NZ186031A - 3,20-dioxo-7alpha-halo-4-pregnenes and-1,4-pregnadines - Google Patents

3,20-dioxo-7alpha-halo-4-pregnenes and-1,4-pregnadines

Info

Publication number
NZ186031A
NZ186031A NZ186031A NZ18603177A NZ186031A NZ 186031 A NZ186031 A NZ 186031A NZ 186031 A NZ186031 A NZ 186031A NZ 18603177 A NZ18603177 A NZ 18603177A NZ 186031 A NZ186031 A NZ 186031A
Authority
NZ
New Zealand
Prior art keywords
group
dione
pregnadiene
methyl
hydrogen
Prior art date
Application number
NZ186031A
Other languages
English (en)
Inventor
M J Green
H-J Shue
E L Shapiro
M A Gentles
Original Assignee
Scheico Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/753,257 external-priority patent/US4076708A/en
Application filed by Scheico Ltd filed Critical Scheico Ltd
Publication of NZ186031A publication Critical patent/NZ186031A/en

Links

Classifications

    • E—FIXED CONSTRUCTIONS
    • E04—BUILDING
    • E04G—SCAFFOLDING; FORMS; SHUTTERING; BUILDING IMPLEMENTS OR AIDS, OR THEIR USE; HANDLING BUILDING MATERIALS ON THE SITE; REPAIRING, BREAKING-UP OR OTHER WORK ON EXISTING BUILDINGS
    • E04G11/00—Forms, shutterings, or falsework for making walls, floors, ceilings, or roofs
    • E04G11/06—Forms, shutterings, or falsework for making walls, floors, ceilings, or roofs for walls, e.g. curved end panels for wall shutterings; filler elements for wall shutterings; shutterings for vertical ducts
    • E04G11/20—Movable forms; Movable forms for moulding cylindrical, conical or hyperbolical structures; Templates serving as forms for positioning blocks or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001—Lactones
    • C07J21/003—Lactones at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0084—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkylene group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
    • C07J7/0045—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • E—FIXED CONSTRUCTIONS
    • E04—BUILDING
    • E04G—SCAFFOLDING; FORMS; SHUTTERING; BUILDING IMPLEMENTS OR AIDS, OR THEIR USE; HANDLING BUILDING MATERIALS ON THE SITE; REPAIRING, BREAKING-UP OR OTHER WORK ON EXISTING BUILDINGS
    • E04G17/00—Connecting or other auxiliary members for forms, falsework structures, or shutterings
    • E04G17/14—Bracing or strutting arrangements for formwalls; Devices for aligning forms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Architecture (AREA)
  • Engineering & Computer Science (AREA)
  • Civil Engineering (AREA)
  • Mechanical Engineering (AREA)
  • Structural Engineering (AREA)
  • Animal Behavior & Ethology (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NZ186031A 1976-12-22 1977-12-19 3,20-dioxo-7alpha-halo-4-pregnenes and-1,4-pregnadines NZ186031A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75325676A 1976-12-22 1976-12-22
US05/753,257 US4076708A (en) 1976-12-22 1976-12-22 Process for the preparation of 7α-halogeno-3-oxo-4-dehydro steroids and novel 7α-halogeno derivatives produced thereby

Publications (1)

Publication Number Publication Date
NZ186031A true NZ186031A (en) 1984-07-31

Family

ID=27115720

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ186031A NZ186031A (en) 1976-12-22 1977-12-19 3,20-dioxo-7alpha-halo-4-pregnenes and-1,4-pregnadines

Country Status (20)

Country Link
JP (1) JPS604198B2 (da)
AR (1) AR226806A1 (da)
AT (2) AT373269B (da)
BE (1) BE862089A (da)
DE (1) DE2756550C2 (da)
DK (1) DK153494C (da)
FI (1) FI63947C (da)
FR (1) FR2384793A1 (da)
GB (1) GB1575983A (da)
HK (1) HK584A (da)
HU (1) HU179784B (da)
IE (1) IE45950B1 (da)
IL (1) IL53636A (da)
MY (1) MY8500082A (da)
NL (1) NL180479C (da)
NO (1) NO151826C (da)
NZ (1) NZ186031A (da)
PT (1) PT67432B (da)
SE (1) SE429865B (da)
SG (1) SG58683G (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109680036A (zh) 2017-10-02 2019-04-26 爱科来株式会社 糖化蛋白质的测定

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3429926A (en) * 1964-05-25 1969-02-25 Squibb & Sons Inc 7-halo and 6-halo,6-dehydro a-norprogesterones

