NZ245170A - Insulin and proinsulin analogues with arg at b31, b32 and ao and pharmaceutical compositions - Google Patents

Insulin and proinsulin analogues with arg at b31, b32 and ao and pharmaceutical compositions

Info

Publication number
NZ245170A
NZ245170A NZ24517092A NZ24517092A NZ245170A NZ 245170 A NZ245170 A NZ 245170A NZ 24517092 A NZ24517092 A NZ 24517092A NZ 24517092 A NZ24517092 A NZ 24517092A NZ 245170 A NZ245170 A NZ 245170A
Authority
NZ
New Zealand
Prior art keywords
arg
insulin
pharmaceutical compositions
proinsulin analogues
proinsulin
Prior art date
Application number
NZ24517092A
Other languages
English (en)
Inventor
James Arthur Hoffmann
Peter Karl Lambooy
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NZ245170A publication Critical patent/NZ245170A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NZ24517092A 1991-11-26 1992-11-18 Insulin and proinsulin analogues with arg at b31, b32 and ao and pharmaceutical compositions NZ245170A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80116391A 1991-11-26 1991-11-26

Publications (1)

Publication Number Publication Date
NZ245170A true NZ245170A (en) 1994-07-26

Family

ID=25180362

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ24517092A NZ245170A (en) 1991-11-26 1992-11-18 Insulin and proinsulin analogues with arg at b31, b32 and ao and pharmaceutical compositions

Country Status (17)

Country Link
US (2) US5491216A (enExample)
EP (1) EP0544466A1 (enExample)
JP (1) JP3304442B2 (enExample)
KR (1) KR930009591A (enExample)
CN (1) CN1072723A (enExample)
AU (1) AU2857692A (enExample)
BR (1) BR9204542A (enExample)
CA (1) CA2083360A1 (enExample)
CZ (1) CZ342492A3 (enExample)
FI (1) FI925343L (enExample)
HU (2) HU9203688D0 (enExample)
IL (1) IL103849A0 (enExample)
MX (1) MX9206724A (enExample)
NO (1) NO924525L (enExample)
NZ (1) NZ245170A (enExample)
TW (1) TW224471B (enExample)
ZA (1) ZA928916B (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2289751T3 (es) * 1995-02-20 2008-02-01 The Walter And Eliza Hall Institute Of Medical Research Moleculas inmunorreactivas e inmunoterapeuticas que interaccionan en sujetos con diabetes mellitus insulinodependientes (dmid).
ES2218622T3 (es) * 1996-07-26 2004-11-16 Aventis Pharma Deutschland Gmbh Derivados de insulina con actividad de union al zinc incrementada.
US6444641B1 (en) 1997-10-24 2002-09-03 Eli Lilly Company Fatty acid-acylated insulin analogs
US6933272B1 (en) 1998-09-22 2005-08-23 Erik Helmerhorst Use of non-peptidyl compounds for the treatment of insulin related ailments
JP2003528149A (ja) 2000-03-24 2003-09-24 ジェネンテック・インコーポレーテッド 軟骨性疾患の治療のためのインスリンの使用
US20050014679A1 (en) * 2001-12-20 2005-01-20 Beals John Michael Insulin molecule having protracted time action
CA2518776A1 (en) * 2003-04-29 2004-11-11 Eli Lilly And Company Insulin analogs having protracted time action
WO2007081824A2 (en) * 2006-01-06 2007-07-19 Case Western Reserve University Fibrillation resistant proteins
EP2049149B1 (en) 2006-07-31 2015-04-15 Novo Nordisk A/S Pegylated extended insulins
BRPI0717098B8 (pt) 2006-09-22 2021-05-25 Novo Nordisk As análogos de insulina humana resistentes à protease, composição farmacêutica e processo para sua preparação
ES2554773T3 (es) 2006-10-04 2015-12-23 Case Western Reserve University Insulina y análogos de la insulina resistentes a la fibrilación
US9387176B2 (en) 2007-04-30 2016-07-12 Novo Nordisk A/S Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
US8691759B2 (en) 2008-03-18 2014-04-08 Novo Nordisk A/S Protease stabilized, acylated insulin analogues
US8993516B2 (en) * 2008-04-14 2015-03-31 Case Western Reserve University Meal-time insulin analogues of enhanced stability
US20110195896A1 (en) * 2008-04-22 2011-08-11 Case Western Reserve University Isoform-specific insulin analogues
KR20120129875A (ko) 2008-07-31 2012-11-28 케이스 웨스턴 리저브 유니버시티 염소화 아미노산을 갖는 인슐린 유사체
US9200053B2 (en) 2008-07-31 2015-12-01 Case Western Reserve University Insulin analogues containing penta-fluoro-Phenylalanine at position B24
US8399407B2 (en) * 2009-09-17 2013-03-19 Case Western Reserve University Non-standard insulin analogues
EA201200717A1 (ru) 2009-12-11 2013-03-29 Кейз Вестерн Ризев Юнивесити Аналоги инсулина, содержащие хлорированные аминокислоты
US9187547B2 (en) * 2011-03-15 2015-11-17 Novo Nordisk A/S Human insulin analogues and derivatives comprising cysteine substitutions
CN104364260B (zh) 2012-04-11 2017-02-22 诺和诺德股份有限公司 胰岛素制剂
US9896496B2 (en) 2013-10-07 2018-02-20 Novo Nordisk A/S Derivative of an insulin analogue
CN104017809A (zh) * 2014-06-05 2014-09-03 山东省农业科学院生物技术研究中心 改造的人Insulin蛋白表达基因及表达方法
CN107108716A (zh) 2014-10-06 2017-08-29 卡斯西部储备大学 双相性单链胰岛素类似物
CA2979397A1 (en) * 2015-03-12 2016-09-15 Board Of Trustees Of Michigan State University Compositions and methods for measuring c-peptide binding and diagnosing immune-mediated diseases
CN108473548A (zh) * 2015-09-24 2018-08-31 韩美药品股份有限公司 胰岛素生产方法
SI3554534T1 (sl) 2016-12-16 2021-09-30 Novo Nordisk A/S Farmacevtski sestavki, ki vsebujejo inzulin

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3326473A1 (de) * 1983-07-22 1985-01-31 Hoechst Ag, 6230 Frankfurt Pharmazeutisches mittel zur behandlung des diabetes mellitus
DE3326472A1 (de) * 1983-07-22 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
US4569792A (en) * 1984-06-14 1986-02-11 Eli Lilly And Company Anti-diabetic compounds
US4569791A (en) * 1984-06-14 1986-02-11 Eli Lilly And Company Anti-diabetic compounds
US4581165A (en) * 1984-06-14 1986-04-08 Eli Lilly And Company Anti-diabetic compounds
US5008241A (en) * 1985-03-12 1991-04-16 Novo Nordisk A/S Novel insulin peptides
DK129385A (da) * 1985-03-22 1986-09-23 Novo Industri As Peptider og fremstilling deraf
CA1339955C (en) * 1986-10-14 1998-07-14 Richard Eugene Heiney Process for transforming a human insulin precursor to human insulin
US4992418A (en) * 1987-07-17 1991-02-12 Mount Sinai School Of Medicine Superactive human insulin analogue-[10-Aspartic Acid-B]Human Insulin
ES2061797T3 (es) * 1988-06-23 1994-12-16 Hoechst Ag Mini-proinsulina, su preparacion y empleo.
DE3844211A1 (de) * 1988-12-29 1990-07-05 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DK134189D0 (da) * 1989-03-20 1989-03-20 Nordisk Gentofte Insulinforbindelser
DE3936876A1 (de) * 1989-11-06 1991-05-23 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
US5130236A (en) * 1989-12-07 1992-07-14 Eli Lilly And Company Process for producing des(64,65)-proinsulin
US5139716A (en) * 1990-02-20 1992-08-18 Loral Aerospace Corp. Method of fabricating coolable ceramic structures

Also Published As

Publication number Publication date
FI925343A7 (fi) 1993-05-27
CZ342492A3 (en) 1993-06-16
JP3304442B2 (ja) 2002-07-22
BR9204542A (pt) 1993-06-01
NO924525L (no) 1993-05-27
AU2857692A (en) 1993-05-27
NO924525D0 (no) 1992-11-24
KR930009591A (ko) 1993-06-21
JPH05286998A (ja) 1993-11-02
TW224471B (enExample) 1994-06-01
CN1072723A (zh) 1993-06-02
HU9203688D0 (en) 1993-03-29
ZA928916B (en) 1994-05-18
US5698669A (en) 1997-12-16
FI925343L (fi) 1993-05-27
US5491216A (en) 1996-02-13
EP0544466A1 (en) 1993-06-02
IL103849A0 (en) 1993-04-04
HUT63457A (en) 1993-08-30
MX9206724A (es) 1993-05-01
CA2083360A1 (en) 1993-05-27
FI925343A0 (fi) 1992-11-25

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