NZ183540A - 5-(1,1-diphenyl-3-(5- or 6-hydroxy-2-aza-bicyclo-(2,2,2) oct-2-yl) propyl)-2-alkyl-1,3,4-oxadiazoles and certain acylates thereof - Google Patents

5-(1,1-diphenyl-3-(5- or 6-hydroxy-2-aza-bicyclo-(2,2,2) oct-2-yl) propyl)-2-alkyl-1,3,4-oxadiazoles and certain acylates thereof

Info

Publication number
NZ183540A
NZ183540A NZ183540A NZ18354077A NZ183540A NZ 183540 A NZ183540 A NZ 183540A NZ 183540 A NZ183540 A NZ 183540A NZ 18354077 A NZ18354077 A NZ 18354077A NZ 183540 A NZ183540 A NZ 183540A
Authority
NZ
New Zealand
Prior art keywords
acylates
oxadiazoles
aza
bicyclo
diphenyl
Prior art date
Application number
NZ183540A
Other languages
English (en)
Inventor
C H Yen
A Karim
G W Adelstein
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of NZ183540A publication Critical patent/NZ183540A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/06—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing isoquinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D303/40—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by ester radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
NZ183540A 1976-03-10 1977-03-09 5-(1,1-diphenyl-3-(5- or 6-hydroxy-2-aza-bicyclo-(2,2,2) oct-2-yl) propyl)-2-alkyl-1,3,4-oxadiazoles and certain acylates thereof NZ183540A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/665,609 US4013668A (en) 1976-03-10 1976-03-10 5-(1,1-diphenyl-3-(5- or 6-hydroxy-2-azabicyclo(2.2.2)oct-2-yl)propyl)-2-alkyl-1,3,4-oxadiazoles and related compounds

Publications (1)

Publication Number Publication Date
NZ183540A true NZ183540A (en) 1980-05-27

Family

ID=24670819

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ183540A NZ183540A (en) 1976-03-10 1977-03-09 5-(1,1-diphenyl-3-(5- or 6-hydroxy-2-aza-bicyclo-(2,2,2) oct-2-yl) propyl)-2-alkyl-1,3,4-oxadiazoles and certain acylates thereof

Country Status (17)

Country Link
US (1) US4013668A (enExample)
JP (1) JPS5951955B2 (enExample)
AT (1) AT350559B (enExample)
AU (1) AU505650B2 (enExample)
BE (1) BE852252A (enExample)
CA (1) CA1078386A (enExample)
CH (1) CH627467A5 (enExample)
DE (1) DE2710242A1 (enExample)
DK (1) DK103777A (enExample)
ES (1) ES456687A1 (enExample)
FR (1) FR2343740A2 (enExample)
GB (1) GB1524653A (enExample)
IE (1) IE44639B1 (enExample)
NL (1) NL7702537A (enExample)
NZ (1) NZ183540A (enExample)
SE (1) SE7702640L (enExample)
ZA (1) ZA771428B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0241180A (ja) * 1988-07-29 1990-02-09 Shinji Kanda 耐火避難用カプセル
DE69220258T2 (de) * 1991-02-11 1997-12-18 Merck Sharp & Dohme Azabicyclische Verbindungen, diese enthaltende pharmazeutische Zubereitungen und ihre therapeutische Verwendung
US5962477A (en) * 1994-04-12 1999-10-05 Adolor Corporation Screening methods for cytokine inhibitors
US6190691B1 (en) 1994-04-12 2001-02-20 Adolor Corporation Methods for treating inflammatory conditions
US5849761A (en) * 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
US6573282B1 (en) 1995-09-12 2003-06-03 Adolor Corporation Peripherally active anti-hyperalgesic opiates
US5667773A (en) * 1996-03-12 1997-09-16 Adolor Corporation Film-forming compositions of antihyperalgesic opiates and method of treating hyperalgesic conditions therewith
US6353004B1 (en) 1997-07-14 2002-03-05 Adolor Coporation Peripherally acting anti-pruritic opiates
US20030158220A1 (en) * 1997-11-03 2003-08-21 Foss Joseph F. Use of methylnaltrexone and related compounds to treat chronic opioid use side effects
PT1615646E (pt) * 2003-04-08 2015-02-12 Progenics Pharm Inc Formulações farmacêuticas com metilnaltrexona
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
TWI489984B (zh) 2006-08-04 2015-07-01 Wyeth Corp 用於非經腸道傳輸化合物之配方及其用途
TW200817048A (en) * 2006-09-08 2008-04-16 Wyeth Corp Dry powder compound formulations and uses thereof
PT2565195E (pt) * 2007-03-29 2015-07-28 Wyeth Llc Antagonistas e receptor opióide periférico e respectivas utilizações
PE20130480A1 (es) 2007-03-29 2013-05-08 Progenics Pharm Inc Compuestos heterociclicos como antagonistas del receptor opioide periferico
MX2009010550A (es) * 2007-03-29 2009-12-14 Progenics Pharm Inc Formas de cristal de bromuro de (r)-n-metilnaltrexona y uso de las mismas.
CA2713568C (en) 2008-02-06 2016-09-20 Progenics Pharmaceuticals, Inc. Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone
WO2010029313A1 (en) * 2008-09-11 2010-03-18 Summit Corporation Plc. Antiinfective compounds
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3917615A (en) * 1974-04-01 1975-11-04 Searle & Co 1,1-Diaryl-1-oxadiazol-alkylamines

Also Published As

Publication number Publication date
DK103777A (da) 1977-09-11
FR2343740A2 (fr) 1977-10-07
CA1078386A (en) 1980-05-27
US4013668A (en) 1977-03-22
IE44639B1 (en) 1982-02-10
JPS5951955B2 (ja) 1984-12-17
IE44639L (en) 1977-09-10
ZA771428B (en) 1978-10-25
GB1524653A (en) 1978-09-13
ES456687A1 (es) 1978-02-01
SE7702640L (sv) 1977-09-11
CH627467A5 (de) 1982-01-15
AT350559B (de) 1979-06-11
JPS52108999A (en) 1977-09-12
AU2302977A (en) 1978-09-14
FR2343740B2 (enExample) 1980-06-20
ATA157477A (de) 1978-11-15
NL7702537A (nl) 1977-09-13
AU505650B2 (en) 1979-11-29
DE2710242A1 (de) 1977-09-22
BE852252A (fr) 1977-09-09

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