NZ215925A - 9-(phosphonylmethoxyalkyl)adenines - Google Patents

9-(phosphonylmethoxyalkyl)adenines

Info

Publication number
NZ215925A
NZ215925A NZ215925A NZ21592586A NZ215925A NZ 215925 A NZ215925 A NZ 215925A NZ 215925 A NZ215925 A NZ 215925A NZ 21592586 A NZ21592586 A NZ 21592586A NZ 215925 A NZ215925 A NZ 215925A
Authority
NZ
New Zealand
Prior art keywords
sup
phosphonylmethoxyalkyl
adenines
ethylene
compounds
Prior art date
Application number
NZ215925A
Other languages
English (en)
Inventor
A Holy
I Rosenberg
Original Assignee
Ceskoslovenska Akademie Ved
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ceskoslovenska Akademie Ved filed Critical Ceskoslovenska Akademie Ved
Publication of NZ215925A publication Critical patent/NZ215925A/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NZ215925A 1985-04-25 1986-04-23 9-(phosphonylmethoxyalkyl)adenines NZ215925A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS853017A CS263951B1 (en) 1985-04-25 1985-04-25 9-(phosponylmethoxyalkyl)adenines and method of their preparation

Publications (1)

Publication Number Publication Date
NZ215925A true NZ215925A (en) 1989-01-27

Family

ID=5369028

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ215925A NZ215925A (en) 1985-04-25 1986-04-23 9-(phosphonylmethoxyalkyl)adenines

Country Status (13)

