单纯疱疹病毒vp5蛋白与人白细胞抗原e的互作方法及应用 |
| WO2024077018A2 (fr) | 2022-10-04 | 2024-04-11 | Alpine Immune Sciences, Inc. | Procédés et utilisations d'une protéine immunomodulatrice de fusion taci-fc |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4429008B1 (en) | 1981-12-10 | 1995-05-16 | Univ California | Thiol reactive liposomes |
| US4603112A (en) | 1981-12-24 | 1986-07-29 | Health Research, Incorporated | Modified vaccinia virus |
| US4769330A (en) | 1981-12-24 | 1988-09-06 | Health Research, Incorporated | Modified vaccinia virus and methods for making and using the same |
| US4866034A (en) | 1982-05-26 | 1989-09-12 | Ribi Immunochem Research Inc. | Refined detoxified endotoxin |
| US4436727A (en) | 1982-05-26 | 1984-03-13 | Ribi Immunochem Research, Inc. | Refined detoxified endotoxin product |
| JPS59116229A (ja) | 1982-12-24 | 1984-07-05 | Teijin Ltd | 細胞毒性複合体を活性成分とする癌治療用剤およびその製造法 |
| US4873088A (en) | 1983-09-06 | 1989-10-10 | Liposome Technology, Inc. | Liposome drug delivery method and composition |
| US4859587A (en) | 1984-06-04 | 1989-08-22 | Institut Merieux | Recombinant herpes simplex viruses, vaccines and methods |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4751180A (en) | 1985-03-28 | 1988-06-14 | Chiron Corporation | Expression using fused genes providing for protein product |
| GB8508845D0 (en) | 1985-04-04 | 1985-05-09 | Hoffmann La Roche | Vaccinia dna |
| US4777127A (en) | 1985-09-30 | 1988-10-11 | Labsystems Oy | Human retrovirus-related products and methods of diagnosing and treating conditions associated with said retrovirus |
| US4935233A (en) | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
| US4699784A (en) | 1986-02-25 | 1987-10-13 | Center For Molecular Medicine & Immunology | Tumoricidal methotrexate-antibody conjugate |
| US4877611A (en) | 1986-04-15 | 1989-10-31 | Ribi Immunochem Research Inc. | Vaccine containing tumor antigens and adjuvants |
| US5075109A (en) | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| GB8702816D0 (en) | 1987-02-07 | 1987-03-11 | Al Sumidaie A M K | Obtaining retrovirus-containing fraction |
| EP0297924A3 (fr) * | 1987-07-01 | 1990-07-11 | City Of Hope | Virus de la vaccine recombinant exprimant la glycoproteine HSV 1 gB |
| US4897268A (en) | 1987-08-03 | 1990-01-30 | Southern Research Institute | Drug delivery system and method of making the same |
| WO1989001973A2 (fr) | 1987-09-02 | 1989-03-09 | Applied Biotechnology, Inc. | Virus variolique recombinant d'immunisation contre des antigenes associes a une tumeur |
| AP129A (en) | 1988-06-03 | 1991-04-17 | Smithkline Biologicals S A | Expression of retrovirus gag protein eukaryotic cells |
| US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
| EP1645635A3 (fr) | 1989-08-18 | 2010-07-07 | Oxford Biomedica (UK) Limited | Retrovirus recombinants défectifs pour la réplication exprimant un palliatif |
| SE466259B (sv) | 1990-05-31 | 1992-01-20 | Arne Forsgren | Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal |
| EP0541692B1 (fr) | 1990-08-02 | 1999-05-06 | Chiron Corporation | Vaccins contre le virus de l'herpes vp16 |
| JPH05236967A (ja) * | 1991-05-07 | 1993-09-17 | Medical Res Council | ヘルペスウイルス粒子及びワクチン |
| CA2090295A1 (fr) | 1992-02-03 | 1993-08-04 | Anthony B. Nesburn | Procede pour l'expression de la glycoproteine e du virus de l'herpes simplex de type-1 et methodes d'utilisation |
| ES2143716T3 (es) | 1992-06-25 | 2000-05-16 | Smithkline Beecham Biolog | Composicion de vacuna que contiene adyuvantes. |
| US5426039A (en) | 1993-09-08 | 1995-06-20 | Bio-Rad Laboratories, Inc. | Direct molecular cloning of primer extended DNA containing an alkane diol |
| GB9325496D0 (en) * | 1993-12-14 | 1994-02-16 | Smithkline Beecham Biolog | Vaccines |
| GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| EP1167377B2 (fr) | 1994-07-15 | 2012-08-08 | University of Iowa Research Foundation | Oliogonucléotides immunomodulateurs |
| CA2211743A1 (fr) * | 1995-02-21 | 1996-08-29 | Cantab Pharmaceuticals Research Limited | Preparations virales, vecteurs, immunogenes et vaccins correspondants |
| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| JPH11510386A (ja) | 1995-07-28 | 1999-09-14 | マリー キュリー キャンサー ケア | 輸送蛋白質およびそれらの使用 |
| WO1997024447A1 (fr) | 1996-01-02 | 1997-07-10 | Chiron Corporation | Immunostimulation a mediation par cellules dendritiques modifiees par des genes |
| GB9615726D0 (en) * | 1996-07-26 | 1996-09-04 | Medical Res Council | Anti-viral agent 11 |
| EP0948508A4 (fr) * | 1996-11-04 | 2001-11-07 | Smithkline Beecham Corp | Nouvelles sequences codantes pour le virus herpes simplex de type 2 |
| EP0984790A1 (fr) * | 1997-06-02 | 2000-03-15 | Chiron Corporation | Vaccins au vp22 contre le virus de l'herpes simplex et procede d'utilisation de ces vaccins |
| KR20010085348A (ko) * | 1998-08-07 | 2001-09-07 | 추후보정 | 면역능을 갖는 헤르페스 심플렉스 바이러스 항원 및 이를이용하는 방법 |
| GB9825953D0 (en) * | 1998-11-26 | 1999-01-20 | Medical Res Council | Protein fragments for use in protein targeting |
| JP2003512305A (ja) * | 1999-09-30 | 2003-04-02 | ユニバーシティ オブ ワシントン | 免疫学的に重要な単純疱疹ウイルス抗原 |
| US6821519B2 (en) * | 2000-06-29 | 2004-11-23 | Corixa Corporation | Compositions and methods for the diagnosis and treatment of herpes simplex virus infection |
| DK1523582T3 (da) * | 2002-07-18 | 2009-03-02 | Univ Washington | Hurtig, effektiv rensning af HSV-specifikke T-lymfocytter samt HSV-antigener identificeret derved |
| JP5872755B2 (ja) * | 2006-07-20 | 2016-03-01 | バイカル インコーポレイテッド | 抗ｈｓｖ−２ワクチン接種のための組成物および方法 |
| US8865185B2 (en) * | 2006-09-08 | 2014-10-21 | The Trustees Of The University Of Pennsylvania | Methods of use for HSV-1 and HSV-2 vaccines |
-
1999
- 1999-08-05 KR KR1020017001641A patent/KR20010085348A/ko not_active IP Right Cessation
- 1999-08-05 US US09/368,770 patent/US6375952B1/en not_active Expired - Lifetime
- 1999-08-05 WO PCT/US1999/017803 patent/WO2000008051A2/fr not_active Application Discontinuation
- 1999-08-05 AU AU54678/99A patent/AU5467899A/en not_active Abandoned
- 1999-08-05 PL PL99346213A patent/PL346213A1/xx not_active Application Discontinuation
- 1999-08-05 IL IL14104499A patent/IL141044A0/xx unknown
- 1999-08-05 BR BR9912671-0A patent/BR9912671A/pt not_active IP Right Cessation
- 1999-08-05 EP EP99940918.8A patent/EP1102790B1/fr not_active Expired - Lifetime
- 1999-08-05 CA CA2336523A patent/CA2336523C/fr not_active Expired - Fee Related
- 1999-08-05 CN CN99810454A patent/CN1348463A/zh active Pending
- 1999-08-05 TR TR2001/00373T patent/TR200100373T2/xx unknown
- 1999-08-05 NZ NZ509974A patent/NZ509974A/en not_active IP Right Cessation
- 1999-08-05 DK DK10182295.5T patent/DK2272859T3/en active
- 1999-08-05 JP JP2000563684A patent/JP2002522451A/ja not_active Withdrawn
- 1999-08-05 EP EP10182295.5A patent/EP2272859B1/fr not_active Expired - Lifetime
- 1999-08-06 AR ARP990103950A patent/AR020134A1/es not_active Application Discontinuation
-
2001
- 2001-02-02 NO NO20010576A patent/NO20010576L/no unknown
-
2002
- 2002-02-11 US US10/073,834 patent/US6855317B2/en not_active Expired - Fee Related
-
2005
- 2005-02-10 US US11/055,477 patent/US7744903B2/en not_active Expired - Fee Related
-
2010
- 2010-05-10 US US12/777,156 patent/US8067010B2/en not_active Expired - Fee Related
-
2011
- 2011-10-18 US US13/276,166 patent/US8852602B2/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8460674B2 (en) | 2009-02-07 | 2013-06-11 | University Of Washington | HSV-1 epitopes and methods for using same |
| US9328144B2 (en) | 2009-02-07 | 2016-05-03 | University Of Washington | HSV-1 epitopes and methods for using same |
| US9044447B2 (en) | 2009-04-03 | 2015-06-02 | University Of Washington | Antigenic peptide of HSV-2 and methods for using same |
| US9579376B2 (en) | 2009-04-03 | 2017-02-28 | University Of Washington | Antigenic peptide of HSV-2 and methods for using same |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000008051A3 (fr) | 2000-08-03 |
| US7744903B2 (en) | 2010-06-29 |
| US20030118611A1 (en) | 2003-06-26 |
| EP2272859A2 (fr) | 2011-01-12 |
| IL141044A0 (en) | 2002-02-10 |
| US20120027790A1 (en) | 2012-02-02 |
| JP2002522451A (ja) | 2002-07-23 |
| US20050163794A1 (en) | 2005-07-28 |
| US20100215693A1 (en) | 2010-08-26 |
| NO20010576D0 (no) | 2001-02-02 |
| EP2272859A3 (fr) | 2011-06-08 |
| CA2336523A1 (fr) | 2000-02-17 |
| US8852602B2 (en) | 2014-10-07 |
| US6855317B2 (en) | 2005-02-15 |
| TR200100373T2 (tr) | 2001-09-21 |
| CN1348463A (zh) | 2002-05-08 |
| US6375952B1 (en) | 2002-04-23 |
| CA2336523C (fr) | 2015-06-30 |
| NO20010576L (no) | 2001-04-02 |
| EP1102790A2 (fr) | 2001-05-30 |
| EP2272859B1 (fr) | 2014-10-22 |
| BR9912671A (pt) | 2001-05-02 |
| US8067010B2 (en) | 2011-11-29 |
| EP1102790B1 (fr) | 2014-05-07 |
| WO2000008051A2 (fr) | 2000-02-17 |
| DK2272859T3 (en) | 2015-01-19 |
| PL346213A1 (en) | 2002-01-28 |
| KR20010085348A (ko) | 2001-09-07 |
| AU5467899A (en) | 2000-02-28 |
| AR020134A1 (es) | 2002-04-10 |
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| Date | Code | Title | Description |
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| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| LAPS | Patent lapsed |