NO992315L - Benzotiazo og beslektet heterosykliske gruppe-inneholdende cystein og serinprotease inhibitorer - Google Patents
Benzotiazo og beslektet heterosykliske gruppe-inneholdende cystein og serinprotease inhibitorerInfo
- Publication number
- NO992315L NO992315L NO992315A NO992315A NO992315L NO 992315 L NO992315 L NO 992315L NO 992315 A NO992315 A NO 992315A NO 992315 A NO992315 A NO 992315A NO 992315 L NO992315 L NO 992315L
- Authority
- NO
- Norway
- Prior art keywords
- benzotiazo
- heterocyclic group
- protease inhibitors
- serine protease
- related heterocyclic
- Prior art date
Links
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 title abstract 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 title abstract 2
- 235000018417 cysteine Nutrition 0.000 title abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 title abstract 2
- 239000002852 cysteine proteinase inhibitor Substances 0.000 title 1
- 239000003001 serine protease inhibitor Substances 0.000 title 1
- 102000005927 Cysteine Proteases Human genes 0.000 abstract 1
- 108010005843 Cysteine Proteases Proteins 0.000 abstract 1
- 102000012479 Serine Proteases Human genes 0.000 abstract 1
- 108010022999 Serine Proteases Proteins 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
- C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
- C07D285/20—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
- C07D285/22—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D285/24—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
- C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
- C07D327/06—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6544—Six-membered rings
- C07F9/6547—Six-membered rings condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3052696P | 1996-11-13 | 1996-11-13 | |
| US08/968,035 US5952328A (en) | 1997-11-12 | 1997-11-12 | Benzothiazo and related heterocyclic group-containing cysteine and serine protease inhibitors |
| PCT/US1997/020782 WO1998021186A1 (en) | 1996-11-13 | 1997-11-13 | Benzothiazo and related heterocyclic group-containing cysteine and serine protease inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO992315D0 NO992315D0 (no) | 1999-05-12 |
| NO992315L true NO992315L (no) | 1999-06-11 |
Family
ID=26706137
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO992315A NO992315L (no) | 1996-11-13 | 1999-05-12 | Benzotiazo og beslektet heterosykliske gruppe-inneholdende cystein og serinprotease inhibitorer |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0938477A4 (de) |
| JP (1) | JP2002514192A (de) |
| AU (1) | AU7179598A (de) |
| CA (1) | CA2271116A1 (de) |
| NO (1) | NO992315L (de) |
| WO (1) | WO1998021186A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6143931A (en) * | 1997-04-16 | 2000-11-07 | Arqule, Inc. | Synthesis and use of α-ketoamide derivatives and arrays |
| CA2286660A1 (en) * | 1997-04-16 | 1998-10-22 | Arqule, Inc. | Synthesis and use of .alpha.-ketoamide derivatives and arrays |
| US6150378A (en) * | 1997-10-07 | 2000-11-21 | Cephalon, Inc. | Peptidyl-containing α-ketoamide cysteine and serine protease inhibitors |
| AU2594799A (en) * | 1998-02-11 | 1999-08-30 | Du Pont Pharmaceuticals Company | Novel cyclic sulfonamide derivatives as metalloproteinase inhibitors |
| KR20010042296A (ko) * | 1998-03-31 | 2001-05-25 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | 세린 프로테아제 억제제로서의 벤즈옥사지논/벤조티아지논 |
| WO2000051624A2 (en) | 1999-03-05 | 2000-09-08 | The Trustees Of University Technology Corporation | Methods and compositions useful in inhibiting apoptosis |
| FR2818641B1 (fr) * | 2000-12-21 | 2004-03-05 | Servier Lab | Nouveaux derives de 1,1-dioxo-2h-1,2-benzothiazine 3-carboxamides, leur procede de preparation et les compositions pharmaceutiques que les contiennent |
| US7850970B2 (en) | 2003-08-26 | 2010-12-14 | The Regents Of The University Of Colorado | Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections |
| ES2425476T3 (es) | 2004-04-02 | 2013-10-15 | Prana Biotechnology Limited | Compuestos neurológicamente activos |
| KR101589551B1 (ko) | 2005-07-15 | 2016-02-02 | 알바니 몰레큘라 리써치, 인크. | 아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도 |
| WO2009015917A2 (en) | 2007-05-14 | 2009-02-05 | F. Hoffmann-La Roche Ag | Dihydroquinone and dihydronaphthridine inhibitors of jnk |
| US8236798B2 (en) * | 2009-05-07 | 2012-08-07 | Abbott Gmbh & Co. Kg | Carboxamide compounds and their use as calpain inhibitors |
| US10590084B2 (en) | 2016-03-09 | 2020-03-17 | Blade Therapeutics, Inc. | Cyclic keto-amide compounds as calpain modulators and methods of production and use thereof |
