NO990832L - Syntese av bis-endolylmaleimider - Google Patents
Syntese av bis-endolylmaleimiderInfo
- Publication number
- NO990832L NO990832L NO990832A NO990832A NO990832L NO 990832 L NO990832 L NO 990832L NO 990832 A NO990832 A NO 990832A NO 990832 A NO990832 A NO 990832A NO 990832 L NO990832 L NO 990832L
- Authority
- NO
- Norway
- Prior art keywords
- endolylmaleimides
- bis
- synthesis
- reaction
- optionally substituted
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- ZOAMBXDOGPRZLP-UHFFFAOYSA-N indole-3-acetamide Chemical class C1=CC=C2C(CC(=O)N)=CNC2=C1 ZOAMBXDOGPRZLP-UHFFFAOYSA-N 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
- C07D207/408—Radicals containing only hydrogen and carbon atoms attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2412096P | 1996-08-23 | 1996-08-23 | |
| PCT/US1997/014771 WO1998007693A1 (en) | 1996-08-23 | 1997-08-22 | Synthesis of bisindolylmalimides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO990832D0 NO990832D0 (no) | 1999-02-22 |
| NO990832L true NO990832L (no) | 1999-04-13 |
Family
ID=21818966
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO990832A NO990832L (no) | 1996-08-23 | 1999-02-22 | Syntese av bis-endolylmaleimider |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US5990319A (ja) |
| EP (1) | EP0825190A1 (ja) |
| JP (1) | JP2000516632A (ja) |
| KR (1) | KR20000068323A (ja) |
| CN (1) | CN1228082A (ja) |
| AU (1) | AU716840B2 (ja) |
| BR (1) | BR9711363A (ja) |
| CA (1) | CA2263862A1 (ja) |
| EA (1) | EA001392B1 (ja) |
| HU (1) | HUP0003203A3 (ja) |
| IL (1) | IL128376A0 (ja) |
| NO (1) | NO990832L (ja) |
| NZ (1) | NZ334030A (ja) |
| PL (1) | PL331899A1 (ja) |
| WO (1) | WO1998007693A1 (ja) |
| YU (1) | YU9499A (ja) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR017200A1 (es) | 1997-12-23 | 2001-08-22 | Astrazeneca Ab | Compuestos inhibidores de la proteina cinasa c, sales farmaceuticamente aceptables de los mismos, formulaciones farmaceuitcas que los comprenden, usode las mismas y proceso para la sintesis de dichos compuestos |
| SE9800835D0 (sv) | 1998-03-13 | 1998-03-13 | Astra Ab | New Compounds |
| US6492406B1 (en) | 1999-05-21 | 2002-12-10 | Astrazeneca Ab | Pharmaceutically active compounds |
| SI1846406T1 (sl) | 2005-02-09 | 2011-02-28 | Arqule Inc | Maleimidni derivati, farmacevtski sestavki in postopki za zdravljenje raka |
| EP2173724B1 (en) | 2007-06-22 | 2012-12-05 | ArQule, Inc. | Quinazolinone compounds and methods of use thereof |
| WO2009002807A2 (en) | 2007-06-22 | 2008-12-31 | Arqule, Inc. | Indolyl pyrrolidines for the treatment of cancer |
| CN101801961B (zh) | 2007-06-22 | 2014-09-24 | 艾科尔公司 | 吡咯烷酮、吡咯烷-2,5-二酮、吡咯烷和硫代琥珀酰亚胺衍生物、组合物以及治疗癌症的方法 |
| FR2927075A1 (fr) * | 2008-02-04 | 2009-08-07 | Centre Nat Rech Scient | Molecules comprenant un squelette bis-(heteroaryl)maleimide, et leur utilisation dans l'inhibition d'enzymes |
