NZ333201A - Chimeric mutational vectors having non-natural nucleotides - Google Patents

Chimeric mutational vectors having non-natural nucleotides

Info

Publication number
NZ333201A
NZ333201A NZ333201A NZ33320197A NZ333201A NZ 333201 A NZ333201 A NZ 333201A NZ 333201 A NZ333201 A NZ 333201A NZ 33320197 A NZ33320197 A NZ 33320197A NZ 333201 A NZ333201 A NZ 333201A
Authority
NZ
New Zealand
Prior art keywords
nucleobases
strand
ribo
type
compound
Prior art date
Application number
NZ333201A
Other languages
English (en)
Inventor
Eric B Kmiec
Original Assignee
Univ Jefferson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Jefferson filed Critical Univ Jefferson
Publication of NZ333201A publication Critical patent/NZ333201A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8213—Targeted insertion of genes into the plant genome by homologous recombination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/108—Plasmid DNA episomal vectors

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NZ333201A 1996-06-17 1997-06-16 Chimeric mutational vectors having non-natural nucleotides NZ333201A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/664,487 US5731181A (en) 1996-06-17 1996-06-17 Chimeric mutational vectors having non-natural nucleotides
PCT/US1997/010538 WO1997048714A1 (en) 1996-06-17 1997-06-16 Chimeric mutational vectors having non-natural nucleotides

Publications (1)

Publication Number Publication Date
NZ333201A true NZ333201A (en) 2000-06-23

Family

ID=24666178

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ333201A NZ333201A (en) 1996-06-17 1997-06-16 Chimeric mutational vectors having non-natural nucleotides

Country Status (8)

Country Link
US (2) US5731181A (enExample)
EP (1) EP0968224A4 (enExample)
JP (1) JP4063326B2 (enExample)
KR (1) KR20000011075A (enExample)
AU (1) AU732417B2 (enExample)
CA (1) CA2258090A1 (enExample)
NZ (1) NZ333201A (enExample)
WO (1) WO1997048714A1 (enExample)

Families Citing this family (164)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6524613B1 (en) 1997-04-30 2003-02-25 Regents Of The University Of Minnesota Hepatocellular chimeraplasty
GB9711015D0 (en) * 1997-05-28 1997-07-23 Zeneca Ltd Improvements in or relating to organic compounds
EP1007712A4 (en) * 1997-08-05 2004-06-30 Kimeragen Inc USE OF DUPLEX OLIGONUCLEOTIDES TO AFFECT LOCAL GENETIC CHANGES IN PLANTS
US20030125278A1 (en) * 1997-08-13 2003-07-03 Tang De-Chu C. Immunization of animals by topical applications of a salmonella-based vector
US6716823B1 (en) 1997-08-13 2004-04-06 The Uab Research Foundation Noninvasive genetic immunization, expression products therefrom, and uses thereof
US20030045492A1 (en) * 1997-08-13 2003-03-06 Tang De-Chu C. Vaccination by topical application of recombinant vectors
US6706693B1 (en) 1997-08-13 2004-03-16 The Uab Research Foundation Vaccination by topical application of genetic vectors
US6348450B1 (en) 1997-08-13 2002-02-19 The Uab Research Foundation Noninvasive genetic immunization, expression products therefrom and uses thereof
US7102055B1 (en) 1997-11-18 2006-09-05 Pioneer Hi-Bred International, Inc. Compositions and methods for the targeted insertion of a nucleotide sequence of interest into the genome of a plant
EP1032692A1 (en) * 1997-11-18 2000-09-06 Pioneer Hi-Bred International, Inc. Targeted manipulation of herbicide-resistance genes in plants
PT1034262E (pt) 1997-11-18 2005-10-31 Pioneer Hi Bred Int Composicoes e metodos para a modificacao genetica de plantas
US6010907A (en) * 1998-05-12 2000-01-04 Kimeragen, Inc. Eukaryotic use of non-chimeric mutational vectors
US6004804A (en) * 1998-05-12 1999-12-21 Kimeragen, Inc. Non-chimeric mutational vectors
US6150105A (en) * 1998-08-20 2000-11-21 Genetic Assays, Inc. Methods of screening nucleic acids for nucleotide variations
DE19956568A1 (de) * 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
AU2008202208C1 (en) * 1999-01-30 2014-04-24 Alnylam Pharmaceuticals, Inc. Method and medicament for inhibiting the expression of a defined gene
AU4188100A (en) * 1999-04-08 2000-11-14 Gregory M. Glenn Dry formulation for transcutaneous immunization
US6348050B1 (en) * 1999-04-30 2002-02-19 Medtronic, Inc. Infusion systems for creating microenvironments in a living body
US20040009936A1 (en) * 1999-05-03 2004-01-15 Tang De-Chu C. Vaccine and drug delivery by topical application of vectors and vector extracts
WO2000071165A2 (en) * 1999-05-21 2000-11-30 The University Of Miami Use of chimeric mutational vectors to change endogenous sequences in solid tissues
US6271360B1 (en) * 1999-08-27 2001-08-07 Valigen (Us), Inc. Single-stranded oligodeoxynucleotide mutational vectors
AR025996A1 (es) * 1999-10-07 2002-12-26 Valigen Us Inc Plantas no transgenicas resistentes a los herbicidas.
WO2001025460A2 (en) * 1999-10-07 2001-04-12 Valigen, Inc. Compositions and methods for plant genetic modification
US7217699B2 (en) * 2000-01-03 2007-05-15 Panagenic International, Inc. Compositions comprising genome segments and methods of using the same
JP2003528607A (ja) * 2000-03-27 2003-09-30 ユニバーシティー、オブ、デラウェア 修飾一本鎖オリゴヌクレオチドを使用した標的染色体ゲノム変換
US6936467B2 (en) 2000-03-27 2005-08-30 University Of Delaware Targeted chromosomal genomic alterations with modified single stranded oligonucleotides
WO2001087914A2 (en) * 2000-05-17 2001-11-22 University Of Delaware Plant gene targeting using oligonucleotides
US6656700B2 (en) * 2000-05-26 2003-12-02 Amersham Plc Isoforms of human pregnancy-associated protein-E
US6686188B2 (en) * 2000-05-26 2004-02-03 Amersham Plc Polynucleotide encoding a human myosin-like polypeptide expressed predominantly in heart and muscle
US20030017593A1 (en) * 2000-06-05 2003-01-23 Gamper Howard B. Binary hybrid mutational vectors
CA2417344A1 (en) * 2000-07-27 2002-02-07 University Of Delaware Methods for enhancing targeted gene alteration using oligonucleotides
US6875907B2 (en) 2000-09-13 2005-04-05 Pioneer Hi-Bred International, Inc. Antimicrobial peptides and methods of use
WO2002026967A2 (en) * 2000-09-25 2002-04-04 Thomas Jefferson University Targeted gene correction by single-stranded oligodeoxynucleotides
US20020123474A1 (en) * 2000-10-04 2002-09-05 Shannon Mark E. Human GTP-Rho binding protein2
US7560622B2 (en) 2000-10-06 2009-07-14 Pioneer Hi-Bred International, Inc. Methods and compositions relating to the generation of partially transgenic organisms
US20040063922A1 (en) * 2001-04-17 2004-04-01 Conrad Charles A. Methods and compositions for catalytic DNA exchange in a sequence specific manner
US7053195B1 (en) 2001-06-12 2006-05-30 Syngenta Participatious Ag Locked nucleic acid containing heteropolymers and related methods
US20040078837A1 (en) * 2001-08-02 2004-04-22 Shannon Mark E. Four human zinc-finger-containing proteins: MDZ3, MDZ4, MDZ7 and MDZ12
US20030109476A1 (en) * 2001-08-07 2003-06-12 Kmiec Eric B. Compositions and methods for the prevention and treatment of Huntington's disease
US20030084473A1 (en) * 2001-08-09 2003-05-01 Valigen Non-transgenic herbicide resistant plants
EP1448766A2 (en) * 2001-09-27 2004-08-25 University Of Delaware Coisogenic eukaryotic cell collections
EP1446503A2 (en) * 2001-09-27 2004-08-18 University Of Delaware Composition and methods for enhancing oligonucleotide-directed nucleic acid sequence alteration
US20030105047A1 (en) * 2001-11-30 2003-06-05 Medtronic, Inc. Techniques for treating neurodegenerative disorders by brain infusion of mutational vectors
DE60331297D1 (de) * 2002-03-07 2010-04-01 Univ Delaware Verfahren zur verstärkung der oligonucleotid-vermittelten nucleinsäuresequenzänderung unter verwendung von zusammensetzungen mit einem hydroxyharnstoff
US20030228558A1 (en) * 2002-06-11 2003-12-11 Bloom William Dennis Method of training brokers in a multi-level marketing business
EP1550463A4 (en) * 2002-09-20 2006-12-27 Dainippon Sumitomo Pharma Co PREPARATION FOR FACILITATING SITECOUS GENERAL TRANSFORMATION AND PREPARATION FOR GENDER THERAPY
WO2004033708A2 (en) * 2002-10-07 2004-04-22 University Of Delaware Methods and compositions for reducing screening in oligonucleotide-directed nucleic acid sequence alteration
EP1570075A2 (en) * 2002-12-03 2005-09-07 Aarhus Universitet Method for determing predisposition to manifestation of immune system related diseases
US20070072815A1 (en) * 2004-05-04 2007-03-29 Kmiec Eric B Methods and kits to increase the efficiency of oligonucleotide-directed nucleic acid sequence alteration
EP2003205B1 (en) 2004-12-28 2013-05-01 Pioneer Hi-Bred International, Inc. Improved grain quality through altered expression of seed proteins
EP2338905B1 (en) 2005-02-23 2017-11-29 North Carolina State University Alteration of tobacco alkaloid content through modification of specific cytochrome p450 genes
WO2006091722A2 (en) * 2005-02-23 2006-08-31 Uab Research Foundation Alkyl-glycoside enhanced vaccination
US7680604B2 (en) 2005-03-11 2010-03-16 Roche Molecular Systems, Inc. PCR elbow determination by rotational transform after zero slope alignment
CA2651376A1 (en) 2005-05-11 2006-11-16 Aarhus Universitet Method for diagnosis and treatment of a mental disease
AU2006249522A1 (en) 2005-05-25 2006-11-30 Pioneer Hi-Bred International, Inc. Methods for improving crop plant architecture and yield
US7671254B2 (en) * 2005-08-25 2010-03-02 The Board Of Trustees Of The University Of Illinois Herbicide resistance gene, compositions and methods
US7842856B2 (en) 2005-08-25 2010-11-30 The Board Of Trustees Of The University Of Illinois Herbicide resistance gene, compositions and methods
US20070107084A1 (en) 2005-11-10 2007-05-10 Pioneer Hi-Bred International, Inc. Dof (DNA binding with one finger) sequences and methods of use
US20070199096A1 (en) 2005-11-14 2007-08-23 E.I. Du Pont De Nemours And Company Compositions and Methods for Altering Alpha- and Beta-Tocotrienol Content
WO2007073149A1 (en) * 2005-12-22 2007-06-28 Keygene N.V. Alternative nucleotides for improved targeted nucleotide exchange
US7592505B2 (en) 2005-12-30 2009-09-22 Pioneer Hi-Bred International, Inc. UDP-xylose synthases (UXS) polynucleotides, polypeptides, and uses thereof
EP2923563B1 (en) 2006-01-12 2024-09-18 Cibus Europe B.V. EPSPS mutants
RU2313349C2 (ru) 2006-01-16 2007-12-27 Михаил Аркадьевич Шурдов Способ лечения онкологических заболеваний
CA2821436A1 (en) 2006-02-09 2007-08-16 Pioneer Hi-Bred International, Inc. Genes for enhancing nitrogen utilization efficiency in crop plants
EP2007799A2 (en) 2006-04-19 2008-12-31 Pioneer Hi-Bred International, Inc. Isolated polynucleotide molecules corresponding to mutant and wild-type alleles of the maize d9 gene and methods of use
CA2893168C (en) 2006-06-28 2017-11-07 Nucelis Inc. Fatty acid blends and uses therefor
EP2182056B1 (de) 2006-10-06 2015-12-23 BASF Plant Science GmbH Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in transgenen nicht-humanen Organismen
RU2345792C2 (ru) * 2007-04-03 2009-02-10 Михаил Аркадьевич Шурдов Способ лечения онкологических заболеваний
GEP20135945B (en) 2007-04-04 2013-10-25 Basf Ag Ahas mutants
PL3243905T3 (pl) * 2007-04-04 2023-01-09 Basf Se Rośliny brassica odporne na herbicydy i sposoby stosowania
AU2008257572A1 (en) 2007-05-25 2008-12-04 Cropdesign N.V. Yield enhancement in plants by modulation of maize Alfins
CN108342376A (zh) * 2007-10-05 2018-07-31 赛布斯欧洲公司 芸苔属中突变的乙酰羟酸合酶基因
BRPI0820042B1 (pt) 2007-11-12 2020-05-19 North Carolina State University método de obtenção de uma planta de tabaco, ou célula ou parte desta, tendo níveis reduzidos de nornicotina, produto de tabaco, método para fabricar um produto de tabaco, polinucleotídeo isolado, cassete de expressão, polipetpídeo isolado e método de obtenção de uma planta, ou parte de planta desta, do gênero nicotiana
BRPI0819743A2 (pt) 2007-11-20 2014-10-07 Pioneer Hi Bred Int Ácido nucléico isolado, cassete de expressão, célula hospedeira, planta transgênica, semente transgênica, método para modular a resposta de etileno em uma planta, proteína isolada
EP2235187B1 (en) 2007-12-21 2013-12-11 Keygene N.V. An improved mutagenesis method using polyethylene glycol mediated introduction of mutagenic nucleobases into plant protoplasts
JP2011508047A (ja) * 2007-12-27 2011-03-10 サイバス，エルエルシー アルキルエステル脂肪酸配合物およびその用途
AU2009248852B9 (en) 2008-05-23 2015-08-13 Cibus Europe B.V. Production of squalene using yeast
PL2733212T3 (pl) 2008-09-26 2019-06-28 Basf Agrochemical Products, B.V. Mutanty ahas odporne na herbicyd i sposoby ich zastosowania
CA2741006A1 (en) 2008-10-30 2010-05-20 Pioneer Hi-Bred International, Inc. Manipulation of glutamine synthetases (gs) to improve nitrogen use efficiency and grain yield in higher plants
CA2743707A1 (en) 2008-12-04 2010-06-10 Pioneer Hi-Bred International, Inc. Methods and compositions for enhanced yield by targeted expression of knotted1
EP2669380B1 (en) 2008-12-12 2017-09-27 BASF Plant Science GmbH Desaturases and process for the production of polyunsaturated fatty acids in transgenic organisms
EP2376637A1 (en) 2008-12-22 2011-10-19 Keygene N.V. Use of double stranded rna to increase the efficiency of targeted gene alteration in plant protoplasts
EP2387567B1 (en) 2009-01-14 2014-06-11 The Salk Institute for Biological Studies Compounds that protect against amyloid diseases
US8716553B2 (en) 2009-03-02 2014-05-06 Pioneer Hi Bred International Inc NAC transcriptional activators involved in abiotic stress tolerance
UA108071C2 (uk) 2009-04-14 2015-03-25 Піонер Хай-Бред Інтернешнл, Інк. Спосіб поліпшення витривалості до нестачі азоту у рослини
EP2666781A1 (en) 2009-05-04 2013-11-27 Pioneer Hi-Bred International, Inc. Yield enhancement in plants by modulation of AP2 transcription factor
AU2010274146A1 (en) 2009-07-24 2012-02-02 Pioneer Hi-Bred International, Inc. The use of dimerization domain component stacks to modulate plant architecture
RU2429019C2 (ru) * 2009-08-03 2011-09-20 Михаил Аркадьевич Шурдов Способ лечения онкологических заболеваний
US20110035843A1 (en) 2009-08-05 2011-02-10 Pioneer Hi-Bred International, Inc. Novel eto1 genes and use of same for reduced ethylene and improved stress tolerance in plants
AR078502A1 (es) 2009-10-02 2011-11-09 Pioneer Hi Bred Int Regulacion hacia abajo de acc (acido 1-aminociclopropano-1-carboxilico) sintasa para el rendimiento mejorado de plantas
CN107058145A (zh) 2009-11-23 2017-08-18 纽塞利斯公司 使用酵母产生角鲨烯的方法和组合物
WO2011082304A1 (en) 2009-12-31 2011-07-07 Pioneer Hi-Bred International, Inc. Engineering plant resistance to diseases caused by pathogens
CA2786741A1 (en) 2010-01-06 2011-07-14 Pioneer Hi-Bred International, Inc. Identification of diurnal rhythms in photosynthetic and non-photosynthetic tissues from zea mays and use in improving crop plants
US9611485B2 (en) 2010-01-26 2017-04-04 Pioneer Hi-Bred International, Inc. Polynucleotide and polypeptide sequences associated with herbicide tolerance
US20110277182A1 (en) 2010-05-06 2011-11-10 E.I. Dupont De Nemours And Company Maize acc synthase 3 gene and protein and uses thereof
US20120122223A1 (en) 2010-08-03 2012-05-17 Cibus Us Llc Mutated protoporphyrinogen ix oxidase (ppx) genes
UA112969C2 (uk) 2010-08-03 2016-11-25 Сібас Юс Ллс Рослина, стійка до одного або більше ррх-інгібуючих гербіцидів, яка містить мутантний ген протопорфіриноген ix оксидази (ррх)
US9187762B2 (en) 2010-08-13 2015-11-17 Pioneer Hi-Bred International, Inc. Compositions and methods comprising sequences having hydroxyphenylpyruvate dioxygenase (HPPD) activity
WO2012028673A1 (en) 2010-09-02 2012-03-08 Ludwig-Maximilians-Universitaet Muenchen Spontaneous organogenesis in plants
EP2426204A1 (en) 2010-09-02 2012-03-07 Ludwig-Maximilians-Universität München Spontaneous nodule organogenesis in plants
CN103459596B (zh) 2010-12-02 2016-12-14 关键基因股份有限公司 靶向改变dna
EP2646550B1 (en) 2010-12-02 2015-02-18 Keygene N.V. Targeted alteration of dna with oligonucleotides
CN103502269A (zh) 2011-04-29 2014-01-08 先锋国际良种公司 下调同源域-亮氨酸拉链i类同源盒基因以改进植物性能
EP2721160A2 (en) 2011-06-14 2014-04-23 Synthon Biopharmaceuticals B.V. Compositions and methods for making and biocontaining auxotrophic transgenic plants
US20130097734A1 (en) 2011-07-12 2013-04-18 Two Blades Foundation Late blight resistance genes
BR112014010537A2 (pt) 2011-10-31 2017-05-02 Pioneer Hi Bred Int método para modular a sensibilidade ao etileno, planta transgênica, proteína isolada, sequência de polinucleotídeos isolada, polipeptídeo com atividade regulatória de etileno, método para aumentar o rendimento em uma planta, método para melhorar um parâmetro agronômico de uma planta, método de seleção assistida por marcador de uma planta
WO2013138358A1 (en) 2012-03-13 2013-09-19 Pioneer Hi-Bred International, Inc. Genetic reduction of male fertility in plants
WO2013138309A1 (en) 2012-03-13 2013-09-19 Pioneer Hi-Bred International, Inc. Genetic reduction of male fertility in plants
US10045499B2 (en) 2012-05-24 2018-08-14 Iowa State University Research Foundation, Inc. Arabidopsis nonhost resistance gene(s) and use thereof to engineer disease resistant plants
US10006041B2 (en) 2012-08-16 2018-06-26 Vib Vzw Means and methods for altering the lignin pathway in plants
AU2013361220A1 (en) 2012-12-21 2015-04-02 Pioneer Hi-Bred International, Inc. Compositions and methods for auxin-analog conjugation
US20160002648A1 (en) 2013-03-11 2016-01-07 Mei Guo Genes for improving nutrient uptake and abiotic stress tolerance in plants
US10329574B2 (en) 2013-03-12 2019-06-25 E I Du Pont De Nemours And Company Methods for the identification of variant recognition sites for rare-cutting engineered double-strand-break-inducing agents and compositions and uses thereof
US9803214B2 (en) 2013-03-12 2017-10-31 Pioneer Hi-Bred International, Inc. Breeding pair of wheat plants comprising an MS45 promoter inverted repeat that confers male sterility and a construct that restores fertility
WO2014164116A1 (en) 2013-03-13 2014-10-09 Pioneer Hi-Bred International, Inc. Functional expression of bacterial major facilitator superfamily (sfm) gene in maize to improve agronomic traits and grain yield
US20160010101A1 (en) 2013-03-13 2016-01-14 Pioneer Hi-Bred International, Inc. Enhanced nitrate uptake and nitrate translocation by over- expressing maize functional low-affinity nitrate transporters in transgenic maize
US20160024513A1 (en) 2013-03-14 2016-01-28 Pioneer Hi-Bred International Inc. Maize stress related transcription factor 18 and uses thereof
US9790515B2 (en) 2013-03-14 2017-10-17 Cibus Us Llc Mutated allene oxide synthase 2 (AOS2) genes
EA201591447A1 (ru) 2013-03-15 2016-05-31 Сибас Юс Ллс Способы и композиции для повышения эффективности направленной модификации генов с применением опосредованной олигонуклеотидами репарации генов
US12331303B2 (en) 2013-03-15 2025-06-17 Cibus Us Llc Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
US9957515B2 (en) 2013-03-15 2018-05-01 Cibus Us Llc Methods and compositions for targeted gene modification
WO2014152507A2 (en) 2013-03-15 2014-09-25 Pioneer Hi-Bred International, Inc. Modulation of acc deaminase expression
US20160017350A1 (en) 2013-03-15 2016-01-21 Pioneer Hi-Bred International, Inc. Compositions and methods of use of acc oxidase polynucleotides and polypeptides
UA120033C2 (uk) * 2013-03-15 2019-09-25 Сібас Юс Ллс Спосіб підвищення ефективності спрямованої модифікації генів із застосуванням опосередкованої олігонуклеотидами репарації генів
AU2014234265B2 (en) 2013-03-21 2020-01-30 Universiteit Gent Means and methods for the reduction of photorespiration in crops
US11459579B2 (en) 2013-07-09 2022-10-04 Board Of Trustees Of Michigan State University Transgenic plants produced with a K-domain, and methods and expression cassettes related thereto
BR112015032956B1 (pt) 2013-07-09 2022-09-13 Board Of Trustees Of Michigan State University Método para produzir uma planta transgênica e cassete de expressão
WO2015116680A1 (en) 2014-01-30 2015-08-06 Two Blades Foundation Plants with enhanced resistance to phytophthora
AU2015229095B2 (en) 2014-03-14 2022-01-27 Cibus Europe B.V. Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
WO2015171603A1 (en) 2014-05-06 2015-11-12 Two Blades Foundation Methods for producing plants with enhanced resistance to oomycete pathogens
US20170159065A1 (en) 2014-07-08 2017-06-08 Vib Vzw Means and methods to increase plant yield
CA3239747A1 (en) 2014-09-26 2016-03-31 Pioneer Hi-Bred International, Inc. Wheat ms1 polynucleotides, polypeptides, and methods of use
EP3739053B1 (en) 2014-10-06 2023-08-30 Altria Client Services LLC Genetic control of axillary bud growth in tobacco plants
WO2016100309A1 (en) 2014-12-16 2016-06-23 Pioneer Hi-Bred International, Inc. Restoration of male fertility in wheat
WO2016105185A1 (en) 2014-12-22 2016-06-30 Keygene N.V. Plant callus populations
CA2985458A1 (en) 2015-05-09 2016-11-17 Two Blades Foundation Late blight resistance gene from solanum americanum and methods of use
WO2017062790A1 (en) 2015-10-09 2017-04-13 Two Blades Foundation Cold shock protein receptors and methods of use
BR112018016278A2 (pt) 2016-02-09 2019-01-02 Cibus Europe Bv métodos e composições para aumentar a eficiência da modificação do gene direcionada usando reparação de gene mediada por oligonucleotídeo
US10731173B2 (en) 2016-03-11 2020-08-04 Altria Client Services Llc Compositions and methods for producing tobacco plants and products having reduced or eliminated suckers
US11193136B2 (en) 2016-08-09 2021-12-07 Vib Vzw Cellulose synthase inhibitors and mutant plants
US10647989B2 (en) 2016-10-07 2020-05-12 Altria Client Services Llc Composition and methods for producing tobacco plants and products having reduced tobacco-specific nitrosamines (TSNAs)
JP7016170B2 (ja) * 2016-12-16 2022-02-04 国立大学法人東海国立大学機構 ヌクレオシド誘導体及びその利用
CN110462047B (zh) 2016-12-16 2024-12-27 双刃基金会 晚疫病抗性基因及使用方法
WO2018140214A1 (en) 2017-01-24 2018-08-02 Pioneer Hi-Bred International, Inc. Nematicidal protein from pseudomonas
EP3658675A1 (en) 2017-07-28 2020-06-03 Two Blades Foundation Potyvirus resistance genes and methods of use
WO2019051232A1 (en) 2017-09-11 2019-03-14 Altria Client Services Llc COMPOSITIONS AND METHODS FOR PRODUCING TOBACCO PLANTS AND PRODUCTS HAVING REDUCED OR ELIMINATED GOURMETS
JP7173467B2 (ja) 2017-10-31 2022-11-16 ヤマサ醤油株式会社 ヌクレオシド誘導体及びその利用
WO2019108619A1 (en) 2017-11-28 2019-06-06 Two Blades Foundation Methods and compositions for enhancing the disease resistance of plants
US11034969B2 (en) 2017-12-22 2021-06-15 Altria Client Services Llc Plant comprising recombinant polynucleotides encoding a pigment regulatory transcription factor with a tissue-preferred promoter
WO2019140009A1 (en) 2018-01-09 2019-07-18 Cibus Us Llc Shatterproof genes and mutations
WO2019140351A1 (en) 2018-01-12 2019-07-18 Two Blades Foundation Stem rust resistance genes and methods of use
US11377665B2 (en) 2018-04-03 2022-07-05 Altria Client Services Llc Composition and methods for producing tobacco plants and products having increased phenylalanine and reduced tobacco-specific nitrosamines (TSNAs)
AU2019247403B2 (en) 2018-04-04 2025-04-10 Cibus Europe, B.V. FAD2 genes and mutations
WO2020154466A1 (en) 2019-01-24 2020-07-30 Altria Client Services Llc Tobacco plants comprising reduced nicotine and reduced tobacco specific nitrosamines
CN114450405A (zh) 2019-06-27 2022-05-06 双刃基金会 工程化atrlp23模式识别受体及使用方法
WO2021011348A1 (en) 2019-07-12 2021-01-21 The Regents Of The University Of California Plants with enhanced resistance to bacterial pathogens
CN117917951A (zh) 2021-05-11 2024-04-23 双刃基金会 用于抗病性功能测试的植物抗病基因文库的制备方法
WO2023012342A1 (en) 2021-08-06 2023-02-09 Kws Vegetables B.V. Durable downy mildew resistance in spinach
US20250002929A1 (en) 2021-09-30 2025-01-02 The Sainsbury Laboratory Plant disease resistance genes against stem rust and methods of use
WO2023131616A1 (en) 2022-01-05 2023-07-13 Vib Vzw Means and methods to increase abiotic stress tolerance in plants
WO2023131637A1 (en) 2022-01-06 2023-07-13 Vib Vzw Improved silage grasses
WO2023144199A1 (en) 2022-01-26 2023-08-03 Vib Vzw Plants having reduced levels of bitter taste metabolites
WO2025019283A1 (en) 2023-07-14 2025-01-23 Two Blades Foundation Methods of improving the thermostability of plant immune receptors
WO2025019221A1 (en) 2023-07-15 2025-01-23 Two Blades Foundation Broad-spectrum polerovirus resistance gene

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4503151A (en) * 1980-12-10 1985-03-05 Research Corporation Recombinant cDNA construction method and hybrid nucleotides useful in cloning
US4882279A (en) * 1985-10-25 1989-11-21 Phillips Petroleum Company Site selective genomic modification of yeast of the genus pichia
EP0260032B1 (en) * 1986-09-08 1994-01-26 Ajinomoto Co., Inc. Compounds for the cleavage at a specific position of RNA, oligomers employed for the formation of said compounds, and starting materials for the synthesis of said oligomers
EP0497875B1 (en) * 1989-10-24 2000-03-22 Isis Pharmaceuticals, Inc. 2' modified oligonucleotides
JP3571337B2 (ja) * 1992-02-11 2004-09-29 セル ジェネシス，インコーポレーテッド 遺伝子標的現象による同型遺伝子接合
PT733059E (pt) * 1993-12-09 2001-03-30 Univ Jefferson Compostos e metodos para mutacoes dirigidas ao local em celulas eucarioticas
US5760012A (en) * 1996-05-01 1998-06-02 Thomas Jefferson University Methods and compounds for curing diseases caused by mutations

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