Country Link
US (1) US4808716A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0206459B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS61275289A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE78259T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU580151B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1295614C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CS (1) CS263951B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3686002T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK173625B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EG (1) EG18079A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HK (1) HK213296A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO174510B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ215925A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047533A (en) * 1983-05-24 1991-09-10 Sri International Acyclic purine phosphonate nucleotide analogs
US4845084A (en) * 1984-01-26 1989-07-04 Merck & Co., Inc. Phosphate derivatives of substituted butyl guanines, antiviral compositions containing them, and methods of treating viral infections with them
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
IL84477A (en) * 1986-11-18 1995-12-08 Bristol Myers Squibb Co History of Phosphonomethoxyalkylene Purinopyrimidine and Pharmaceutical Preparations Containing Them
US5650510A (en) * 1986-11-18 1997-07-22 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives
IE883550L (en) * 1987-11-30 1989-05-30 Salvatore Mario Pandolfo Novel compounds
US5247085A (en) * 1987-11-30 1993-09-21 Beecham Group P.L.C. Antiviral purine compounds
EP0335770B1 (en) * 1988-04-01 1997-01-15 Merrell Pharmaceuticals Inc. Novel fluorophosphonate nucleotide derivatives
EP0339161A1 (en) * 1988-04-01 1989-11-02 Merrell Dow Pharmaceuticals Inc. Novel fluorophosphonate nucleotide derivatives
US5284837A (en) * 1988-05-06 1994-02-08 Medivir Ab Derivatives of purine, process for their preparation and a pharmaceutical preparation
EP0353955A3 (en) * 1988-08-02 1991-08-14 Beecham Group Plc Novel compounds
US5744600A (en) * 1988-11-14 1998-04-28 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Phosphonomethoxy carbocyclic nucleosides and nucleotides
US4966895A (en) * 1989-02-02 1990-10-30 Merck & Co. Inc. Cyclic monophosphates of purine and pyrimidine acyclonucleosides as anti-retroviral agents
US5688778A (en) * 1989-05-15 1997-11-18 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Nucleoside analogs
GB8912043D0 (en) * 1989-05-25 1989-07-12 Beecham Group Plc Novel compounds
US5302585A (en) * 1990-04-20 1994-04-12 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents
CS276072B6 (en) * 1990-08-06 1992-03-18 Ustav Organicke Chemie A Bioch (2R)-2-/DI(2-PROPYL)PHOSPHONYLMETHOXY/-3-p-TOLUENESULFONYLOXY -1- TRIMETHYLACETOXYPROPANE AND PROCESS FOR PREPARING THEREOF
EP0574386B1 (en) * 1990-08-10 2000-06-28 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Novel process for the preparation of nucleotides
ATE167679T1 (de) * 1990-09-14 1998-07-15 Acad Of Science Czech Republic Wirkstoffvorläufer von phosphonaten
US5208221A (en) * 1990-11-29 1993-05-04 Bristol-Myers Squibb Company Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives
US6057305A (en) * 1992-08-05 2000-05-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiretroviral enantiomeric nucleotide analogs
US5514798A (en) * 1993-06-02 1996-05-07 Gilead Sciences, Inc. Method and cyclic carbonates for nucleotide analogues
JPH09506333A (ja) * 1993-09-17 1997-06-24 ギリアード サイエンシーズ,インコーポレイテッド 治療化合物の投薬方法
US5798340A (en) 1993-09-17 1998-08-25 Gilead Sciences, Inc. Nucleotide analogs
US5656745A (en) * 1993-09-17 1997-08-12 Gilead Sciences, Inc. Nucleotide analogs
DE4408534A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag Substituierte N-Ethyl-Glycinderivate zur Herstellung von PNA und PNA-/DNA-Hybriden
US6465650B1 (en) 1995-03-13 2002-10-15 Aventis Pharma Deutschland Gmbh Substituted N-ethylglycine derivatives for preparing PNA and PNA/DNA hybrids
US5977061A (en) * 1995-04-21 1999-11-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic N6 - substituted nucleotide analagues and their use
US5877166A (en) * 1996-04-29 1999-03-02 Sri International Enantiomerically pure 2-aminopurine phosphonate nucleotide analogs as antiviral agents
US5733788A (en) * 1996-07-26 1998-03-31 Gilead Sciences, Inc. PMPA preparation
AU713374B2 (en) * 1996-07-26 1999-12-02 Gilead Sciences, Inc. Nucleotide analogs
AU756793B2 (en) * 1997-07-25 2003-01-23 Gilead Sciences, Inc. Nucleotide analog composition and synthesis method
US5935946A (en) * 1997-07-25 1999-08-10 Gilead Sciences, Inc. Nucleotide analog composition and synthesis method
WO2000029414A1 (fr) * 1998-11-18 2000-05-25 Viktor Veniaminovich Tets Dialkyl-1-aryl-1-(2,4-dioxo-5-amino-1,3-pyrimidin-5-yl)methylphosphonates
US7205404B1 (en) * 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
IL153658A0 (en) 2000-07-21 2003-07-06 Gilead Sciences Inc Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same
ES2564144T3 (es) 2001-06-29 2016-03-18 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Derivados de 6-[2-(fosfonometoxi)alcoxi] pirimidina que tienen actividad antivírica
EA200400690A1 (ru) * 2001-11-14 2005-06-30 Байокрист Фармасьютикалз, Инк. Нуклеозиды, их препараты и их применение в качестве ингибиторов вирусных рнк-полимераз
US7388002B2 (en) 2001-11-14 2008-06-17 Biocryst Pharmaceuticals, Inc. Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases
EP1532157A4 (en) * 2002-05-13 2009-02-25 Metabasis Therapeutics Inc NEW PRODRUGS FROM PMEA TO PHOSPHONIC ACID BASE AND ITS ANALOG
WO2003095665A2 (en) 2002-05-13 2003-11-20 Metabasis Therapeutics, Inc. Pmea and pmpa cyclic producing synthesis
KR101101962B1 (ko) * 2002-11-12 2012-01-02 티안진 디실리 인베스트먼트 홀딩 그룹, 리미티드 새로운 결정 형태를 가진 아데포비어 디피복실의 제조 방법
KR20080032014A (ko) * 2003-01-14 2008-04-11 길리애드 사이언시즈, 인코포레이티드 복합 항바이러스 치료를 위한 조성물 및 방법
JP5280631B2 (ja) 2003-06-16 2013-09-04 インスティチュート オブ オーガニック ケミストリー アンド バイオケミストリー, アカデミー オブ サイエンシズ オブ ザ チェコ リパブリック 抗ウイルスヌクレオチド類似物としてのホスホネート基を有するピリミジン化合物
AU2004260789B2 (en) * 2003-07-30 2011-06-30 Gilead Sciences, Inc. Nucleobase phosphonate analogs for antiviral treatment
EP1753762B1 (en) * 2004-06-08 2014-03-19 Metabasis Therapeutics, Inc. Lewis acid mediated synthesis of cyclic esters
CN100338080C (zh) * 2004-06-16 2007-09-19 山东中科泰斗化学有限公司 9-[2-(膦羧基甲氧基)乙基]腺嘌呤双环醇酯及其制备方法
UA93354C2 (ru) 2004-07-09 2011-02-10 Гилиад Сайенсиз, Инк. Местный противовирусный препарат
US8101745B2 (en) * 2004-12-16 2012-01-24 The Regents Of The University Of California Lung-targeted drugs
US20090156545A1 (en) * 2005-04-01 2009-06-18 Hostetler Karl Y Substituted Phosphate Esters of Nucleoside Phosphonates
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
EP1924594A2 (en) 2005-07-25 2008-05-28 Intermune, Inc. Novel macrocyclic inhibitors of hepatitis c virus replication
WO2007013085A1 (en) * 2005-07-26 2007-02-01 Hetero Drugs Limited Novel process for acyclic phosphonate nucleotide analogs
JP2009511595A (ja) * 2005-10-11 2009-03-19 インターミューン・インコーポレーテッド C型肝炎ウイルスの複製を阻害する化合物および方法
JP5231242B2 (ja) * 2005-12-14 2013-07-10 シプラ・リミテッド ヌクレオチド及びヌクレオシド系逆転写酵素阻害剤(テノホビル及びラミブジン)を剤形の異なる部分に含む医薬組合せ
FR2908133B1 (fr) * 2006-11-08 2012-12-14 Centre Nat Rech Scient Nouveaux analogues de nucleotides comme molecules precurseurs d'antiviraux
CN102066369B (zh) 2007-06-18 2013-05-29 广东东阳光药业有限公司 一种溴苯基-取代的噻唑二氢嘧啶
TWI444384B (zh) 2008-02-20 2014-07-11 Gilead Sciences Inc 核苷酸類似物及其在治療惡性腫瘤上的用途
WO2009120358A1 (en) * 2008-03-27 2009-10-01 Nektar Therapeutics Oligomer-nitrogenous base conjugates
US7935817B2 (en) * 2008-03-31 2011-05-03 Apotex Pharmachem Inc. Salt form and cocrystals of adefovir dipivoxil and processes for preparation thereof
WO2009142842A2 (en) * 2008-04-15 2009-11-26 Intermune, Inc. Novel macrocyclic inhibitors of hepatitis c virus replication
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
TW201010692A (en) 2008-06-19 2010-03-16 Public Univ Corp Nagoya City Univ Pharmaceutical composition for treatment or prevention of hbv infection
EA201170441A1 (ru) * 2008-10-15 2012-05-30 Интермьюн, Инк. Терапевтические противовирусные пептиды
KR20110099138A (ko) 2008-12-23 2011-09-06 파마셋 인코포레이티드 뉴클레오시드 포스포르아미데이트
TW201026716A (en) 2008-12-23 2010-07-16 Pharmasset Inc Nucleoside analogs
US8716263B2 (en) 2008-12-23 2014-05-06 Gilead Pharmasset Llc Synthesis of purine nucleosides
KR20100108297A (ko) 2009-03-26 2010-10-06 주식회사 대웅제약 신규 결정형의 아데포비어 디피복실 및 그의 제조방법
US20110081315A1 (en) * 2009-09-28 2011-04-07 Intermune, Inc. Novel macrocyclic inhibitors of hepatitis c virus replication
TW201116540A (en) * 2009-10-01 2011-05-16 Intermune Inc Therapeutic antiviral peptides
EP2752422B1 (en) 2010-03-31 2017-08-16 Gilead Pharmasset LLC Stereoselective synthesis of phosphorus containing actives
CN114010776A (zh) 2010-06-09 2022-02-08 疫苗技术股份有限公司 用于增强抗逆转录病毒治疗的hiv感染者的治疗性免疫
ES2551738T3 (es) 2010-06-11 2015-11-23 Gilead Sciences, Inc. Formulaciones tópicas antivirales para la prevención de la transmisión del VHS-2
MX2013006127A (es) 2010-12-10 2013-09-26 Sigmapharm Lab Llc Composiciones sumamente estables de analogos nucleotidicoas oralmente activos o profarmacos analogos nucleotidicos oralmente activos.
WO2012154698A2 (en) * 2011-05-06 2012-11-15 Mckenna Charles E Method to improve antiviral activity of nucleotide analogue drugs
CN103665043B (zh) 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 一种替诺福韦前药及其在医药上的应用
EP2912047B1 (en) 2012-10-29 2016-08-24 Cipla Limited Antiviral phosphonate analogues and process for preparation thereof
AU2014228321C1 (en) 2013-03-15 2019-07-11 The Regents Of The University Of California Acyclic nucleoside phosphonate diesters
US10449210B2 (en) 2014-02-13 2019-10-22 Ligand Pharmaceuticals Inc. Prodrug compounds and their uses
US10167302B2 (en) * 2014-05-23 2019-01-01 University College Cork Phosphonate nucleosides useful in the treatment of viral diseases
JP2017520545A (ja) 2014-07-02 2017-07-27 リガンド・ファーマシューティカルズ・インコーポレイテッド プロドラッグ化合物およびそれらの使用
PL3194411T3 (pl) 2014-09-15 2022-06-20 The Regents Of The University Of California Analogi nukleotydów
EP3875462A1 (en) 2015-09-15 2021-09-08 The Regents of The University of California Nucleotide analogs
EP3372227A1 (en) 2017-03-06 2018-09-12 MH10 Spolka z ograniczona odpowiedzialnoscia Tablet formulation of adefovir dipivoxil
CN111788196A (zh) 2018-01-09 2020-10-16 配体药物公司 缩醛化合物及其治疗用途
JP2025526212A (ja) 2022-07-21 2025-08-13 アンティバ バイオサイエンシズ インコーポレイテッド Hpv感染症及びhpv誘発性新生物の治療用の組成物及び剤形

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
CS233665B1 (en) * 1983-01-06 1985-03-14 Antonin Holy Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
AU8092587A (en) * 1986-11-18 1988-05-19 Bristol-Myers Squibb Company Synthesis of purin-9-ylalkylenoxymethyl phosphonic acids

Also Published As

Publication number Publication date
AU5632886A (en) 1986-10-30
EP0206459A3 (en) 1987-05-20
DK173625B1 (da) 2001-05-07
DE3686002D1 (de) 1992-08-20
DK167886D0 (da) 1986-04-11
JPS61275289A (ja) 1986-12-05
HK213296A (en) 1996-12-06
CA1295614C (en) 1992-02-11
DK167886A (da) 1986-10-26
CS263951B1 (en) 1989-05-12
NO861621L (no) 1986-10-27
EP0206459B1 (en) 1992-07-15
ATE78259T1 (de) 1992-08-15
JPH0433798B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1992-06-04
EG18079A (en) 1992-06-30
NO174510B (no) 1994-02-07
NO174510C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1994-05-18
DE3686002T2 (de) 1992-12-17
US4808716A (en) 1989-02-28
EP0206459A2 (en) 1986-12-30
AU580151B2 (en) 1989-01-05

Similar Documents

Publication Publication Date Title
AU580151B2 (en) 9-(phosphonylmethoxyalkyl) adenines, the method of preparation and utilization thereof
AU557103B2 (en) S-triazine derivatives and their use as sun screen agents
ES512381A0 (es) "procedimiento de preparacion de disacaridos".
AU527881B2 (en) 9-(hydroxyalkyl) purines
AU586691B2 (en) Diamino-androstane derivatives, process for their preparation and pharmaceutical compositions containing them
ZA932312B (en) 3',5'-Di-tert.-butyl-4'-hydroxy flavones, process for the preparation thereof and pharamceutical compositions containing them.
DE3261797D1 (en) Octahydrobenzo(f)quinoline compounds
DE3666585D1 (en) P-sulphophenyl alkyl carbonates and their use as bleaching activators
ES8706163A1 (es) Procedimiento para la fabricacion de nuevos derivados nu- cleosidos
ES8101550A1 (es) Un procedimiento para la preparacion de nuevos derivados de 2-pirrolidin-metanol.
NO855241L (no) Fremgangsmaate til fremstilling av karbapenemforbindelser.
DE3672446D1 (en) Pantothenolderivate.
PH22418A (en) Triazolyl alcohol derivatives
DE3560110D1 (en) Derivatives of 2-alkoxyaminosulfonylbenzenesulfonylurea
DE3564426D1 (en) Polyprenyl compound, process of producing it and pharmaceutical use
ES8105300A1 (es) Procedimiento para preparar derivados de benoimidazol
AU6306886A (en) Alkylcarboxamides of pyridylalkylamines, their preparation and their use in human and veterinary medicine
JPS548627A (en) 2-alkoxyalkoxy-5-nitrobenzenesulfonic acid and its salt
AU2172688A (en) Preparation of dien-1-ols, 9-hydroxydodec-10-enyl 1-tert-butyl ether and use thereof as an intermediate for synthesizing, 8,10-dodecadienol
ES8201205A1 (es) Procedimiento para la preparacion de nuevos compuestos de aminoantipirina
ES8304990A1 (es) Procedimiento para la preparacion de derivados espiro-1 farmaceuticamente activos.
TH3207A (th) อนุพันธ์ของกรดเฟนนอกซีโปรบีโอนิค