| CN104379144A (zh) * | 2012-04-23 | 2015-02-25 | 艾科尔公司 | 高度纯的吡咯并喹啉基-吡咯-2,5-二酮和吡咯并喹啉基-吡咯烷-2,5-二酮及其制备方法 |
| CN104496970B (zh) * | 2014-12-17 | 2017-01-11 | 河南师范大学 | 3,4-二(3-吲哚)-2,5-二酮-3-吡咯啉亚胺类化合物及其制备方法和应用 |
| CN104710412B (zh) * | 2015-03-27 | 2017-03-22 | 河南师范大学 | 具有抗癌活性的3,4‑二（3‑吲哚）‑2,5‑二酮‑1‑吡咯胺硫脲类化合物及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL89167A (en) * | 1988-02-10 | 1994-02-27 | Hoffmann La Roche | Substituted pyrroles, their manufacture and pharmaceutical compositions containing them |
| GB9123396D0 (en) * | 1991-11-04 | 1991-12-18 | Hoffmann La Roche | A process for the manufacture of substituted maleimides |
| US5339712A (en) * | 1993-10-25 | 1994-08-23 | Daryoush Keyvani | Hand tool having offset work elements |
| US5541347A (en) * | 1993-12-07 | 1996-07-30 | Eli Lilly And Company | Synthesis of bisindolylmaleimides |
| US5624949A (en) * | 1993-12-07 | 1997-04-29 | Eli Lilly And Company | Protein kinase C inhibitors |
| US5559228A (en) * | 1995-03-30 | 1996-09-24 | Eli Lilly And Company | Synthesis of bisindolylmaleimides |
-
1997
- 1997-08-22 WO PCT/US1997/014771 patent/WO1998007693A1/en not_active Ceased
- 1997-08-22 HU HU0003203A patent/HUP0003203A3/hu unknown
- 1997-08-22 CN CN97197361A patent/CN1228082A/zh active Pending
- 1997-08-22 AU AU41570/97A patent/AU716840B2/en not_active Ceased
- 1997-08-22 EA EA199900221A patent/EA001392B1/ru not_active IP Right Cessation
- 1997-08-22 CA CA002263862A patent/CA2263862A1/en not_active Abandoned
- 1997-08-22 US US08/917,052 patent/US5990319A/en not_active Expired - Fee Related
- 1997-08-22 KR KR1019997001485A patent/KR20000068323A/ko not_active Withdrawn
- 1997-08-22 NZ NZ334030A patent/NZ334030A/xx unknown
- 1997-08-22 EP EP97306438A patent/EP0825190A1/en not_active Withdrawn
- 1997-08-22 YU YU9499A patent/YU9499A/sh unknown
- 1997-08-22 IL IL12837697A patent/IL128376A0/xx unknown
- 1997-08-22 JP JP10510991A patent/JP2000516632A/ja active Pending
- 1997-08-22 PL PL97331899A patent/PL331899A1/xx unknown
- 1997-08-22 BR BR9711363A patent/BR9711363A/pt unknown
-
1998
- 1998-05-19 US US09/081,252 patent/US5948907A/en not_active Expired - Fee Related
-
1999
- 1999-02-22 NO NO990832A patent/NO990832L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU716840B2 (en) | 2000-03-09 |
| YU9499A (sh) | 2000-03-21 |
| BR9711363A (pt) | 1999-08-17 |
| KR20000068323A (ko) | 2000-11-25 |
| CA2263862A1 (en) | 1998-02-26 |
| EA199900221A1 (ru) | 1999-08-26 |
| NZ334030A (en) | 2000-08-25 |
| IL128376A0 (en) | 2000-01-31 |
| PL331899A1 (en) | 1999-08-16 |
| EA001392B1 (ru) | 2001-02-26 |
| US5948907A (en) | 1999-09-07 |
| HUP0003203A2 (hu) | 2001-06-28 |
| WO1998007693A1 (en) | 1998-02-26 |
| JP2000516632A (ja) | 2000-12-12 |
| HUP0003203A3 (en) | 2002-01-28 |
| AU4157097A (en) | 1998-03-06 |
| US5990319A (en) | 1999-11-23 |
| EP0825190A1 (en) | 1998-02-25 |
| CN1228082A (zh) | 1999-09-08 |
| NO990832D0 (no) | 1999-02-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |