ES2140362T1 - Variantes de la lactoferrina y usos de las mismas. - Google Patents

Variantes de la lactoferrina y usos de las mismas.

Info

Publication number
ES2140362T1
ES2140362T1 ES97927932T ES97927932T ES2140362T1 ES 2140362 T1 ES2140362 T1 ES 2140362T1 ES 97927932 T ES97927932 T ES 97927932T ES 97927932 T ES97927932 T ES 97927932T ES 2140362 T1 ES2140362 T1 ES 2140362T1
Authority
ES
Spain
Prior art keywords
variants
parts
refers
procedures
nucleic acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
ES97927932T
Other languages
English (en)
Inventor
Orla M Conneely
Pauline P Ward
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baylor College of Medicine
Original Assignee
Baylor College of Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor College of Medicine filed Critical Baylor College of Medicine
Publication of ES2140362T1 publication Critical patent/ES2140362T1/es
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UNOS ACIDOS NUCLEICOS RECOMBINANTES QUE CODIFICAN VARIANTES DE LACTOFERRINA Y PARTES DE DICHAS VARIANTES, QUE TIENEN UNA CAPACIDAD MODIFICADA DE FIJACION DE HIERRO Y VECTORES QUE COMPRENDEN DICHOS ACIDOS NUCLEICOS RECOMBINANTES. LA PRESENTE INVENCION SE REFIERE TAMBIEN A UNOS PROCEDIMIENTOS DE PRODUCCION DE DICHOS VECTORES Y A CELULAS TRANSFECTADAS QUE PROTEGEN DICHOS VECTORES. SE REFIERE TAMBIEN A UNOS PROCEDIMIENTOS PARA LA PRODUCCION DE VARIANTES DE LACTOFERRINA Y PARTES DE LAS MISMAS, EN VARIAS CELULAS EUCARIOTAS O PROCARIOTAS. Y FINALMENTE, ESTA INVENCION SE REFIERE A UNAS VARIANTES DE LACTOFERRINA Y A PARTES DE LAS MISMAS CODIFICADAS POR LOS ACIDOS NUCLEICOS DE ESTA INVENCION Y PRODUCIDAS SEGUN LOS PROCEDIMIENTOS DE LA INVENCION. DE ESTE MODO, ESTA INVENCION DESCRIBE UN MEDIO EFICAZ Y ECONOMICO PARA LA PRODUCCION DE VARIANTES DE LACTOFERRINA Y PARTES DE LAS MISMAS.
ES97927932T 1996-05-31 1997-06-02 Variantes de la lactoferrina y usos de las mismas. Pending ES2140362T1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1874796P 1996-05-31 1996-05-31
US08/866,544 US6111081A (en) 1996-05-31 1997-05-30 Lactoferrin variants and uses thereof

Publications (1)

Publication Number Publication Date
ES2140362T1 true ES2140362T1 (es) 2000-03-01

Family

ID=26691448

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97927932T Pending ES2140362T1 (es) 1996-05-31 1997-06-02 Variantes de la lactoferrina y usos de las mismas.

Country Status (12)

Country Link
US (1) US6111081A (es)
EP (1) EP0959898A4 (es)
JP (1) JP2000511424A (es)
KR (1) KR20000016159A (es)
AU (1) AU707476B2 (es)
CA (1) CA2256453A1 (es)
DE (1) DE959898T1 (es)
ES (1) ES2140362T1 (es)
GR (1) GR990300043T1 (es)
IL (1) IL127319A (es)
NZ (1) NZ333215A (es)
WO (1) WO1997045136A1 (es)

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IL94183A (en) * 1989-05-05 2003-09-17 Baylor College Medicine cDNA SEQUENCE CODING FOR HUMAN LACTOFERRIN PROTEIN OR PORTION THEREOF AND LACTOFERRIN PROTEIN PRODUCED FROM SAID SEQUENCE
JP2002515893A (ja) * 1997-02-03 2002-05-28 ファーミング インテレクチュアル プロパティ ビーブイ ヒトラクトフェリンおよびその改変体の有用な特性
ATE297755T1 (de) * 1997-04-10 2005-07-15 Agennix Inc Verwendung von lactoferrin in der behandlung von beschwerden, die von allergenen verursacht sind
US6399570B1 (en) 1999-02-05 2002-06-04 Agennix, Inc. Antimicrobial/endotoxin neutralizing polypeptide
JP3668241B2 (ja) * 2001-12-28 2005-07-06 株式会社Ｎｒｌファーマ 脂質代謝改善用組成物
US20030213007A1 (en) * 2002-03-27 2003-11-13 Slattery Charles Wilbur Human milk produced by human mammary tissue implanted in non-human host animals and uses thereof
EP2286827A1 (en) 2002-05-10 2011-02-23 Agennix Incorporated Lactoferrin in the treatment of malignant neoplasms and other hyperproliferative diseases
AU2003233583A1 (en) * 2002-05-24 2003-12-12 Agennix Incorporated Oral lactoferrin in the treatment of respiratory disorders
DK2298338T3 (da) * 2002-09-16 2012-09-24 Agennix Inc Lactoferrin-sammensætninger og fremgangsmåder til behandling af hudsår
JP4795021B2 (ja) * 2002-12-06 2011-10-19 エイジェニックス インコーポレイテッド 敗血症治療における経口用ラクトフェリン
US7592306B2 (en) * 2002-12-10 2009-09-22 Agennix, Inc. Lactoferrin as an agent in the prevention of organ transplant rejection and graft-versus-host-disease
WO2004060392A1 (en) * 2002-12-20 2004-07-22 Ventria Bioscience Lactoferrin protein with iron for treating iron deficiency and anemia
AU2004289170B2 (en) * 2003-06-06 2009-12-17 Agennix Incorporated Lactoferrin as an adjuvant in cancer vaccines
US20040259770A1 (en) * 2003-06-19 2004-12-23 Rush University Medical Center Method for determining leukocyte activation
US20050075277A1 (en) * 2003-07-10 2005-04-07 Agennix Incorporated Use of lactoferrin in prophylaxis against infection and/or inflammation in immunosuppressed subjects
WO2006047744A2 (en) * 2004-10-26 2006-05-04 Agennix Incorporated Compositions of lactoferrin related peptides and uses thereof
NZ555163A (en) 2007-05-14 2010-05-28 Fonterra Co Operative Group Methods of immune or hematological enhancement, inhibiting tumour formation or growth, and treating or preventing cancer, cancer symptoms, or the symptoms of cancer treatments
RU2340674C1 (ru) * 2007-06-01 2008-12-10 Борис Савельевич Народицкий Способ получения рекомбинантного лактоферрина человека
JP5855239B2 (ja) * 2012-04-23 2016-02-09 株式会社Ｎｒｌファーマ ラクトフェリン融合タンパク質及びその製造方法
EP3533870A4 (en) 2016-10-28 2020-04-08 NRL Pharma, Inc. LACTOFERRIN / ALBUMIN FUSION PROTEIN AND PROCESS FOR PRODUCING THE SAME
WO2020096672A1 (en) 2018-11-09 2020-05-14 The Wistar Institute Of Anatomy And Biology Use of lactoferrin for generating myeloid-derived suppressor cells

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IN150740B (es) * 1978-11-24 1982-12-04 Hoffmann La Roche
GB2046092B (en) * 1979-03-05 1983-11-02 Toyama Chemical Co Ltd Pharmaceutical composition containing a lysophospholid and a phospholipid
US4634665A (en) * 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4394443A (en) * 1980-12-18 1983-07-19 Yale University Method for cloning genes
US4452747A (en) * 1982-03-22 1984-06-05 Klaus Gersonde Method of and arrangement for producing lipid vesicles
US4766075A (en) * 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
US4652639A (en) * 1982-05-06 1987-03-24 Amgen Manufacture and expression of structural genes
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US5571697A (en) * 1989-05-05 1996-11-05 Baylor College Of Medicine Texas Medical Center Expression of processed recombinant lactoferrin and lactoferrin polypeptide fragments from a fusion product in Aspergillus
US5155037A (en) * 1989-08-04 1992-10-13 The Texas A&M University System Insect signal sequences useful to improve the efficiency of processing and secretion of foreign genes in insect systems
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Also Published As

Publication number Publication date
AU3227197A (en) 1998-01-05
US6111081A (en) 2000-08-29
NZ333215A (en) 2000-05-26
JP2000511424A (ja) 2000-09-05
KR20000016159A (ko) 2000-03-25
GR990300043T1 (en) 2000-01-31
CA2256453A1 (en) 1997-12-04
EP0959898A4 (en) 2002-08-14
WO1997045136A1 (en) 1997-12-04
AU707476B2 (en) 1999-07-08
EP0959898A1 (en) 1999-12-01
DE959898T1 (de) 2000-05-04
IL127319A0 (en) 1999-09-22
IL127319A (en) 2004-08-31

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