NO985066L - Terapeutisk behandling for VEGF-relaterte sykdommer - Google Patents
Terapeutisk behandling for VEGF-relaterte sykdommerInfo
- Publication number
- NO985066L NO985066L NO985066A NO985066A NO985066L NO 985066 L NO985066 L NO 985066L NO 985066 A NO985066 A NO 985066A NO 985066 A NO985066 A NO 985066A NO 985066 L NO985066 L NO 985066L
- Authority
- NO
- Norway
- Prior art keywords
- vegf
- therapeutic treatment
- related diseases
- stimulated
- neoplasia
- Prior art date
Links
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 title abstract 3
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 title abstract 3
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010037423 Pulmonary oedema Diseases 0.000 abstract 1
- 230000004856 capillary permeability Effects 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 210000002889 endothelial cell Anatomy 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000009826 neoplastic cell growth Effects 0.000 abstract 1
- 208000005333 pulmonary edema Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Fremgangsmåte for inhibering av VEGF-stimulert endotelcellevekst, slik som forbundet med neoplasi, og VEGF- stimulert kapillarpermeabilitet, slik som forbundet med pulmonalt ødem, er beskrevet, særlig under anvendelse av p-isozymet som er selektivt for PKC- inhibitoren (S)-3,4-[N,N'-l,l'-((2' '- etoksy)-3'''(O)-4r''-(N,N-dimetyl- amino)-butan)-bis-(3,3'-indolyl)]-l(H)- pyrrol-2,5-dionhydrokloridsalt.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1665896P | 1996-05-01 | 1996-05-01 | |
US84163597A | 1997-04-30 | 1997-04-30 | |
PCT/US1997/007752 WO1997040830A1 (en) | 1996-05-01 | 1997-05-01 | Therapeutic treatment for vegf related diseases |
Publications (2)
Publication Number | Publication Date |
---|---|
NO985066D0 NO985066D0 (no) | 1998-10-30 |
NO985066L true NO985066L (no) | 1998-12-21 |
Family
ID=26688913
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO985066A NO985066L (no) | 1996-05-01 | 1998-10-30 | Terapeutisk behandling for VEGF-relaterte sykdommer |
Country Status (15)
Country | Link |
---|---|
US (1) | US6284751B1 (no) |
EP (1) | EP0915698A4 (no) |
JP (1) | JP2002504086A (no) |
KR (1) | KR20000065171A (no) |
CN (1) | CN1233177A (no) |
AU (1) | AU736333B2 (no) |
BR (1) | BR9710706A (no) |
CA (1) | CA2253608A1 (no) |
CZ (1) | CZ350098A3 (no) |
EA (1) | EA001779B1 (no) |
IL (1) | IL126837A0 (no) |
NO (1) | NO985066L (no) |
NZ (1) | NZ332645A (no) |
PL (1) | PL329851A1 (no) |
WO (1) | WO1997040830A1 (no) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6093740A (en) * | 1997-04-30 | 2000-07-25 | Eli Lilly And Company | Therapeutic treatment for skin disorders |
US6103712A (en) * | 1998-03-05 | 2000-08-15 | Eli Lilly And Company | Therapeutic treatment for asthma |
US6103713A (en) * | 1998-03-05 | 2000-08-15 | Eli Lilly And Company | Therapeutic treatment for autoimmune diseases |
US6979441B2 (en) * | 1998-09-16 | 2005-12-27 | Wilson T Crandall | Method for topical treatment of carpal tunnel syndrome |
US6306383B1 (en) * | 1998-09-16 | 2001-10-23 | Wilson T Crandall | Method for topical treatment of scars with protein kinase C inhibitors |
US6921763B2 (en) | 1999-09-17 | 2005-07-26 | Abbott Laboratories | Pyrazolopyrimidines as therapeutic agents |
IL151045A0 (en) | 2000-02-07 | 2003-04-10 | Abbott Gmbh & Co Kg | 2-benzothiazolyl urea derivatives and their use as protein kinase inhibitors |
AU2001296558A1 (en) | 2000-10-03 | 2002-04-15 | Oncopharmaceutical, Inc. | Inhibitors of angiogenesis and tumor growth for local and systemic administration |
US6875165B2 (en) | 2001-02-22 | 2005-04-05 | Retinalabs, Inc. | Method of radiation delivery to the eye |
MXPA03008560A (es) | 2001-03-22 | 2004-06-30 | Abbot Gmbh & Co Kg | Pirazolopirimidinas como agentes terapeuticos. |
CN102813923B (zh) | 2003-08-27 | 2015-04-01 | 奥普索特克公司 | 用于治疗眼新血管疾病的组合治疗 |
CN101005873B (zh) * | 2004-02-12 | 2010-07-21 | 内奥维斯塔公司 | 用于眼内近程治疗的设备 |
EP1734996B1 (en) | 2004-04-02 | 2013-05-22 | The Regents of The University of California | Methods and compositions for treating and preventing disease associated with alpha v beta 5 integrin |
EP1740591B1 (en) | 2004-04-02 | 2009-06-17 | OSI Pharmaceuticals, Inc. | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors |
US7795205B2 (en) * | 2004-04-12 | 2010-09-14 | Canyon Pharmaceuticals, Inc. | Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor |
TW200613306A (en) | 2004-07-20 | 2006-05-01 | Osi Pharm Inc | Imidazotriazines as protein kinase inhibitors |
AU2006313724B2 (en) * | 2005-11-14 | 2010-12-23 | Universitat Zurich | Staurosporine derivatives for use in alveolar rhabdomyosarcoma |
JP2009515655A (ja) | 2005-11-15 | 2009-04-16 | ネオビスタ、インコーポレイテッド | 眼内近接照射療法のための方法および装置 |
AR057960A1 (es) | 2005-12-02 | 2007-12-26 | Osi Pharm Inc | Inhibidores de proteina quinasa biciclicos |
AU2014201660B2 (en) * | 2007-10-19 | 2015-09-03 | Centre Hospitalier Universitaire De Bordeaux | Use of a beta blocker for the manufacture of a medicament for the treatment of hemangiomas |
US8987262B2 (en) | 2007-10-19 | 2015-03-24 | Universite de Bordeaux | Use of a beta blocker for the manufacture of a medicament for the treatment of hemangiomas |
EP2050441A1 (en) | 2007-10-19 | 2009-04-22 | Université Victor Segalen Bordeaux 2 | Use of beta blocker for the manufacture of a medicament for the treatment of hemangiomas |
AU2009256236A1 (en) | 2008-06-04 | 2009-12-10 | Neovista, Inc. | Handheld radiation delivery system for advancing a radiation source wire |
EP2758079A4 (en) * | 2011-09-21 | 2015-05-13 | Univ North Carolina | PROCESS WITH BIOMARKERS FOR LIVER DISEASE |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ227850A (en) | 1988-02-10 | 1991-11-26 | Hoffmann La Roche | Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders |
EP0699204B1 (en) * | 1993-05-28 | 1998-04-15 | Cephalon, Inc. | Use of indolocarbazole derivatives to treat a pathological condition of the prostate |
UA44690C2 (uk) * | 1993-12-07 | 2002-03-15 | Елі Ліллі Енд Компані | Макроциклічна сполука іміду біс-індол-малеїнової кислоти, спосіб її одержання та фармацевтична композиція, макроциклічні сполуки іміду біс-індол-малеїнової кислоти та біс-індол-малеїнового ангідриду, спосіб одержання (варіанти) |
US5624949A (en) | 1993-12-07 | 1997-04-29 | Eli Lilly And Company | Protein kinase C inhibitors |
JPH07238044A (ja) | 1993-12-07 | 1995-09-12 | Eli Lilly & Co | ビスインドリルマレイミドの改良合成法 |
US5545636A (en) | 1993-12-23 | 1996-08-13 | Eli Lilly And Company | Protein kinase C inhibitors |
US5491242A (en) | 1994-06-22 | 1996-02-13 | Eli Lilly And Company | Protein kinase C inhibitors |
US5481003A (en) | 1994-06-22 | 1996-01-02 | Eli Lilly And Company | Protein kinase C inhibitors |
-
1997
- 1997-05-01 CN CN97196010A patent/CN1233177A/zh active Pending
- 1997-05-01 KR KR1019980708798A patent/KR20000065171A/ko not_active Application Discontinuation
- 1997-05-01 AU AU29355/97A patent/AU736333B2/en not_active Ceased
- 1997-05-01 WO PCT/US1997/007752 patent/WO1997040830A1/en not_active Application Discontinuation
- 1997-05-01 CZ CZ983500A patent/CZ350098A3/cs unknown
- 1997-05-01 BR BR9710706A patent/BR9710706A/pt not_active IP Right Cessation
- 1997-05-01 PL PL97329851A patent/PL329851A1/xx unknown
- 1997-05-01 EP EP97923587A patent/EP0915698A4/en not_active Withdrawn
- 1997-05-01 JP JP53929397A patent/JP2002504086A/ja active Pending
- 1997-05-01 CA CA002253608A patent/CA2253608A1/en not_active Abandoned
- 1997-05-01 NZ NZ332645A patent/NZ332645A/xx unknown
- 1997-05-01 EA EA199800969A patent/EA001779B1/ru not_active IP Right Cessation
- 1997-05-01 IL IL12683797A patent/IL126837A0/xx not_active IP Right Cessation
-
1998
- 1998-10-30 NO NO985066A patent/NO985066L/no not_active Application Discontinuation
-
1999
- 1999-06-18 US US09/335,887 patent/US6284751B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EA001779B1 (ru) | 2001-08-27 |
CA2253608A1 (en) | 1997-11-06 |
NZ332645A (en) | 2000-07-28 |
AU736333B2 (en) | 2001-07-26 |
US6284751B1 (en) | 2001-09-04 |
PL329851A1 (en) | 1999-04-12 |
EP0915698A4 (en) | 1999-08-11 |
KR20000065171A (ko) | 2000-11-06 |
JP2002504086A (ja) | 2002-02-05 |
BR9710706A (pt) | 1999-08-17 |
WO1997040830A1 (en) | 1997-11-06 |
NO985066D0 (no) | 1998-10-30 |
EA199800969A1 (ru) | 1999-06-24 |
EP0915698A1 (en) | 1999-05-19 |
CZ350098A3 (cs) | 1999-11-17 |
CN1233177A (zh) | 1999-10-27 |
AU2935597A (en) | 1997-11-19 |
IL126837A0 (en) | 1999-09-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |