WO1994029447A3 - Dna coding for the human thyrotropin-releasing hormone receptor - Google Patents

Dna coding for the human thyrotropin-releasing hormone receptor Download PDF

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Publication number
WO1994029447A3
WO1994029447A3 PCT/GB1994/001250 GB9401250W WO9429447A3 WO 1994029447 A3 WO1994029447 A3 WO 1994029447A3 GB 9401250 W GB9401250 W GB 9401250W WO 9429447 A3 WO9429447 A3 WO 9429447A3
Authority
WO
WIPO (PCT)
Prior art keywords
hormone receptor
releasing hormone
dna coding
gene
human thyrotropin
Prior art date
Application number
PCT/GB1994/001250
Other languages
French (fr)
Other versions
WO1994029447A2 (en
Inventor
Karin Ann Eidne
Sarah Macdonald Duthie
Original Assignee
Medical Res Council
Karin Ann Eidne
Sarah Macdonald Duthie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU70025/94A priority Critical patent/AU7002594A/en
Application filed by Medical Res Council, Karin Ann Eidne, Sarah Macdonald Duthie filed Critical Medical Res Council
Priority to EP94918925A priority patent/EP0701610A1/en
Priority to JP7501490A priority patent/JPH09501310A/en
Publication of WO1994029447A2 publication Critical patent/WO1994029447A2/en
Publication of WO1994029447A3 publication Critical patent/WO1994029447A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention provides a human TRH receptor gene (seq ID No.1), and polynucleotide probes specifically binding to this gene or naturally occurring variants thereof, as well as polypeptide probes specifically binding to the receptor polypeptide or naturally occurring variants thereof. Expression of the gene in a host is also useful for providing means for use in the evaluation of TRH-agonists and -antagonists.
PCT/GB1994/001250 1993-06-09 1994-06-09 Dna coding for the human thyrotropin-releasing hormone receptor WO1994029447A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU70025/94A AU7002594A (en) 1993-06-09 1994-06-08 Dna coding for the human thyrotropin-releasing hormone receptor
EP94918925A EP0701610A1 (en) 1993-06-09 1994-06-09 Dna coding for the human thyrotropin-releasing hormone receptor
JP7501490A JPH09501310A (en) 1993-06-09 1994-06-09 DNA encoding the human thyroid stimulating hormone releasing receptor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9311854.5 1993-06-09
GB939311854A GB9311854D0 (en) 1993-06-09 1993-06-09 Trh receptor action

Publications (2)

Publication Number Publication Date
WO1994029447A2 WO1994029447A2 (en) 1994-12-22
WO1994029447A3 true WO1994029447A3 (en) 1995-02-02

Family

ID=10736852

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1994/001250 WO1994029447A2 (en) 1993-06-09 1994-06-09 Dna coding for the human thyrotropin-releasing hormone receptor

Country Status (5)

Country Link
EP (1) EP0701610A1 (en)
JP (1) JPH09501310A (en)
AU (1) AU7002594A (en)
GB (1) GB9311854D0 (en)
WO (1) WO1994029447A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0638645A1 (en) * 1993-08-10 1995-02-15 Takeda Chemical Industries, Ltd. Human TRH receptor, its production and use
CA2229287A1 (en) * 1995-08-14 1997-02-27 Cornell Research Foundation, Inc. Regulation of cellular functions by ectopic expression of non-endogenous cell signalling receptors
SE9604439D0 (en) * 1996-12-02 1996-12-02 Astra Pharma Inc New receptor
EP0950711A3 (en) * 1998-02-06 2003-09-17 Akzo Nobel N.V. Gonadotropin receptor
SE9801455D0 (en) * 1998-04-24 1998-04-24 Astra Pharma Inc New receptor
JP2004503241A (en) * 2000-06-13 2004-02-05 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング Thyrotropin-releasing hormone receptor-like GPCR (GPRFWKI)
IE20120542A1 (en) * 2012-12-19 2014-07-02 Provost Fellows Foundation Scholars And Other Members Of Board Of The College Of The Holy And Undivi Novel TRH binding site in human CNS

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
R.E. SELLAR ET AL.;: "Functional expression and molecular characterization of the thyrotrophin-releasing hormone receptor from the rat anterior pituitary gland", J. MOL. ENDOCRINOL., vol. 10, 1993, pages 199 - 206 *
R.E. STRAUB ET AL.;: "Expression cloning of a cDNA encoding the mouse pituitary thyrotropin-releasing hormone receptor", PROC. NATL. ACAD. SCI. USA, vol. 87, 1990, pages 9514 - 9518 *
S. MANAKER ET AL.;: "Autoradiographic localization of thyrotropin releasing hormone receptors in human brain", NEUROLOGY, vol. 36, 1986, pages 641 - 644 *
V. MATRE ET AL.;: "Molecular cloning of a functional human thyrotropin-releasing hormone receptor", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 195, 1993, pages 179 - 185 *

Also Published As

Publication number Publication date
JPH09501310A (en) 1997-02-10
EP0701610A1 (en) 1996-03-20
GB9311854D0 (en) 1993-07-28
AU7002594A (en) 1995-01-03
WO1994029447A2 (en) 1994-12-22

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