NO986158D0 - Enzymatisk fjernbare linkere for fastfase-synteser - Google Patents
Enzymatisk fjernbare linkere for fastfase-synteserInfo
- Publication number
- NO986158D0 NO986158D0 NO986158A NO986158A NO986158D0 NO 986158 D0 NO986158 D0 NO 986158D0 NO 986158 A NO986158 A NO 986158A NO 986158 A NO986158 A NO 986158A NO 986158 D0 NO986158 D0 NO 986158D0
- Authority
- NO
- Norway
- Prior art keywords
- linker
- solid phase
- bound
- spacer
- synthesized
- Prior art date
Links
- 239000007790 solid phase Substances 0.000 title abstract 6
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 3
- 108090000790 Enzymes Proteins 0.000 abstract 3
- 150000002894 organic compounds Chemical class 0.000 abstract 3
- 125000006850 spacer group Chemical group 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- USYNNOOUZJVHHX-UHFFFAOYSA-N 2-acetyloxy-5-(hydroxymethyl)benzoic acid Chemical compound CC(=O)OC1=CC=C(CO)C=C1C(O)=O USYNNOOUZJVHHX-UHFFFAOYSA-N 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 229920002401 polyacrylamide Polymers 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B80/00—Linkers or spacers specially adapted for combinatorial chemistry or libraries, e.g. traceless linkers or safety-catch linkers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B61/00—Other general methods
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
- Y10S530/815—Carrier is a synthetic polymer
- Y10S530/816—Attached to the carrier via a bridging agent
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19626762A DE19626762A1 (de) | 1996-07-03 | 1996-07-03 | Enzymatisch spaltbare Linker für Festphasensynthesen |
| PCT/EP1997/003379 WO1998001406A1 (de) | 1996-07-03 | 1997-06-27 | Enzymatisch spaltbare linker für festphasensynthesen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO986158D0 true NO986158D0 (no) | 1998-12-28 |
| NO986158L NO986158L (no) | 1998-12-30 |
Family
ID=7798802
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO986158A NO986158L (no) | 1996-07-03 | 1998-12-28 | Enzymatisk fjernbare linkere for fastfase-synteser |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6271345B1 (no) |
| EP (1) | EP0914307B1 (no) |
| JP (1) | JP2000514432A (no) |
| AT (1) | ATE276218T1 (no) |
| AU (1) | AU3438597A (no) |
| BR (1) | BR9710190A (no) |
| CA (1) | CA2258551A1 (no) |
| CZ (1) | CZ432798A3 (no) |
| DE (2) | DE19626762A1 (no) |
| IL (1) | IL127556A (no) |
| NO (1) | NO986158L (no) |
| RU (1) | RU2198155C2 (no) |
| WO (1) | WO1998001406A1 (no) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6582726B1 (en) | 2000-06-21 | 2003-06-24 | Smithkline Beecham Corporation | Cross linked solid supports for solid phase synthesis |
| EP1352243A4 (en) * | 2001-01-12 | 2008-07-02 | Ge Healthcare Ltd | PERFLUOR SULFONYLHALOGENIDES AND RELATED SPECIES AS MODIFICATORS POLYMERIC SUPPORTS |
| WO2002095044A2 (en) * | 2001-05-21 | 2002-11-28 | Molecular Electronics Corporation | Lipase catalyzed esterification, transesterification, and hydrolysis of arylthiols and aryl-thioesters |
| WO2004062598A2 (en) * | 2003-01-13 | 2004-07-29 | Beta Pharma, Inc. | Anti-inflammatory and anti-thrombotic compounds and their compositions |
| EP1631597A4 (en) * | 2003-05-22 | 2007-07-11 | Gryphon Therapeutics Inc | SOLID PHASE CHEMICAL LIGATION CARRIED OUT WITH A MOBILE BONDING AGENT |
| DE502005006284D1 (de) * | 2004-05-24 | 2009-01-29 | Basf Se | Keratin-bindende polypeptide |
