NZ206600A - Osmotic drug delivery device - Google Patents

Info

Publication number

NZ206600A

NZ206600A NZ206600A NZ20660083A NZ206600A NZ 206600 A NZ206600 A NZ 206600A NZ 206600 A NZ206600 A NZ 206600A NZ 20660083 A NZ20660083 A NZ 20660083A NZ 206600 A NZ206600 A NZ 206600A

Authority

NZ

New Zealand

Prior art keywords

composition

osmotic

wall

cellulose

compartment

Prior art date

1983-05-11

Links

• Espacenet
• Global Dossier
• Discuss

• 230000003204 osmotic effect Effects 0.000 title description 160
• 238000012377 drug delivery Methods 0.000 title 1
• 239000000203 mixture Substances 0.000 claims description 160
• 239000003795 chemical substances by application Substances 0.000 claims description 97
• -1 poly(ethylene oxide) Polymers 0.000 claims description 75
• 239000012530 fluid Substances 0.000 claims description 72
• 239000003814 drug Substances 0.000 claims description 68
• 229940079593 drug Drugs 0.000 claims description 64
• 230000009286 beneficial effect Effects 0.000 claims description 60
• 229920002301 cellulose acetate Polymers 0.000 claims description 23
• 229920002678 cellulose Polymers 0.000 claims description 22
• 239000001913 cellulose Substances 0.000 claims description 21
• 235000010980 cellulose Nutrition 0.000 claims description 20
• 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 16
• 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 16
• 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 16
• UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 16
• 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 14
• HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 claims description 10
• 229960001597 nifedipine Drugs 0.000 claims description 10
• SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 claims description 5
• 229960001722 verapamil Drugs 0.000 claims description 5
• LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 claims description 4
• CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims description 4
• 229920006217 cellulose acetate butyrate Polymers 0.000 claims description 3
• 229920000609 methyl cellulose Polymers 0.000 claims description 3
• 239000001923 methylcellulose Substances 0.000 claims description 3
• 235000010981 methylcellulose Nutrition 0.000 claims description 3
• 229920001223 polyethylene glycol Polymers 0.000 claims description 3
• AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 claims description 3
• ODIGIKRIUKFKHP-UHFFFAOYSA-N (n-propan-2-yloxycarbonylanilino) acetate Chemical compound CC(C)OC(=O)N(OC(C)=O)C1=CC=CC=C1 ODIGIKRIUKFKHP-UHFFFAOYSA-N 0.000 claims description 2
• 229920008347 Cellulose acetate propionate Polymers 0.000 claims description 2
• 229920001747 Cellulose diacetate Polymers 0.000 claims description 2
• 229920002284 Cellulose triacetate Polymers 0.000 claims description 2
• 239000001856 Ethyl cellulose Substances 0.000 claims description 2
• ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 2
• HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims description 2
• MYEJFUXQJGHEQK-ALRJYLEOSA-N Proscillaridin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1C=C2CC[C@H]3[C@@]4(O)CC[C@H](C5=COC(=O)C=C5)[C@@]4(C)CC[C@@H]3[C@@]2(C)CC1 MYEJFUXQJGHEQK-ALRJYLEOSA-N 0.000 claims description 2
• NNLVGZFZQQXQNW-ADJNRHBOSA-N [(2r,3r,4s,5r,6s)-4,5-diacetyloxy-3-[(2s,3r,4s,5r,6r)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6s)-4,5,6-triacetyloxy-2-(acetyloxymethyl)oxan-3-yl]oxyoxan-2-yl]methyl acetate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@H]1[C@@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)OC(C)=O)COC(=O)C)[C@@H]1[C@@H](COC(C)=O)O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O NNLVGZFZQQXQNW-ADJNRHBOSA-N 0.000 claims description 2
• WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 2
• 229940106164 cephalexin Drugs 0.000 claims description 2
• HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 claims description 2
• 229960004166 diltiazem Drugs 0.000 claims description 2
• 229920001249 ethyl cellulose Polymers 0.000 claims description 2
• 235000019325 ethyl cellulose Nutrition 0.000 claims description 2
• 235000010944 ethyl methyl cellulose Nutrition 0.000 claims description 2
• 229960003878 haloperidol Drugs 0.000 claims description 2
• 229960001680 ibuprofen Drugs 0.000 claims description 2
• 229960000905 indomethacin Drugs 0.000 claims description 2
• DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 claims description 2
• 229960000991 ketoprofen Drugs 0.000 claims description 2
• 229920003087 methylethyl cellulose Polymers 0.000 claims description 2
• 125000000217 alkyl group Chemical group 0.000 claims 2
• IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 1
• 101000842302 Homo sapiens Protein-cysteine N-palmitoyltransferase HHAT Proteins 0.000 claims 1
• 239000002202 Polyethylene glycol Substances 0.000 claims 1
• 102100030616 Protein-cysteine N-palmitoyltransferase HHAT Human genes 0.000 claims 1
• 125000004432 carbon atom Chemical group C* 0.000 claims 1
• ZAIPMKNFIOOWCQ-UEKVPHQBSA-N cephalexin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=CC=C1 ZAIPMKNFIOOWCQ-UEKVPHQBSA-N 0.000 claims 1
• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 58
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 46
• 229920000642 polymer Polymers 0.000 description 39
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 36
• 235000019359 magnesium stearate Nutrition 0.000 description 29
• 238000000034 method Methods 0.000 description 29
• 235000002639 sodium chloride Nutrition 0.000 description 29
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 27
• 239000011780 sodium chloride Substances 0.000 description 23
• 239000010410 layer Substances 0.000 description 22
• 239000011148 porous material Substances 0.000 description 22
• WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 20
• 230000001186 cumulative effect Effects 0.000 description 20
• 239000000463 material Substances 0.000 description 20
• 239000000243 solution Substances 0.000 description 18
• 239000000725 suspension Substances 0.000 description 18
• 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 17
• 238000005213 imbibition Methods 0.000 description 17
• YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 16
• 239000002904 solvent Substances 0.000 description 16
• 239000007787 solid Substances 0.000 description 15
• CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 11
• 150000001875 compounds Chemical class 0.000 description 11
• 241001465754 Metazoa Species 0.000 description 10
• 230000004907 flux Effects 0.000 description 10
• 238000001727 in vivo Methods 0.000 description 10
• 238000002156 mixing Methods 0.000 description 10
• 229920000036 polyvinylpyrrolidone Polymers 0.000 description 10
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 10
• 239000001103 potassium chloride Substances 0.000 description 10
• 235000011164 potassium chloride Nutrition 0.000 description 10
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
• KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 9
• 229920002125 Sokalan® Polymers 0.000 description 9
• 239000012528 membrane Substances 0.000 description 9
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• 239000000126 substance Substances 0.000 description 8
• 239000003826 tablet Substances 0.000 description 8
• 238000005303 weighing Methods 0.000 description 8
• KPHWPUGNDIVLNH-UHFFFAOYSA-M diclofenac sodium Chemical compound [Na+].[O-]C(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl KPHWPUGNDIVLNH-UHFFFAOYSA-M 0.000 description 7
• 238000005469 granulation Methods 0.000 description 7
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• 238000000338 in vitro Methods 0.000 description 7
• 239000004615 ingredient Substances 0.000 description 7
• 238000005259 measurement Methods 0.000 description 7
• 229920001277 pectin Polymers 0.000 description 7
• 239000001814 pectin Substances 0.000 description 7
• 235000010987 pectin Nutrition 0.000 description 7
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 6
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• 229960001855 mannitol Drugs 0.000 description 6
• 230000035699 permeability Effects 0.000 description 6
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• 230000001225 therapeutic effect Effects 0.000 description 6
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• 230000004584 weight gain Effects 0.000 description 5
• 235000019786 weight gain Nutrition 0.000 description 5
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• 239000005715 Fructose Substances 0.000 description 4
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
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• KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 description 4
• 229920000867 polyelectrolyte Polymers 0.000 description 4
• 229920002635 polyurethane Polymers 0.000 description 4
• OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 description 4
• 229910052939 potassium sulfate Inorganic materials 0.000 description 4
• 235000011151 potassium sulphates Nutrition 0.000 description 4
• 150000003839 salts Chemical class 0.000 description 4
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• PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
• UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 2
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