Also Published As

Publication number Publication date
NL180479C (nl) 1987-03-02
MY8500082A (en) 1985-12-31
IL53636A (en) 1983-05-15
FI773825A (fi) 1978-06-23
PT67432A (en) 1978-01-01
DK153494B (da) 1988-07-18
DE2756550A1 (de) 1978-07-06
JPS604198B2 (ja) 1985-02-01
SE7714538L (sv) 1978-06-23
NO151826C (no) 1985-06-12
HU179784B (en) 1982-12-28
FI63947C (fi) 1983-09-12
DE2756550C2 (de) 1986-10-16
BE862089A (fr) 1978-06-20
DK569977A (da) 1978-09-28
AR226806A1 (es) 1982-08-31
IL53636A0 (en) 1978-03-10
NO774359L (no) 1978-06-23
IE45950B1 (en) 1983-01-12
ATA575980A (de) 1982-04-15
IE45950L (en) 1978-06-22
NL180479B (nl) 1986-10-01
DK153494C (da) 1989-02-20
NL7714056A (nl) 1978-06-26
NO151826B (no) 1985-03-04
AT377566B (de) 1985-04-10
FR2384793A1 (fr) 1978-10-20
PT67432B (en) 1979-05-23
AT373269B (de) 1984-01-10
JPS5379850A (en) 1978-07-14
SE429865B (sv) 1983-10-03
SG58683G (en) 1985-01-11
GB1575983A (en) 1980-10-01
FR2384793B1 (da) 1981-11-13
FI63947B (fi) 1983-05-31
ATA909477A (de) 1983-05-15
HK584A (en) 1984-01-13

Similar Documents

Publication Publication Date Title
US4124707A (en) 7α-Halogeno-3,20-dioxo-1,4-pregnadienes, methods for their manufacture, their use as anti-inflammatory agents, and pharmaceutical formulations useful therefor
CA1099254A (en) PROCESS FOR THE PREPARATION OF 7 .alpha.-HALOGENO-3-OXO-4- DEHYDRO STEROIDS AND NOVEL 7.alpha.-HALOGENO DERIVATIVES PRODUCED THEREBY
US3312590A (en) Topically active anti-inflammatory 17-mono- and 17,21-diesters of betamethasone and its 9-chloro-analogs, compositions and use thereof
US4267173A (en) Use of 6β-fluoro-7α-halogenocorticoids as topical anti-inflammatories and pharmaceutical formulations useful therefor
US4172132A (en) 1,3,5(10),6,8,14-19-Nor-pregnahexaenes, their use as anti-psoriatic agents, and pharmaceutical formulations useful therefor
NZ199600A (en) 17-(heterocyclic carboxylate)-substituted steroids
US4619921A (en) Polyhalogeno-steroids
US4036831A (en) Trimethyl siloxane steroid intermediates
US4336200A (en) 17α-Acyloxy-5β-corticoids
US4576936A (en) 6α-Fluoro-9α-chloro-prednisolone 17,21-diesters
US4318853A (en) 9β,11β-Epoxy-5β-corticoids
US4201778A (en) 6-Acyloxy-1,4,6-pregnatrienes, their use as anti-inflammatory agents, methods for their manufacture, and 6-oxo-1,4-pregnadiene intermediates
US4024131A (en) 16-Methyl-9α-halo steroid esters, ethers and preparation thereof
GB1563638A (en) 21-halogenopregnane compounds
US4427591A (en) Reduced A ring-Δ9(11) -corticoids
NZ186031A (en) 3,20-dioxo-7alpha-halo-4-pregnenes and-1,4-pregnadines
US4185101A (en) 1,3,5(10),6,8-19-Nor-pregnapentaenes, their use as anti-psoriatic agents, and pharmaceutical formulations useful therefor
US3637670A (en) Intermediates and process for preparing useful 17alpha-hydroxy-20-keto and 17alpha 21-dihydroxy-20-keto pregnanes and derivatives thereof
US3931167A (en) Process for the manufacture of 3-keto-6-azido-4,6-bis-dehydro-steroids and intermediates useful therein
ROTHMAN et al. Steroidal Sapogenins. LXIV. C-21 Acetoxylation of 12-Keto Steroids2
US3933799A (en) 11β-Halo-9,12-unsubstituted-C19 -steroids
US3980680A (en) Process for the preparation of 21-desoxy-17-acyloxy-4-pregnenes and of 21-iodo-21-desoxy-17-acyl oxy-4-pregnene intermediates useful therein
US3519619A (en) 16-alkylidene pregnanes and process for their manufacture
EP0000609B1 (en) Novel 19-nor-pregnahexaenes, process for the preparation thereof, and pharmaceutical compositions containing them
US3842075A (en) Ethers of the pregnane series