| US7968085B2 (en) * | 2004-07-05 | 2011-06-28 | Ascendis Pharma A/S | Hydrogel formulations |
| ES2530190T3 (es) | 2007-06-20 | 2015-02-27 | Basf Se | Proteínas repetitivas sintéticas, su producción y su uso |
| CN101842118B (zh) * | 2007-09-13 | 2012-08-08 | 巴斯夫欧洲公司 | 疏水蛋白多肽作为渗透增强剂的用途 |
| AU2010277560B2 (en) | 2009-07-31 | 2014-12-11 | Sanofi-Aventis Deutschland Gmbh | Long acting insulin composition |
| SG178193A1 (en) | 2009-07-31 | 2012-03-29 | Sanofi Aventis Deutschland | Prodrugs comprising an insulin linker conjugate |
| EP2498763A4 (en) | 2009-11-09 | 2015-10-07 | Spotlight Technology Partners Llc | HYDROGELS BASED ON POLYSACCHARIDE |
| JP2013509963A (ja) | 2009-11-09 | 2013-03-21 | スポットライト テクノロジー パートナーズ エルエルシー | 断片化ヒドロゲル |
| EP2438930A1 (en) | 2010-09-17 | 2012-04-11 | Sanofi-Aventis Deutschland GmbH | Prodrugs comprising an exendin linker conjugate |
| US20140155272A1 (en) * | 2012-12-04 | 2014-06-05 | Src, Inc. | Use Of Diatomaceous Earth As The Base Substrate For Nucleic Acid Tags |
| WO2017214145A1 (en) * | 2016-06-06 | 2017-12-14 | The Regents Of The University Of California | Methods for detecting oligonucleotides in a sample |
| WO2023102255A1 (en) * | 2021-12-03 | 2023-06-08 | Massachusetts Institute Of Technology | Peptide-encoded libraries of small molecules for de novo drug discovery |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5650489A (en) | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
| US5288514A (en) | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
| US5324483B1 (en) | 1992-10-08 | 1996-09-24 | Warner Lambert Co | Apparatus for multiple simultaneous synthesis |
| US5635598A (en) * | 1993-06-21 | 1997-06-03 | Selectide Corporation | Selectively cleavabe linners based on iminodiacetic acid esters for solid phase peptide synthesis |
| EP0734398B1 (en) | 1993-12-15 | 2002-02-27 | Smithkline Beecham Corporation | Compounds and methods |
| US5369017A (en) | 1994-02-04 | 1994-11-29 | The Scripps Research Institute | Process for solid phase glycopeptide synthesis |
| AU691296B2 (en) | 1994-05-06 | 1998-05-14 | Pharmacopeia Drug Discovery, Inc. | Combinatorial dihydrobenzopyran library |
| US5549974A (en) | 1994-06-23 | 1996-08-27 | Affymax Technologies Nv | Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof |
| AU2871195A (en) | 1994-06-23 | 1996-01-19 | Affymax Technologies N.V. | Methods for the synthesis of diketopiperazines |
| JP2000502068A (ja) * | 1995-12-07 | 2000-02-22 | ジェンザイム・リミテッド | 固相有機合成 |
-
1996
- 1996-07-03 DE DE19626762A patent/DE19626762A1/de not_active Withdrawn
-
1997
- 1997-06-27 US US09/214,100 patent/US6271345B1/en not_active Expired - Fee Related
- 1997-06-27 WO PCT/EP1997/003379 patent/WO1998001406A1/de active IP Right Grant
- 1997-06-27 IL IL12755697A patent/IL127556A/xx not_active IP Right Cessation
- 1997-06-27 AU AU34385/97A patent/AU3438597A/en not_active Abandoned
- 1997-06-27 BR BR9710190A patent/BR9710190A/pt unknown
- 1997-06-27 JP JP10504716A patent/JP2000514432A/ja not_active Withdrawn
- 1997-06-27 RU RU99101933/04A patent/RU2198155C2/ru not_active IP Right Cessation
- 1997-06-27 CZ CZ984327A patent/CZ432798A3/cs unknown
- 1997-06-27 EP EP97930430A patent/EP0914307B1/de not_active Expired - Lifetime
- 1997-06-27 AT AT97930430T patent/ATE276218T1/de not_active IP Right Cessation
- 1997-06-27 CA CA002258551A patent/CA2258551A1/en not_active Abandoned
- 1997-06-27 DE DE59711916T patent/DE59711916D1/de not_active Expired - Fee Related
-
1998
- 1998-12-28 NO NO986158A patent/NO986158L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US6271345B1 (en) | 2001-08-07 |
| AU3438597A (en) | 1998-02-02 |
| NO986158L (no) | 1998-12-30 |
| JP2000514432A (ja) | 2000-10-31 |
| EP0914307A1 (de) | 1999-05-12 |
| CZ432798A3 (cs) | 1999-03-17 |
| IL127556A0 (en) | 1999-10-28 |
| ATE276218T1 (de) | 2004-10-15 |
| DE59711916D1 (de) | 2004-10-21 |
| IL127556A (en) | 2003-10-31 |
| EP0914307B1 (de) | 2004-09-15 |
| WO1998001406A1 (de) | 1998-01-15 |
| BR9710190A (pt) | 1999-08-10 |
| DE19626762A1 (de) | 1998-01-08 |
| RU2198155C2 (ru) | 2003-02-10 |
| CA2258551A1 (en) | 1998-01-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO986158D0 (no) | Enzymatisk fjernbare linkere for fastfase-synteser | |
| ATE251174T1 (de) | Synthese von markierten oligonucleotiden auf festphasenträgern | |
| EP1547998A4 (en) | NOVEL COMPOSITION CONTAINING AN ACYL GROUP | |
| DK0861223T3 (da) | Fremgangsmåde til syntese af curcumin-relaterede forbindelser | |
| Holzapfel et al. | Antineoplastic agents. Par 108. Structural biochemistry. Part 23. Synthesis of the dolastatin thiazole amino acid component (gln) Thz | |
| EA200200253A1 (ru) | Ингибиторы клеточной адгезии | |
| DK0751144T3 (da) | Nye antracyclin-pro-drugs, fremgangsmåde til fremstilling deraf samt antitumorsammensætninger og et komponentkit indeholdende disse pro-drugs | |
| Guo et al. | Synthesis and evaluation of a cyclic imine derivative conjugated to a fluorescent molecule for labeling of proteins | |
| Chandrasekhar et al. | Proline–threonine dipeptide as an organocatalyst for the direct asymmetric aldol reaction | |
| RU99101933A (ru) | Ферментативно отщепляемые линкеры для твердофазных синтезов | |
| Goodfellow et al. | p-Nitrophenyl 3-diazopyruvate and diazopyruvamides, a new family of photoactivatable cross-linking bioprobes | |
| Fujita et al. | An efficient and stereoselective synthesis of platelet-activating factors and the enantiomers from d-and l-tartaric acids | |
| PL355159A1 (en) | Process of synthesis of (2s, 3as, 7ss)-1-[(s)-alanyle]-octahydro-1h-indole-2-carboxylic acid compounds and their application in perindopril synthesis | |
| DE60309019D1 (de) | Verfahren zur herstellung von peptidamiden durch seitenkettenanknüpfung an einer festphase | |
| EA200000900A1 (ru) | Способ получения защищенного 4-аминометилпирролидин-3-она | |
| Débieux et al. | The all-photochemical synthesis of an OGP (10–14) precursor | |
| Paradisi et al. | Proline–glutamate chimeras in isopeptides. Synthesis and biological evaluation of conformationally restricted glutathione analogues | |
| MY118006A (en) | Process for the preparation of e-caprolactam | |
| EA200000413A1 (ru) | Способ синтеза пирроламидов | |
| DK1100768T3 (da) | Fremgangsmåde til fremstilling af R-(-)-carnitin | |
| CA2194119A1 (en) | Process for the preparation of 2-substituted 5-chloroimidazole-4-carbaldehydes | |
| EP1340743A4 (en) | OPTICALLY ACTIVE AMINO DERIVATIVE AND METHOD OF SYNTHESIS | |
| ATE243707T1 (de) | Organische festphasensynthese | |
| Enders et al. | Synthesis of β-Benzylsulfanyl-β-trifluoromethyl-α-amino Acids Via Michael Addition in the Presence of Et3N/LiBr | |
| BR9808278A (pt) | Sequências de ácido nucleico isolado, de proteìna isolada e de dna, célula de planta transformada, e, planta |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |