NZ333215A - a nucleic acid sequence encoding a lactoferrin variant or portion thereof which has modified iron binding capacity - Google Patents
a nucleic acid sequence encoding a lactoferrin variant or portion thereof which has modified iron binding capacityInfo
- Publication number
- NZ333215A NZ333215A NZ333215A NZ33321597A NZ333215A NZ 333215 A NZ333215 A NZ 333215A NZ 333215 A NZ333215 A NZ 333215A NZ 33321597 A NZ33321597 A NZ 33321597A NZ 333215 A NZ333215 A NZ 333215A
- Authority
- NZ
- New Zealand
- Prior art keywords
- nucleic acid
- acid sequence
- lactoferrin
- tyr
- sequence encoding
- Prior art date
Links
- 102000008133 Iron-Binding Proteins Human genes 0.000 title abstract 4
- 108010035210 Iron-Binding Proteins Proteins 0.000 title abstract 4
- 102000010445 Lactoferrin Human genes 0.000 title abstract 4
- 108010063045 Lactoferrin Proteins 0.000 title abstract 4
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 title abstract 4
- 229940078795 lactoferrin Drugs 0.000 title abstract 4
- 235000021242 lactoferrin Nutrition 0.000 title abstract 4
- 108091028043 Nucleic acid sequence Proteins 0.000 title abstract 3
- 150000007523 nucleic acids Chemical group 0.000 title abstract 3
- 150000002505 iron Chemical class 0.000 title abstract 2
- PMVSDNDAUGGCCE-TYYBGVCCSA-L Ferrous fumarate Chemical compound [Fe+2].[O-]C(=O)\C=C\C([O-])=O PMVSDNDAUGGCCE-TYYBGVCCSA-L 0.000 abstract 1
- 101000798114 Homo sapiens Lactotransferrin Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 210000003527 eukaryotic cell Anatomy 0.000 abstract 1
- 102000050459 human LTF Human genes 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 238000013518 transcription Methods 0.000 abstract 1
- 230000005026 transcription initiation Effects 0.000 abstract 1
- 230000014621 translational initiation Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1874796P | 1996-05-31 | 1996-05-31 | |
| US08/866,544 US6111081A (en) | 1996-05-31 | 1997-05-30 | Lactoferrin variants and uses thereof |
| PCT/US1997/009531 WO1997045136A1 (en) | 1996-05-31 | 1997-06-02 | Lactoferrin variants and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ333215A true NZ333215A (en) | 2000-05-26 |
Family
ID=26691448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ333215A NZ333215A (en) | 1996-05-31 | 1997-06-02 | a nucleic acid sequence encoding a lactoferrin variant or portion thereof which has modified iron binding capacity |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6111081A (enExample) |
| EP (1) | EP0959898A4 (enExample) |
| JP (1) | JP2000511424A (enExample) |
| KR (1) | KR20000016159A (enExample) |
| AU (1) | AU707476B2 (enExample) |
| CA (1) | CA2256453A1 (enExample) |
| DE (1) | DE959898T1 (enExample) |
| ES (1) | ES2140362T1 (enExample) |
| GR (1) | GR990300043T1 (enExample) |
| IL (1) | IL127319A (enExample) |
| NZ (1) | NZ333215A (enExample) |
| WO (1) | WO1997045136A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL94183A (en) * | 1989-05-05 | 2003-09-17 | Baylor College Medicine | cDNA SEQUENCE CODING FOR HUMAN LACTOFERRIN PROTEIN OR PORTION THEREOF AND LACTOFERRIN PROTEIN PRODUCED FROM SAID SEQUENCE |
| JP2002515893A (ja) * | 1997-02-03 | 2002-05-28 | ファーミング インテレクチュアル プロパティ ビーブイ | ヒトラクトフェリンおよびその改変体の有用な特性 |
| ATE297755T1 (de) * | 1997-04-10 | 2005-07-15 | Agennix Inc | Verwendung von lactoferrin in der behandlung von beschwerden, die von allergenen verursacht sind |
| US6399570B1 (en) | 1999-02-05 | 2002-06-04 | Agennix, Inc. | Antimicrobial/endotoxin neutralizing polypeptide |
| JP3668241B2 (ja) * | 2001-12-28 | 2005-07-06 | 株式会社Ｎｒｌファーマ | 脂質代謝改善用組成物 |
| US20030213007A1 (en) * | 2002-03-27 | 2003-11-13 | Slattery Charles Wilbur | Human milk produced by human mammary tissue implanted in non-human host animals and uses thereof |
| EP2286827A1 (en) | 2002-05-10 | 2011-02-23 | Agennix Incorporated | Lactoferrin in the treatment of malignant neoplasms and other hyperproliferative diseases |
| AU2003233583A1 (en) * | 2002-05-24 | 2003-12-12 | Agennix Incorporated | Oral lactoferrin in the treatment of respiratory disorders |
| DK2298338T3 (da) * | 2002-09-16 | 2012-09-24 | Agennix Inc | Lactoferrin-sammensætninger og fremgangsmåder til behandling af hudsår |
| JP4795021B2 (ja) * | 2002-12-06 | 2011-10-19 | エイジェニックス インコーポレイテッド | 敗血症治療における経口用ラクトフェリン |
| US7592306B2 (en) * | 2002-12-10 | 2009-09-22 | Agennix, Inc. | Lactoferrin as an agent in the prevention of organ transplant rejection and graft-versus-host-disease |
| WO2004060392A1 (en) * | 2002-12-20 | 2004-07-22 | Ventria Bioscience | Lactoferrin protein with iron for treating iron deficiency and anemia |
| AU2004289170B2 (en) * | 2003-06-06 | 2009-12-17 | Agennix Incorporated | Lactoferrin as an adjuvant in cancer vaccines |
| US20040259770A1 (en) * | 2003-06-19 | 2004-12-23 | Rush University Medical Center | Method for determining leukocyte activation |
| US20050075277A1 (en) * | 2003-07-10 | 2005-04-07 | Agennix Incorporated | Use of lactoferrin in prophylaxis against infection and/or inflammation in immunosuppressed subjects |
| WO2006047744A2 (en) * | 2004-10-26 | 2006-05-04 | Agennix Incorporated | Compositions of lactoferrin related peptides and uses thereof |
| NZ555163A (en) | 2007-05-14 | 2010-05-28 | Fonterra Co Operative Group | Methods of immune or hematological enhancement, inhibiting tumour formation or growth, and treating or preventing cancer, cancer symptoms, or the symptoms of cancer treatments |
| RU2340674C1 (ru) * | 2007-06-01 | 2008-12-10 | Борис Савельевич Народицкий | Способ получения рекомбинантного лактоферрина человека |
| JP5855239B2 (ja) * | 2012-04-23 | 2016-02-09 | 株式会社Ｎｒｌファーマ | ラクトフェリン融合タンパク質及びその製造方法 |
| EP3533870A4 (en) | 2016-10-28 | 2020-04-08 | NRL Pharma, Inc. | LACTOFERRIN / ALBUMIN FUSION PROTEIN AND PROCESS FOR PRODUCING THE SAME |
| WO2020096672A1 (en) | 2018-11-09 | 2020-05-14 | The Wistar Institute Of Anatomy And Biology | Use of lactoferrin for generating myeloid-derived suppressor cells |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5186117A (en) * | 1975-01-27 | 1976-07-28 | Tanabe Seiyaku Co | Johoseibiryushiseizainoseiho |
| GB1575343A (en) * | 1977-05-10 | 1980-09-17 | Ici Ltd | Method for preparing liposome compositions containing biologically active compounds |
| US4529561A (en) * | 1978-03-24 | 1985-07-16 | The Regents Of The University Of California | Method for producing liposomes in selected size range |
| IN150740B (enExample) * | 1978-11-24 | 1982-12-04 | Hoffmann La Roche | |
| GB2046092B (en) * | 1979-03-05 | 1983-11-02 | Toyama Chemical Co Ltd | Pharmaceutical composition containing a lysophospholid and a phospholipid |
| US4634665A (en) * | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4394443A (en) * | 1980-12-18 | 1983-07-19 | Yale University | Method for cloning genes |
| US4452747A (en) * | 1982-03-22 | 1984-06-05 | Klaus Gersonde | Method of and arrangement for producing lipid vesicles |
| US4766075A (en) * | 1982-07-14 | 1988-08-23 | Genentech, Inc. | Human tissue plasminogen activator |
| US4652639A (en) * | 1982-05-06 | 1987-03-24 | Amgen | Manufacture and expression of structural genes |
| US4725442A (en) * | 1983-06-17 | 1988-02-16 | Haynes Duncan H | Microdroplets of water-insoluble drugs and injectable formulations containing same |
| US4703008A (en) * | 1983-12-13 | 1987-10-27 | Kiren-Amgen, Inc. | DNA sequences encoding erythropoietin |
| US4740461A (en) * | 1983-12-27 | 1988-04-26 | Genetics Institute, Inc. | Vectors and methods for transformation of eucaryotic cells |
| US4710465A (en) * | 1984-04-19 | 1987-12-01 | Yale University | Junction-fragment DNA probes and probe clusters |
| US5008050A (en) * | 1984-06-20 | 1991-04-16 | The Liposome Company, Inc. | Extrusion technique for producing unilamellar vesicles |
| LU85479A1 (fr) * | 1984-07-25 | 1986-02-12 | Oleofina Sa | Compositions antibacteriennes de nourriture pour animaux et procede pour les preparer |
| US4921706A (en) * | 1984-11-20 | 1990-05-01 | Massachusetts Institute Of Technology | Unilamellar lipid vesicles and method for their formation |
| JPS61145200A (ja) * | 1984-12-19 | 1986-07-02 | Snow Brand Milk Prod Co Ltd | ウシラクトフェリンの分離精製法 |
| US4886747A (en) * | 1985-03-22 | 1989-12-12 | Genentech, Inc. | Nucleic acid encoding TGF-β and its uses |
| AU5912586A (en) * | 1985-06-20 | 1986-12-24 | Salk Institute Biotechnology/Industrial Associates, Inc., The | Alpha-factor leader peptide-facilitated secretion from transformed s cerevisiae |
| FR2583676B1 (fr) * | 1985-06-24 | 1988-03-25 | Induplast Sa | Procede et appareils d'extrusion de structures alveolaires en matiere thermoplastique et structures ainsi obtenues |
| US4959318A (en) * | 1985-06-27 | 1990-09-25 | Zymogenetics, Inc. | Expression of protein C |
| US4800159A (en) * | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| US4737323A (en) * | 1986-02-13 | 1988-04-12 | Liposome Technology, Inc. | Liposome extrusion method |
| US4965190A (en) * | 1986-07-31 | 1990-10-23 | Howard Hughes Medical Institute | Methods for the identification of mutations in the human phenylalanine hydroxylase gene using DNA probes |
| US4920016A (en) * | 1986-12-24 | 1990-04-24 | Linear Technology, Inc. | Liposomes with enhanced circulation time |
| US5009956A (en) * | 1987-02-24 | 1991-04-23 | Univ Minnesota | Phospholipase A2-resistant liposomes |
| US5019508A (en) * | 1987-08-27 | 1991-05-28 | Biotechnology Research Partners, Ltd. | Synovial phospholipases |
| DE3886221T3 (de) * | 1987-09-04 | 2000-12-21 | Novo Nordisk A/S, Bagsvaerd | VERFAHREN ZUR HERSTELLUNG VON PROTEINPRODUKTEN IN -i(ASPERGILLUS) UND PROMOTOREN ZUR VERWENDUNG IN -i(ASPERGILLUS). |
| US5081227A (en) * | 1988-03-04 | 1992-01-14 | La Jolla Cancer Research Foundation | Germ cell alkaline phosphatase |
| US4927637A (en) * | 1989-01-17 | 1990-05-22 | Liposome Technology, Inc. | Liposome extrusion method |
| US4944948A (en) * | 1989-02-24 | 1990-07-31 | Liposome Technology, Inc. | EGF/Liposome gel composition and method |
| US5571691A (en) * | 1989-05-05 | 1996-11-05 | Baylor College Of Medicine | Production of recombinant lactoferrin and lactoferrin polypeptides using CDNA sequences in various organisms |
| US5571697A (en) * | 1989-05-05 | 1996-11-05 | Baylor College Of Medicine Texas Medical Center | Expression of processed recombinant lactoferrin and lactoferrin polypeptide fragments from a fusion product in Aspergillus |
| US5155037A (en) * | 1989-08-04 | 1992-10-13 | The Texas A&M University System | Insect signal sequences useful to improve the efficiency of processing and secretion of foreign genes in insect systems |
| IL95697A0 (en) * | 1989-09-28 | 1991-06-30 | Granada Biosciences Inc | Cdna sequence for porcine lactoferrin protein |
| AU7453391A (en) * | 1990-03-08 | 1991-10-10 | Ferrodynamics, Inc. | Genetically engineered human lactoferrin |
| JP2818056B2 (ja) * | 1990-09-07 | 1998-10-30 | 森永乳業株式会社 | 抗菌性ペプチドおよび抗菌剤 |
| US5166145A (en) * | 1990-09-10 | 1992-11-24 | Alza Corporation | Antiemetic therapy |
| NZ245713A (en) * | 1992-02-10 | 1994-12-22 | Novopharm Ltd | Production of the antibiotic lovastatin from genetically engineered aspergillus strains |
| ZA932568B (en) * | 1992-04-24 | 1993-11-12 | Baylor College Midecine A Non | Production of recombinant human lactoferrin |
| US5571619A (en) * | 1994-05-24 | 1996-11-05 | Exxon Chemical Patents, Inc. | Fibers and oriented films of polypropylene higher α-olefin copolymers |
-
1997
- 1997-05-30 US US08/866,544 patent/US6111081A/en not_active Expired - Lifetime
- 1997-06-02 NZ NZ333215A patent/NZ333215A/xx not_active IP Right Cessation
- 1997-06-02 DE DE0959898T patent/DE959898T1/de active Pending
- 1997-06-02 IL IL12731997A patent/IL127319A/en not_active IP Right Cessation
- 1997-06-02 WO PCT/US1997/009531 patent/WO1997045136A1/en not_active Ceased
- 1997-06-02 AU AU32271/97A patent/AU707476B2/en not_active Ceased
- 1997-06-02 CA CA002256453A patent/CA2256453A1/en not_active Abandoned
- 1997-06-02 GR GR990300043T patent/GR990300043T1/el unknown
- 1997-06-02 JP JP09543045A patent/JP2000511424A/ja not_active Ceased
- 1997-06-02 ES ES97927932T patent/ES2140362T1/es active Pending
- 1997-06-02 EP EP97927932A patent/EP0959898A4/en not_active Withdrawn
- 1997-06-02 KR KR1019980709727A patent/KR20000016159A/ko not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU3227197A (en) | 1998-01-05 |
| US6111081A (en) | 2000-08-29 |
| JP2000511424A (ja) | 2000-09-05 |
| KR20000016159A (ko) | 2000-03-25 |
| GR990300043T1 (en) | 2000-01-31 |
| ES2140362T1 (es) | 2000-03-01 |
| CA2256453A1 (en) | 1997-12-04 |
| EP0959898A4 (en) | 2002-08-14 |
| WO1997045136A1 (en) | 1997-12-04 |
| AU707476B2 (en) | 1999-07-08 |
| EP0959898A1 (en) | 1999-12-01 |
| DE959898T1 (de) | 2000-05-04 |
| IL127319A0 (en) | 1999-09-22 |
| IL127319A (en) | 2004-08-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO1998013493A3 (en) | A family of genes encoding apoptosis-related peptides, peptides encoded thereby and methods of use thereof | |
| CA2121798A1 (en) | Novel cytokine | |
| WO1995018830A3 (en) | Inhibitors of human plasmin derived from the kunitz domains | |
| WO1997035990A3 (en) | Histone deacetylases, and uses related thereto | |
| CA2216601A1 (en) | Intracellular domain of the her-2/neu protein for prevention or treatment of malignancies | |
| BG101813A (en) | Osteoprotegerin | |
| PL315791A1 (en) | Multivariant haemopoesive fusion protein il-3 | |
| EP0305488A4 (en) | Mycobacterial recombinants and peptides | |
| WO1998021328A3 (en) | Human proteins having transmembrane domains and dnas encoding these proteins | |
| MX9709447A (es) | Nueva muteina cd4ol. | |
| CA2249233A1 (en) | Mch4 and mch5, apoptotic protease, nucleic acids encoding and methods of use | |
| PL313445A1 (en) | Grb3-3 gene, variants thereof and their use | |
| AU3850997A (en) | Immunologically active proteins of borrelia burgdorferi, coded nuclein acids of such and their use in test kits and vaccines | |
| CA2204151A1 (en) | Cdna encoding a bmp type ii receptor | |
| AU3711597A (en) | A novel galanin receptor | |
| AU8811298A (en) | Novel peptides and polypeptides useful for regenerating the nervous system | |
| AU5327198A (en) | Nucleotide sequence coding for a flavin-containing monooxygenase, corresponding protein and their applications in the fields of diagnosis and therapy | |
| WO1996003122A3 (en) | Use of gabapentin in the treatment of anxiety and panic | |
| WO1998027200A3 (en) | Human and mammalian dna replication origin consensus sequences | |
| WO1999002724A3 (en) | Methods for identifying genes expressed in selected lineages, and a novel genes identified using the methods | |
| WO2000000506A3 (en) | Human proteins having hydrophobic domains and dnas encoding these proteins | |
| CA2210871A1 (en) | Human dnase i variants | |
| WO1994029447A3 (en) | Dna coding for the human thyrotropin-releasing hormone receptor | |
| AU4744397A (en) | A keratinocyte derived protease | |
| WO2001098355A3 (en) | Cgi-69 compositions and methods of use |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| EXPY | Patent expired |