| WO2018009417A1 (en) | 2016-07-05 | 2018-01-11 | Blade Therapeutics, Inc. | Calpain modulators and therapeutic uses thereof |
| EP3512836A1 (de) * | 2016-09-13 | 2019-07-24 | Haplogen GmbH | Antivirale verbindungen |
| KR20190063473A (ko) | 2016-09-28 | 2019-06-07 | 블레이드 테라퓨틱스, 인크. | 칼페인 조정자 및 그 치료학적 용도 |
| GB201713962D0 (en) * | 2017-08-31 | 2017-10-18 | Ctxt Pty Ltd | Compounds |
| GB201810581D0 (en) | 2018-06-28 | 2018-08-15 | Ctxt Pty Ltd | Compounds |
| MD3986890T2 (ro) | 2019-06-18 | 2024-04-30 | Pfizer | Derivați de benzizoxazolsulfonamide |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3960854A (en) * | 1972-03-20 | 1976-06-01 | Merck & Co., Inc. | 7-Mercapto(or thio)-benzothiadiazine products |
| JPS58225076A (ja) * | 1982-06-23 | 1983-12-27 | Mitsui Toatsu Chem Inc | ベンゾチアジンカルボキシアミド誘導体およびそれを含有する医薬組成物 |
| US4585793A (en) * | 1983-05-09 | 1986-04-29 | Georgia Tech Research Institute | Thioester inhibitors of serine proteases |
| GB2146026A (en) * | 1983-09-07 | 1985-04-11 | Tanabe Seiyaku Co | Peptides and process for preparing the same |
| US4889851A (en) * | 1986-11-21 | 1989-12-26 | Fujisawa Pharmaceutical Co, Ltd. | Benzothiadiazine compounds, and pharmaceutical composition comprising the same |
| JPH0629271B2 (ja) * | 1988-03-09 | 1994-04-20 | 株式会社日本ハイポックス | ベンゾチアジン―１，１―ジオキシド誘導体及びそれを含有する医薬組成物 |
| US5384411A (en) * | 1991-06-20 | 1995-01-24 | Hewlett-Packard Company | Immobilization of PH-sensitive dyes to solid supports |
| ATE198328T1 (de) * | 1992-09-28 | 2001-01-15 | Hoechst Ag | Antiarrhythmische und cardioprotektive substituierte 1(2h)-isochinoline, verfahren zu deren herstellung, diese enthaltende arzneimittel und ihre anwendung für die herstellung eines arzneimittels zur behandlung von herzinsuffizienzen |
| EP0871454B1 (de) * | 1995-07-17 | 2003-11-12 | Cephalon, Inc. | Phosphor enthaltende hemmer von cystein- und serin-proteasen |
-
1997
- 1997-11-13 JP JP52284598A patent/JP2002514192A/ja active Pending
- 1997-11-13 WO PCT/US1997/020782 patent/WO1998021186A1/en not_active Application Discontinuation
- 1997-11-13 EP EP97949430A patent/EP0938477A4/de not_active Withdrawn
- 1997-11-13 CA CA002271116A patent/CA2271116A1/en not_active Abandoned
- 1997-11-13 AU AU71795/98A patent/AU7179598A/en not_active Abandoned
-
1999
- 1999-05-12 NO NO992315A patent/NO992315L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002514192A (ja) | 2002-05-14 |
| AU7179598A (en) | 1998-06-03 |
| EP0938477A1 (de) | 1999-09-01 |
| CA2271116A1 (en) | 1998-05-22 |
| NO992315D0 (no) | 1999-05-12 |
| EP0938477A4 (de) | 1999-12-29 |
| WO1998021186A1 (en) | 1998-05-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO992315L (no) | Benzotiazo og beslektet heterosykliske gruppe-inneholdende cystein og serinprotease inhibitorer | |
| DE69637307D1 (de) | Aus d-aminosäuren abgeleitete cystein- und serinproteasehemmer | |
| ATE335485T1 (de) | Quinolin-enthaltende alpha-ketoamid-basierte inhibitoren von cystein- und serin protease | |
| DK0871454T3 (da) | Phosphorholdige inhibitorer af cystein- og serinprotease | |
| NO990548L (no) | Inhibitorer for cystein-protease | |
| DE69819349D1 (de) | 1-amino-7-isochinolin-derivate als serin protease inhibitoren | |
| DE69832268D1 (en) | Peptidyl-2-amino-1hydroxyalkansulfonsäuren als cystein-protease-inhibitoren | |
| DK204290D0 (da) | Enzymatisk detergentkomposition og fremgangsmaade til enzymstabilisering | |
| UY27972A1 (es) | Derivados de hidantoína | |
| MX9703564A (es) | Inhibidores de proteasa multicatalitica. | |
| DK0691988T3 (da) | Inhibitor af stamcelleproliferation og anvendelser deraf | |
| DK1084146T3 (da) | Hybridprotein til inhibering af degranuleringen af mastocyter og anvendelse deraf | |
| NO992734D0 (no) | Serin-protease inhibitorer | |
| DE69705838D1 (de) | Substrate und inhibitoren von proteolytischen enzymen | |
| NO983688D0 (no) | Serin-protease-inhibitorer | |
| NO964416D0 (no) | Fremgangsmåter for å fremstille effektive rekombinante serin protease inhibitorer og anvendelser av disse inhibitorene | |
| TR199902751T2 (xx) | Proteaz inhibit�rleri. | |
| DK0784677T3 (da) | Inhibitor af stamcelle-proliferation og anvendelser deraf | |
| KR960701085A (ko) | 단백 분해 효소 억제 활성을 지닌 펩티드 보론산 유도체(peptide boronic acid derivatives having protease inhibiting activity) | |
| ATE277074T1 (de) | Serine-protease-inhibitoren | |
| DE69714222D1 (de) | Serine-protease-inhibitoren | |
| NO20002848D0 (no) | Nye forbindelser | |
| DE69941152D1 (de) | Hydroxamat-enthaltende inhibitoren der cystein- und serinproteasen | |
| DK0941975T3 (da) | Injiceringscement indeholdende korrosionshæmmere | |
| MX9805948A (es) | Substratos e inhibidores para proteasa de cisteina ich-1. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |