NZ277946A - Apoptosis modulating protein and nucleotide sequence compositions using bcl-2 homologs termed cdn-1, cdn-2 and cdn3 - Google Patents
Apoptosis modulating protein and nucleotide sequence compositions using bcl-2 homologs termed cdn-1, cdn-2 and cdn3Info
- Publication number
- NZ277946A NZ277946A NZ277946A NZ27794694A NZ277946A NZ 277946 A NZ277946 A NZ 277946A NZ 277946 A NZ277946 A NZ 277946A NZ 27794694 A NZ27794694 A NZ 27794694A NZ 277946 A NZ277946 A NZ 277946A
- Authority
- NZ
- New Zealand
- Prior art keywords
- cdn
- composition according
- nucleotide sequence
- cell
- depicted
- Prior art date
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Applications Claiming Priority (3)
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PCT/US1994/013930 WO1995015084A1 (en) | 1993-11-30 | 1994-11-30 | Novel apoptosis-modulating proteins, dna encoding the proteins and methods of use thereof |
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NZ277946A NZ277946A (en) | 1993-11-30 | 1994-11-30 | Apoptosis modulating protein and nucleotide sequence compositions using bcl-2 homologs termed cdn-1, cdn-2 and cdn3 |
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US (7) | US6586395B1 (de) |
EP (1) | EP0731636B1 (de) |
JP (4) | JP4129055B2 (de) |
CN (1) | CN1139871A (de) |
AT (1) | ATE315643T1 (de) |
AU (1) | AU688839B2 (de) |
CA (1) | CA2177827C (de) |
DE (1) | DE69434614T2 (de) |
ES (1) | ES2256843T3 (de) |
FI (1) | FI962247A (de) |
HU (1) | HUT74276A (de) |
NO (1) | NO962188L (de) |
NZ (1) | NZ277946A (de) |
WO (1) | WO1995015084A1 (de) |
Families Citing this family (28)
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EP0731636B1 (de) | 1993-11-30 | 2006-01-11 | Tanox, Inc. | Cdn apoptosis modulierende proteine, sie kodierende dns und verfahren zu ihrer verwendung |
US5998131A (en) * | 1994-10-07 | 1999-12-07 | Lxr Biotechnology, Inc. | Screening methods for the identification of compounds capable of abrogating BaK-BHRF-1 protein interactions |
JPH1189573A (ja) * | 1994-10-14 | 1999-04-06 | Yutaka Shindo | アポトーシス関与遺伝子 |
WO1996033416A1 (en) * | 1995-04-20 | 1996-10-24 | Lxr Biotechnology Inc. | Methods of screening for therapeutic agents using novel apoptosis-modulating proteins |
AU6165598A (en) * | 1997-02-18 | 1998-09-08 | Lxr Biotechnology Inc. | Bak promotor expression system |
US6441135B1 (en) * | 1997-03-20 | 2002-08-27 | Tanox, Inc. | Bak binding protein, DNA encoding the protein, and methods of use thereof |
US20030215445A1 (en) | 1997-05-23 | 2003-11-20 | Ginette Serrero | Methods and compositions for inhibiting the growth of hematopoietic malignant cells |
US20100111928A1 (en) * | 1997-05-23 | 2010-05-06 | A & G Pharmaceutical, Inc. | Methods and kits for diagnosis tumorgenicity |
US6218144B1 (en) * | 1997-06-30 | 2001-04-17 | The Board Of Trustees Of The Leland Stanford Junior University | Costal2 genes and their uses |
US6641998B2 (en) * | 1997-10-10 | 2003-11-04 | Stratagene | Methods and kits to enrich for desired nucleic acid sequences |
DE69937835T2 (de) * | 1998-09-24 | 2009-01-02 | Promega Corp., Madison | Antikörper für apoptosemarker und anwendungsverfahren |
US6570002B1 (en) | 1999-02-26 | 2003-05-27 | The Johns Hopkins University | Inhibitor of programmed cell death |
US6737511B1 (en) * | 1999-08-16 | 2004-05-18 | The United States Of America As Represented By The Department Of Health And Human Services | Receptor-mediated uptake of an extracellular BCL-xL fusion protein inhibits apoptosis |
US20010053769A1 (en) | 2000-01-21 | 2001-12-20 | Christiane Ferran | Use of pro-apoptotic factors in treatment of atherosclerosis |
EP1349929A2 (de) * | 2000-07-14 | 2003-10-08 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Apoptose-induzierende dna-sequenzen |
WO2002074908A2 (en) * | 2001-03-02 | 2002-09-26 | Mds Proteomics, Inc. | Methods and reagents for regulating apoptosis |
EP1253200A1 (de) * | 2001-04-25 | 2002-10-30 | Société des Produits Nestlé S.A. | Kakao-Polypeptide und ihre Anwendung zur Herstellung von Kakao- und Schokoladenaroma |
CN100352510C (zh) * | 2001-10-03 | 2007-12-05 | 拜奥尼茨生命科学公司 | 可用于治疗的三甘醇胆甾烯基寡核苷酸 |
US7411045B2 (en) * | 2002-11-19 | 2008-08-12 | A&G Pharmaceutical, Inc. | Autocrine growth factor receptor antibodies and methods |
WO2004050858A2 (en) * | 2002-12-04 | 2004-06-17 | Diadexus, Inc. | Compositions, splice variants and methods relating to colon specific genes and proteins |
WO2004072225A2 (en) * | 2003-02-12 | 2004-08-26 | Ramot At Tel Aviv University Ltd. | Transgenic fungi expressing bcl-2 and methods of using bcl-2 or portions thereof for improving biomass production, survival, longevity, stress resistance and pathogenicity of fungi |
KR20060070491A (ko) * | 2003-06-23 | 2006-06-23 | 에이 앤드 지 파마슈티컬즈, 인코포레이티드 | 항종양 요법에 대한 종양 세포의 감수성 회복 및 세포 사멸유도를 위한 조성물 및 방법 |
WO2005011590A2 (en) * | 2003-08-01 | 2005-02-10 | A & G Pharmaceutical, Inc. | Compositions and methods for restoring sensitivity to treatment with her2 antagonists |
HUE031122T2 (en) * | 2005-10-31 | 2017-07-28 | Oncomed Pharm Inc | Preparations and methods for the treatment of cancer based on human FZD receptors |
WO2011056886A2 (en) * | 2009-11-03 | 2011-05-12 | The Johns Hopkins University | Method and composition for generating programmed cell death resistant algal cells |
EP2418286A1 (de) * | 2010-08-10 | 2012-02-15 | QIAGEN GmbH | Verbessertes Verfahren zur isothermalen Amplifikation von Nukleinsäuren |
US20130166458A1 (en) * | 2011-12-22 | 2013-06-27 | Embraer S.A. | System and method for remote and automatic assessment of structural damage and repair |
US20230392166A1 (en) * | 2020-10-21 | 2023-12-07 | Wisconsin Alumni Research Foundation | Anti-apoptotic vector and method of using the same |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2515992A (en) * | 1991-08-20 | 1993-03-16 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
US5474796A (en) * | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
US5395767A (en) | 1992-06-22 | 1995-03-07 | Regents Of The University Of California | Gene for ataxia-telangiectasia complementation group D (ATDC) |
US5646008A (en) * | 1993-06-22 | 1997-07-08 | The Regent Of The University Of Michigan | Vertebrate apoptosis gene: compositions and methods |
JPH08511690A (ja) | 1993-06-24 | 1996-12-10 | ザ・ジェネラル・ホスピタル・コーポレーション | プログラムされた細胞死遺伝子及びタンパク質 |
WO1995005738A1 (en) * | 1993-08-20 | 1995-03-02 | Massachusetts Institute Of Technology | Anticancer agents and apoptosis |
US5700638A (en) * | 1993-08-26 | 1997-12-23 | Washington University | Cell death regulator |
EP0731636B1 (de) * | 1993-11-30 | 2006-01-11 | Tanox, Inc. | Cdn apoptosis modulierende proteine, sie kodierende dns und verfahren zu ihrer verwendung |
US5672686A (en) * | 1994-08-09 | 1997-09-30 | Immunogen, Inc. | Bcl-Y - specific antibodies |
WO1996033416A1 (en) * | 1995-04-20 | 1996-10-24 | Lxr Biotechnology Inc. | Methods of screening for therapeutic agents using novel apoptosis-modulating proteins |
US5656725A (en) * | 1995-05-12 | 1997-08-12 | Apoptosis Technology, Inc. | Peptides and compositions which modulate apoptosis |
CA2427858A1 (en) * | 2000-11-03 | 2002-05-10 | University Of Vermont And State Agricultural College | Compositions for inhibiting grb7 |
-
1994
- 1994-11-30 EP EP95904808A patent/EP0731636B1/de not_active Expired - Lifetime
- 1994-11-30 CA CA002177827A patent/CA2177827C/en not_active Expired - Lifetime
- 1994-11-30 HU HU9601448A patent/HUT74276A/hu unknown
- 1994-11-30 NZ NZ277946A patent/NZ277946A/en not_active IP Right Cessation
- 1994-11-30 JP JP51579895A patent/JP4129055B2/ja not_active Expired - Lifetime
- 1994-11-30 CN CN94194717A patent/CN1139871A/zh active Pending
- 1994-11-30 AU AU13351/95A patent/AU688839B2/en not_active Expired
- 1994-11-30 ES ES95904808T patent/ES2256843T3/es not_active Expired - Lifetime
- 1994-11-30 DE DE69434614T patent/DE69434614T2/de not_active Expired - Lifetime
- 1994-11-30 AT AT95904808T patent/ATE315643T1/de not_active IP Right Cessation
- 1994-11-30 WO PCT/US1994/013930 patent/WO1995015084A1/en active IP Right Grant
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1995
- 1995-06-06 US US08/470,865 patent/US6586395B1/en not_active Expired - Lifetime
- 1995-06-06 US US08/471,057 patent/US6015687A/en not_active Expired - Lifetime
- 1995-06-06 US US08/471,058 patent/US5770443A/en not_active Expired - Lifetime
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1996
- 1996-05-29 FI FI962247A patent/FI962247A/fi unknown
- 1996-05-29 NO NO962188A patent/NO962188L/no unknown
-
2000
- 2000-08-07 US US09/633,200 patent/US6903195B1/en not_active Expired - Fee Related
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2002
- 2002-03-18 US US10/101,482 patent/US7108989B2/en not_active Expired - Fee Related
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2005
- 2005-03-16 US US11/082,485 patent/US7754418B2/en not_active Expired - Fee Related
- 2005-09-14 JP JP2005267710A patent/JP2006061159A/ja not_active Withdrawn
-
2006
- 2006-07-14 US US11/457,765 patent/US20070117748A1/en not_active Abandoned
-
2007
- 2007-06-12 JP JP2007155798A patent/JP2007252391A/ja not_active Withdrawn
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Also Published As
Publication number | Publication date |
---|---|
HUT74276A (en) | 1996-11-28 |
DE69434614T2 (de) | 2006-10-05 |
AU1335195A (en) | 1995-06-19 |
FI962247A0 (fi) | 1996-05-29 |
NO962188D0 (no) | 1996-05-29 |
US6015687A (en) | 2000-01-18 |
CA2177827A1 (en) | 1995-06-08 |
JPH09509567A (ja) | 1997-09-30 |
EP0731636A4 (de) | 1998-04-15 |
CN1139871A (zh) | 1997-01-08 |
US7754418B2 (en) | 2010-07-13 |
US6903195B1 (en) | 2005-06-07 |
NO962188L (no) | 1996-07-23 |
JP2006061159A (ja) | 2006-03-09 |
JP2009189377A (ja) | 2009-08-27 |
HU9601448D0 (en) | 1996-07-29 |
US5770443A (en) | 1998-06-23 |
US20030008837A1 (en) | 2003-01-09 |
CA2177827C (en) | 2007-08-28 |
FI962247A (fi) | 1996-07-22 |
ATE315643T1 (de) | 2006-02-15 |
US7108989B2 (en) | 2006-09-19 |
WO1995015084A1 (en) | 1995-06-08 |
EP0731636A1 (de) | 1996-09-18 |
US20050164284A1 (en) | 2005-07-28 |
US20070117748A1 (en) | 2007-05-24 |
US6586395B1 (en) | 2003-07-01 |
JP4129055B2 (ja) | 2008-07-30 |
ES2256843T3 (es) | 2006-07-16 |
JP2007252391A (ja) | 2007-10-04 |
AU688839B2 (en) | 1998-03-19 |
DE69434614D1 (de) | 2006-04-06 |
EP0731636B1 (de) | 2006-01-11 |
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